scholarly journals Association between daily level of objective physical activity and C-Reactive protein in a representative national sample of adults with self-reported diagnosed arthritis or fibromyalgia

2020 ◽  
Vol 40 (9) ◽  
pp. 1463-1471 ◽  
Author(s):  
Celia Kingsbury ◽  
Anthony. D. Karelis ◽  
Gabriel Hains-Monfette ◽  
Paquito Bernard
2019 ◽  
Author(s):  
Celia Kingsbury ◽  
Antony Karelis ◽  
Gabriel Hains-Monfette ◽  
Paquito Bernard

Objective: Examine the transversal association between objectively measured physical activity (PA) and sedentary time (SED-time) with high sensitivity C-Reactive Protein (hsCRP) levels in adults with arthritis and fibromyalgia. We also investigated the dose of PA that was associated with lower clinical levels of hsCRP (< 3 mg/L).Design: Observational designSetting: Canadian Health Measures Survey (CHMS) cycle 1 to 3 (2007 – 2012)Participants: CHMS respondents with self-reported diagnosed arthritis or fibromyalgia from the CHMS cycle 1 to 3 (2007 – 2012)Main Outcome Measure: Generalized adjusted additive models were used to explore the shape of the association between hsCRP, daily PA, step count and SED-time. HsCRP was measured with blood samples. PA, number of steps and SED-time were objectively assessed using an Actical accelerometer. Results: Daily moderate to vigorous PA and step count were significantly associated with lower hsCRP levels, but daily LPA and SED-time were not associated with hsCRP levels, even after controlling for age, sex, daily smoking, body mass index (BMI), household income, level of education levels, marital status, work year and accelerometer wear time and season of accelerometer. Non-linear dose-response patterns were observed between daily moderate to vigorous PA as well as step count with hsCRP levels. Optimal and specific doses of daily minutes of moderate to vigorous PA and daily steps were independently related to lower hsCRP in adults with arthritis and fibromyalgia.Conclusions: Daily MVPA and step count were associated with hsCRP levels that were below the clinical threshold. Given the positive outcomes of PA on health, adults with arthritis and fibromyalgia may benefit from these specific recommendations.


2003 ◽  
Vol 35 (7) ◽  
pp. 1160-1166 ◽  
Author(s):  
ERIC S. RAWSON ◽  
PATTY S. FREEDSON ◽  
STAVROULA K. OSGANIAN ◽  
CHARLES E. MATTHEWS ◽  
GEORGE REED ◽  
...  

2018 ◽  
Vol 52 (7) ◽  
pp. 545-551 ◽  
Author(s):  
Catherine M Sabiston ◽  
Carsten Wrosch ◽  
Andrée L Castonguay ◽  
Benjamin D Sylvester

2018 ◽  
Author(s):  
Paquito Bernard ◽  
Isabelle Doré ◽  
Romain Ahmed Jérôme ◽  
Gabriel Hains-Monfette ◽  
Kingsbury ◽  
...  

Although higher physical activity (PA) levels are associated with better mental health, previous findings about the shape of the dose–response relationship between PA and mental health are inconsistent. Furthermore, this association may differ according to sedentary levels. We investigated the cross-sectional dose-response associations between objectively measured PA and mental health in a representative national sample of adults. We also examined whether sedentary time modified the PA - mental health associations. Based on 2007-2013 Canadian Health Measures Survey data, PA and sedentary time were measured using accelerometry among 8150 participants, aged 20 to 79 years. Generalized additive models with a smooth function were fitted to examine associations between minutes per day of moderate and vigorous PA (MVPA), light PA (LPA), daily steps (combined or not with sedentary time) and self-rated mental health. A significant curvilinear relationship between average daily minutes of MVPA and mental health was observed, with increasing benefits up to 50 minutes/day. For LPA, a more complex shape (monotonic and curvilinear) was found. For daily steps, inverted U-shaped curve suggested increasing benefits until a plateau between 5000 and 16000 steps. The MVPA-LPA combination was significantly associated with mental health but with a complex pattern. The tested PA-sedentary time combinations showed that increasing sedentary time decreased the positive PA-mental health associations. Non-linear dose-response patterns between the PA modalities and self-reported mental health were observed. Optimal doses of daily minutes of MVPA, LPA, MVPA combined with LPA and daily steps are independently associated with better mental health in adults. The results also suggest that PA-mental health associations could be hampered by daily sedentary time.


2021 ◽  
Vol 8 (1) ◽  
pp. 21
Author(s):  
Deny Yudi Fitranti ◽  
Bunga Syifarahmi ◽  
Martha Ardiaria ◽  
Nurmasari Widyastuti

<p>Proses penuaan mempengaruhi peningkatan distribusi lemak abdominal dengan indikator lingkar pinggang (LP) dan rasio lingkar pinggang panggul (RLPP). Penimbunan lemak abdominal menyebabkan disfungsi jaringan adiposa sehingga mempengaruhi biomarker proinflamasi yaitu kadar serum <em>high-sensitivity C-reactive Protein</em> (hs-CRP). Penelitian bertujuan untuk mengetahui hubungan LP dan RLPP dengan kadar hs-CRP lansia wanita. Rancangan penelitian <em>cross sectional</em> pada 53 subjek dipilih secara <em>consecutive sampling</em>. Antropometri yang diukur adalah LP dan RLPP. Pengukuran kadar serum hs-CRP dianalisis dengan metode <em>enyme-linked immunosorbent assay</em> (ELISA). Wawancara yang dilakukan yaitu data diri, asupan, aktivitas fisik, dan riwayat konsumsi obat. Data asupan diperoleh dengan metode <em>food recall</em> 3x24 jam. Aktivitas fisik diperoleh menggunakan <em>International Physical Activity Questionnaire</em> (IPAQ). Analisis data digunakan uji korelasi <em>Spearman</em>. Hasil penelitian menunjukkan bahwa persentase LP pada lansia wanita yang berisiko sebesar 90,6%, RLPP yang berisiko sebesar 98,1%, dan kadar hs-CRP tinggi sebesar 30,2%. Terdapat hubungan positif antara LP dengan kadar serum hs-CRP (r=0,417 ; p=0,002). Dalam penelitian ini RLPP, aktivitas fisik, asupan energi, karbohidrat, protein, lemak, serat, vitamin A, vitamin C, vitamin D,vitamin E, dan selenium tidak berkorelasi dengan kadar hs-CRP. Simpulan penelitian ini adalah LP berkorelasi positif dengan kadar serum hs-CRP, namun RLPP tidak berkorelasi dengan kadar serum hs-CRP</p>


Appetite ◽  
2015 ◽  
Vol 89 ◽  
pp. 305
Author(s):  
C. Agostinis ◽  
J. Oliveira-Santos ◽  
S. Abreu ◽  
C. Moreira ◽  
L. Lopes ◽  
...  

2008 ◽  
Vol 93 (8) ◽  
pp. 3226-3229 ◽  
Author(s):  
Alessandra Bosutti ◽  
Grazia Malaponte ◽  
Michela Zanetti ◽  
Pietro Castellino ◽  
Martina Heer ◽  
...  

Abstract Context: Energy balance and physical activity potentially influence systemic inflammation. Objective: Our objective was to test the hypothesis that moderate energy restriction may prevent activation of inactivity-induced inflammatory response. Design: Participants were studied four times at the end of 14-d periods of experimental bed rest or controlled ambulation, after receiving eucaloric or hypocaloric diets. Setting: The study was conducted at the clinical research center of the German Space Agency. Subjects: Nine healthy young volunteers participated. Interventions: Energy intake was calibrated to physical activity and decreased by about 20% in hypocaloric conditions. Main Outcome Measures: Changes in body fat by dual-energy x-ray absorptiometry as well as plasma inflammatory markers and cytokine mRNA levels in blood cells were measured. Results: Fat mass did not change significantly in eucaloric conditions and decreased in hypocaloric periods (−1.0 ± 0.3 and −1.0 ± 0.3 kg in ambulatory and bed rest, respectively). Bed rest in eucaloric conditions increased plasma C-reactive protein (CRP) (+143 ± 53%) and both the ratios between plasma IL-6 and IL-10 (4±1 times) and white blood cell IL-6 and IL-10 mRNAs (5 ± 1 times). Energy restriction prevented bed-rest-mediated increases in CRP and the IL-6 to IL-10 ratio. Bed rest increased (P = 0.03) long pentraxin-3 (PTX3) plasma concentration, without significant activity-by-diet interaction. In all conditions (n = 36), CRP and PTX3 were inversely correlated (r = −0.61; P &lt; 0.001). Changes in fat mass, leptin, and IL-6 directly correlated with CRP and inversely correlated with PTX3. IL-10 inversely correlated with CRP and directly correlated with PTX3 (r = 0.52; P &lt; 0.01). Conclusions: Calorie restriction prevents the inflammatory response induced by 14 d of bed rest. We suggest an inverse regulation of CRP and PTX3 in response to changes in energy balance.


PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0125984 ◽  
Author(s):  
Aírton J. Rombaldi ◽  
Lúcia C. Pellanda ◽  
Renata M. Bielemann ◽  
Denise P. Gigante ◽  
Pedro C. Hallal ◽  
...  

2017 ◽  
Vol 61 (6) ◽  
pp. 709-715 ◽  
Author(s):  
Bethany D. Williams ◽  
Michael R. Richardson ◽  
Tammie M. Johnson ◽  
James R. Churilla

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