Process optimisation of encapsulated pandan(Pandanus amaryllifolius) powder using spray-drying method

2005 ◽  
Vol 85 (12) ◽  
pp. 1999-2004 ◽  
Author(s):  
Seng Kean Loh ◽  
Yaakob B Che Man ◽  
Chin Ping Tan ◽  
Azizah Osman ◽  
Nazimah Sheik A Hamid
Keyword(s):  
Spray Drying ◽  
Process Optimisation ◽  
Drying Method ◽  
Pandanus Amaryllifolius

scholarly journals Metode Pengeringan Sari Pandan (Pandanus amaryllifolius) untuk Meningkatkan Kualitas Bubuk Sari Pandan

2022 ◽  
Vol 4 (3) ◽  
pp. 107
Author(s):  
Nurwanto Nurwanto
Keyword(s):  
Content Analysis ◽  
Moisture Content ◽  
Physical Properties ◽  
Water Content ◽  
Spray Drying ◽  
Vacuum Drying ◽  
Powder Form ◽  
Drying Method ◽  
Pandanus Amaryllifolius

Sari pandan merupakan hasil ekstraksi daun pandan. Sari pandan siap pakai yang beredar di Indonesia mayoritas berbentuk pasta, yang memiliki beberapa kelemahan, diantaranya mudah rusak, lengket, dan susah ditakar. Pembuatan sari pandan dalam bentuk bubuk diharapkan dapat meningkatkan mutu sari pandan. Metode yang digunakan dalam penelitian ini adalah pengeringan spray drying dan pengeringan vakum. Pengujian kadar air menunjukkan bahwa sari pandan yang dibuat dengan metode spray drying memiliki kadar air yang lebih rendah daripada metode pengeringan vakum. Pengamatan sifat fisik sari pandan dalam kondisi siap pakai menunjukkan bahwa metode spray drying menghasilkan warna dan aroma sari pandan yang lebih kuat daripada metode pengeringan vakum. Uji organoleptik menunjukkan bahwa panelis lebih menyukai warna dan aroma sari pandan yang dibuat dengan metode spray drying. Pandan extracts is made from pandan leaves. The majority of ready-to-use pandan extracts in Indonesia are in the form of pasta which has several disadvantages, including perishable, sticky, and hard to be measured. Pandan extract in powder form is expected to improve the quality of the pandan extract. The method used in this study are spray drying and vacuum drying. Water content analysis shows that pandan extract made by spray drying method has a lower moisture content than the vacuum drying method. Observation of the physical properties of pandan extract in ready-to-use form showed that the spray drying method produced stronger color and aroma than the vacuum drying  method. Organoleptic tests showed that panelists preferred the color and aroma of pandan extract made using the spray drying method.

scholarly journals Preparation of LiFePO4 Powders by Ultrasonic Spray Drying Method and Their Memory Effect

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3193
Author(s):  
Tu Lan ◽  
Xiaolong Guo ◽  
De Li ◽  
Yong Chen
Keyword(s):  
Spray Drying ◽  
Memory Effect ◽  
Electrode Materials ◽  
Average Particle Size ◽  
Lithium Ion ◽  
Average Particle ◽  
Preparation Process ◽  
Drying Method ◽  
Drying Temperature ◽  
Ultrasonic Spray

The memory effect of lithium-ion batteries (LIBs) was first discovered in LiFePO4, but its origin and dependence are still not clear, which is essential for regulating the memory effect. In this paper, a home-made spray drying device was used to successfully synthesize LiFePO4 with an average particle size of about 1 μm, and we studied the influence of spray drying temperature on the memory effect of LiFePO4 in LIBs. The results showed that the increasing of spray drying temperature made the memory effect of LiFePO4 strengthen from 1.3 mV to 2.9 mV, while the capacity decreased by approximately 6%. The XRD refinement and FTIR spectra indicate that the enhancement of memory effect can be attributed to the increment of Li–Fe dislocations. This work reveals the dependence of memory effect of LiFePO4 on spray drying temperature, which will guide us to optimize the preparation process of electrode materials and improve the management system of LIBs.

scholarly journals Preparation of Ce-doped yttrium aluminum garnet phosphor particles using spray drying method

2020 ◽  
pp. 1-8
Author(s):  
Shao-Ju Shih ◽  
Lewi Peter Richardo ◽  
Kevin Indrawan Sucipto ◽  
Zhi-Meng Wang
Keyword(s):  
Spray Drying ◽  
Yttrium Aluminum Garnet ◽  
Drying Method ◽  
Yttrium Aluminum

Solid dispersion particles of tolbutamide prepared with fine silica particles by the spray-drying method

2004 ◽  
Vol 141 (3) ◽  
pp. 187-195 ◽  
Author(s):  
Hirofumi Takeuchi ◽  
Shinsuke Nagira ◽  
Hiromitsu Yamamoto ◽  
Yoshiaki Kawashima
Keyword(s):  
Spray Drying ◽  
Solid Dispersion ◽  
Silica Particles ◽  
Drying Method

Inhalable Spray Dried Pro-Liposome Powder Containing Budesonide for Pulmonary Delivery

2021 ◽  
Vol 14 (4) ◽  
pp. 5538-5548
Author(s):  
Aliasgar J Kundawala ◽  
Khushbu S Chauhan ◽  
Harsha V Patel ◽  
Swati K Kurtkoti
Keyword(s):  
Drug Release ◽  
Spray Drying ◽  
Entrapment Efficiency ◽  
Geometric Standard Deviation ◽  
Drying Method ◽  
Dry Powder ◽  
Liposomal Drug ◽  
Vesicle Size ◽  
Aerodynamic Properties ◽  
Spray Dried

Budesonide is an anti-asthmatic agent which is used to control the symptoms of asthma like bronchospasm, oedema. Drug delivered to lung through inhalation will provide systemic and local drug delivery at lower dose in chronic and acute diseases. Dry powder inhalers are the best choice for targeting the anti-asthmatic drugs through pulmonary route. The objective of the present study is to prepare inhalable lipid coated budesonide microparticles by spray drying method so effective delivery of budesonide to the lungs can be achieved. The microparticles in the form of dry powder were obtained by either spray drying liposomal drug suspension or lipid drug suspension. The liposomes were initially prepared by solvent evaporation method using Hydrogenated Soyabean Phosphatidylcholine and Cholesterol (1:1, 1:2, 2:1) as lipid carrier and then spray dried later with mannitol as bulking agent at different lipid to diluent ratio (1:1.25, 1:2.5 & 1:5). The liposomes and liposomal dry powder were evaluated for vesicle size, % entrapment efficiency, in vitro drug release studies, powder characteristics, aerosol performance and stability studies. The liposomes prepared showed vesicle size (2-8 µm), Entrapment efficiency (92.22%) at lipid: drug ratio of (2.5:1) and observed 80.41 % drug release in 24 hrs. Pro-liposomes prepared by spray drying of liposomal drug suspension (LSD1) showed emitted dose, mean mass aerodynamic diameter, geometric standard deviation and fine particle fraction of 99.01%, 3.12 µm, 1.78 and 43.5% along with good powder properties. The spray dried powder was found to be stable at 4 ± 2 °C & 65% ± 5 % RH. The inhalable microparticles containing Budesonide containing lipid dry powder was successfully prepared by spray drying method that showed good aerodynamic properties and stability with mannitol as diluent. The microparticles produced with this novel approach could deliver drug on target via inhalation route and also ease manufacture process at large scale in fewer production steps.

Structure and Soft-Packed Cell Performance of Nano-Particle LiFePO4 Prepared by Spray-Drying Method

2020 ◽  
Vol 1003 ◽  
pp. 268-274
Author(s):  
Ling Li Zuo ◽  
Lin Chen ◽  
Shuo Yin ◽  
Ji Yun Liu ◽  
Cheng Lu ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Electrochemical Properties ◽  
Spray Drying ◽  
Diffusion Coefficients ◽  
Rate Capability ◽  
Chemical Diffusion ◽  
Nano Particle ◽  
Drying Method ◽  
Capacity Retention ◽  
Lithium Ions

Well-crystallized and nanosized LiFePO4/C composite have been successfully synthesized by spray-drying under N2 atmosphere. The morphology, physical and electrochemical properties of the LiFePO4/C were tested and analyzed. The charge transfer resistances (Rct) and chemical diffusion coefficients of lithium ions (DLi+) in LiFePO4/C was systematically tested by EIS. The results show that the lithium ions diffusion coefficients obtained from EIS is 1.58×10-14 cm2·s-1. The assembled soft-packed cell with LiFePO4/C show better rate capability and cycling stability. The average capacity retention of LiFePO4/C soft-packed cell decreases to 100%, 98.9%, 96.5%, 92.4%, and 90.3% when current rate increases to 0.3, 0.5, 1, 2, and 3C, respectively. The capacity retention after 80 cycles is retained at more than 99%.

scholarly journals A DESIGN OF EXPERIMENT APPROACH FOR OPTIMIZATION AND CHARACTERIZATION OF ETODOLAC TERNARY SYSTEM USING SPRAY DRYING

2017 ◽  
Vol 9 (2) ◽  
pp. 233
Author(s):  
Amir A. Shaikh ◽  
Praveen D. Chaudhari ◽  
Sagar S. Holkar
Keyword(s):  
Particle Size ◽  
Ternary System ◽  
Spray Drying ◽  
Design Of Experiment ◽  
Particle Size Analysis ◽  
Polyvinyl Pyrrolidone ◽  
Size Analysis ◽  
Drying Method ◽  
Physical Mixtures ◽  
Pvp K30

<p><strong>Objective: </strong>The objective of the present investigation was to prepare and characterize Etodolac (ETO), Polyvinyl pyrrolidone K30 (PVP K30) and Hydroxypropyl β-cyclodextrin (HPB) ternary system in order to study the effect of complexation on solubility of ETO.</p><p><strong>Methods: </strong>Physical mixtures of a drug and polymers in different weight ratios (1:1, 1:2, 1:4) were prepared to study the effect of individual polymers on solubility of ETO. Spray drying method was used to investigate the combined effect of PVP K30 and HPB on saturation solubility (SS), Dissolution efficiency (DE) and mean dissolution time (MDT) of ETO. Design of experiment (DoE) was used for preparation and optimization of ternary system. Drug polymer interactions were analyzed with Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), Scanning electron microscopy (SEM), Xray diffraction (XRD) and particle size analysis.<strong></strong></p><p><strong>Results: </strong>Results of solubility study suggested that there was significant increase in solubility of ETO with increase in the concentration of PVP K30, Polyvinyl pyrrolidone K 90 (PVP K90) and HPB (*p&lt;0.05). This might be due to the solubilizing effect of PVP K30, PVPK90 and complex formation of ETO with HPB. Various combinations of PVP K30 and HPB prepared using DoE approach by spray drying method showed greater solubility of ETO than its physical mixtures (*p&lt;0.05). Results of FTIR, DSC, SEM, XRD and particle size analysis revealed the interaction between ETO, PVP K30 and HPB. This suggested formation of amorphous ternary system with mean particle diameter in the range of 763±1.35 nm.</p><p><strong>Conclusion: </strong>Combine use of PVP K30 and HPB with DoE approach was an effective tool for formulating ternary system of ETO.</p>

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