A Study of Models for Forecasting E-Commerce Sales During a Price War in the Medical Product Industry

Author(s):  
Pei-Hsuan Hsieh
2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Ridvan Yamanoglu

In the world market, medical products emerge as a sector that directly concerns people’s life quality and related activities. The medical product industry continues to grow rapidly in the world, especially in developed countries in line with the advances in technology, along with the elderly population and welfare level. In this context, biomedical implants constitute an important branch of the medical product industry. Among the materials preferred for implant production, the metallic biomaterials are very popular due to their superior mechanical properties. Ti and Ti alloys, among the metallic biomaterials, draw more attention considerably compared to stainless steel and Co-Cr alloys due to their characteristic features such as high specific strength and superior corrosion resistance, low density and low modulus of elasticity. Although the elastic modulus of titanium and its alloys is low compared to the other metallic biomaterials, it remains higher than bone. β-type Ti alloys have been developed to prevent the stress shielding effect caused by the elastic modulus mismatch and sterilization of the biomaterials used in the body from toxic alloy elements. In this article, the effect of the use of β-type Ti alloys, which are extremely prospective materials and open to development, in the body on host organisms, and the efficiency of the developed alloys have been investigated.


Author(s):  
C. P. Guimarães ◽  
R.M. Naveiro ◽  
J.E.A. Pereira

BMJ ◽  
2021 ◽  
pp. e066576
Author(s):  
Susan Chimonas ◽  
Maha Mamoor ◽  
Sophia A Zimbalist ◽  
Brooke Barrow ◽  
Peter B Bach ◽  
...  

Abstract Objective To identify all known ties between the medical product industry and the healthcare ecosystem. Design Scoping review. Methods From initial literature searches and expert input, a map was created to show the network of medical product industry ties across parties and activities in the healthcare ecosystem. Through a scoping review, the ties were then verified, cataloged, and characterized, with data abstracted on types of industry ties (financial, non-financial), applicable policies for conflict of interests, and publicly available data sources. Main outcome measures Presence and types of medical product industry ties to activities and parties, presence of policies for conflict of interests, and publicly available data. Results A map derived through synthesis of 538 articles from 37 countries shows an extensive network of medical product industry ties to activities and parties in the healthcare ecosystem. Key activities include research, healthcare education, guideline development, formulary selection, and clinical care. Parties include non-profit entities, the healthcare profession, the market supply chain, and government. The medical product industry has direct ties to all parties and some activities through multiple pathways; direct ties extend through interrelationships among parties and activities. The most frequently identified parties were within the healthcare profession, with individual professionals described in 422 (78%) of the included studies. More than half (303, 56%) of the publications documented medical product industry ties to research, with clinical care (156, 29%), health professional education (145, 27%), guideline development (33, 6%), and formulary selection (8, 1%) appearing less often. Policies for conflict of interests exist for some financial and a few non-financial ties; publicly available data sources seldom describe or quantify these ties. Conclusions An extensive network of medical product industry ties to activities and parties exists in the healthcare ecosystem. Policies for conflict of interests and publicly available data are lacking, suggesting that enhanced oversight and transparency are needed to protect patient care from commercial influence and to ensure public trust.


2009 ◽  
Vol 3 (4) ◽  
pp. 47-54
Author(s):  
P. Iskanius ◽  
◽  
Thomas Page ◽  

Author(s):  
Jessica M. Franklin ◽  
Kai‐Li Liaw ◽  
Solomon Iyasu ◽  
Cathy Critchlow ◽  
Nancy Dreyer

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Tuomas Granlund ◽  
Vlad Stirbu ◽  
Tommi Mikkonen

AbstractAgile software development embraces change and manifests working software over comprehensive documentation and responding to change over following a plan. The ability to continuously release software has enabled a development approach where experimental features are put to use, and, if they stand the test of real use, they remain in production. Examples of such features include machine learning (ML) models, which are usually pre-trained, but can still evolve in production. However, many domains require more plan-driven approach to avoid hazard to environment and humans, and to mitigate risks in the process. In this paper, we start by presenting continuous software engineering practices in a regulated context, and then apply the results to the emerging practice of MLOps, or continuous delivery of ML features. Furthermore, as a practical contribution, we present a case study regarding Oravizio, first CE-certified medical software for assessing the risks of joint replacement surgeries. Towards the end of the paper, we also reflect the Oravizio experiences to MLOps in regulatory context.


Viruses ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 234 ◽  
Author(s):  
Constanze Yue ◽  
Sebastian Teitz ◽  
Tomoyuki Miyabashi ◽  
Klaus Boller ◽  
Lia Lewis-Ximenez ◽  
...  

Background: Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are closely related members of the Semliki Forest complex within the genus alphavirus and are transmitted by arthropods, causing acute febrile illness in humans. CHIKV has spread to almost all continents, whereas autochthonous MAYV infections have been reported in South America and in the Caribbean. Nevertheless, there was concern about potential spread of MAYV to other regions similar to CHIKV in the past. The risk for transmission of emerging viruses by blood transfusion and the safety of plasma-derived medicinal products (PDMPs) are constant concerns. The manufacturing processes of PDMPs include procedures to inactivate/remove viruses. Methods: In this study, we investigated the reduction of MAYV and CHIKV by heat inactivation in various matrices, solvent/detergent treatment and nanofiltration. Results: Unexpectedly, MAYV was significantly more resistant to heat and solvent/detergent treatment compared to CHIKV. However, being similar in size, both MAYV and CHIKV were removed below the detection limit by 35 nm virus filters. Conclusions: The inactivation profiles of different alphavirus members vary considerably, even within the Semliki Forest Complex. However, robust dedicated viral inactivation/removal procedures commonly used in the plasma product industry are effective in inactivating or removing MAYV and CHIKV.


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