The impact of Alzheimer's disease susceptibility loci on lateral ventricular surface morphology in older adults

2022 ◽  
Author(s):  
Shan Li ◽  
Na An ◽  
Nan Chen ◽  
Yin Wang ◽  
Lin Yang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Surface Morphology ◽  
Disease Susceptibility ◽  
Susceptibility Loci ◽  
Ventricular Surface ◽  
The Impact

scholarly journals Home-Based Care for People with Alzheimer’s Disease and Related Dementias (ADRD) during COVID-19 Pandemic: From Challenges to Solutions

2020 ◽  
Vol 17 (24) ◽  
pp. 9303
Author(s):  
Atiqur sm-Rahman ◽  
Chih Hung Lo ◽  
Azra Ramic ◽  
Yasmin Jahan
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Supporting Evidence ◽  
Psychological Issues ◽  
Home Based ◽  
The Social ◽  
Novel Coronavirus ◽  
Home Based Care ◽  
The Impact

There has been supporting evidence that older adults with underlying health conditions form the majority of the fatal cases in the current novel coronavirus disease (COVID-19) pandemic. While the impact of COVID-19 is affecting the general public, it is clear that these distressful experiences will be magnified in older adults, particularly people living with Alzheimer’s disease and related dementia (ADRD), making them the most vulnerable group during this time. People with differing degrees of ADRD are especially susceptible to the virus, not only because of their difficulties in assessing the threat or remembering the safety measures, but also because of the likelihood to be subject to other risk factors, such as lack of proper care and psychological issues. Therefore, in this article, we will discuss the challenges related to home-based care for people with ADRD during a pandemic and propose a formulation of systematic solutions to address these challenges and to alleviate the social and economic impact resulting from the crisis.

scholarly journals Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

2008 ◽  
Vol 83 (5) ◽  
pp. 623-632 ◽  
Author(s):  
Lars Bertram ◽  
Christoph Lange ◽  
Kristina Mullin ◽  
Michele Parkinson ◽  
Monica Hsiao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Analysis ◽  
Disease Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide Association Analysis ◽  
Genome Wide

Possible selves and illness: A comparison of individuals with Parkinson's disease, early-stage Alzheimer's disease, and healthy older adults

2003 ◽  
Vol 27 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Leslie D. Frazier ◽  
Victoria Cotrell ◽  
Karen Hooker
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Possible Selves ◽  
Early Stage ◽  
Healthy Older Adults ◽  
Patient Groups ◽  
The Impact

This study examined how future self-representations are affected by two different chronic illnesses, one focused on cognitive losses, early-stage Alzheimer's disease (AD), and one focused on physical losses, Parkinson's disease (PD). The impact of illness on possible selves (perceptions of self in the future) was made salient by a comparison with healthy older adults in order to better understand developmental issues in later life. Findings show that although there were no differences in the total number of domains reported by the groups, specific domains were reported differently by patient groups and all domains were likely to become infused with illness. As expected, patient groups had less self-efficacy and lower outcome expectancies for their future selves, and PD patients reported less distance from their feared selves. Although these findings are intuitive, this is the first empirical effort to document the impact of illness on older adults' self-representations. Group differences are explained in terms of disease context, and the importance of possible selves and self-regulatory functions as therapeutic mechanisms for adaptation to illness are emphasised.

Feasibility and Perception of the Impact From Aerobic Exercise in Older Adults With Alzheimer’s Disease

2012 ◽  
Vol 27 (6) ◽  
pp. 397-405 ◽  
Author(s):  
Fang Yu ◽  
Ruth M. Swartwood
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Aerobic Exercise ◽  
Family Caregivers ◽  
Subjective Experience ◽  
Exercise Intervention ◽  
Exercise Program ◽  
Moderate Intensity ◽  
The Impact

Background: The subjective experience of participating in aerobic exercise is unknown in Alzheimer’s disease (AD). Objective: The purpose of this study was to understand the subjective perceptions of the feasibility and impact of a 6-month, moderate-intensity aerobic exercise intervention by older adults with AD and their family caregivers. Methods: Ten older adults with AD who completed the intervention and their family caregivers participated in four focus group interviews. Results: Four converging themes were identified: “There was no perceived positive change in cognitive symptoms,” “The 6-month exercise program was socially rewarding,” “The 6-month exercise program increased physical strength,” and “Participation in aerobic exercise was a positive experience.” Family caregivers further identified two additional themes: “The exercise program led to improved attitude in older adults with AD” and “The exercise program reduced caregiver stress.” Discussion: Aerobic exercise is a feasible and well-perceived intervention for older adults with AD and their family caregivers.

scholarly journals The impact of air pollution on mortality risk in the older adults with Alzheimer's disease and related dementias (ADRD)

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Shuxin Dong ◽  
Danielle Braun ◽  
Xiao Wu ◽  
Maayan Yitshak Sade ◽  
Deborah Blacker ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Air Pollution ◽  
Mortality Risk ◽  
The Impact

scholarly journals Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults

2021 ◽  
Vol 12 ◽  
Author(s):  
James R. Hall ◽  
Melissa Petersen ◽  
Leigh Johnson ◽  
Sid E. O’Bryant
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Significant Relationship ◽  
Sleep Disturbances ◽  
Cognitively Normal ◽  
Total Tau ◽  
Neurobehavioral Symptoms ◽  
The Impact

Depression and related neurobehavioral symptoms are common features of Alzheimer’s disease and other dementias. The presence of these potentially modifiable neurobehavioral symptoms in cognitively intact older adults may represent an early indication of pathophysiological processes in the brain. Tau pathology is a key feature of a number of dementias. A number of studies have found an association between tau and neurobehavioral symptoms. The current study investigated the relationship of a blood-based biomarker of tau and symptoms of depression, anxiety, worry, and sleep disturbances in 538 community based, cognitively normal older adults. Logistic regression revealed no significant relationship between plasma total tau and any measures of neurobehavioral symptoms. To assess the impact of level of tau on these relationships, participants were divided into those in the highest quintile of tau and those in the lower four quintiles. Regression analyses showed a significant relationship between level of plasma total tau and measures of depression, apathy, anxiety, worry and sleep. The presence of higher levels of plasma tau and elevated neurobehavioral symptoms may be an early indicator of cognitive decline and prodromal Alzheimer’s disease. Longitudinal research is needed to evaluate the impact of these factors on the development of dementia and may suggest areas for early intervention.

P1-226: Alzheimer's Disease Susceptibility Loci: Evidence for Natural Selection and Altered Gene Expression

2011 ◽  
Vol 7 ◽  
pp. S183-S183
Author(s):  
Towfique Raj ◽  
Joshua Shulman ◽  
Lori Chibnik ◽  
Brendan Keenan ◽  
Barbara Stranger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Selection ◽  
Disease Susceptibility ◽  
Susceptibility Loci ◽  
Altered Gene Expression ◽  
Altered Gene

scholarly journals p-tau/Aβ42 Ratio Associates with Cognitive Decline in Alzheimer’s disease, Mild Cognitive Impairment, and Cognitively Unimpaired Older Adults

2020 ◽  
Author(s):  
Ruchika Shaurya Prakash ◽  
Michael R. McKenna ◽  
Oyetunde Gbadeyan ◽  
Rebecca Andridge ◽  
Douglas W. Scharre ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Executive Functioning ◽  
Episodic Memory ◽  
Cognitive Decline ◽  
Cognitive Functioning ◽  
The Impact

AbstractINTRODUCTIONThe most well-studied biomarkers in AD are CSF amyloid beta-42 (Aβ42), tau, p-tau, and the ratio p-tau/Aβ42. The ratiometric measure of p-tau/Aβ42 shows the best diagnostic accuracy, and correlates reliably with metrics of cognition in unimpaired participants. However, no study has examined the impact of the CSF p-tau/Aβ42 ratio in predicting cognitive decline in both healthy and AD individuals in one sample. The goal of this study was to examine whether CSF-based p-tau/Aβ42 predicts changes in global cognitive functioning, episodic memory, and executive functioning over a two-year period in cognitively impaired older adults (CU), and in individuals with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD).METHODSThis study involves secondary analysis of data from 1215 older adults available in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Neuropsychological variables, collected at baseline, 6-month, 12-month, and 24-month follow-ups, included the Preclinical Alzheimer’s Cognitive Composite (PACC) to assess global cognitive functioning, ADNI-MEM to assess episodic memory functioning, and ADNI-EF to assess executive functioning. Linear mixed models were constructed to examine the effect of CSF p-tau/Aβ42, diagnostic group, and change over time (baseline, 6-month, 12-month, and 24-month) on cognitive scores.RESULTSCSF p-tau/Aβ42 ratios predicted worsening cognitive impairment, both on global cognition and episodic memory in individuals with MCI and AD, but not in CU older adults and predicted decline in executive functioning for all three diagnostic groups.DISCUSSIONOur study, including CU, MCI, and AD individuals, provides evidence for differential cognitive consequences of accumulated AD pathology based on diagnostic groups.

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