Geographical addressing strategy for space‐ground integrated network

2020 ◽  
Author(s):  
Yunlu Xiao ◽  
Tao Zhang ◽  
Meng Sun
Keyword(s):  
Integrated Network

Spatial Representations as an Emergent Feature of Perceptual Processing

2010 ◽  
Vol 24 (3) ◽  
pp. 161-172 ◽  
Author(s):  
Edmund Wascher ◽  
C. Beste
Keyword(s):  
Common Ground ◽  
Event Related Potentials ◽  
Vertical Axis ◽  
Relevant Information ◽  
Sources Of Information ◽  
Integrated Network ◽  
Perceptual Maps ◽  
Emergent Feature ◽  
Related Potentials ◽  
Selection Of

Spatial selection of relevant information has been proposed to reflect an emergent feature of stimulus processing within an integrated network of perceptual areas. Stimulus-based and intention-based sources of information might converge in a common stage when spatial maps are generated. This approach appears to be inconsistent with the assumption of distinct mechanisms for stimulus-driven and top-down controlled attention. In two experiments, the common ground of stimulus-driven and intention-based attention was tested by means of event-related potentials (ERPs) in the human EEG. In both experiments, the processing of a single transient was compared to the selection of a physically comparable stimulus among distractors. While single transients evoked a spatially sensitive N1, the extraction of relevant information out of a more complex display was reflected in an N2pc. The high similarity of the spatial portion of these two components (Experiment 1), and the replication of this finding for the vertical axis (Experiment 2) indicate that these two ERP components might both reflect the spatial representation of relevant information as derived from the organization of perceptual maps, just at different points in time.

scholarly journals Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sinead M. O’Donovan ◽  
Ali Imami ◽  
Hunter Eby ◽  
Nicholas D. Henkel ◽  
Justin Fortune Creeden ◽  
...  
Keyword(s):  
Infected Cell ◽  
Mek Inhibitor ◽  
Therapeutic Agents ◽  
The Novel ◽  
Integrated Network ◽  
Candidate Drug ◽  
Novel Targets ◽  
Additional Support ◽  
Bioinformatics Workflow

AbstractThe COVID-19 pandemic caused by the novel SARS-CoV-2 is more contagious than other coronaviruses and has higher rates of mortality than influenza. Identification of effective therapeutics is a crucial tool to treat those infected with SARS-CoV-2 and limit the spread of this novel disease globally. We deployed a bioinformatics workflow to identify candidate drugs for the treatment of COVID-19. Using an “omics” repository, the Library of Integrated Network-Based Cellular Signatures (LINCS), we simultaneously probed transcriptomic signatures of putative COVID-19 drugs and publicly available SARS-CoV-2 infected cell lines to identify novel therapeutics. We identified a shortlist of 20 candidate drugs: 8 are already under trial for the treatment of COVID-19, the remaining 12 have antiviral properties and 6 have antiviral efficacy against coronaviruses specifically, in vitro. All candidate drugs are either FDA approved or are under investigation. Our candidate drug findings are discordant with (i.e., reverse) SARS-CoV-2 transcriptome signatures generated in vitro, and a subset are also identified in transcriptome signatures generated from COVID-19 patient samples, like the MEK inhibitor selumetinib. Overall, our findings provide additional support for drugs that are already being explored as therapeutic agents for the treatment of COVID-19 and identify promising novel targets that are worthy of further investigation.

scholarly journals Research on Task-Oriented Computation Offloading Decision in Space-Air-Ground Integrated Network

2021 ◽  
Vol 13 (5) ◽  
pp. 128
Author(s):  
Jun Liu ◽  
Xiaohui Lian ◽  
Chang Liu
Keyword(s):  
Energy Consumption ◽  
Decision Process ◽  
Learning Algorithm ◽  
Low Cost ◽  
Transition Process ◽  
Computation Offloading ◽  
Processing Efficiency ◽  
Integrated Network ◽  
Decision Scheme ◽  
Task Offloading

In Space–Air–Ground Integrated Networks (SAGIN), computation offloading technology is a new way to improve the processing efficiency of node tasks and improve the limitation of computing storage resources. To solve the problem of large delay and energy consumption cost of task computation offloading, which caused by the complex and variable network offloading environment and a large amount of offloading tasks, a computation offloading decision scheme based on Markov and Deep Q Networks (DQN) is proposed. First, we select the optimal offloading network based on the characteristics of the movement of the task offloading process in the network. Then, the task offloading process is transformed into a Markov state transition process to build a model of the computational offloading decision process. Finally, the delay and energy consumption weights are introduced into the DQN algorithm to update the computation offloading decision process, and the optimal offloading decision under the low cost is achieved according to the task attributes. The simulation results show that compared with the traditional Lyapunov-based offloading decision scheme and the classical Q-learning algorithm, the delay and energy consumption are respectively reduced by 68.33% and 11.21%, under equal weights when the offloading task volume exceeds 500 Mbit. Moreover, compared with offloading to edge nodes or backbone nodes of the network alone, the proposed mixed offloading model can satisfy more than 100 task requests with low energy consumption and low delay. It can be seen that the computation offloading decision proposed in this paper can effectively reduce the delay and energy consumption during the task computation offloading in the Space–Air–Ground Integrated Network environment, and can select the optimal offloading sites to execute the tasks according to the characteristics of the task itself.

scholarly journals Mechanism of protective effect of xuan-bai-cheng-qi decoction on LPS-induced acute lung injury based on an integrated network pharmacology and RNA-sequencing approach

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Huahe Zhu ◽  
Shun Wang ◽  
Cong Shan ◽  
Xiaoqian Li ◽  
Bo Tan ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Rna Sequencing ◽  
Target Genes ◽  
Mammalian Target Of Rapamycin ◽  
Network Pharmacology ◽  
Protective Mechanism ◽  
Rna Seq ◽  
Active Components ◽  
Integrated Network

AbstractXuan-bai-cheng-qi decoction (XCD), a traditional Chinese medicine (TCM) prescription, has been widely used to treat a variety of respiratory diseases in China, especially to seriously infectious diseases such as acute lung injury (ALI). Due to the complexity of the chemical constituent, however, the underlying pharmacological mechanism of action of XCD is still unclear. To explore its protective mechanism on ALI, firstly, a network pharmacology experiment was conducted to construct a component-target network of XCD, which identified 46 active components and 280 predicted target genes. Then, RNA sequencing (RNA-seq) was used to screen differentially expressed genes (DEGs) between ALI model rats treated with and without XCD and 753 DEGs were found. By overlapping the target genes identified using network pharmacology and DEGs using RNA-seq, and subsequent protein–protein interaction (PPI) network analysis, 6 kernel targets such as vascular epidermal growth factor (VEGF), mammalian target of rapamycin (mTOR), AKT1, hypoxia-inducible factor-1α (HIF-1α), and phosphoinositide 3-kinase (PI3K) and gene of phosphate and tension homology deleted on chromsome ten (PTEN) were screened out to be closely relevant to ALI treatment. Verification experiments in the LPS-induced ALI model rats showed that XCD could alleviate lung tissue pathological injury through attenuating proinflammatory cytokines release such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β. Meanwhile, both the mRNA and protein expression levels of PI3K, mTOR, HIF-1α, and VEGF in the lung tissues were down-regulated with XCD treatment. Therefore, the regulations of XCD on PI3K/mTOR/HIF-1α/VEGF signaling pathway was probably a crucial mechanism involved in the protective mechanism of XCD on ALI treatment.

scholarly journals Adjustment of an Integrated Geodetic Network Composed of GNSS Vectors and Classical Terrestrial Linear Pseudo-Observations

2021 ◽  
Vol 11 (10) ◽  
pp. 4352
Author(s):  
Tadeusz Gargula
Keyword(s):  
Three Dimensional ◽  
Geodetic Network ◽  
Global Navigation Satellite Systems ◽  
Adjustment Process ◽  
Dimensional System ◽  
Integrated Network ◽  
Satellite Systems ◽  
Linear Distance ◽  
Easy Integration ◽  
Global Navigation Satellite

The paper proposes a new method for adjusting classical terrestrial observations (total station) together with satellite (GNSS-Global Navigation Satellite Systems) vectors. All the observations are adjusted in a single common three-dimensional system of reference. The proposed method does not require the observations to be projected onto an ellipsoid or converted between reference systems. The adjustment process follows the transformation of a classical geodetic network (distances and horizontal and vertical angles) into a spatial linear (distance) network. This step facilitates easy integration with GNSS vectors when results are numerically processed. The paper offers detailed formulas for calculating pseudo-observations (spatial distances) from input terrestrial observations (horizontal and vertical angles, horizontal distances, height of instrument and height of target). The next stage was to set observation equations and transform them into a linear form (functional adjustment model of geodetic observations). A method was provided as well for determining the mean errors of the pseudo-observations, necessary to assess the accuracy of the values following the adjustment (point coordinates). The proposed algorithm was verified in practice whereby an integrated network made up of a GNSS vector network and a classical linear-angular network was adjusted.

scholarly journals Ruxolitinib Combined with Gemcitabine against Cholangiocarcinoma Growth via the JAK2/STAT1/3/ALDH1A3 Pathway

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 885
Author(s):  
Shin-Yi Chung ◽  
Yi-Ping Hung ◽  
Yi-Ru Pan ◽  
Yu-Chan Chang ◽  
Chiao-En Wu ◽  
...  
Keyword(s):  
Cell Lines ◽  
Nuclear Translocation ◽  
Vital Role ◽  
First Line ◽  
Current Standard ◽  
Integrated Network ◽  
Jak2 Inhibitor ◽  
Therapeutic Drugs ◽  
Cholangiocarcinoma Cell ◽  
Malignant Behavior

Cholangiocarcinoma is the most common primary malignant tumor of the bile duct. The current standard first-line treatment for advanced or metastatic cholangiocarcinoma is gemcitabine and cisplatin. However, few effective treatment choices exist for refractory cholangiocarcinoma, and additional therapeutic drugs are urgently required. Our previous work demonstrated that the ALDH isoform 1A3 plays a vital role in the malignant behavior of cholangiocarcinoma and may serve as a new therapeutic target. In this study, we found a positive correlation between ALDH1A3 protein expression levels and the cell migration abilities of three cholangiocarcinoma cell lines, which was verified using ALDH1A3-overexpressing and ALDH1A3-knockdown clones. We also used ALDH1A3-high and ALDH1A3-low populations of cholangiocarcinoma cell lines from the library of integrated network-based cellular signatures (LINCS) program and assessed the effects of ruxolitinib, a commercially available JAK2 inhibitor. Ruxolitinib had a higher cytotoxic effect when combined with gemcitabine. Furthermore, the nuclear translocation STAT1 and STAT3 heterodimers were markedly diminished by ruxolitinib treatment, possibly resulting in decreased ALDH1A3 activation. Notably, ruxolitinib alone or combined with gemcitabine led to significantly reduced tumor size and weight. Collectively, our studies suggest that ruxolitinib might suppress the ALDH1A3 activation through the JAK2/STAT1/3 pathway in cholangiocarcinoma, and trials should be undertaken to evaluate its efficacy in clinical therapy.

Autonomous Raman Amplifiers using Standard Integrated Network Equipment

2021 ◽  
pp. 1-1
Author(s):  
Giacomo Borraccini ◽  
Stefano Staullu ◽  
Stefano Piciaccia ◽  
Alberto Tanzi ◽  
Antonino Nespola ◽  
...  
Keyword(s):  
Integrated Network ◽  
Raman Amplifiers ◽  
Network Equipment
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