The Impact of Implant Surface Characteristic and Genetics on Peri-implant Diseases

2020 ◽  
pp. 99-113
Author(s):  
Shan-Huey Yu ◽  
Hom-Lay Wang
Keyword(s):  
Surface Characteristic ◽  
Implant Surface ◽  
The Impact

scholarly journals The Impact of Dental Implant Surface Modifications on Osseointegration and Biofilm Formation

2021 ◽  
Vol 10 (8) ◽  
pp. 1641
Author(s):  
Stefanie Kligman ◽  
Zhi Ren ◽  
Chun-Hsi Chung ◽  
Michael Angelo Perillo ◽  
Yu-Cheng Chang ◽  
...  
Keyword(s):  
Dental Implant ◽  
Biofilm Formation ◽  
Bacterial Colonization ◽  
Surface Modifications ◽  
Implant Surface ◽  
Oral Rehabilitation ◽  
Surface Design ◽  
Polyether Ether Ketone ◽  
Dental Implant Surface ◽  
The Impact

Implant surface design has evolved to meet oral rehabilitation challenges in both healthy and compromised bone. For example, to conquer the most common dental implant-related complications, peri-implantitis, and subsequent implant loss, implant surfaces have been modified to introduce desired properties to a dental implant and thus increase the implant success rate and expand their indications. Until now, a diversity of implant surface modifications, including different physical, chemical, and biological techniques, have been applied to a broad range of materials, such as titanium, zirconia, and polyether ether ketone, to achieve these goals. Ideal modifications enhance the interaction between the implant’s surface and its surrounding bone which will facilitate osseointegration while minimizing the bacterial colonization to reduce the risk of biofilm formation. This review article aims to comprehensively discuss currently available implant surface modifications commonly used in implantology in terms of their impact on osseointegration and biofilm formation, which is critical for clinicians to choose the most suitable materials to improve the success and survival of implantation.

scholarly journals Relevance of Biofilm Models in Periodontal Research: From Static to Dynamic Systems

2021 ◽  
Vol 9 (2) ◽  
pp. 428
Author(s):  
María Carmen Sánchez ◽  
Andrea Alonso-Español ◽  
Honorato Ribeiro-Vidal ◽  
Bettina Alonso ◽  
David Herrera ◽  
...  
Keyword(s):  
Research Group ◽  
Surface Composition ◽  
Bacterial Colonization ◽  
Implant Surface ◽  
Biofilm Growth ◽  
Biofilm Model ◽  
Dental Implant Surface ◽  
The Impact

Microbial biofilm modeling has improved in sophistication and scope, although only a limited number of standardized protocols are available. This review presents an example of a biofilm model, along with its evolution and application in studying periodontal and peri-implant diseases. In 2011, the ETEP (Etiology and Therapy of Periodontal and Peri-Implant Diseases) research group at the University Complutense of Madrid developed an in vitro biofilm static model using representative bacteria from the subgingival microbiota, demonstrating a pattern of bacterial colonization and maturation similar to in vivo subgingival biofilms. When the model and its methodology were standardized, the ETEP research group employed the validated in vitro biofilm model for testing in different applications. The evolution of this model is described in this manuscript, from the mere observation of biofilm growth and maturation on static models on hydroxyapatite or titanium discs, to the evaluation of the impact of dental implant surface composition and micro-structure using the dynamic biofilm model. This evolution was based on reproducing the ideal microenvironmental conditions for bacterial growth within a bioreactor and reaching the target surfaces using the fluid dynamics mimicking the salivary flow. The development of this relevant biofilm model has become a powerful tool to study the essential processes that regulate the formation and maturation of these important microbial communities, as well as their behavior when exposed to different antimicrobial compounds.

scholarly journals Human Periodontal Ligament Stem Cells Response to Titanium Implant Surface: Extracellular Matrix Deposition

Biology ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 931
Author(s):  
Guya Diletta Marconi ◽  
Luigia Fonticoli ◽  
Ylenia Della Della Rocca ◽  
Thangavelu Soundara Rajan ◽  
Adriano Piattelli ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Dental Implants ◽  
Dental Implant ◽  
Periodontal Ligament ◽  
Implant Surface ◽  
Periodontal Ligament Stem Cells ◽  
Matrix Deposition ◽  
Dental Implant Surface ◽  
The Impact

The major challenge for dentistry is to provide the patient an oral rehabilitation to maintain healthy bone conditions in order to reduce the time for loading protocols. Advancement in implant surface design is necessary to favour and promote the osseointegration process. The surface features of titanium dental implant can promote a relevant influence on the morphology and differentiation ability of mesenchymal stem cells, induction of the osteoblastic genes expression and the release of extracellular matrix (ECM) components. The present study aimed at evaluating the in vitro effects of two different dental implants with titanium surfaces, TEST and CTRL, to culture the human periodontal ligament stem cells (hPDLSCs). Expression of ECM components such as Vimentin, Fibronectin, N-cadherin, Laminin, Focal Adhesion Kinase (FAK) and Integrin beta-1 (ITGB1), and the osteogenic related markers, as runt related transcription factor 2 (RUNX2) and alkaline phosphatase (ALP), were investigated. Human PDLSCs cultured on the TEST implant surface demonstrated a better cell adhesion capability as observed by Scanning Electron Microscopy (SEM) and immunofluorescence analysis. Moreover, immunofluorescence and Western blot experiments showed an over expression of Fibronectin, Laminin, N-cadherin and RUNX2 in hPDLSCs seeded on TEST implant surface. The gene expression study by RT-PCR validated the results obtained in protein assays and exhibited the expression of RUNX2, ALP, Vimentin (VIM), Fibronectin (FN1), N-cadherin (CDH2), Laminin (LAMB1), FAK and ITGB1 in hPDLSCs seeded on TEST surface compared to the CTRL dental implant surface. Understanding the mechanisms of ECM components release and its regulation are essential for developing novel strategies in tissue engineering and regenerative medicine. Our results demonstrated that the impact of treated surfaces of titanium dental implants might increase and accelerate the ECM apposition and provide the starting point to initiate the osseointegration process.

scholarly journals The Impact of Instrumentation and Implant Surface Technology on Cervical and Thoracolumbar Fusion

2021 ◽  
Vol 21 (Supplement_1) ◽  
pp. S12-S22
Author(s):  
Timothy Y Wang ◽  
Vikram A Mehta ◽  
Eric W Sankey ◽  
Christopher I Shaffrey ◽  
Muhammad M Abd-El-Barr ◽  
...  
Keyword(s):  
Spinal Fusion ◽  
Materials Science ◽  
Spinal Instrumentation ◽  
Spine Fusion ◽  
Implant Surface ◽  
New Era ◽  
The Past ◽  
Spinal Arthrodesis ◽  
The Impact ◽  
Existing Data

Abstract Spinal fusion has undergone significant evolution and improvement over the past 50 yr. Historically, spine fusion was noninstrumented and arthrodesis was based entirely on autograft. Improved understanding of spinal anatomy and materials science ushered in a new era of spinal fusion equipped with screw-based technologies and various interbody devices. Osteobiologics is another important realm of spine fusion, and the evolution of various osteobiologics has perhaps undergone the most change within the past 20 yr. A new element to spinal instrumentation has recently gained traction—namely, surface technology. New data suggest that surface treatments play an increasingly well-recognized role in inducing osteogenesis and successful fusion. Until now, however, there has yet to be a unified resource summarizing the existing data and a lack of consensus exists on superior technology. Here, authors provide an in-depth review on surface technology and its impact on spinal arthrodesis.

scholarly journals Modification of joint prosthesis surfaces by ultrashort pulse laser treatment for improved joint lubrication

2019 ◽  
Vol 5 (1) ◽  
pp. 57-60 ◽  
Author(s):  
Philipp Drescher ◽  
Paul Oldorf ◽  
Tim Dreier ◽  
Rigo Peters ◽  
Hermann Seitz
Keyword(s):  
Life Cycle ◽  
Synovial Fluid ◽  
Joint Fluid ◽  
Test Fluid ◽  
Joint Interface ◽  
Implant Surface ◽  
Ultrashort Pulse Laser ◽  
Wear Process ◽  
Three Body Abrasion ◽  
The Impact

AbstractEndoprostheses such as hip replacements are subject to wear. Lubrication of the joint interface plays a key role in the wear process, but the mechanisms of lubrication is challenging to understand. The main issue is the three-body abrasion which leads to a shorter life cycle. In order to improve the life cycle, the surfaces of the articulating components can be modified, for example by pulsed femtosecond-laser microstructuring. By microstructuring of the implant surface, the viscosity of the synovial fluid between the joint can be increased due to the non-Newtonian properties of the synovia. This leads to better lubrication and therefore lower particle abrasion. The objective of this study was to evaluate the impact of different microstructures on the viscosity of a joint fluid substitute. Various microstructures were investigated in a modified rheometer setup featuring a decreased gap size. As a test fluid, a synovial fluid substitute was used. The results show that an increase in the viscosity of the synovial fluid substitute can be achieved by microstructuring. An increase of viscosity of up to 20 % compared to the unstructured reference was observed with ring-structures with a diameter of 100 μm and a depth of 20 μm.

scholarly journals Establishment and Characterization of Bacterial Infection of Breast Implants in a Murine Model

2019 ◽  
Vol 40 (5) ◽  
pp. 516-528 ◽  
Author(s):  
Jennifer N Walker ◽  
Louis H Poppler ◽  
Chloe L Pinkner ◽  
Scott J Hultgren ◽  
Terence M Myckatyn
Keyword(s):  
Staphylococcus Epidermidis ◽  
Breast Implant ◽  
Breast Implants ◽  
Surface Characteristics ◽  
Implant Surface ◽  
Colony Forming Units ◽  
Common Causes ◽  
The Impact ◽  
Post Implantation

Abstract Background Staphylococcus epidermidis and Pseudomonas aeruginosa are the most common causes of Gram-positive and Gram-negative breast implant–associated infection. Little is known about how these bacteria infect breast implants as a function of implant surface characteristics and timing of infection. Objectives The aim of this work was to establish a mouse model for studying the impact of various conditions on breast implant infection. Methods Ninety-one mice were implanted with 273 breast implant shells and infected with S. epidermidis or P. aeruginosa. Smooth, microtextured, and macrotextured breast implant shells were implanted in each mouse. Bacterial inoculation occurred during implantation or 1 day later. Implants were retrieved 1 or 7 days later. Explanted breast implant shells were sonicated, cultured, and colony-forming units determined or analyzed with scanning electron microscopy. Results P. aeruginosa could be detected on all device surfaces at 1- and 7- days post infection (dpi), when mice were implanted and infected concurrently or when they were infected 1- day after implantation. However, P. aeruginosa infection was more robust on implant shells retrieved at 7 dpi and particularly on the macrotextured devices that were infected 1 day post implantation. S. epidermidis was mostly cleared from implants when mice were infected and implanted concurrently. Other the other hand, S. epidermidis could be detected on all device surfaces at 1 dpi and 2 days post implantation. However, S. epidermdis infection was suppressed by 7 dpi and 8 days post implantation. Conclusions S. epidermidis required higher inoculating doses to cause infection and was cleared within 7 days. P. aeruginosa infected at lower inoculating doses, with robust biofilms noted 7 days later.

scholarly journals The Effect of Diclofenac Sodium-Loaded Poly(Lactide-co-Glycolide) Rods on Bone Formation and Inflammation: A Histological and Histomorphometric Study in the Femora of Rats

Micromachines ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1098
Author(s):  
Karoline M. Reich ◽  
Petrus Viitanen ◽  
Ehsanul Hoque Apu ◽  
Stefan Tangl ◽  
Nureddin Ashammakhi
Keyword(s):  
Bone Regeneration ◽  
Diclofenac Sodium ◽  
Giant Cells ◽  
Host Tissue ◽  
Negative Effects ◽  
Implant Surface ◽  
Histomorphometric Study ◽  
Tissue Reactions ◽  
Local Release ◽  
The Impact

Implants made of poly(lactide-co-glycolide) (PLGA) are biodegradable and frequently provoke foreign body reactions (FBR) in the host tissue. In order to modulate the inflammatory response of the host tissue, PLGA implants can be loaded with anti-inflammatory drugs. The aim of this study was to analyze the impact of PLGA 80/20 rods loaded with the diclofenac sodium (DS) on local tissue reactions in the femur of rats. Special emphasis was put on bone regeneration and the presence of multinucleated giant cells (MGCs) associated with FBR. PLGA 80/20 alone and PLGA 80/20 combined with DS was extruded into rods. PLGA rods loaded with DS (PLGA+DS) were implanted into the femora of 18 rats. Eighteen control rats received unloaded PLGA rods. The follow-up period was of 3, 6 and 12 weeks. Each group comprised of six rats. Peri-implant tissue reactions were histologically and histomorphometrically evaluated. The implantation of PLGA and PLGA+DS8 rods induced the formation of a layer of newly formed bone islands parallel to the contour of the implants. PLGA+DS rods tended to reduce the presence of multi-nucleated giant cells (MGCs) at the implant surface. Although it is known that the systemic administration of DS is associated with compromised bone healing, the local release of DS via PLGA rods did not have negative effects on bone regeneration in the femora of rats throughout 12 weeks.

Research on the Impact of Surface Characteristic of Paper on Digital Printing Color Reproduction

2012 ◽  
Vol 549 ◽  
pp. 610-614
Author(s):  
Xue Lin Huang
Keyword(s):  
Surface Characteristics ◽  
Surface Characteristic ◽  
Digital Printing ◽  
Color Reproduction ◽  
Color Gamut ◽  
Printing Quality ◽  
Color Rendering ◽  
The Impact

The different paper has the different Surface Characteristic, which has the different influences on the printing color Reproduction. Through the paper printability, the color gamut experiments of digital printing, The influence of surface characteristics of paper on digital printing color reproduction was analyzed according to color rendering ability, The results indicated that the printed matter had better color efficiency, greater color gamut and smaller hue error and grayscale which had higher paper smoothness and glossiness, the higher paper whiteness is in favor of color reproduction. The surface characteristic of paper limits color reproduction. To ensure printing quality, should choose better color efficiency of paper.

Histomorphometric Evaluation of Six Dental Implant Surfaces After Early Loading in Augmented Human Sinuses

10.1563/812.1 ◽  
2006 ◽  
Vol 32 (4) ◽  
pp. 153-166 ◽  
Author(s):  
Marzio Todisco ◽  
Paolo Trisi
Keyword(s):  
Histomorphometric Analysis ◽  
Implant Surface ◽  
Native Bone ◽  
Early Loading ◽  
Single Tooth ◽  
Bone To Implant Contact ◽  
Etched Surface ◽  
Plasma Sprayed ◽  
The Impact ◽  
Limited Scope

Abstract This study investigated the bone-to-implant contact (BIC) and osteoconductive capacity (OC) of 6 different implant surfaces after early loading in humans. Two implants with different surfaces were placed side-by-side in the grafted (n = 5) and nongrafted (n = 1) sinuses of 3 volunteers. Single-tooth restorations were delivered 60 days later. After 6 months of full occlusal loading, implants were retrieved in block sections for histomorphometric analysis. One implant (acid etched) placed in grafted bone failed when loaded. There were no other complications. In grafted bone, the microtextured surface achieved the highest BIC value (94.08%), followed by the oxidized (77.32%), hydroxyapatite (HA) (74.51%), sandblasted and acid-etched (51.85%), and titanium plasma-sprayed (TPS) (41.48%) surfaces. In native bone, the acid-etched surface achieved a higher BIC value (69.03%) than the HA surface (59.03%). The highest OC value in grafted bone was exhibited by the microtextured surface (34.31%), followed by the HA (28.62%), sandblasted and acid-etched (25.08%), oxidized (17.55%), and TPS (−20.47%) surfaces. The HA surface exhibited a higher OC value (30.39%) in native bone compared with the acid-etched surface (24.0%). As a whole, highest BIC and OC values were exhibited by the microtextured surface, and lowest values were exhibited by the TPS surface. All other surfaces demonstrated excellent BIC (>50%) but varied in OC (range = 17.55%–28.62%). These findings are tempered by the limited scope and sample size of the study and should be considered preliminary. More research is needed to determine the impact of implant surface texture on BIC and OC.

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