scholarly journals Febrile seizures: perceptions and knowledge of parents of affected and unaffected children

2021 ◽  
Author(s):  
Steven Alan Rice ◽  
Ruth Melinda Müller ◽  
Sarah Jeschke ◽  
Birthe Herziger ◽  
Thilo Bertsche ◽  
...  
Keyword(s):  
Patient Safety ◽  
Febrile Seizure ◽  
Rescue Medication ◽  
Seizure Control ◽  
Febrile Seizures ◽  
Control Group ◽  
Solid Object ◽  
Unaffected Control

AbstractFebrile seizures (FS) in children are common, but little is known about parents’ perceptions and knowledge of FS. We interviewed parents of children aged 6 months to 6 years affected by FS (FS group, 65 parents) or unaffected (control group, 54 parents). In the FS group, 32% said they knew their child had an FS when the first event occurred, and 89% described fear when the child had a seizure, with a median intensity of 10/10 (Q25/Q75: 9/10). Related to follow-up, 77% in the FS group (will) observe their child more carefully after the first seizure happened, and 63% (will) give antipyretics earlier at a median temperature of 38.2 °C (100.8 °F). In the FS group, 62% were unaware of FS before the first event (54% of control group did not know about FS thus far, n.s.). In the FS group, 20% would put a solid object in the mouth of a child having a seizure (control group, 39%, p = 0.030), and 92% would administer an available anti-seizure rescue medication (control group, 78%, p = 0.019). In the FS group, 71% feared that children with FS might suffocate (control group, 70%, n.s.).Conclusion: Information about FS and their management should be more available to improve parents’ coping and patient safety. What is Known:• Febrile seizures in children are common.• The prognosis of children suffering from febrile seizures is usually rather good. What is New:• Over half of parents had not informed themselves about febrile seizures so far; and only 32% of parents realized their child had a febrile seizure when it occurred.• Most parents described own fear with a median intensity of 10/10; and 63% (will) give antipyretics earlier at a median temperature of 38.2 °C (100.8 °F).

scholarly journals Febrile Seizures: Perceptions and Knowledge of Parents of Affected and Unaffected Children

2021 ◽  
Author(s):  
Steven Alan Rice ◽  
Ruth Melinda Müller ◽  
Sarah Jeschke ◽  
Birthe Herziger ◽  
Thilo Bertsche ◽  
...  
Keyword(s):  
Patient Safety ◽  
Rescue Medication ◽  
Febrile Seizures ◽  
Solid Object

Abstract Febrile seizures (FS) in children are common. Little is known on parents’ perceptions and knowledge of FS. We interviewed parents of children aged 6 months to 6 years affected (FS-group, 65 parents) or unaffected by FS (unaffected group, 54 parents). Of the FS-group, 32% said they knew their child had a FS when the first event occurred. Of the FS-group, 89% described fear when the child had a seizure with a median intensity of 10/10 (Q25/Q75: 9/10). Of the FS-group, 77% said they (will) observe their child more carefully since the first seizure had happened, 63% (will) give antipyretics earlier at a median temperature of 38.2°C (100.8°F). Of the FS-group, 62% had not informed themselves about FS before the first event occurred (unaffected group: 54% had not informed themselves about FS so far). Of the FS-group, 20% would put a solid object in the mouth of a child having a seizure (unaffected group 39%), and 92% would administer an available anti-seizure rescue medication (unaffected group 78%). Of the FS-group, 71% stated children with FS might suffocate (unaffected group 70%). Conclusion: Information about FS and its management should be more widespread to improve parents’ coping and patient safety.

scholarly journals Low serum zinc and magnesium–a possible risk factor for first episode Simple febrile seizures in children between 6 months to 5 years of age

2021 ◽  
Author(s):  
Aishwarya Lakshmi L. G. ◽  
Mohanraj Kannan ◽  
Rajakumar P. G. ◽  
Selvaraj R.
Keyword(s):  
Febrile Seizure ◽  
Serum Magnesium ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Mean Value ◽  
First Episode ◽  
Control Group ◽  
Case Group ◽  
High Grade Fever ◽  
Low Serum

Background: Febrile seizure is the most common type of seizure in children. The incidence of febrile seizure is 5-10% in India. There are multiple aetiologies like high grade fever; genetic predisposition, viral infections and trace elements deficiency like iron, zinc, magnesium and calcium are postulated to be risk factors for developing febrile seizures. Recent studies had shown there is a significant association between low serum zinc, low serum magnesium levels and febrile seizures in children.Methods: This was a case control study with 40 children in each group. Children aged 6 months to 5 years with first episode of simple febrile seizures who attends the out-patient department/emergency room (OPD/ER) were included in case group consecutively and 40 children with acute febrile illness without febrile seizures were included in control group. Serum zinc and magnesium levels were estimated for all the children along with other investigations after proper consent from parents. Using statistical package for the social sciences (SPSS) software, independent sample t test was used to analysis the observations between the two groups. Normal lab reference value of serum zinc was 60-120 μg/dl and serum magnesium was 1.7-2.5 mg/dl.Results: The incidence of febrile seizure was high (37.5%) in children between 1-2 years and male (55%) children had increased incidence when compared to female children in case group. The children with febrile seizure had significantly low levels of serum zinc with mean value of 35.08 μg/dl (±8.56) when compared to control group with mean value of 70.23 μg/dl (±13.41) and serum magnesium level in case group was 1.35 mg/dl (±0.29) versus 1.68 mg/dl (±0.42) in control group, which was also statistically significant.Conclusions: The incidence of febrile seizure was high in children between 1-2 years of age with male preponderance. The serum levels of both zinc and magnesium is significantly low in children with febrile seizure pointing a need of further studies in role of supplemental zinc and magnesium in this age group to reduce the incidence of febrile seizures. 

Cerebral Cysticercosis

PEDIATRICS ◽  
1979 ◽  
Vol 63 (5) ◽  
pp. 761-763
Author(s):  
William G. Tasker ◽  
Stanley A. Plotkin
Keyword(s):  
United States ◽  
Differential Diagnosis ◽  
Seizure Control ◽  
Febrile Seizures ◽  
The United States ◽  
American Child ◽  
Focal Seizures ◽  
Cerebral Cysticercosis ◽  
Csf Pleocytosis

A case of cerebral cysticercosis in an American child is described. The patient was only 2 years old and had never left the United States. Her symptoms began with febrile seizures and progressed to focal motor seizures. Cerebrospinal fuid pleocytosis with eosinophilia, candle-guttering of the walls of the ventricles on pneumoencephalography, and a titer of 1:4,096 against cysticercosis antigen in her blood led to the diagnosis. Over a five-year follow-up period, the patient's course has been one of resolution of her symptoms, improvement in her electroencephalogram, and excellent seizure control with anticonvulsant therapy. cysticercosis should be considered in the differential diagnosis of a child who shows CSF pleocytosis with eosinophilia, particularly if accompanied by focal seizures.

scholarly journals L’absence épileptique de l’enfance dont le controle nécessite plus d’un medicament.

2008 ◽  
Vol 35 (3) ◽  
pp. 297-300 ◽  
Author(s):  
B. Nadler ◽  
M. I. Shevell
Keyword(s):  
Seizure Control ◽  
Absence Epilepsy ◽  
Control Group ◽  
Epilepsy Syndrome ◽  
Absence Seizures ◽  
Significant Difference ◽  
Age Of Diagnosis ◽  
Group 2 ◽  
Group 1

Introduction:Absence epilepsy is the most common primary generalized epilepsy syndrome encountered in pediatric practice. Treatment is pharmacologically specific and usually successful with a single medication. The objective of this study was to identify any clinical or electroencephalographic features at initial presentation in a consecutive cohort of children with absence epilepsy that may be associated with the need for a second medication.Methods:A computerized pediatric neurology database (1991-2007 inclusive) was retrospectively searched for all patients with typical absence seizures, 3 Hz spike and wave on EEG and no apparent symptomatic etiology who were over the age of two years at seizure onset with at least one year of follow-up. All such children were then divided into two groups; a) those requiring a single medication for seizure control (Group 1), and b) those requiring two medications for seizure control despite optimal management with the initial medication as determined by serum drug monitoring (Group 2). Clinical and electrographic features evident at diagnosis were then contrasted between Group 1 and 2.Results:Seventy-five children with absence seizures were initially identified with 52 meeting the study’s inclusion and none of the exclusion criteria. Of these 52 children, 43 required a single medication for seizure control (Group 1), while 9 required two or more medications for seizure control (Group 2). A significant difference (p<0.05) was apparent between Group 1 and 2 with respect to gender (16/43 males vs 8/9 males) and mean age of diagnosis (8.19 years +/− 3.00 vs 6.06 years +/− 2.22). Age of onset of seizures, interval duration of seizures prior to treatment initiation, duration of seizures, presence of automatisms, family history, presence of co-morbid conditions and EEG findings were not found to be significantly different between the two Groups.Conclusions:Male gender and an earlier age of diagnosis is associated with the need for two medications for seizure control in children with absence epilepsy. This observation may suggest the need for more intensive early programmatic follow-up for young male children with newly diagnosed absence epilepsy to effect more rapid attainment of seizure control.

scholarly journals Study of iron deficiency as a risk factor for first episode of simple febrile siezure

2017 ◽  
Vol 4 (5) ◽  
pp. 1881
Author(s):  
Rakesh Kumawat ◽  
Pukhraj Garg ◽  
B. S. Karnawat ◽  
Ishwari P. Verma ◽  
Akansha Arora ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Febrile Seizure ◽  
Serum Iron ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
First Episode ◽  
Control Group ◽  
Age Group ◽  
Text Book

Background: Febrile seizure are seizure that occur between the age of 6 month to 60 months with a temperature of 100.4f or higher, that are not the result of central nervous system infection or any metabolic imbalance and that occur in the absence of a history of prior afebrile seizure. Febrile seizures are the commonest cause of seizures in children, occuring in 2-5% of children. The maximum age of febrile convulsion occurrence is 14-18 months, which overlap with the maximum prevalence of iron deficiency anaemia which is 1-2 year old. 7 So far, the dilemma of cause of febrile seizure could not be solved. Standard text book still mention iron deficiency is associated with an increased risk of febrile seizure, thus screening for that problem and treating it appears appropriate.Methods: This case control study was done from June 2015 to December 2016. 60 cases of first episode of simple febrile seizure in age group of 6 month to 5 years were included in the study. A control group was selected from age and sex matched children admitted with febrile illness but without seizure. In all cases detailed clinical history, anthropometry, clinical sign of iron deficiency, CNS examination, CBC, PBF, Red cell indices, serum iron, serum ferritin and serum TIBC level was done. These were analysed in three groups mild, moderate, severe deficiency of anemia. A clinical correlation is tried to establish between overt and subtle iron deficiency with seizure.Results: Majority of subjects with first episode of simple febrile seizure were males (63.3%). Majority of cases of febrile seizure occur in the 6-24 months age group (83.3%). Incidence of anemia among case group subjects was 90.0% whereas the same in control group was 30 %. Mean RDW and TIBC levels in cases were significantly higher as compared to that in controls. MCV, Mean Serum ferritin and Serum Iron levels in cases were significantly lower as compared to that in controls.Conclusions: The findings in present study established an association between iron deficiency anemia and first episode of simple febrile seizures. 

scholarly journals Recurrence Risk of Febrile Seizures in Children

1970 ◽  
Vol 32 (1) ◽  
pp. 33-36 ◽  
Author(s):  
AR Ojha ◽  
KN Shakya ◽  
UR Aryal
Keyword(s):  
Risk Factors ◽  
At Risk ◽  
Febrile Seizure ◽  
Febrile Seizures ◽  
Recurrence Risk ◽  
Seizure Recurrence ◽  
Key Words Epilepsy ◽  
Medical College ◽  
Risk Factors For Recurrence

Introduction: Febrile seizure is a common paediatric problem. Identifying children with febrile seizure who are at risk for recurrence is important so that special attention can be given to them. The objective of this study was to identify the risk factors for recurrence of febrile seizures in children. Materials and Methods: This was a prospective cohort study done at Kathmandu Medical College and Teaching Hospital, Kathmandu, Nepal. This study is a continuation of a previous study which looked at the leucocytosis in peripheral blood of children with febrile seizure. A detailed history including the risk factors for febrile seizure recurrence was obtained from the caregiver during follow up on subsequent days after discharge of children from the hospital who were previously admitted for febrile seizure. All children with febrile seizure belonging to age group of 6 months to 6 years were included in the study. Those with afebrile seizures or on anticonvulsants and those who refused to give consent were excluded. Each child was also examined and investigated for the cause of fever. Results: A total of 115 children with febrile seizure admitted for febrile seizure during the study period and all of them were followed up at outpatient department. Males accounted 62% and females 38%. Simple Febrile Seizures were seen in 80% of the cases and complex febrile seizures were seen in 20%. Out of all the cases 68(59%) had symptoms of viral prodrome. 59(51%) had recurrent febrile seizure. Low temperature at onset of Febrile Seizure (p=0.001), short duration of fever before onset of Febrile Seizure (0.026) and atypical Febrile Seizure (p=0.022) were the risk factors for recurrent febrile seizure. Conclusion: Febrile Seizure is a common paediatric problem commonly seen in males. Almost half of children with Febrile Seizure are at risk for recurrence in later date. The risk factors for these recurrences are modest rise in body temperature at the onset of febrile seizure, onset of seizure within 12 hours of fever and atypical presentation. Key words: Epilepsy; Febrile Seizure; Typical Febrile Seizure; Recurrence   DOI: http://dx.doi.org/10.3126/jnps.v32i1.5947   J. Nepal Paediatr. Soc. Vol.32(1) 2012 33-36  

scholarly journals A Randomized Placebo-Controlled Trial of Efficacy and Safety: Drug-Free Gel Containing Ultra-Deformable Phospholipid Vesicles (TDT 064) in Osteoarthritic Knees

2021 ◽  
Vol 14 ◽  
pp. 117954412110313
Author(s):  
Varah Yuenyongviwat ◽  
Khanin Iamthanaporn ◽  
Pakjai Tuntarattanapong ◽  
Theerawit Hongnaparak ◽  
Boonsin Tangtrakulwanich
Keyword(s):  
Knee Osteoarthritis ◽  
Rescue Medication ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Controlled Trial ◽  
Topical Therapy ◽  
Phospholipid Vesicles ◽  
Control Group ◽  
Drug Free

Background: There are a number of topical agents that are used for treatment of knee osteoarthritis. Drug-free gels, containing ultra-deformable phospholipid vesicles (TDT 064) are one such topical therapy, which have been stated to act as a bio lubricant. However, the evidence of TDT 064 in treatment of knee osteoarthritis is limited. Hence, the aim of this study was to evaluate the efficacy of pain control as a primary outcome and safety of TDT 064 compared with a topical placebo. Methods: Sixty-four patients with primary osteoarthritis, with radiographic showing Kellgren and Lawrence classification grade II to III, were randomized into 2 groups. In the first group of 32 patients TDT 064 was used as topical agent, whilst in the second group of 32 patients a placebo identical in appearance was used instead. The verbal numerical rating scale (VNRS) was used for recording pain levels, Self-reported Knee Injury and Osteoarthritis Outcome Scores (KOOS) as well as amounts of rescue medication were also recorded. The data were recorded at the start of the study, and then at follow-up appointments of 14 days, 6 weeks, and 3 months. Results: The mean VNRS for pain in both groups were significantly improved, when compared to the start of treatment ( P < .0001); however, there were no differences between groups at any follow up visit. KOOS in all subscales were not significantly different between both groups at baseline and at the end of treatment. However, the average amount of NSAIDs in the TDT 064 group was 26.39 ± 22.11 tabs, which was significantly lower than the control group; which used an average 37.03 ± 19.22 tabs in 3 months ( P = .047). Conclusions: There were no differences in the VNRS for pain and KOOS scores between the active and placebo groups. Although, TDT 064 could decrease usage of rescue medication the difference with use of a placebo was minimal. Further, larger trials would also be beneficial to demonstrate any differences between TDT 064 and a placebo. Trial Registration: TCTR, TCTR 20190302001. Registered 1 March, 2019: http://www.clinicaltrials.in.th

scholarly journals Association of Serum Zinc Level with Febrile Seizures in Children

2021 ◽  
pp. 200-203
Author(s):  
Maryum Naveed ◽  
Rimsha Mohsin ◽  
Palwasha Khan
Keyword(s):  
Febrile Seizure ◽  
Serum Zinc ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Control Group ◽  
Case Group ◽  
Serum Zinc Level ◽  
Cross Sectional

Introduction: Febrile seizure (FS), previously known as febrile convulsion, is the most common seizure in children. FS usually occurs between six months and five years of age. Aims and objectives: The main objective of the study is to find the association of serum zinc level with febrile seizures in children of Pakistan. Material and methods: This cross sectional study was conducted at Mayo Hospital, Lahore during June 2020 to January 2021. The data was collected from 164 patients of both genders. Results: The data was collected from 164 patients. In the case group, 46 children were male (53.3%), and 36 children (46.7%) were female. In the control group 44 children were male (43.3%) and 38 children were female (56.7%). The age of all participants was between one months and six years. Conclusion: It is concluded that low serum zinc levels are fairly un-sufficient to support the hypothesis that Zinc deficiency could not be a potential risk factor for febrile seizure in children.

Outcome after resective epilepsy surgery in the elderly

2021 ◽  
pp. 1-10
Author(s):  
Attila Rácz ◽  
Kathryn Menne ◽  
Valeri Borger ◽  
Kevin G. Hampel ◽  
Hartmut Vatter ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Epilepsy Surgery ◽  
Seizure Control ◽  
Surgical Complication ◽  
The Elderly ◽  
Neurological Deficits ◽  
Control Group ◽  
Chi Square ◽  
Postoperative Seizure

OBJECTIVE The objective of this study was to compare complications, seizures, and neuropsychological outcomes after resective epilepsy surgery in patients ≥ 60 years of age who underwent operations to younger and matched controls. METHODS Charts of 2243 patients were screened for operated patients in the authors’ center between 2000 and 2015. Patients with available postsurgical follow-up data who were operated on at the age of 60 years or older and matched (by gender, histopathology, and side of surgery) controls who were between 20 and 40 years of age at the time of surgery were included. Outcomes regarding postoperative seizure control were scored according to the Engel classification and group comparisons were performed by using chi-square statistics. RESULTS Data of 20 older patients were compared to those of 60 younger controls. Postoperative seizure control was favorable in the majority of the elderly patients (Engel classes I and II: 75% at 12 months, 65% at last follow-up), but the proportion of patients with favorable outcome tended to be larger in the control group (Engel classes I and II: 90% at 12 months, p = 0.092; 87% at last follow-up, p = 0.032, chi-square test). The surgical complication rate was higher in the elderly population (65% vs 27%, p = 0.002), but relevant persistent deficits occurred in 2 patients of each group only. Neuropsychological and behavioral assessments displayed considerable preoperative impairment and additional postoperative worsening, particularly of verbal skills, memory (p < 0.05), and mood in the elderly. CONCLUSIONS The overall favorable postsurgical outcome regarding seizure control and the moderate risk of disabling persistent neurological deficits in elderly patients supports the view that advanced age should not be a barrier per se for resective epilepsy surgery and underscores the importance of an adequate presurgical evaluation and of referral of elderly patients to presurgical assessment.

Role of SCN2A c.56G/A Gene Polymorphism in Egyptian Children with Genetic Epilepsy with Febrile Seizure Plus

2021 ◽  
Vol 20 ◽  
Author(s):  
Naglaa Fathy Barseem ◽  
Essam Shawky A. E. H. Khattab ◽  
Dalia Saber Saad ◽  
Sameh Abdulla Abd Elnaby
Keyword(s):  
Febrile Seizure ◽  
Positive Family History ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Control Group ◽  
University Hospitals ◽  
Cross Sectional ◽  
Egyptian Children ◽  
Significant Difference ◽  
Systemic Examination

Background: Febrile seizures (FS) are the most common seizures in children younger than 5 years. In the last decade, various coding and noncoding sequence variations of voltage-gated sodium channels SCN2A have been identified in patients with seizures, implying their genetic base. We aimed to evaluate the association between SCN2A c. G/A genetic polymorphism among Egyptian children with febrile seizure plus. Methods: The present cross-sectional study was carried out on 100 epileptic infants and children, attendants of the Neurology Unit, pediatric department, Menoufia University Hospitals (Group Ι). The patients were sub-classified into two groups, according to response to anti-epileptic treatment; Group Ι a (drug responder) and Group Ι b (drug-resistant). Evenly divided number of apparently healthy, age and gender-matched children were selected as controls (Group II). A complete history, throughout the systemic examination and radiological & metabolic assessment, whenever needed was provided, all participants were genotyped for SCN2A rs17183814polymorphism by Restriction Fragment Length Polymorphism (PCR-RFLP). Results: Both of A allele and AA, GA genotypes of SCN2A c. 56 G/A were detected more in patients with febrile seizure plus comparison to the control group with a statistically significant difference at frequencies of 17% and 11% and 12% respectively; OR (CI95%): 10.04 (3.49-28.87) and p <0.001. On classifying epileptic patients into 2 subgroups, carriers of SCN2A rs17183814 AA genotype tended to respond poorly to anti-epileptic drugs (AEDs). Moreover, multivariate analysis revealed that rs17183814 A allele and positive family history of epilepsy were considered the highest predicted risk factors for the development of epilepsy p<0.05. Conclusion: SCN2A rs17183814 (A) allele was specifically associated with developing febrile seizure plus and could modulate the patient's response to anti-epileptic medications.

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