Degenerative Retinal Diseases: Cell Sources for Cell-Based Therapy

2019 ◽  
pp. 53-80
Author(s):  
Ricardo P. Casaroli-Marano ◽  
Núria Nieto-Nicolau ◽  
Raquel A. Martínez-García de la Torre
Keyword(s):  
Retinal Diseases ◽  
Cell Based Therapy ◽  
Cell Sources

scholarly journals A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1333
Author(s):  
Benjamin Motais ◽  
Sandra Charvátová ◽  
Matouš Hrdinka ◽  
Michal Šimíček ◽  
Tomáš Jelínek ◽  
...  
Keyword(s):  
Hematological Malignancies ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors ◽  
Blood Cancer ◽  
Cell Based Therapy ◽  
Cell Source ◽  
Different Types ◽  
Cell Sources ◽  
The One ◽  
Initial Results

Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approach to treat those incurable hematological malignancies with striking results in different clinical trials. The most investigated, and the one that has advanced the most, is the cell-based therapy with T lymphocytes modified with chimeric antigen receptors. Those promising initial results prepared the ground to explore other cell-based therapies to treat patients with blood cancer. In this review, we want to provide an overview of the different types of cell-based therapies in blood cancer, describing them according to the cell source.

scholarly journals Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19

2020 ◽  
Vol 55 (6) ◽  
pp. 2000858 ◽  
Author(s):  
Maroun Khoury ◽  
Jimena Cuenca ◽  
Fernanda F. Cruz ◽  
Fernando E. Figueroa ◽  
Patricia R.M. Rocco ◽  
...  
Keyword(s):  
Respiratory Virus ◽  
Current Status ◽  
Virus Infections ◽  
Cell Based Therapy ◽  
Clinical Investigations ◽  
Lung Injuries ◽  
Cell Sources ◽  
Dosing Strategies ◽  
Respiratory Virus Infections ◽  
Virus Influenza

The severe respiratory consequences of the coronavirus disease 2019 (COVID-19) pandemic have prompted urgent need for novel therapies. Cell-based approaches, primarily using mesenchymal stem (stromal) cells (MSCs), have demonstrated safety and possible efficacy in patients with acute respiratory distress syndrome (ARDS), although they are not yet well studied in respiratory virus-induced ARDS. Limited pre-clinical data suggest that systemic MSC administration can significantly reduce respiratory virus (influenza strains H5N1 and H9N2)-induced lung injury; however, there are no available data in models of coronavirus respiratory infection.There is a rapidly increasing number of clinical investigations of cell-based therapy approaches for COVID-19. These utilise a range of different cell sources, doses, dosing strategies and targeted patient populations. To provide a rational strategy to maximise potential therapeutic use, it is critically important to understand the relevant pre-clinical studies and postulated mechanisms of MSC actions in respiratory virus-induced lung injuries. This review presents these, along with consideration of current clinical investigations.

scholarly journals The Rise of Retinal Organoids for Vision Research

2020 ◽  
Vol 21 (22) ◽  
pp. 8484 ◽  
Author(s):  
Kritika Sharma ◽  
Tim U. Krohne ◽  
Volker Busskamp
Keyword(s):  
Molecular Mechanisms ◽  
Cell Types ◽  
Therapeutic Interventions ◽  
Retinal Cell ◽  
Retinal Diseases ◽  
Organ Systems ◽  
Cell Sources ◽  
Retinal Degenerative Diseases

Retinal degenerative diseases lead to irreversible blindness. Decades of research into the cellular and molecular mechanisms of retinal diseases, using either animal models or human cell-derived 2D systems, facilitated the development of several therapeutic interventions. Recently, human stem cell-derived 3D retinal organoids have been developed. These self-organizing 3D organ systems have shown to recapitulate the in vivo human retinogenesis resulting in morphological and functionally similar retinal cell types in vitro. In less than a decade, retinal organoids have assisted in modeling several retinal diseases that were rather difficult to mimic in rodent models. Retinal organoids are also considered as a photoreceptor source for cell transplantation therapies to counteract blindness. Here, we highlight the development and field’s improvements of retinal organoids and discuss their application aspects as human disease models, pharmaceutical testbeds, and cell sources for transplantations.

Cell Sources in Cardiac Tissue Engineering: Current Choices

2021 ◽  
Vol 16 ◽  
Author(s):  
Peiman Brouki Milan ◽  
Naser Amini ◽  
Arezu Mehrabi ◽  
Sepideh Mousazadeh ◽  
Shima Ababzadeh ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Therapy ◽  
Therapeutic Strategy ◽  
Cardiac Tissue ◽  
Heart Diseases ◽  
Cell Transplant ◽  
Cell Based Therapy ◽  
Different Types ◽  
Cell Sources

The past decade has evidenced numerous developments in the treatment of heart diseases, however many patients with chronic heart failure suffer from quality of life. Therapeutic methods including drug-delivery, the heart’s outside and inside the gadget, as well as heart transplantation, have been used to improve life. Cell therapy and tissue engineering have been recently introduced to medicine as a novel therapeutic approach. Treatment of heart diseases has been entered into novel lines through the introduction of cell therapy approaches. Based on the evidence, cell therapy has emerged as a promising therapeutic strategy for the treatment of cardiac diseases. Since the first cell transplant to patients, different types of (stem) cells have been studied. The following aims to provide a comprehensive review on different types of cells and their roles used in cardiac cell-based therapy.

scholarly journals MSC-based therapy in female pelvic floor disorders

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yizhen Sima ◽  
Yisong Chen
Keyword(s):  
Pelvic Floor ◽  
Stromal Cells ◽  
Pelvic Floor Disorders ◽  
Biological Properties ◽  
Great Promise ◽  
Therapeutic Effects ◽  
Novel Therapy ◽  
Cell Based Therapy ◽  
Wide Range ◽  
Cell Sources

Abstract Mesenchymal stem cells (MSCs), also referred to as multipotent stromal cells or mesenchymal stromal cells, are present in multiple tissues and capable of differentiating into diverse cell lineages, holding a great promise in developing cell-based therapy for a wide range of conditions. Pelvic floor disorders (PFDs) is a common degenerative disease in women and may diminish a woman’s quality of life at any age. Since the treatments for this disease are limited by the high rates of recurrence and surgical complications, seeking an ideal therapy in the restoration of pelvic floor function is an urgent issue at present. Herein, we summarize the cell sources of MSCs used for PFDs and discuss the potential mechanisms of MSCs in treating PFDs. Specifically, we also provide a comprehensive review of current preclinical and clinical trials dedicated to investigating MSC-based therapy for PFDs. The novel therapy has presented promising therapeutic effects which include relieving the symptoms of urinary or fecal incontinence, improving the biological properties of implanted meshes and promoting the injured tissue repair. Nevertheless, MSC-based therapies for PFDs are still experimental and the unstated issues on their safety and efficacy should be carefully addressed before their clinical applications.

scholarly journals Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility

2020 ◽  
Author(s):  
Sahar Esfandyari ◽  
Rishi Man Chugh ◽  
Hang-Soo Park ◽  
Elie Hobeika ◽  
Mara Ulin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Medical Condition ◽  
Polycystic Ovary ◽  
High Capacity ◽  
Female Infertility ◽  
Great Promise ◽  
Cell Based Therapy ◽  
Therapeutic Outcomes ◽  
Cell Sources

Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency and to improve reproductive health for a significant number of women worldwide.

Establishment of Immortalized Human Hepatocytes by Introduction of HPV16 E6/E7 and hTERT as Cell Sources for Liver Cell-Based Therapy

2008 ◽  
Vol 17 (9) ◽  
pp. 1083-1094 ◽  
Author(s):  
Yosuke Tsuruga ◽  
Tohru Kiyono ◽  
Michiaki Matsushita ◽  
Tohru Takahashi ◽  
Hironori Kasai ◽  
...  
Keyword(s):  
Liver Cell ◽  
Human Hepatocytes ◽  
Hpv16 E6 ◽  
Cell Based Therapy ◽  
Cell Sources

scholarly journals Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2253
Author(s):  
Sahar Esfandyari ◽  
Rishi Man Chugh ◽  
Hang-soo Park ◽  
Elie Hobeika ◽  
Mara Ulin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Medical Condition ◽  
Polycystic Ovary ◽  
High Capacity ◽  
Female Infertility ◽  
Great Promise ◽  
Cell Based Therapy ◽  
Therapeutic Outcomes ◽  
Cell Sources

Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy, with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency, and to improve reproductive health for a significant number of women worldwide.

scholarly journals Unraveling the therapeutic effects of mesenchymal stem cells in asthma

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Fatemeh Mirershadi ◽  
Mahdi Ahmadi ◽  
Aysa Rezabakhsh ◽  
Hadi Rajabi ◽  
Reza Rahbarghazi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Current Knowledge ◽  
Chronic Inflammatory Disease ◽  
Therapeutic Effects ◽  
Pulmonary Tissue ◽  
Chronic Inflammatory Response ◽  
Asthmatic Patients ◽  
Cell Based Therapy ◽  
Cell Sources

Abstract Asthma is a chronic inflammatory disease associated with airway hyper-responsiveness, chronic inflammatory response, and excessive structural remodeling. The current therapeutic strategies in asthmatic patients are based on controlling the activity of type 2 T helper lymphocytes in the pulmonary tissue. However, most of the available therapies are symptomatic and expensive and with diverse side outcomes in which the interruption of these modalities contributes to the relapse of asthmatic symptoms. Up to date, different reports highlighted the advantages and beneficial outcomes regarding the transplantation of different stem cell sources, and relevant products from for the diseases’ alleviation and restoration of injured sites. However, efforts to better understand by which these cells elicit therapeutic effects are already underway. The precise understanding of these mechanisms will help us to translate stem cells into the clinical setting. In this review article, we described current knowledge and future perspectives related to the therapeutic application of stem cell-based therapy in animal models of asthma, with emphasis on the underlying therapeutic mechanisms.

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