scholarly journals Rational Development of MAGL Inhibitors

2018 ◽  
pp. 335-346
Author(s):  
Carlotta Granchi ◽  
Flavio Rizzolio ◽  
Isabella Caligiuri ◽  
Marco Macchia ◽  
Adriano Martinelli ◽  
...  
Keyword(s):  
Rational Development

REINTEGRATION OF THE CHORNOBYL NPP EXCLUSION ZONE ON THE BASIS OF THE DESIGN-PLANNING COMPLEX

2020 ◽  
pp. 11-18
Author(s):  
I.I. Ustinova ◽  
◽  
M.M. Dyomin ◽  
G.V. Aylikova ◽  
◽  
...  
Keyword(s):  
Urban Planning ◽  
City Planning ◽  
Biosphere Reserve ◽  
Brand Name ◽  
Exclusion Zone ◽  
Rational Development ◽  
Production Complex ◽  
Design Planning ◽  
Renewable Energy Generation ◽  
First Time

The aim of the publication is to determine the prerequisites of and to elaborate on the foundations of the Exclusion Zone reintegration in order to address the issue of rational development of urban-planning documentation complex regarding the legitimacy of said territory exploitation. It is established that for the implementation of the «Radioactive waste management strategy» the production complex «Vector» is being constructed on the Exclusion Zone territory; a powerful park of renewable energy generation is being created to implement the «Chornobyl - a Territory of Change» strategy; a Chornobyl Radiation-Ecological Biosphere Reserve was established to support and increase the barrier function of the zone; in order to promote the Safe Chornobyl brand-name, the tourist traffic is being increased and the conditions for the visitors are improving. In the absence of developed and approved city planning documentation, the listed above causes the problem of legitimacy and rationality of the exclusion zone territory use. The paper for the first time raises the question of the need to elaborate the concept of functional planning of the Chornobyl NPP exclusion zone territory and the development of the design-planning complex (urban planning documentation): from the territory.

The Importance Of Energy Solutions For A Safe And Rational Development

2014 ◽  
Vol 1 (1) ◽  
pp. 379-384
Author(s):  
Daniela Cristina Momete ◽  
Tudor Prisecaru
Keyword(s):  
Industrial Revolution ◽  
New Technology ◽  
Energy System ◽  
Crucial Importance ◽  
Gas Processing ◽  
Energy Technologies ◽  
Rational Development ◽  
Oil Exploitation ◽  
New Energy ◽  
Energy Domain

AbstractA new industrial revolution is on the verge in the energy domain considering the knowledge and skills acquired through the development of new energy technologies. Shale gas processing, unconventional oil exploitation, new exploring/drilling methods, mature renewable energy or in progress, all generated a wealth of knowledge in new technology. Therefore, this paper aims to analyse the positive and negative aspects of energy solutions, and to reveal the way to a world where a valid sustainable development, based on safe and rational premises, is actually considered. The paper also introduces suggestions for the energy system, which has a crucial importance in coping with the resource management of the future, where the economic, social, and environmental/climate needs of the post-crisis world should be suitably considered.

Development of 'S', 'N’ Heterocycles as Antimycobacterials Targeting Fatty Acid Biosynthesis

2019 ◽  
Vol 15 ◽  
Author(s):  
L. K. Dahiwade ◽  
S. R. Rochlani ◽  
P. B. Choudhari ◽  
R. P. Dhavale ◽  
H. N. Moreira
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Biosynthesis ◽  
Antimycobacterial Activity ◽  
Drug Candidate ◽  
Causative Organism ◽  
Present Communication ◽  
Acid Biosynthesis ◽  
Rational Development ◽  
After Cancer ◽  
Drug Resistant Strains

Background: Mycobacterium tuberculosis is a causative organism of tuberculosis, which is most deadly disease after cancer in a current decade. The development of multidrug and broadly drug- resistant strains making the tuberculosis problem more and more critical. In last 40 years, only one molecule is added to the treatment regimen. Generally, drug design and development programs are targeted proteins whose function is known to be essential to the bacterial cell. Objectives: Reported here are the development of 'S', 'N’ heterocycles as antimycobacterials targeting fatty acid biosynthesis. Material and Methods: In the present communication, rational development of anti-mycobacterial agent's targeting fatty acid biosynthesis has been done by integrating the pocket modelling and virtual analysis. Results: The identified potential 33 lead compounds were synthesized, characterized by physicochemical and spectroscopic methods like IR, NMR spectroscopy and further screened for antimycobacterial activity using isoniazid as standard. All the designed compounds have shown profound antimycobacterial activity. Conclusion: In this present communication, we found that 3c, 3f, 3l and 4k molecules had expressive desirable biological activity and specific interactions with fatty acids. Further optimization of these leads is necessary for the development of potential antimycobacterial drug candidate having less side effects.

Estimation of Forest Biomass Energy Resources Based on Bottom-up Approach in China

2015 ◽  
Vol 8 (1) ◽  
pp. 272-275
Author(s):  
Lan Zhang ◽  
Dan Yu ◽  
Caihong Zhang ◽  
Weidong Zhang
Keyword(s):  
Forest Biomass ◽  
Estimation Method ◽  
Energy Resource ◽  
Biomass Energy ◽  
Energy Resources ◽  
Theoretical Ground ◽  
Estimation Model ◽  
Bottom Up ◽  
Rational Development ◽  
Calculation Results

Currently, the forest biomass energy development is at an initial stage and the estimation method for the forest biomass energy resource reserve is to be unified and refined although there is a great value and potential in the development and utilization of forest biomass energy in China. Based on the existing studies, the present paper analyzes the origins and types of forest biomass energy resources in the perspective of sustainable forestry management, constructs the estimation model using a bottom-up approach, and estimates the total existing forest biomass energy resource reserve in China based on the data of the 7th Forest Resource Survey. The estimation method and the calculation results provide the important theoretical ground for promoting the rational development of forest biomass energy in China.

Simulation and Modeling of Turbulent Flows

1996 ◽  
Keyword(s):  
Numerical Simulation ◽  
Turbulent Flow ◽  
Turbulent Flows ◽  
Simulation And Modeling ◽  
Simulation Techniques ◽  
Rational Development ◽  
Group Methods ◽  
Turbulent Closure ◽  
The Subject ◽  
Renormalization Group Methods

This book provides students and researchers in fluid engineering with an up-to-date overview of turbulent flow research in the areas of simulation and modeling. A key element of the book is the systematic, rational development of turbulence closure models and related aspects of modern turbulent flow theory and prediction. Starting with a review of the spectral dynamics of homogenous and inhomogeneous turbulent flows, succeeding chapters deal with numerical simulation techniques, renormalization group methods and turbulent closure modeling. Each chapter is authored by recognized leaders in their respective fields, and each provides a thorough and cohesive treatment of the subject.

MOF-derived PtCo/Co3O4 nanocomposites in carbonaceous matrices as high-performance ORR electrocatalysts synthesized via Laser Ablation techniques

2021 ◽  
Author(s):  
Erick Leonar Ribeiro ◽  
Elijah M Davis ◽  
Mahshid Mokhtarnejad ◽  
Sheng Hu ◽  
Dibyendu Mukherjee ◽  
...  
Keyword(s):  
Fuel Cell ◽  
Laser Ablation ◽  
Energy Conversion ◽  
High Performance ◽  
Sustainable Energy ◽  
Ablation Techniques ◽  
Global Energy ◽  
Cell Technology ◽  
Energy Demands ◽  
Rational Development

Rapidly expanding global energy demands due to fast-paced human-technology interfaces have propelled fuel cell technology as a sustainable energy-conversion alternative. Nonetheless, the rational development of such technology demands the engineering...

scholarly journals Dynamic variations in salinity and potassium grade of a potassium-rich brine deposit in Lop Nor basin, China

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lichun Ma ◽  
Kai Wang ◽  
Yu Zhang ◽  
Qingfeng Tang ◽  
Hui Yan
Keyword(s):  
Large Scale ◽  
Sustainable Use ◽  
Potassium Sulfate ◽  
Middle Pleistocene ◽  
Underground Brine ◽  
Average Decrease ◽  
Rational Development ◽  
Mining History ◽  
Before And After ◽  
Lop Nor

AbstractThe Quaternary Lop Nor playa is the largest production base of potassium sulfate in the world. It has a mining history of more than 10 years, and its share in the Chinese potassium sulfate market is about 50% to-date. In this basin, the high-salinity potassium-rich brines are mainly contained in Middle Pleistocene–Holocene glauberite strata. Based on the monitoring of the underground brine table and geochemical analysis, this study reveals variations in the underground brine table and potassium-bearing grade before and after large-scale mining in the Lop Nor potash deposit. The results showed that the underground brine table and potassium sulfate grade decreased by varying degrees over sub-mineral areas after large-scale mining. The underground brine table declined by 8.5 m, on average, in the Luobei depression, by 6.4 m in the Tenglong platform and by 1.9 m in the Xinqing platform. However, the potassium-bearing grade showed the different trend. The Tenglong platform had the largest decline with average decreases in layers W1, W2 and W3 of 18.2%, 13.0% and 24.8%, respectively. In the Xinqing platform, the average decrease in layersW2 and W3 were 17.4% and 16.0% respectively. The Luobei depression decreases were relatively small (W1, W2 and W3 decreased 4.3%, 4.2% and 3.1%, respectively). This research provides a theoretical basis for the rational development and sustainable use of the potassium-rich brines in the Lop Nor basin.

scholarly journals Engineering of Bio-Adhesive Ligand Containing Recombinant RGD and PHSRN Fibronectin Cell-Binding Domains in Fusion with a Colored Multi Affinity Tag: Simple Approach for Fragment Study from Expression to Adsorption

2021 ◽  
Vol 22 (14) ◽  
pp. 7362
Author(s):  
Amina Ben Abla ◽  
Guilhem Boeuf ◽  
Ahmed Elmarjou ◽  
Cyrine Dridi ◽  
Florence Poirier ◽  
...  
Keyword(s):  
Specific Binding ◽  
Cellular Adhesion ◽  
High Yield ◽  
Adhesion Assay ◽  
Cell Binding ◽  
Affinity Tag ◽  
Binding Domains ◽  
Rational Development ◽  
Fibronectin Type Iii ◽  
Arginine Glycine Aspartic Acid

Engineering of biomimetic motives have emerged as promising approaches to improving cells’ binding properties of biomaterials for tissue engineering and regenerative medicine. In this study, a bio-adhesive ligand including cell-binding domains of human fibronectin (FN) was engineered using recombinant protein technology, a major extracellular matrix (ECM) protein that interacts with a variety of integrins cell-surface’s receptors and other ECM proteins through specific binding domains. 9th and 10th fibronectin type III repeat containing Arginine-Glycine-Aspartic acid (RGD) and Pro-His-Ser-Arg-Asn (PHSRN) synergic site (FNIII9-10) were expressed in fusion with a Colored Multi Affinity Tag (CMAT) to develop a simplified production and characterization process. A recombinant fragment was produced in the bacterial system using E. coli with high yield purified protein by double affinity chromatography. Bio-adhesive surfaces were developed by passive coating of produced fragment onto non adhesive surfaces model. The recombinant fusion protein (CMAT-FNIII9/10) demonstrated an accurate monitoring capability during expression purification and adsorption assay. Finally, biological activity of recombinant FNIII9/10 was validated by cellular adhesion assay. Binding to α5β1 integrins were successfully validated using a produced fragment as a ligand. These results are robust supports to the rational development of bioactivation strategies for biomedical and biotechnological applications.

Sign in / Sign up

Export Citation Format

Share Document