Placental Disorders of Uncertain Etiology

2021 ◽  
pp. 729-751
Author(s):  
Philip J. Katzman
Keyword(s):  
Author(s):  
A. W. Fetter ◽  
C. C. Capen

Atrophic rhinitis in swine is a disease of uncertain etiology in which infectious agents, hereditary predisposition, and metabolic disturbances have been reported to be of primary etiologic importance. It shares many similarities, both clinically and pathologically, with ozena in man. The disease is characterized by deformity and reduction in volume of the nasal turbinates. The fundamental cause for the localized lesion of bone in the nasal turbinates has not been established. Reduced osteogenesis, increased resorption related to inflammation of the nasal mucous membrane, and excessive resorption due to osteocytic osteolysis stimulated by hyperparathyroidism have been suggested as possible pathogenetic mechanisms.The objectives of this investigation were to evaluate ultrastructurally bone cells in the nasal turbinates of pigs with experimentally induced atrophic rhinitis, and to compare these findings to those in control pigs of the same age and pigs with the naturally occurring disease, in order to define the fundamental lesion responsible for the progressive reduction in volume of the osseous core.


2011 ◽  
Vol 87 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Biruck Desalegn ◽  
Shanika Nanayakkara ◽  
Kouji H. Harada ◽  
Toshiaki Hitomi ◽  
Rohana Chandrajith ◽  
...  

2014 ◽  
Vol 28 (4) ◽  
pp. 413-418 ◽  
Author(s):  
Roger Cady ◽  
Sandy Yacoub Garas ◽  
Ketu Patel ◽  
Andrew Peterson ◽  
Richard Wenzel

Headache, a nearly universal experience, remains costly, disabling, and often suboptimally managed. The most common presentations in the United States are migraine, tension-type headache (TTH) and “sinus” headache, but their extensive symptomatic overlap suggests that these conditions can be approached as variations in the same underlying pathology and managed accordingly. We use case studies of patients with varying prior diagnoses (none, migraine, TTH, and sinus headache), as well as a 4-question diagnostic screening tool, to illustrate how pharmacists can use this conceptual framework to simplify identification, management, and referral of patients with primary headache conditions of uncertain etiology.


2021 ◽  
Vol 3 (6) ◽  
Author(s):  
W. M. Dimuthu Nilmini Wijeyaratne ◽  
Ellewaththe Arachchilage Charuni Se Kumari

AbstractCentella asiatica is a commonly consumed green leafy vegetable in many developing countries due its high nutritious value and availability at low cost. The present study was conducted to assess the Cd, Cr and Pb uptake associated health risks of Centella asiatica harvested from organic and non-organic cultivations in a chronic kidney disease of uncertain etiology (CKDue) prevalent area in Sri Lanka. The health risk assessment was conducted in terms of the bioconcentration factor (BCF), soil-to-root and root-to-leaf translocation factors ($${\text{TF}}\,({\text{soil-root}})$$ TF ( soil-root ) and $${\text{TF}}\,({\text{root-leaf}})$$ TF ( root-leaf ) ), Target hazard quotient for each heavy metal (THQ) and hazard index (HI). In addition, the spatial variation of physical and chemical parameters of the root zone soil were assessed using MINITAB 17 statistical software. Results indicated significant spatial variations in conductivity, organic matter content and Cr concentrations among organic and non-organic study sites. The Cr, Cd and Pb concentrations recorded from roots and leaves of Centella asiatica were higher than the safe limits for consumption established by the European Union. The health risk analysis indicated that there is a potential of hyper-accumulating Cd in the roots of Centella asiatica. Further, the THQ and HI of the heavy metals indicated possible adverse non-cancer health risks associated with long-term consumption of leaves of Centella asiatica. Therefore, necessary precautionary actions to prevent the excessive buildup of Cr, Cd and Pb in the edible portions of Centella asiatica are essential in order to ensure consumer safety.


PEDIATRICS ◽  
1978 ◽  
Vol 61 (3) ◽  
pp. 506-506
Author(s):  
Alex J. Steigman

Infectious mononucleosis (IM) is a defined clinical syndrome, until recently regarded as of uncertain etiology affecting only a limited number of persons. The etiology of IM can now be ascribed correctly to primary infection with Epstein-Barr virus (EBV), a member of the herpesvirus family. It is increasingly evident that primary infection with EBV may also induce a range of clinical responses from no detectable illness1 to a variety of disorders without the clinical or hematologic hallmarks of the IM syndrome.


2021 ◽  
Author(s):  
M.H.Ashan Madusanka ◽  
◽  
Sandun Sadanayake ◽  
lkMeththika Vithanage ◽  
◽  
...  

In several regions of the dry zone of Sri Lanka, excessive quantities of fluoride (F-) in groundwater have affected the water quality significantly. Apart from the well-known prevalence of dental fluorosis, Chronic Kidney Disease of uncertain etiology (CKDu) is widespread in different pockets in the dry zone of Sri Lanka [1]. Fluoride is one of the substances suspected of being causative of CKDu in the area. Since the kidneys retain more F- than in any other soft tissue and excess F- exposure can cause kidney disease. Within the same zone, the prevalence of CKDu varies by geographic area in a ground water and spatial distribution of selected trace elements in groundwater. The optimum F- level in drinking water, according to WHO guidelines, is 1.5 (mg/L); however, due to the unfavorable climatic conditions that exist in tropical countries, people ingest more water than normal intake, resulting in a high F- intake. The source of F- is geogenic. It has been found that the F- content of basement rocks ranges from 9.5×10-5 to 1.44×10-3 kg/L in the region [3]. Farmers consume about 2-3 liters of water a day to quench their thirst, resulting in a daily F- intake of 3×10-3-1×10-2 kg/L [4].


2014 ◽  
Vol 4 (3) ◽  
pp. 192-198
Author(s):  
C. Takahashi ◽  
M. Mass ◽  
B. Hamilton ◽  
S. H. Guletkin ◽  
D. Bourdette

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