Adhesion barriers inhibit cell proliferation, adhesion and invasion of primary endometriosis cells

Our study elucidates the effect of folate polyamide amine dendrimer nanoparticles targeting delivery of miRNA-200c inhibitor and CDDP on lung cancer cells proliferation. We established polyamide amine dendrimer nanoparticles binding with CDDP and miRNA-200c inhibitor (Den-PEI-CDDP-siRNA-FA), TEM was employed to detect the morphology of nanoparticles. Agarose gel assay was selected for stabilization test. Cell proliferation were detected by trypanosoma blue exclusion method. The expression of miRNA-200c targeted APKPA12 and apoptosis-related proteins were detected by Western blot and PCR. Finally, apoptosis was analyzed by flow cytometry. Den-PEI-CDDP-siRNA-FA nanoparticles showed excellent stability and drug encapsulation ability. Nanoparticles targeting for FRA to co-deliver siRNA and CDDP could significantly promote cell apoptosis, increase apoptosis-related protein expression, and inhibit cell proliferation. Besides, nanoparticles exerted less venomous effect than untargeted nanoparticles in MRC9 lung fibroblast. Den nanoparticle targeting FRA might be used as the carrier for joint applications with siRNA and CDDP for treating lung cancer.

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Euphorbia lunulata extract acts on multidrug resistant gastric cancer cells to inhibit cell proliferation, migration and invasion, arrest cell cycle progression, and induce apoptosis

Journal of Ethnopharmacology ◽

10.1016/j.jep.2017.08.014 ◽

2018 ◽

Vol 212 ◽

pp. 8-17 ◽

Cited By ~ 7

Author(s):

Zhaoying Fu ◽

Xiaodong Han ◽

Juan Du ◽

Xiaoxiao Han ◽

Weipeng Liu ◽

...

Keyword(s):

Gastric Cancer ◽

Cell Cycle ◽

Cell Proliferation ◽

Cell Cycle Progression ◽

Multidrug Resistant ◽

Migration And Invasion ◽

Gastric Cancer Cells ◽

Cycle Progression ◽

Inhibit Cell Proliferation ◽

Arrest Cell Cycle Progression

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MicroRNA‑877 is downregulated in cervical cancer and directly targets MACC1 to inhibit cell proliferation and invasion

Experimental and Therapeutic Medicine ◽

10.3892/etm.2019.7989 ◽

2019 ◽

Cited By ~ 1

Author(s):

Fanxu Meng ◽

Jian Ou ◽

Jinyu Liu ◽

Xindi Li ◽

Yanli Meng ◽

...

Keyword(s):

Cervical Cancer ◽

Cell Proliferation ◽

Proliferation And Invasion ◽

Inhibit Cell Proliferation

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Role of Antioxidant Vitamins in Neurogenesis

Journal of Undergraduate Life Sciences ◽

10.33137/juls.v15i1.37312 ◽

2021 ◽

Vol 15 (1) ◽

pp. 11

Author(s):

Shreyashish Roy-Chowdhury ◽

Daivat Bhavsar ◽

Jasrita Singh ◽

Austin Mardon

Keyword(s):

Cell Proliferation ◽

Neural Differentiation ◽

Scientific Evidence ◽

Antioxidant Vitamins ◽

Antioxidant Vitamin ◽

Regulatory Factor ◽

Functional Aspects ◽

Cycle Regulation ◽

Inhibit Cell Proliferation

Neurogenesis is vital in the preservation of cognition. Previous studies have reported antioxidant vitamins as a key regulatory factor in neurogenesis. However, current research investigating their role is inconclusive due to the limited number of studies that have been conducted and conflicting results. This review evaluates the scientific evidence behind the potential roles of antioxidant vitamins in neurogenesis. Observations concerned with the mechanistic and functional aspects of how antioxidant vitamins modulate neurogenesis are both assessed. Vitamin A is evidently involved in cell cycle regulation and cell proliferation; vitamin C reportedly promotes neural differentiation and maturation while inhibiting neurite outgrowth; vitamin E is identified to inhibit cell proliferation while improving cell viability. Varying antioxidant vitamin concentrations have been implicated in facilitating cognition in terms of attention, memory, language, and executive function. Moreover, this review suggests a threshold antioxidant vitamin concentration that should be maintained to promote optimal levels of adult neurogenesis.

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RNA-guided cell targeting with CRISPR/RfxCas13d collateral activity in human cells

10.1101/2021.11.30.470032 ◽

2021 ◽

Author(s):

Peiguo Shi ◽

Michael R Murphy ◽

Alexis O Aparicio ◽

Jordan S Kesner ◽

Zhou Fang ◽

...

Keyword(s):

Cell Proliferation ◽

Single Cell ◽

State Transition ◽

Cell Types ◽

Rapid Identification ◽

Human Cells ◽

Single Cell Sequencing ◽

Functional Studies ◽

Single Marker ◽

Inhibit Cell Proliferation

While single-cell sequencing has allowed rapid identification of novel cell types or states and associated RNA markers, functional studies remain challenging due to the lack of tools that are able to target specific cells based on these markers. Here we show that targeting a single marker RNA with CRISPR/RfxCas13d led to collateral transcriptome destruction in human cells, which can be harnessed to inhibit cell proliferation or to suppress cell state transition.

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