Kadar High Sensitivity C-Reactive Protein Berkaitan dengan Lingkar Pinggang pada Lansia

Proses penuaan mempengaruhi peningkatan distribusi lemak abdominal dengan indikator lingkar pinggang (LP) dan rasio lingkar pinggang panggul (RLPP). Penimbunan lemak abdominal menyebabkan disfungsi jaringan adiposa sehingga mempengaruhi biomarker proinflamasi yaitu kadar serum high-sensitivity C-reactive Protein (hs-CRP). Penelitian bertujuan untuk mengetahui hubungan LP dan RLPP dengan kadar hs-CRP lansia wanita. Rancangan penelitian cross sectional pada 53 subjek dipilih secara consecutive sampling. Antropometri yang diukur adalah LP dan RLPP. Pengukuran kadar serum hs-CRP dianalisis dengan metode enyme-linked immunosorbent assay (ELISA). Wawancara yang dilakukan yaitu data diri, asupan, aktivitas fisik, dan riwayat konsumsi obat. Data asupan diperoleh dengan metode food recall 3x24 jam. Aktivitas fisik diperoleh menggunakan International Physical Activity Questionnaire (IPAQ). Analisis data digunakan uji korelasi Spearman. Hasil penelitian menunjukkan bahwa persentase LP pada lansia wanita yang berisiko sebesar 90,6%, RLPP yang berisiko sebesar 98,1%, dan kadar hs-CRP tinggi sebesar 30,2%. Terdapat hubungan positif antara LP dengan kadar serum hs-CRP (r=0,417 ; p=0,002). Dalam penelitian ini RLPP, aktivitas fisik, asupan energi, karbohidrat, protein, lemak, serat, vitamin A, vitamin C, vitamin D,vitamin E, dan selenium tidak berkorelasi dengan kadar hs-CRP. Simpulan penelitian ini adalah LP berkorelasi positif dengan kadar serum hs-CRP, namun RLPP tidak berkorelasi dengan kadar serum hs-CRP

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Associations of 25 Hydroxyvitamin D and High Sensitivity C-reactive Protein Levels in Early Life

Nutrients ◽

10.3390/nu14010015 ◽

2021 ◽

Vol 14 (1) ◽

pp. 15

Author(s):

Nicklas Brustad ◽

Nadia R. Fink ◽

Jakob Stokholm ◽

Klaus Bønnelykke ◽

Nilofar V. Følsgaard ◽

...

Keyword(s):

Vitamin D ◽

Early Life ◽

High Sensitivity ◽

Low Grade ◽

C Reactive Protein ◽

Cross Sectional ◽

Hydroxyvitamin D ◽

Reactive Protein ◽

25 Hydroxyvitamin D ◽

Hs Crp

Vitamin D deficiency and elevated high sensitivity C-reactive protein (hs-CRP) have been associated with several health outcomes, but knowledge on early life trajectories and association between 25 hydroxyvitamin D (25(OH)D) and hs-CRP is lacking. We investigated the association between longitudinal measurements of 25(OH)D and hs-CRP, respectively, from pregnancy to childhood and throughout childhood in two Danish mother–child cohorts—the COPSAC2010 and COPSAC2000. In COPSAC2010, there was an association between 25(OH)D concentrations at week 24 in pregnancy and at age 6 months in childhood (n = 633): estimate (95% CI); 0.114 (0.041;0.187), p = 0.002, and between 25(OH)D at age 6 months and 6 years (n = 475): 0.155 (0.083;0.228), p < 0.001. This was also demonstrated in the COPSAC2000 cohort between 25(OH)D concentrations in cord blood and at age 4 years (n = 188): 0.294 (0.127;0.461), p < 0.001 and at age 6 months and 4 years (n = 264): 0.260 (0.133;0.388), p < 0.001. In COPSAC2000, we also found an association between hs-CRP at age 6 months and 12 years in childhood (n = 232): 0.183 (0.076;0.289), p < 0.001. Finally, we found a negative association between the cross-sectional measurements of 25(OH)D and hs-CRP at age 6 months (n = 613) in COPSAC2010: −0.004 (−0.008;−0.0004), p = 0.030, but this was not replicated in COPSAC2000. In this study, we found evidence of associations across timepoints of 25(OH)D concentrations from mid-pregnancy to infancy and through childhood and associations between hs-CRP levels during childhood, although with weak correlations. We also found a negative cross-sectional association between 25(OH)D and hs-CRP concentrations in COPSAC2010 proposing a role of vitamin D in systemic low-grade inflammation, though this association was not present in COPSAC2000.

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Korelasi antara High Sensitivity C-Reactive Protein dengan Kadar Glukosa Darah dan Profil Lipid pada Mahasiswa Obesitas Fakultas Farmasi Universitas Pancasila

Syntax Literate ; Jurnal Ilmiah Indonesia ◽

10.36418/syntax-literate.v7i1.5736 ◽

2022 ◽

Vol 7 (1) ◽

pp. 384

Author(s):

Manuppak Irianto Tampubolon ◽

Ros Sumarny ◽

Yati Sumiyati

Keyword(s):

Interleukin 1 ◽

High Sensitivity ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Consecutive Sampling ◽

Kolmogorov Smirnov ◽

Hs Crp ◽

Factor Α ◽

Necrosis Factor

Obesitas merupakan keadaan dimana terjadi ketidaknormalan atau kelebihan akumulasi lemak dalam tubuh yang disimpan dalam jaringan adiposa. Keadaan obesitas akan mempengaruhi sekresi adiponektin. C-reactive protein merupakan suatu globulin yang disintesis oleh hepatosit, produksi CRP ini diinduksi oleh interleukin-6, interleukin-1 dan tumor necrosis factor α, yang kemudian akan disekresi ke dalam darah. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara inflamasi dengan gangguan metabolisme karbohidrat dan metabolisme lipid serta mendapatkan data kadar High Sensitivity C-Reactive Protein sebagai penanda inflamasi, Kadar glukosa darah untuk menilai gangguan metabolisme glukosa, sedangkan kolesterol, trigliserida, LDL untuk menilai gangguan metabolisme lipid dan mengetahui hubungan antara High Sensitivity C-Reactive Protein dengan glukosa darah dan profil lipid (kolesterol total, trigliserida dan LDL) pada mahasiswa obesitas Fakultas Farmasi Universitas Pancasila. Penelitian ini dilakukan menggunakan metode observasional dengan rancangan penelitian cross sectional dengan pengambilan data secara consecutive sampling dimana peneliti melalukan pengukuran terhadap indikator obesitas (berat badan, tinggi badan, lingkar pinggang) kadar C-Reactive Protein (CRP) dan profil lipid. Uji statisitik yang digunakan dalam penelitian ini adalah Kolmogorov smirnov, Leaven test dan Spearman. Karakteristik responden berdasarkan parameter indeks massa tubuh didapatkan sebesar 27.54 kg/m2. Distribusi frekuensi pada parameter jenis kelamin yang paling banyak dengan jenis kelamin perempuan sebanyak 74,1%. Rerata lingkar perut sebesar 91.97 cm. Diketahui rata-rata 48,1% mahasiswa obesitas fakultas farmasi mengalami hiperglikemia, 48,1% mengalami hiperkoleterolemia, 37% hipertrigliseridemia, 88,9% hiperbetalipoprotenemia dan 29,6% mahasiswa memiliki kadar hs-CRP > 3 mg/L. Terdapat hubungan bermakna antara hs-CRP dan indeks massa tubuh (r = 0.503 dan p = 0.007) serta didapatkan juga hubungan bermakna antara indeks massa tubuh dan tekanan darah diastolik (r= 0.506 dan p = 0.007). Dapat disimpulkan bahwa indeks massa tubuh (IMT) berkolerasi dengan hs-CRP dan tekanan darah diastolik.

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High Sensitivity CReactive Protein (hsCRP) Level on Premature Rupture of Membrane (PROM) at Term Pregnancy

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v5i1.458 ◽

2017 ◽

pp. 12-15

Author(s):

Meily Manoppo ◽

Hermie MM Tendean ◽

Joice MM Sondakh

Keyword(s):

High Sensitivity ◽

C Reactive Protein ◽

Term Pregnancy ◽

Premature Rupture ◽

Cross Sectional ◽

Reactive Protein ◽

Significant Difference ◽

Hs Crp ◽

Cross Sectional Design ◽

Parametric Statistical Test

Objective: To compare the level of high sensitivity C-Reactive Protein (hs-CRP) on patients with premature rupture of membranes (PROM) at term pregnancy. Methods: The study was cross-sectional design. The data collection included age, parity, gestational age, birth weight, and APGAR score on 28 pregnant women at term pregnancy consisting of 14 subjects of Premature Rupture of Membrane (PROM) less than 12 hours and the remaining one was equal or more than 12 hours. We took blood samples from the subjects for the examination of hs-CRP level. Data were analyzed using non-parametric statistical test and processed using Statistical Package for Social Sciences (SPSS) version 20. Results: The mean hs-CRP level on PROM <12-hour and 12-hour group was 12.9 and 17.8 mg/l. There was not significant difference on hs-CRP level between both of group at term pregnancy (p=0.734). Conclusion: The level of hs-CRP does not have association with the incidence of PROM. [Indones J Obstet Gynecol 2017; 5-1: 12-15] Keywords: high sensitivity C-Reactive Protein, premature ruptures of membranes, term pregnancy

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A STUDY TO EVALUATE THE ROLE OF HIGH SENSITIVITY C-REACTIVE PROTEIN IN CEREBROVASCULAR ACCIDENT IN THE DARBHANGA MEDICAL COLLEGE AND HOSPITAL

10.36106/ijsr/3720009 ◽

2021 ◽

pp. 71-73

Author(s):

Amit Kumar Tiwari ◽

Umesh Chandra Jha ◽

Debarshi Jana

Keyword(s):

Cerebrovascular Accident ◽

High Sensitivity ◽

Serum Levels ◽

Cross Sectional Study ◽

Abrupt Onset ◽

C Reactive Protein ◽

Cross Sectional ◽

Medical College ◽

Reactive Protein ◽

Hs Crp

INTRODUCTION:Cerebrovascular accident (commonly called stroke) is dened as an abrupt onset of a neurologic decit that is attributable to a focal vascular cause. Thus, the diagnosis of stroke is clinical and laboratory studies including brain imaging are used to support the diagnosis AIMS AND OBJECTIVES: To evaluate the serum levels of high sensitivity C-reactive protein (hsCRP) in different types of cerebrovascular accidents on admission. MATERIALS AND METHODS: This study was an institution based cross-sectional study designed to investigate the association of hs-CRP levels with stroke and its types in Indian patients. The study was done in the Department of Medicine, Darbhanga Medical College and Hospital, Laheriasarai, Bihar from march 2019 to March 2020. 50 patients of either sex above 12 years of age admitted in Medicine Department of DMCH, Laheriasarai, Bihar with clinically or radiologically diagnosed stroke. RESULT: The mean level of hsCRP (mean ± s.d.) of the cases in our study was 7.65±7.01 with range 1.4 – 26 and the median was 3.7 and 58% of the cases were having level of hsCRP≥3 (p=0.023).Mean level of hsCRPof cases was signicantly higher than that of control (t98=7.25;p=0.001). CONCLUSION:We concluded that hs-CRPlevel is increased in cases of cerebrovascular accident- ischemic as well as haemorrhagic, suggesting an inammatory response in acute cerebrovascular accident. hs-CRP level is increased in patients with ischemic cerebrovascular accident dramatically but not in haemorrhagic cerebrovascular accident which might be considered as useful adjunct method for determining type of stroke in patients with cerebrovascular problems.

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Vitamin D Treatment Effect on Serum Endocan and High-Sensitivity C-Reactive Protein Levels in Renal Transplant Patients

Progress in Transplantation ◽

10.1177/1526924816664086 ◽

2016 ◽

Vol 26 (4) ◽

pp. 335-339 ◽

Cited By ~ 5

Author(s):

Omer Atis ◽

Mustafa Keles ◽

Erdem Cankaya ◽

Hasan Dogan ◽

Hulya Aksoy ◽

...

Keyword(s):

Vitamin D ◽

Endothelial Dysfunction ◽

Renal Transplant ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Transplant Patients ◽

Vitamin D Levels ◽

Hs Crp ◽

25 Oh Vitamin D

Context: Endocan is a marker showing endothelial dysfunction and inflammation. Significantly increased endocan levels have been observed in serum of patients with sepsis and cancer. Objective: Our aim was to investigate the relationship between vitamin D treatment and serum endocan and high-sensitivity C-reactive protein (hs-CRP) levels as inflammatory markers in transplant patients. Design: Prospective. Setting: Nephrology clinic. Patients: Thirty-eight renal transplant patients with serum 25-hydroxy-vitamin D (25-OH-vitamin D) levels below 20 ng/mL and transplanted at least 12 months. Intervention: One-time oral dose of 300 000 IU vitamin D3. Main Outcome Measures: Before and after vitamin D treatment, serum endocan, hs-CRP, calcium, phosphorus, and parathyroid hormone (PTH) levels were measured. Results: Median serum endocan and PTH values before vitamin D were significantly higher than those of after treatment values ( P = .001 and P < .001, respectively). On the other hand, serum total calcium and phosphorus levels before vitamin D treatment were lower than the values obtained after vitamin D treatment ( P = .0013 and P < .001, respectively). Serum hs-CRP was lower after vitamin D therapy than before, but the difference was not statistically significant ( P = .06). A moderate negative correlation was determined between endocan and 25-OH-vitamin D levels after treatment with vitamin D ( r = −.36, P = .02). Conclusion: This study has revealed that vitamin D treatment reduced markers of endothelial dysfunction in patients with renal transplantation and vitamin D deficiency.

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Serum high sensitivity C reactive protein levels in patients with diabetic retinopathy: a cross sectional study

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20200483 ◽

2020 ◽

Vol 7 (3) ◽

pp. 391

Author(s):

Harishchandra R. Chaudhari ◽

Gaurav A. Chaudhari

Keyword(s):

Diabetic Retinopathy ◽

Blood Glucose ◽

High Sensitivity ◽

Cross Sectional Study ◽

Postprandial Blood Glucose ◽

Sectional Study ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Hs Crp

Background: Diabetic retinopathy (DR) is one of the major visual morbidities associated with diabetes. This study determined the levels of serum high-sensitivity C-reactive protein (hs-CRP) in patients with DR and to correlate the estimated levels of serum hs-CRP with the severity of DR and other coexisting factors.Methods: This was a cross-sectional study conducted between March 2009 and August 2010 and included patients with type 2 diabetes mellitus (T2DM) with or without DR. A detailed fundus evaluation was performed using direct and indirect ophthalmoscopy. The retinopathies were observed and documented in accordance with the Kanski's system of classification as background DR (BDR), pre-proliferative DR (PPDR), and proliferative DR (PDR). Laboratory investigations determined the levels of fasting blood glucose (FBG), postprandial blood glucose (PPBG), glycosylated hemoglobin, urine albumin excretion, and serum hs-CRP levels.Results: In total, 80 patients with T2DM were included (DR group, n=40 [BDR, n=22; PDR, n=11; PPDR, n=7]; control group, n=40). Highest serum hs-CRP levels were found in PDR group (6.68 mg/L), followed by PPDR and BDR group (3.2 mg/L and 1.56 mg/L, respectively). The PDR group showed the longest duration of diabetes (16 years), highest FBG (221.8 mg/dL) and HbA1c (6.68 mg/L). The incidence of albuminuria and maculopathy was higher in PDR group (72.7% and 54.54%, respectively). A significant association of hs-CRP levels with DR in patients with T2DM was observed. A significantly (<0.005) positive correlation of hs-CRP was also observed with age, duration of disease, FBG, PPBG, and HbA1c.Conclusions: Patients with severe grades of retinopathy had significantly higher hs-CRP levels than patients with the milder grades.

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HUBUNGAN KADAR TRIASILGLISEROL DARAH DENGAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

Jurnal e-Biomedik ◽

10.35790/ebm.2.1.2014.3647 ◽

2014 ◽

Vol 2 (1) ◽

Author(s):

Melda Melatunan

Keyword(s):

Cardiovascular Disease ◽

High Sensitivity ◽

Nonparametric Test ◽

Inflammatory Factors ◽

C Reactive Protein ◽

Cross Sectional ◽

Obese Adolescents ◽

Reactive Protein ◽

Triacylglycerol Level ◽

Hs Crp

Abstract: Obesity is one of the health problem in the world, also in Indonesia. Obesity is caused by an increased amount of fat that stored in the form triacylglycerol ( TAG ) which is acquired from food. Increase of triacylglycerol level may cause higher risk of cardiovascular disease. High Sensitivity C-Reactive Protein (hs-CRP) is a marker of inflammatory factors that can be used as a marker for cardiovascular disease. This study aimed to determine the correlations between TAG levels on blood and hs-CRP levels on obese adolescents. This study performed by observational analytic study design with the cross-sectional approach. The number of sample in this study were 17 sample who was willing to join. Analysis of bivariate using Spearman nonparametric test. The results showed a significance value ( p ) 0.272 which indicates that the correlation between TAG levels and hs-CRP levels were not significant. Spearman value showed 0.282 that indicates that the direction of a positive correlation with the strength of the correlation is weak. It can be concluded that there is no correlations between TAG levels in blood with hs-CRP levels on obese adolescents. Keyword: Obesity, TAG, hs-CRP, Adolescents Abstrak: Obesitas merupakan masalah kesehatan di seluruh dunia, termasuk di Indonesia. Obesitas disebabkan akibat peningkatan jumlah lemak yang disimpan dalam bentuk triasilgliserol (TAG) yang diperoleh dari makanan. Peningkatan triasilgliserol ini akan meningkatkan risiko penyakit kardiovaskuler. High Sensitivity C-Reactive Protein (hs-CRP) merupakan faktor penanda inflamasi yang dapat digunakan sebagai penanda risiko penyakit kardiovaskuler. Penelitian ini bertujuan untuk mengetahui hubungan kadar TAG darah dengan kadar hs-CRP pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional dengan pendekatan cross-sectional. Sampel pada penelitian ini berjumlah 17 sampel yang diambil dari seluruh populasi yang bersedia. Analisis bivariat menggunakan uji nonparametrik Spearman. Hasil penelitian didapatkan nilai signifikansi (p) 0,272 yang menunjukkan bahwa korelasi antara kadar TAG dan kadar hs-CRP tidak signifikan. Nilai Spearman sebesar 0,282 menunjukkan bahwa arah korelasi positif dengan kekuatan korelasi yang lemah. Dapat disimpulkan bahwa tidak terdapat hubungan antara kadar TAG darah dengan kadar hs-CRP pada remaja obes. Kata Kunci : Obesitas, TAG, hs-CRP, Remaja

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Amount of physical activity necessary for a normal level of high-sensitivity C-reactive protein in ELSA-Brasil: a cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2019.0301.r2.20102019 ◽

2020 ◽

Vol 138 (1) ◽

pp. 19-26

Author(s):

Ciro Oliveira Queiroz ◽

Francisco Pitanga ◽

Paulo Andrade Lotufo ◽

Maria Del Carmen Bisi Molina ◽

Estela Maria Leão de Aquino ◽

...

Keyword(s):

Physical Activity ◽

Normal Level ◽

High Sensitivity ◽

Cross Sectional Study ◽

Sectional Study ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein

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High-Sensitivity C-Reactive Protein Elevation Is Independently Associated with Subclinical Renal Impairment in the Middle-Aged and Elderly Population—A Community-Based Study in Northern Taiwan

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17165878 ◽

2020 ◽

Vol 17 (16) ◽

pp. 5878

Author(s):

Hai-Hua Chuang ◽

Rong-Ho Lin ◽

Wen-Cheng Li ◽

Wei-Chung Yeh ◽

Yen-An Lin ◽

...

Keyword(s):

Renal Function ◽

Renal Impairment ◽

High Sensitivity ◽

C Reactive Protein ◽

Middle Aged ◽

Community Based ◽

Cross Sectional ◽

Reactive Protein ◽

Hs Crp ◽

Northern Taiwan

This cross-sectional study aimed to investigate the associations between high-sensitivity C-reactive protein (hs-CRP) and renal impairment (RI) among middle-aged and elderly people. We collected and analyzed demographic, anthropometric, metabolic, and renal function data in a community-based population in Northern Taiwan. We excluded subjects with acute inflammation from this study and defined RI as the presence of urinary albumin–creatinine ratio 30–300 mg/g or an estimated glomerular filtration rate of <60 mL/min/1.73 m2. There were 131, 125, and 125 participants in the low (≤0.80 mg/L), middle (0.81–1.76 mg/L), and high (>1.77 mg/L) hs-CRP tertiles, respectively. hs-CRP exhibited significantly positive correlations with body mass index, waist circumference, systolic blood pressure, triglyceride, and fasting plasma glucose, and a negative correlation with high-density lipoprotein. The prevalence and odds ratio of RI significantly increased across hs-CRP tertiles from low to high, and this trend remained significant after adjusting for the conventional cardiometabolic risk factors. hs-CRP ≥ 1.61 mg/L in the total group and ≥2.03 mg/L in the elderly group accurately predicted RI (p = 0.01 and 0.03, respectively). These findings suggest that we should carefully evaluate the renal function for at-risk individuals with hs-CRP elevation.

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Vitamin D Deficiency is Associated With Higher Level of High Sensitivity C-reactive Protein (Hs-crp) in Patients Undergoing Elective Coronary Stenting

10.21203/rs.3.rs-73096/v1 ◽

2020 ◽

Author(s):

farzaneh foroughinia ◽

Shaghayegh Mottaghi ◽

Mohammad Reza Alimardani

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Inflammatory Diseases ◽

Inflammatory Marker ◽

Venous Blood ◽

High Sensitivity ◽

Vitamin D Status ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

Abstract Background: Vitamin D deficiency, a prevalent worldwide concern, has been reported to have a pivotal role in many cardiovascular and inflammatory diseases. Percutaneous coronary intervention (PCI) is a therapeutic approach that may have several short-term and long-term cardiovascular complications, supposing to be mediated with high sensitive C-reactive protein (hs-CRP), an inflammatory marker. This study aimed to investigate the association between vitamin D status and hs-CRP level, as a prognostic marker, in patients undergoing elective PCI. Methods: The study population comprised of 150 patients who underwent elective coronary angioplasty. In order to measure vitamin D and hs-CRP levels, venous blood samples were obtained at baseline and 24 hours after PCI. Results: Our results showed a significant inverse relationship between post-PCI hs-CRP and also pre-post hs-CRP difference levels and vitamin D status. Conclusion: Hs-CRP content is higher in vitamin D deficient patients. Therefore, these patients, especially severely-deficient ones (25(OH)D<10ng/ml), may benefit from supplementation with vitamin D prior to PCI.

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