Cross-Linking Method-Based Nanogels for Biomedical Applications

2021 ◽  
pp. 3289-3305
Author(s):  
Mohamed Mohamady Ghobashy
Keyword(s):  
Biomedical Applications ◽  
Cross Linking

scholarly journals How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1510
Author(s):  
Sylwia Grabska-Zielińska ◽  
Alina Sionkowska
Keyword(s):  
Silk Fibroin ◽  
Biomedical Applications ◽  
Magnetic Particles ◽  
Chemical Properties ◽  
Ternary Mixtures ◽  
Cross Linking ◽  
Advantages And Disadvantages ◽  
Physico Chemical ◽  
Binary And Ternary Mixtures ◽  
To Receive

This review supplies a report on fresh advances in the field of silk fibroin (SF) biopolymer and its blends with biopolymers as new biomaterials. The review also includes a subsection about silk fibroin mixtures with synthetic polymers. Silk fibroin is commonly used to receive biomaterials. However, the materials based on pure polymer present low mechanical parameters, and high enzymatic degradation rate. These properties can be problematic for tissue engineering applications. An increased interest in two- and three-component mixtures and chemically cross-linked materials has been observed due to their improved physico-chemical properties. These materials can be attractive and desirable for both academic, and, industrial attention because they expose improvements in properties required in the biomedical field. The structure, forms, methods of preparation, and some physico-chemical properties of silk fibroin are discussed in this review. Detailed examples are also given from scientific reports and practical experiments. The most common biopolymers: collagen (Coll), chitosan (CTS), alginate (AL), and hyaluronic acid (HA) are discussed as components of silk fibroin-based mixtures. Examples of binary and ternary mixtures, composites with the addition of magnetic particles, hydroxyapatite or titanium dioxide are also included and given. Additionally, the advantages and disadvantages of chemical, physical, and enzymatic cross-linking were demonstrated.

scholarly journals Hydrogel-Silver Nanoparticle Composites for Biomedical Applications

2020 ◽  
Vol 65 (5) ◽  
pp. 446
Author(s):  
O. Nadtoka ◽  
N. Kutsevol ◽  
T. Bezugla ◽  
P. Virych ◽  
A. Naumenko
Keyword(s):  
Silver Nanoparticle ◽  
Biomedical Applications ◽  
Polymer Network ◽  
Cross Linking ◽  
Polyacrylamide Hydrogels ◽  
Photochemical Generation ◽  
Vis Spectroscopy ◽  
Swelling Capacity ◽  
Swelling Studies ◽  
Nanoparticle Composites

Polyacrylamide and dextran-graft-polyacrylamide hydrogels are prepared and used as nanoreactors and networks for the synthesis of silver nanoparticles (AgNPs). Photochemical generation of AgNPs is carried out under UV-irradiation of Ag+ ions in swollen hydrogels of different cross-linking densities. The obtained hydrogels and hydrogel/AgNPs composites are characterized by TEM, FTIR, and UV–Vis spectroscopy. Swelling studies have shown a relationship between the structure of the hydrogels and their ability to swell. It is shown that the presence of AgNPs in the polymer network leads to a decrease of the swelling capacity. An increase in the cross-linking density leads to an expansion of the AgNPs size distribution for both types of hydrogels. All synthesized hydrogel-silver nanoparticle composites have shown a high activity in the growth retardation of Staphylococcus aureus microorganisms.

scholarly journals Gamma Ray-Induced Polymerization and Cross-Linking for Optimization of PPy/PVP Hydrogel as Biomaterial

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 111 ◽  
Author(s):  
Jin-Oh Jeong ◽  
Jong-Seok Park ◽  
Young-Ah Kim ◽  
Su-Jin Yang ◽  
Sung-In Jeong ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Cell Viability ◽  
Gamma Rays ◽  
Biomedical Applications ◽  
Gamma Ray ◽  
The Other ◽  
Cross Linking ◽  
Gamma Ray Irradiation ◽  
Good Cell ◽  
Scanning Electron

Conducting polymer (CP)-based hydrogels exhibit the behaviors of bending or contraction/relaxation due to electrical stimulation. They are similar in some ways to biological organs and have advantages regarding manipulation and miniaturization. Thus, these hydrogels have attracted considerable interest for biomedical applications. In this study, we prepared PPy/PVP hydrogel with different concentrations and content through polymerization and cross-linking induced by gamma-ray irradiation at 25 kGy to optimize the mechanical properties of the resulting PPy/PVP hydrogel. Optimization of the PPy/PVP hydrogel was confirmed by characterization using scanning electron microscopy, gel fraction, swelling ratio, and Fourier transform infrared spectroscopy. In addition, we assessed live-cell viability using live/dead assay and CCK-8 assay, and found good cell viability regardless of the concentration and content of Py/pTS. The conductivity of PPy/PVP hydrogel was at least 13 mS/cm. The mechanical properties of PPy/PVP hydrogel are important factors in their application for biomaterials. It was found that 0.15PPy/PVP20 (51.96 ± 6.12 kPa) exhibited better compressive strength than the other samples for use in CP-based hydrogels. Therefore, it was concluded that gamma rays can be used to optimize PPy/PVP hydrogel and that biomedical applications of CP-based hydrogels will be possible.

scholarly journals Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Eltjani-Eltahir Hago ◽  
Xinsong Li
Keyword(s):  
Mechanical Properties ◽  
Mtt Assay ◽  
Biomedical Applications ◽  
Polymer Network ◽  
Physical And Mechanical Properties ◽  
Morphological Characterization ◽  
Interpenetrating Polymer Network ◽  
Synthesis And Characterization ◽  
Cross Linking ◽  
New Approach

In this work, a new approach was introduced to prepare interpenetrating polymer network PVA/GE hydrogels by cross-linking of various concentration gelatin in the presence of transglutaminase enzyme by using the freezing-thawing cycles technique. The effects of freezing-thawing cycles on the properties of morphological characterization, gel fraction, swelling, mechanical, and MTT assay were investigated. The IPN PVA/GE hydrogels showed excellent physical and mechanical Properties. MTT assay data and the fibroblasts culture also showed excellent biocompatibility and good proliferation. This indicates that the IPN hydrogels are stable enough for various biomedical applications.

Injectable and mechanically robust 4-arm PPO–PEO/graphene oxide composite hydrogels for biomedical applications

2015 ◽  
Vol 51 (42) ◽  
pp. 8876-8879 ◽  
Author(s):  
Yunki Lee ◽  
Jin Woo Bae ◽  
Thai Thanh Hoang Thi ◽  
Kyung Min Park ◽  
Ki Dong Park
Keyword(s):  
Graphene Oxide ◽  
Biomedical Applications ◽  
Cross Linking ◽  
Oxide Composite ◽  
Composite Hydrogels

Graphene-based nanomaterials with different oxidation degrees were incorporated into Tetronic–tyramine (Tet–TA) hydrogels via enzymatic cross-linking.

Modifying Fish Gelatin Electrospun Membranes for Biomedical Applications: Cross-Linking and Swelling Behavior

2014 ◽  
Vol 12 (3) ◽  
pp. 247-252 ◽  
Author(s):  
J. Padrão ◽  
J. P. Silva ◽  
L. R. Rodrigues ◽  
F. Dourado ◽  
S. Lanceros-Méndez ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Swelling Behavior ◽  
Cross Linking ◽  
Fish Gelatin ◽  
Electrospun Membranes

scholarly journals Thiol-ene cross-linking and functionalisation of Polydimethylsiloxane for biomedical applications

2016 ◽  
Vol 4 ◽  
Author(s):  
Nguyen Khai Duong Quang ◽  
Megone William Valentine ◽  
Kong Dexu ◽  
Gautrot Julien
Keyword(s):  
Biomedical Applications ◽  
Cross Linking

scholarly journals Oxytetracycline versus Doxycycline Collagen Sponges Designed as Potential Carrier Supports in Biomedical Applications

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 363 ◽  
Author(s):  
Tihan ◽  
Rău ◽  
Zgârian ◽  
Ungureanu ◽  
Barbaresso ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Structural Integrity ◽  
Release Kinetics ◽  
Collagen Sponge ◽  
Application Site ◽  
Cross Linking ◽  
Drug Kinetic ◽  
In Vitro Biocompatibility ◽  
Kinetic Release

Many research studies are directed toward developing safe and efficient collagen-based biomaterials as carriers for drug delivery systems. This article presents a comparative study of the properties of new collagen sponges prepared and characterized by different methods intended for biomedical applications. The structural integrity is one of the main properties for a biomaterial in order for it to be easily removed from the treated area. Thus, the effect of combining a natural polymer such as collagen with an antimicrobial drug such as oxytetracycline or doxycycline and glutaraldehyde as the chemical cross-linking agent influences the cross-linking degree of the material, which is in direct relation to its resistance to collagenase digestion, the drug kinetic release profile, and in vitro biocompatibility. The enzymatic degradation results identified oxytetracycline as the best inhibitor of collagenase when the collagen sponge was cross-linked with 0.5% glutaraldehyde. The drug release kinetics revealed an extended release of the antibiotic for oxytetracycline-loaded collagen sponges compared with doxycycline-loaded collagen sponges. Considering the behavior of differently prepared sponges, the collagen sponge with oxytetracycline and 0.5% glutaraldehyde could represent a viable polymeric support for the prevention/treatment of infections at the application site, favoring tissue regeneration.

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