G protein ?2 subunit antisense oligonucleotides inhibit cell proliferation and disorganize microtubule and mitotic spindle organization

2001 ◽  
Vol 83 (1) ◽  
pp. 136-146 ◽  
Author(s):  
Han-Chung Wu ◽  
Pie-Hsien Huang ◽  
Chien-Yu Chiu ◽  
Chin-Tarng Lin
Keyword(s):  
Cell Proliferation ◽  
G Protein ◽  
Mitotic Spindle ◽  
Antisense Oligonucleotides ◽  
Inhibit Cell Proliferation

Adhesion barriers inhibit cell proliferation, adhesion and invasion of primary endometriosis cells

2014 ◽  
Vol 74 (S 01) ◽  
Author(s):  
SP Renner ◽  
MW Beckmann ◽  
S Burghaus ◽  
R Strick ◽  
PL Strissel ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Adhesion And Invasion ◽  
Inhibit Cell Proliferation

Antisense oligonucleotides against aldehyde dehydrogenase 3 inhibit hepatoma cell proliferation by affecting MAP kinases

2003 ◽  
Vol 143-144 ◽  
pp. 37-43 ◽  
Author(s):  
Giuliana Muzio ◽  
Antonella Trombetta ◽  
Germana Martinasso ◽  
Rosa A Canuto ◽  
Marina Maggiora
Keyword(s):  
Cell Proliferation ◽  
Aldehyde Dehydrogenase ◽  
Antisense Oligonucleotides ◽  
Map Kinases ◽  
Hepatoma Cell

Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors

2014 ◽  
Vol 42 (5) ◽  
pp. 1372-1377 ◽  
Author(s):  
Emily L. Ruban ◽  
Riccardo Ferro ◽  
Syamsul Ahmad Arifin ◽  
Marco Falasca
Keyword(s):  
Cell Proliferation ◽  
G Protein ◽  
Cancer Progression ◽  
Multidrug Resistance Protein 1 ◽  
Autocrine Loop ◽  
Cell Functions ◽  
Cytosolic Phospholipase ◽  
Signalling Cascades ◽  
Novel Strategy ◽  
G Protein Coupled

Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumorigenesis. Our previous work suggested that LPI is involved in cancer progression since it can be released in the medium of Ras-transformed fibroblasts and can function as an autocrine modulator of cell growth. Different research groups have established that LPI is the specific and functional ligand for G-protein-coupled receptor 55 (GPR55) and that this GPR55–LPI axis is able to activate signalling cascades that are relevant for different cell functions. Work in our laboratory has recently unravelled an autocrine loop, by which LPI synthesized by cytosolic phospholipase A2 (cPLA2) is pumped out of the cell by ATP-binding cassette (ABC) transporter C1 (ABCC1)/multidrug resistance protein 1 (MRP1), initiating a signalling cascade downstream of GPR55. Our current work suggests that blockade of this pathway may represent a novel strategy to inhibit cancer cell proliferation.

Polyamide Amine Dendrimer Nanoparticles Conjugated with Cis-Diamminedichloroplatinum (CDDP) and miRNA-200c Inhibitor Suppresses Lung Cancer Cell Proliferation

2021 ◽  
Vol 11 (9) ◽  
pp. 1760-1768
Author(s):  
Fang Zhang ◽  
Jili Zou ◽  
Dandan Huang
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Targeting Delivery ◽  
Apoptosis Related Protein ◽  
Related Proteins ◽  
Exclusion Method ◽  
Inhibit Cell Proliferation ◽  
Excellent Stability

Our study elucidates the effect of folate polyamide amine dendrimer nanoparticles targeting delivery of miRNA-200c inhibitor and CDDP on lung cancer cells proliferation. We established polyamide amine dendrimer nanoparticles binding with CDDP and miRNA-200c inhibitor (Den-PEI-CDDP-siRNA-FA), TEM was employed to detect the morphology of nanoparticles. Agarose gel assay was selected for stabilization test. Cell proliferation were detected by trypanosoma blue exclusion method. The expression of miRNA-200c targeted APKPA12 and apoptosis-related proteins were detected by Western blot and PCR. Finally, apoptosis was analyzed by flow cytometry. Den-PEI-CDDP-siRNA-FA nanoparticles showed excellent stability and drug encapsulation ability. Nanoparticles targeting for FRA to co-deliver siRNA and CDDP could significantly promote cell apoptosis, increase apoptosis-related protein expression, and inhibit cell proliferation. Besides, nanoparticles exerted less venomous effect than untargeted nanoparticles in MRC9 lung fibroblast. Den nanoparticle targeting FRA might be used as the carrier for joint applications with siRNA and CDDP for treating lung cancer.

scholarly journals Role of Antioxidant Vitamins in Neurogenesis

2021 ◽  
Vol 15 (1) ◽  
pp. 11
Author(s):  
Shreyashish Roy-Chowdhury ◽  
Daivat Bhavsar ◽  
Jasrita Singh ◽  
Austin Mardon
Keyword(s):  
Cell Proliferation ◽  
Neural Differentiation ◽  
Scientific Evidence ◽  
Antioxidant Vitamins ◽  
Antioxidant Vitamin ◽  
Regulatory Factor ◽  
Functional Aspects ◽  
Cycle Regulation ◽  
Inhibit Cell Proliferation

Neurogenesis is vital in the preservation of cognition. Previous studies have reported antioxidant vitamins as a key regulatory factor in neurogenesis. However, current research investigating their role is inconclusive due to the limited number of studies that have been conducted and conflicting results. This review evaluates the scientific evidence behind the potential roles of antioxidant vitamins in neurogenesis. Observations concerned with the mechanistic and functional aspects of how antioxidant vitamins modulate neurogenesis are both assessed. Vitamin A is evidently involved in cell cycle regulation and cell proliferation; vitamin C reportedly promotes neural differentiation and maturation while inhibiting neurite outgrowth; vitamin E is identified to inhibit cell proliferation while improving cell viability. Varying antioxidant vitamin concentrations have been implicated in facilitating cognition in terms of attention, memory, language, and executive function. Moreover, this review suggests a threshold antioxidant vitamin concentration that should be maintained to promote optimal levels of adult neurogenesis.

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