Role of C-reactive protein, D-dimer, and fibrinogen levels in the differential diagnosis of central and peripheral vertigo

Background: Complications of coronavirus disease 2019 (COVID-19) include coagulopathy. We performed a meta-analysis on the association of COVID-19 severity with changes in hemostatic parameters. Methods: Data on prothrombin time (PT), activated partial thromboplastin time (aPTT), D-Dimer, platelets (PLT), or fibrinogen in severe versus mild COVID-19 patients, and/or in non-survivors to COVID-19 versus survivors were systematically searched. The standardized mean difference (SMD) was calculated. Results: Sixty studies comparing 5487 subjects with severe and 9670 subjects with mild COVID-19 documented higher PT (SMD: 0.41; 95%CI: 0.21, 0.60), D-Dimer (SMD: 0.67; 95%CI: 0.52, 0.82), and fibrinogen values (SMD: 1.84; 95%CI: 1.21, 2.47), with lower PLT count (SMD: −0.74; 95%CI: −1.01, −0.47) among severe patients. Twenty-five studies on 1511 COVID-19 non-survivors and 6287 survivors showed higher PT (SMD: 0.67; 95%CI: 0.39, 0.96) and D-Dimer values (SMD: 3.88; 95%CI: 2.70, 5.07), with lower PLT count (SMD: −0.60, 95%CI: −0.82, −0.38) among non-survivors. Regression models showed that C-reactive protein values were directly correlated with the difference in PT and fibrinogen. Conclusions: Significant hemostatic changes are associated with COVID-19 severity. Considering the risk of fatal complications with residual chronic disability and poor long-term outcomes, further studies should investigate the prognostic role of hemostatic parameters in COVID-19 patients.

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Clinical Evaluation for the Role of High-Sensitivity C-Reactive Protein in Combination with D-Dimer and Wells Score Probability Test to Predict the Incidence of Deep Vein Thrombosis Among Cancer Patients

International Journal of General Medicine ◽

10.2147/ijgm.s261718 ◽

2020 ◽

Vol Volume 13 ◽

pp. 587-594

Author(s):

Budi Setiawan ◽

Rosalina Rosalina ◽

Eko Adhi Pangarsa ◽

Damai Santosa ◽

Catharina Suharti

Keyword(s):

Deep Vein Thrombosis ◽

Cancer Patients ◽

High Sensitivity ◽

C Reactive Protein ◽

Vein Thrombosis ◽

Reactive Protein ◽

Wells Score ◽

Deep Vein ◽

D Dimer

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Role of biomarkers in predicting prognosis of Coronavirus disease 2019 (COVID-19): A retrospective cross-sectional study: Perspective of a tertiary care hospital in India

World Journal of Advanced Research and Reviews ◽

10.30574/wjarr.2021.11.1.0300 ◽

2021 ◽

Vol 11 (1) ◽

pp. 081-090

Author(s):

Arushi Mohan ◽

Padmini SN ◽

Brunda MS ◽

Abhinaya Shekhar ◽

Paul Matthew ◽

...

Keyword(s):

Inflammatory Markers ◽

Cross Sectional Study ◽

Sectional Study ◽

C Reactive Protein ◽

Oxygen Requirement ◽

Cross Sectional ◽

Reactive Protein ◽

Significant Difference ◽

D Dimer

Background: COVID-19 is a novel disease triggered by the SARS-CoV-2 virus, a beta coronavirus similar to MERS-CoV and SARS CoV. Inflammatory markers have a vital role in the pathogenesis of nCOVID 19; understanding the importance of these inflammatory markers in determining disease status is essential given the impact of the disease on healthcare. Thus, being able to triage cases with minimal tests is momentous to capture, which we have investigated as per our study guidelines of the role of inflammatory markers such as D-dimer, CRP (C - reactive protein), Ferritin, LDH (Lactate Dehydrogenase) in patients with COVID 19. In addition, limited data is available comparing the utility of these inflammatory markers to predict the following parameters as the need for ICU, oxygen support requirement, and duration of in-hospital stay, which can help guide the management protocol. Aim: This study aims to determine markers associated with poor prognosis in patients with Coronavirus disease 2019 (COVID-19). Objectives: 1) To assess the inflammatory markers that are routinely investigated in COVID- 19 patients. 2) To determine the most probable factor to estimate severity in COVID- 19 and thus predict prognosis. Methods: This is a retrospective cross-sectional observational study of patients who tested SARS COV 2 positive by RT PCR. The laboratory inflammatory markers, namely Lactate Dehydrogenase, C reactive protein, D-dimer, Ferritin, were assessed in the selected patients, and their clinical data and demographic details were taken into account. The parameters considered for contributing to the severity included the number of days of stay in the hospital, oxygen requirement, and ICU needs. Analyses relied upon analysis of variance for cross-sectional study design and a P< 0.05 statistical significance criterion. Results: There was a statistically significant difference found between oxygen requirement and D dimer (p<0.001), LDH (p= 0.002), and CRP (p= 0.024). There was a statistically significant difference found between admission to ICU and D Dimer (p= 0.001). Conclusion: A statistically significant association between the increasing D-dimer levels and all the outcome measures considered was found. The D-dimer, LDH, and CRP help predict oxygen requirement, and all the inflammatory markers can predict the number of days of stay in the hospital.

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The Role of Procalcitonin, C-reactive Protein and White Blood Cells in the Differential Diagnosis Between Sepsis and SIRS in Cardiac Surgery Patients

10.1055/s-0039-1678851 ◽

2019 ◽

Author(s):

D. Brugnetti ◽

M. Genoni ◽

U. Held ◽

K. Reeve ◽

L. Rings ◽

...

Keyword(s):

Differential Diagnosis ◽

Cardiac Surgery ◽

Blood Cells ◽

White Blood Cells ◽

C Reactive Protein ◽

Reactive Protein

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Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study

Clinics ◽

10.6061/clinics/2021/e3547 ◽

2021 ◽

Vol 76 ◽

Author(s):

Fabio Augusto Rodrigues Gonçalves ◽

Bruno Adler Maccagnan Pinheiro Besen ◽

Clarice Antunes de Lima ◽

Aline Pivetta Corá ◽

Antônio José Rodrigues Pereira ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

C Reactive Protein ◽

Post Hoc Analysis ◽

Reactive Protein ◽

Post Hoc ◽

D Dimer

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Therapeutic potential of anticoagulant therapy in association with cytokine storm inhibition in severe cases of COVID-19: A case report

Open Life Sciences ◽

10.1515/biol-2021-0088 ◽

2021 ◽

Vol 16 (1) ◽

pp. 809-814

Author(s):

Qiancheng Xu ◽

Tao Wang ◽

Weihua Lu

Keyword(s):

Anticoagulant Therapy ◽

Therapeutic Potential ◽

Clinical Manifestations ◽

Treatment Strategies ◽

Oxygenation Index ◽

C Reactive Protein ◽

Reactive Protein ◽

Timely Treatment ◽

D Dimer

Abstract Inflammation and coagulation are considered to the development of Coronavirus disease 2019 (COVID-19)-related hypoxemia. However, this is still controversial, which brings challenges to clinical treatment. Here, we reviewed the levels of interleukin-6 (IL-6), coagulation indexes, and clinical manifestations of a patient with severe COVID-19 after Tocilizumab administration. In this case, the patient’s body temperature quickly dropped to normal after using Tocilizumab, while C reactive protein progressively decreased and stabilized at a lower level. However, IL-6 and D-dimers increased and were accompanied by a continuous decrease of the oxygenation index. After anticoagulant therapy with heparin, D-dimer decreased slowly, gradually improving the oxygenation index and disease remission. This case suggests that the formation of microthrombus might be the main reason for COVID-19-derived hypoxemia. However, the mechanism of hypoxemia and the role of Tocilizumab in COVID-19 need further research. Nevertheless, these findings might still assist medical workers in formulating timely treatment strategies for similar severe patients.

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EVALUATION OF D-DIMER AND CRP LEVEL IN COVID-19 AND CAP(COMMUNITY ACQUIRED PNEUMONIA) PATIENTS AND THEIR CORRELATION WITH VTE SCORE(VENOUS THROMBOEMBOLISM SCORE)

10.36106/ijar/7014873 ◽

2021 ◽

pp. 69-70

Author(s):

Maitri Bhatt ◽

Toral Jivani ◽

Ashwini Shukla

Keyword(s):

Venous Thromboembolism ◽

Clinical Laboratory ◽

Community Acquired Pneumonia ◽

Rt Pcr ◽

C Reactive Protein ◽

Dynamic Changes ◽

Reactive Protein ◽

Recent Outbreak ◽

D Dimer

BACKGROUND:In recent outbreak of COVID-19 infection,the risk of thrombosis should be concerned.We observed dynamic changes of D-Dimer level,C-Reactive Protein(CRP) level and Venous Thromboembolism risk assessment score(VTE score) during active disease.We included patients of conrmed covid-19 patients who were RT-PCR positive and patients of community acquired pneumonia(CAP) who were conrmed by CT-SCAN ndings.We observed correlation of D-dimer level with both CRP level & VTE score. METHOD:We examined the clinical laboratory result of 50 patients with conrmed COVID-19 positive patients and 50 patients with community acquired pneumonia(CAP).We analysed D-dimer level of this patients by Automated Coagulometer-STAGO in our hematological laboratory and CRP level by latex method.We use pauda prediction score to identify patients at high risk for venous thrombo embolism.We observed D-dimer level of all patients with their correlation to CRP level & VTE score.S RESULT:On admission,Both COVID-19 and CAP patients,D-dimer level were increased,more increased in COVID-19 patient compare to CAP patient. D-dimer level were related to inammatory marker,mainly with CRP level.There was low correlation between VTE score & Ddimer levels weakened the role of D-dimer in the prediction of thrombosis. CONCLUSION:Elevated baseline D-dimer levels are associated with inammation but not with VTE score in COVID patients,So we can't judge whether anticoagulation is needed only according to D-dimer levels. Abnormal D-dimer level with inammatory factors suggest that anticoagulant therapy might be needed.

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