Beneficial effects of lipidic extracts of saladette tomato pomace andSerenoa repenson prostate and bladder health in obese male Wistar rats

Abstract Objectives Vanadium has been reported to possess relevant therapeutic properties such as anti-diabetic and anti-tumoral. This study aimed at determining the effects of vanadium on experimentally induced colitis in rats. Methods Forty-five male Wistar rats (103 ± 3.90 g, n=15) were used for this study and were divided into three groups. Group 1 (Untreated control) had nothing added to their drinking, while groups 2 and 3 received sodium metavanadate at a dose of 50 and 200 mg/L respectively in their drinking water for 10 weeks. Colitis was thereafter induced by intra colonic administration of 1.50 mL of 6% acetic acid. Animals were sacrificed on day 0 (pre-induction), three- and seven-days post induction. Blood samples were collected for haematological variables and the distal 8 cm of the colon was collected for macroscopic, histological and biochemical (malondialdehyde-MDA, superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase- GPx and nitrite concentration- NO) assessment. Results Low dose vanadium proved beneficial in ameliorating acetic acid-induced colitis by improving both histopathological and haematological changes. Gross observation showed a faster healing rate in vanadium treated groups (50 and 200 mg/L) compared with untreated control at day 3 (40 and 26.20 vs. 2.50%) and day 7 (80 and 66.70 vs. 42%) respectively. Vanadium also appears to exert its beneficial effects on acetic acid-induced colitis via up regulation of antioxidant enzymes (SOD, CAT, GPx) and NO while decreasing the over production of MDA. Conclusions Vanadium at small concentration functions as an essential trace element and may be able to promote healing process during ulcerative colitis.

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Cyclophosphamide-induced reproductive toxicity: Beneficial effects of Helichrysum odoratissimum (Asteraceae) in male Wistar rats

Journal of Integrative Medicine ◽

10.1016/j.joim.2019.07.002 ◽

2019 ◽

Vol 17 (5) ◽

pp. 366-373 ◽

Cited By ~ 1

Author(s):

Pierre Watcho ◽

Ismaelle Rosine Mpeck ◽

Patrick Brice Deeh Defo ◽

Modeste Wankeu-Nya ◽

Esther Ngadjui ◽

...

Keyword(s):

Wistar Rats ◽

Reproductive Toxicity ◽

Beneficial Effects ◽

Male Wistar Rats

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Electro-acupuncture reduces the need for additional anesthetics in experimental studies

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502010000400015 ◽

2010 ◽

Vol 25 (4) ◽

pp. 381-384 ◽

Cited By ~ 3

Author(s):

Agamenon Honório Silva ◽

Alberico Ximenes do Prado Neto ◽

Sérgio Botelho Guimarães

Keyword(s):

Stainless Steel ◽

Electrical Stimulation ◽

Wistar Rats ◽

Experimental Studies ◽

Needle Insertion ◽

Additional Treatment ◽

Human Right ◽

Beneficial Effects ◽

Group Control ◽

Male Wistar Rats

PURPOSE: To evaluate the possible beneficial effects of electro-acupuncture in rats subjected to ketamine/xylazine (KX) intra-peritoneal (i.p.) anesthesia. METHODS: Forty-eight male Wistar rats were distributed in four equal groups. All rats received i.p. injections of ketamine (90 mg/kg) +xylazine (10 mg/kg) anesthesia. Basal values group (control) rats (BV) received no additional treatment. The equivalent of the human right ST36 (Zusanli) and CV-12(Zhongwan) acupoints were chosen for needling and electrical stimulation. AC rats were needled with sterilized disposable stainless steel needles at right ST36 and CV12 acupoints; needles were retained for 30 minutes. EAC10 rats, after needle insertion as described, had electrodes connected to both needles and to an electro stimulator model NKL EL-608; pulsed square waves, 10 Hz, 10 mA, was applied for 30 minutes. EAC100 rats were submitted to EA as described. However, a greater frequency (100 Hz) was used. RESULTS: Thirty-seven rats remained under adequate anesthetic level during the experiment. However, maintenance anesthesia was required by 11 rats. Need for additional anesthesia decreased to 9.1% in EAC100 rats compared to BV (36.3%). CONCLUSION: Both the AC and the EAC10/100 prolong the anesthetic effect of the combination Ketamine-xylazine in rats, allowing longer duration of anesthesia with a lower dose of anesthetic, thereby reducing the occurrence of complications.

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Sibutramine reduces feeding, body fat and improves insulin resistance in dietary-obese male Wistar rats independently of hypothalamic neuropeptide Y

British Journal of Pharmacology ◽

10.1038/sj.bjp.0704030 ◽

2001 ◽

Vol 132 (8) ◽

pp. 1898-1904 ◽

Cited By ~ 26

Author(s):

Michael Brown ◽

Chen Bing ◽

Peter King ◽

Lucy Pickavance ◽

David Heal ◽

...

Keyword(s):

Insulin Resistance ◽

Neuropeptide Y ◽

Body Fat ◽

Wistar Rats ◽

Male Wistar Rats ◽

Obese Male

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Effect of 4-h time restricted feeding on body weight, leptin concentration and lipid profile in healthy non-obese male Wistar rats

10.21203/rs.3.rs-336533/v1 ◽

2021 ◽

Author(s):

Michael A. Olamoyegun ◽

Folasade O. Ajao ◽

Marcus O. Iyedupe

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Lipid Profile ◽

Wistar Rats ◽

Metabolic Diseases ◽

Restricted Feeding ◽

Mean Values ◽

Male Wistar Rats ◽

Ad Libitum ◽

Obese Male

Abstract Background: Obesity greatly increases the risk of metabolic diseases and preventive approaches for obesity are often inadequate to effectively prevent and manage the diseases. Altering feeding time strategy intervention decreases caloric intake without calorie counting and may be an effective therapy. Therefore, this study investigates the effect of 4-h time restricted feeding on body weight, leptin concentration and lipid profile in healthy non-obese male Wistar rats. Methods: Rats placed on time-restricted feeding (TRF) regimen had freely access to food for 4 hour per day at designated periods. Twenty four rats divided into four groups (n=6) were used. Group I animals were placed on a 4 hour per day TRF between 8am-12noon. Group II rats were also placed on a 4 hour per day TRF between 12noon-4pm. Group III rats also placed on a 4 hour per day TRF between 8pm-12 midnight while Group IV rats had access food and water ad libitum. This diet strategy resembles taking only breakfast, lunch or dinner once a day. The study lasted for a period of 4 weeks with daily food intake and weekly body weight determined throughout the period. At the end of the experimental period, blood glucose, lipid profile and leptin concentration were assessed. SPSS 21.0 package was used for data analysis, one-way analysis of variance (ANOVA) was used to compare the mean values of variables among the groups and bonferroni’s posthoc test was used for significance of pair wise comparisons of mean values among the groups. Significance was set at p < 0.05.Results: In this study, the body weights and leptin concentrations of 8pm – 12am and ad libitum groups significantly increased compared with the 8am - 12noon and 12noon -4pm groups. Dyslipidemia was observed in the ad libitum group when compared with the 8am - 12noon and 12noon - 4pm groups. Conclusion: From this study, 4-hr time restricted feeding has beneficial effects on body weight, blood glucose, lipid profile and leptin concentration. This feeding restriction patterns may be helpful in obesity management and in preventing metabolic diseases development in non obese.

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Analysing the Hypolipidemic Activities of the Tea Extracts of Moringa oleifera, Glycyrrhiza glabra and their Blend at Different Concentrations, Orally Induced on Adult Male Wistar Rats.

International Journal of Pharmacology Phytochemistry and Ethnomedicine ◽

10.18052/www.scipress.com/ijppe.3.76 ◽

2016 ◽

Vol 3 ◽

pp. 76-83

Author(s):

Olanrewaju Roland Akinseye

Keyword(s):

Wistar Rats ◽

Moringa Oleifera ◽

Glycyrrhiza Glabra ◽

Atherogenic Index ◽

Simultaneous Increase ◽

Hypolipidemic Effect ◽

Aqueous Extracts ◽

Water Control ◽

Beneficial Effects ◽

Male Wistar Rats

Herbal teas ofMoringa oleifera(Moringa) andGlycyrrhiza glabra(Licorice)were known to have many beneficial effects, their possible hypolipidemic effects were investigated in this paper. Albino wistar rats were fed with aqueous extracts ofM. oleifera,G. glabraand their blend teas(10, 30 and 50 mg/kg.BW/ml). The teas were found to lower the serum cholesterol, triglycerides, VLDL, LDL, and atherogenic index at their higher concentration, but were found to slightly increase the HDL as compared to the corresponding normal healthy rats fed with clean water (control). The phytochemicals screening of the teas aqueous extract were also investigated, the chemicals (tannins, saponins, flavonoids, terpenoids and glycosides) which were known to exhibit cholesterol lowering effect by inhibiting its absorption and simultaneous increase its excretion were found to be present in the teas extract. Thus, the study demonstrates and validates thatM.oleifera,G. glabraand their blend possess hypolipidemic effect at higher concentration.

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A Pilot Study for Metabolic Profiling of Obesity-Associated Microbial Gut Dysbiosis in Male Wistar Rats

Biomolecules ◽

10.3390/biom11020303 ◽

2021 ◽

Vol 11 (2) ◽

pp. 303

Author(s):

Julia Hernandez-Baixauli ◽

Pere Puigbò ◽

Helena Torrell ◽

Hector Palacios-Jordan ◽

Vicent J. Ribas Ripoll ◽

...

Keyword(s):

Risk Factors ◽

Gut Microbiota ◽

Metabolic Profile ◽

Wistar Rats ◽

Gut Dysbiosis ◽

Male Wistar Rats ◽

Obesity Risk Factors ◽

Phenylalanine Metabolism ◽

Host Metabolism ◽

Obese Male

Obesity is one of the most incident and concerning disease worldwide. Definite strategies to prevent obesity and related complications remain elusive. Among the risk factors of the onset of obesity, gut microbiota might play an important role in the pathogenesis of the disease, and it has received extensive attention because it affects the host metabolism. In this study, we aimed to define a metabolic profile of the segregated obesity-associated gut dysbiosis risk factor. The study of the metabolome, in an obesity-associated gut dysbiosis model, provides a relevant way for the discrimination on the different biomarkers in the obesity onset. Thus, we developed a model of this obesity risk factors through the transference of gut microbiota from obese to non-obese male Wistar rats and performed a subsequent metabolic analysis in the receptor rats. Our results showed alterations in the lipid metabolism in plasma and in the phenylalanine metabolism in urine. In consequence, we have identified metabolic changes characterized by: (1) an increase in DG:34:2 in plasma, a decrease in hippurate, (2) an increase in 3-HPPA, and (3) an increase in o-coumaric acid. Hereby, we propose these metabolites as a metabolic profile associated to a segregated dysbiosis state related to obesity disease.

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