Psychosocial risk and resistance factors among children with chronic illness, healthy siblings, and healthy controls

1987 ◽  
Vol 15 (2) ◽  
pp. 295-308 ◽  
Author(s):  
Denise Daniels ◽  
Rudolf H. Moos ◽  
Andrew G. Billings ◽  
John J. Miller
Keyword(s):  
Chronic Illness ◽  
Psychosocial Risk ◽  
Healthy Controls ◽  
Resistance Factors ◽  
Healthy Siblings

Fecal microbiota in untreated children with Juvenile Idiopathic Arthritis – a comparison with healthy children and healthy siblings

2020 ◽  
pp. jrheum.200551
Author(s):  
Anders Öman ◽  
Johan Dicksved ◽  
Lars Engstrand ◽  
Lillemor Berntson
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Community Composition ◽  
Alpha Diversity ◽  
Fecal Microbiota ◽  
Rrna Gene ◽  
Healthy Children ◽  
Healthy Controls ◽  
Α Diversity ◽  
Healthy Siblings ◽  
Relative Abundances

Objective Changes in the composition of gut microbiota has been suggested to be associated with Juvenile idiopathic arthritis (JIA). The objective in this study was to investigate if the diversity and composition of the fecal microbiota differed between children with JIA and healthy controls, and if the microbiota differed between children with JIA and their healthy siblings. Methods In this multicenter, case-control study, fecal samples were collected from 75 children with JIA and 32 healthy controls. Eight of the healthy controls were siblings to eight children with JIA and they were compared only pairwise with their siblings. The microbiota was determined using sequencing amplicons from the V3 and V4 regions of the 16S rRNA gene. Alpha diversity, community composition of microbiota and relative abundances of taxa were compared between children with JIA and healthy unrelated controls as well as between children with JIA and healthy siblings. Results Our data revealed no significant differences in α-diversity or community composition of microbiota between children with JIA, healthy unrelated controls or healthy siblings. Analyses of relative abundances of phyla, families and genera identified trends of differing abundances of some taxa in children with JIA, in comparison with both healthy controls and healthy siblings, but none of these findings were significant after adjustment for multiple comparisons. Conclusion There were no significant differences in the composition of fecal microbiota in children with JIA compared with healthy controls. The composition of microbiota in children with JIA did not differ significantly from that in their healthy siblings.

Emotional vulnerability and cognitive control in patients with bipolar disorder and their healthy siblings: a pilot study

2010 ◽  
Vol 22 (2) ◽  
pp. 54-62 ◽  
Author(s):  
Kathrin Houshmand ◽  
Peter Bräunig ◽  
Siegfried Gauggel ◽  
Katrin Kliesow ◽  
Rahul Sarkar ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Pilot Study ◽  
Cognitive Control ◽  
Response Inhibition ◽  
Emotional Regulation ◽  
Mood State ◽  
Emotional Arousal ◽  
Healthy Controls ◽  
Healthy Siblings ◽  
Emotional Vulnerability

Scheuch K, Bräunig P, Gauggel S, Kliesow K, Sarkar R, Krüger S. Emotional vulnerability and cognitive control in patients with bipolar disorder and their healthy siblings: a pilot study.Objective:There is evidence that, even in remission, patients with bipolar disorder (BD) have deficits in cognitive function and emotional regulation. Siblings of patients with BD are also reported to exhibit minor dysfunction in neuropsychological domains. In this study, we examined the interference of acute mood state with reaction time (RT) and response inhibition in euthymic patients with BD, in their healthy siblings and in healthy controls.Methods:A total of 34 patients with bipolar I disorder, 22 healthy siblings and 33 healthy controls performed a stop-signal paradigm after induction of a transient intense sadness and a relaxed mood state. The differences in RT and the response inhibition were compared between the groups.Results:Euthymic patients with BD displayed a higher emotional reactivity compared with their siblings and with controls. Compared with controls, patients with BD showed longer RTs in a relaxed mood state and a delay in response inhibition during emotional activation.Conclusions:The present study provides evidence for the clinical observation that patients with BD have shorter RTs when in a state of emotional arousal rather than in a relaxed state. Inhibitory deficits in these patients may be because of a too strong emotional arousal. The results show that in patients with BD, relaxation and emotional arousal are inversely associated with performance in a neuropsychological task. This is in contrast to findings in healthy individuals suggesting a dysbalance in emotional regulation in these patients.

Self- and Parent/Proxies-Reported Health-Related Quality Of Life In Children and Adolescents With Bleeding Disorders: Cross Sectional Investigation and Comparison With Healthy Siblings and Healthy Peers

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 4773-4773
Author(s):  
Neuner Bruno ◽  
Sylvia von Mackensen ◽  
Susan Halimeh ◽  
Susanne Holzhauer ◽  
Robert Klamroth ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Well Being ◽  
Haemophilia A ◽  
Healthy Controls ◽  
Bleeding Disorders ◽  
Health Related Quality ◽  
Healthy Siblings ◽  
Related Quality ◽  
Health Related

Background Hereditary bleeding disorders (HBD) affect children from birth during their life course. Medical treatment and the overall prognosis of children with HBD have significantly progressed. But even in patients cared for in specialized treatment centers it remains unclear whether survival till adulthood goes along with health-related quality of life [Hr-QoL] comparable to other patients groups respectively comparable to population children. Therefore aim of the present study was to assess self- as well as parents/proxies reported Hr-QoL in children and adolescents with HBD and to compare the results with findings from children affected by another chronic medical condition respectively with healthy siblings and peers. Methods 91 patients with HBD (thrombosis / deep venous thrombosis, DVT, respectively Haemophilia A and B) aged 8 to 16 years from 6 Hemophilia study centers were investigated regarding Hr-QoL. Hr-QoL was assessed in patients and parents/proxies with the generic KINDL-R questionnaire exploring overall well-being and 6 sub-dimensions (physical well-being, psychological well-being, self-esteem, family-related well-being, friend-related well-being, and school-related well-being). Findings were compared with 70 children with stroke / TIA respectively with healthy controls (45 healthy siblings and 106 healthy peers). Results Overall well-being in children with thrombosis / DVT (77.6 ± 9.7 points) was comparable to healthy controls but in children with Haemophilia A or B (76.0 ± 9.6) lower compared with healthy peers (80.2 ± 9.7, p = 0.005). No differences occurred between healthy controls and children with stroke/TIA (74.2 ± 10.3). In children with HBD none of the KINDL-R sub-dimensions showed values below healthy siblings. Two KINDL-R sub-dimensions showed lower values compared with healthy peers. Parents/proxies rated the Hr-QoL of their children with HBD similar to their healthy children. The internal consistency of overall well-being in all study subgroups was acceptable (> 0.7) but showed poor results (< 0.5) in two KINDL-R sub-dimensions. Discussion The application of a generic Hr-QoL questionnaire in a sample of children and adults with HBD seems feasible. Their Hr-QoL seems comparable to their siblings but below their healthy peers. Disclosures: Halimeh: Octapharma AG: Investigator Other, Research Funding.

Psychological Adjustment Among Healthy Siblings of Adolescents with Chronic Illness

1996 ◽  
Vol 17 (4) ◽  
pp. 293???295
Author(s):  
E. J. Silver ◽  
M. J. Frohlinger ◽  
L. E. Westbrook ◽  
J. L. Lauby
Keyword(s):  
Chronic Illness ◽  
Psychological Adjustment ◽  
Healthy Siblings

scholarly journals Quality-of-Life Evaluation of Healthy Siblings of Children with Chronic Illness

2019 ◽  
Author(s):  
Meltem Dinleyici ◽  
Kürşat Bora Carman ◽  
Canan Özdemir ◽  
Koray Harmancı ◽  
Makbule Eren ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Illness ◽  
Life Evaluation ◽  
Healthy Siblings

scholarly journals Depressive symptoms are associated with (sub)clinical psychotic symptoms in patients with non-affective psychotic disorder, siblings and healthy controls

2012 ◽  
Vol 43 (4) ◽  
pp. 747-756 ◽  
Author(s):  
R. M. C. Klaassen ◽  
M. Heins ◽  
L. B. Luteijn ◽  
M. van der Gaag ◽  
N. J. M. van Beveren ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Psychotic Disorder ◽  
Depressed Mood ◽  
Negative Symptoms ◽  
Psychotic Symptoms ◽  
Healthy Controls ◽  
Healthy Siblings ◽  
Depressive Episodes ◽  
Positive And Negative Symptoms ◽  
Subclinical Psychosis

BackgroundDepression is a clinically relevant dimension, associated with both positive and negative symptoms, in patients with schizophrenia. However, in siblings it is unknown whether depression is associated with subclinical positive and negative symptoms.MethodDepressive symptoms and their association with positive and negative symptoms were examined in 813 healthy siblings of patients with a non-affective psychotic disorder, 822 patients and 527 healthy controls. Depressive episodes meeting DSM-IV-TR criteria (lifetime) and depressed mood (lifetime) were assessed with the Comprehensive Assessment of Symptoms and History (CASH) in all three groups. In the patient group, the severity of positive and negative psychosis symptoms was assessed with the CASH. In the siblings and healthy controls, the severity of subclinical psychosis symptoms was assessed with the Community Assessment of Psychic Experiences (CAPE).ResultsPatients reported more lifetime depressed mood and more depressive episodes than both siblings and controls. Siblings had a higher chance of meeting lifetime depressive episodes than the controls; no significant differences in depressed mood were found between siblings and controls. In all three groups the number and duration of depressive symptoms were associated with (sub)clinical negative symptoms. In the patients and siblings the number of depressive symptoms was furthermore associated with (sub)clinical positive symptoms. Finally, lifetime depressed mood showed familial clustering but this clustering was absent for lifetime depressive episodes.ConclusionsThese findings suggest that a co-occurring genetic vulnerability for both depressive and psychotic symptomatology exists on a clinical and a subclinical level.

Antisaccade deficit is present in young first-episode patients with schizophrenia but not in their healthy young siblings

2007 ◽  
Vol 38 (6) ◽  
pp. 871-875 ◽  
Author(s):  
O. M. de Wilde ◽  
L. Bour ◽  
P. Dingemans ◽  
T. Boerée ◽  
D. Linszen
Keyword(s):  
Eye Movements ◽  
Error Rate ◽  
Genetic Factors ◽  
First Episode ◽  
Rate Variation ◽  
Healthy Controls ◽  
Intra Class Correlation ◽  
Healthy Siblings ◽  
Statistical Results ◽  
Better Than

BackgroundResults of studies on antisaccade (AS) deficit in relatives of patients with schizophrenia are inconclusive. We hypothesized that AS performance in siblings of patients with schizophrenia is worse than in healthy controls and better than in patients with schizophrenia.MethodWe included 55 first-episode patients with schizophrenia, 28 healthy siblings and 36 healthy controls to evaluate AS performance. Eye movements were measured electromagnetically by the double magnetic induction (DMI) method.ResultsPatients with schizophrenia had a significantly higher error rate than siblings (d=0.86, p<0.0001) and controls (d=1.35, p<0.0001). Siblings had a higher mean error rate than healthy controls but this did not reach significance (d=0.56, p=0.29). The intra-class correlation (ICC) was 0.33 for the error rate. Mean AS gain was higher in siblings than in patients (d=0.75, p=0.004) and controls (d=0.6, p=0.05). The ICC was 0.08.ConclusionAS parameters in strictly screened healthy young siblings of young first-episode patients with schizophrenia are comparable to results found in studies investigating older relatives. However, the statistical results (i.e. the ICCs) suggest that there is little evidence of shared environmental or genetic factors on error rate variation.

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