scholarly journals Students’ age and parental level of education influence COVID-19 vaccination hesitancy

2021 ◽  
Author(s):  
Anna Zychlinsky Scharff ◽  
Mira Paulsen ◽  
Paula Schaefer ◽  
Fatma Tanisik ◽  
Rizky Indrameikha Sugianto ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Herd Immunity ◽  
Public Information ◽  
Vaccine Hesitancy ◽  
School Students ◽  
Information Campaigns ◽  
Level Of Education ◽  
Parental Level ◽  
To Receive ◽  
Vaccination Hesitancy

AbstractWidespread vaccination in pursuit of herd immunity has been recognized as the most promising approach to ending the global pandemic of coronavirus disease 19 (COVID-19). The vaccination of children and adolescents has been extensively debated and the first COVID-19 vaccine is now approved in European countries for children aged > 12 years of age. Our study investigates vaccination hesitancy in a cohort of German secondary school students. We assessed 903 students between age 9 and 20 in the period between 17 May 2021 and 30 June 2021. 68.3% (n = 617) reported intention to undergo COVID-19 vaccination, while 7% (n = 62) did not want to receive the vaccine and 15% (n = 135) were not yet certain. Age and parental level of education influenced COVID-19 vaccine hesitancy. Children under the age of 16 as well as students whose parents had lower education levels showed significantly higher vaccine hesitancy.  Conclusion: Identifying subsets with higher vaccination hesitancy is important for targeting public information campaigns in support of immunization. What is Known:• The willingness to receive COVID-19 vaccination among adults in Europe is about 70%, but data for children and adolescents is lacking.• The lack of immunization in younger cohorts represents a significant barrier to achieving herd immunity, and also leaves children and adolescents vulnerable to acute and long-term morbidity from natural COVID-19 infections. What is New:• Intention-to-vaccinate among children and adolescents is high (~ 70%); conversely, vaccination hesitancy is low.• Age and parental level of education influenced COVID-19 vaccine hesitancy among children and adolescents.

scholarly journals Prevention of COVID-19 by mRNA-based vaccines within the general population of California

2021 ◽  
Author(s):  
Kristin L Andrejko ◽  
Jake Pry ◽  
Jennifer F Myers ◽  
Nicholas P Jewell ◽  
John Openshaw ◽  
...  
Keyword(s):  
General Population ◽  
Herd Immunity ◽  
Asymptomatic Infection ◽  
Geographic Region ◽  
Vaccine Effectiveness ◽  
Vaccine Hesitancy ◽  
Molecular Diagnostic ◽  
California Department ◽  
Molecular Diagnostic Test ◽  
To Receive

Abstract Background Estimates of COVID-19 vaccine effectiveness under real-world conditions, and understanding of barriers to uptake, are necessary to inform vaccine rollout. Methods We enrolled cases (testing positive) and controls (testing negative) from among the population whose SARS-CoV-2 molecular diagnostic test results from 24 February-29 April 2021 were reported to the California Department of Public Health. Participants were matched on age, sex, and geographic region. We assessed participants’ self-reported history of mRNA-based COVID-19 vaccine receipt (BNT162b2 and mRNA-1273). Participants were considered fully vaccinated two weeks after second dose receipt. Among unvaccinated participants, we assessed willingness to receive vaccination. We measured vaccine effectiveness (VE) via the matched odds ratio of prior vaccination, comparing cases with controls. Results We enrolled 1023 eligible participants aged ≥18 years. Among 525 cases, 71 (13.5%) received BNT162b2 or mRNA-1273; 20 (3.8%) were fully vaccinated with either product. Among 498 controls, 185 (37.1%) received BNT162b2 or mRNA-1273; 86 (16.3%) were fully vaccinated with either product. Two weeks after second dose receipt, VE was 87.0% (95% confidence interval: 68.6-94.6%) and 86.2% (68.4-93.9%) for BNT162b2 and mRNA-1273, respectively. Fully vaccinated participants receiving either product experienced 91.3% (79.3-96.3%) and 68.3% (27.9-85.7%) VE against symptomatic and asymptomatic infection, respectively. Among unvaccinated participants, 42.4% (159/375) residing in rural regions and 23.8% (67/281) residing in urban regions reported hesitancy to receive COVID-19 vaccination. Conclusions Authorized mRNA-based vaccines are effective at reducing documented SARS-CoV-2 infections within the general population of California. Vaccine hesitancy presents a barrier to reaching coverage levels needed for herd immunity.

scholarly journals Determining the Relationship between Bangkokian’s Willingness to Receive COVID-19 Vaccination and their Knowledge, Attitude, and Practice (KAP) towards the Contagion

2021 ◽  
Vol 04 (08) ◽  
Author(s):  
Pendhamma Sindhusen ◽  
Keyword(s):  
Herd Immunity ◽  
Past Research ◽  
Vaccine Hesitancy ◽  
Accurate Information ◽  
Attitude And Practice ◽  
Public Campaign ◽  
Initial Hypothesis ◽  
Knowledge And Attitude ◽  
To Receive ◽  
Knowledge Attitude And Practice

In the age of COVID-19 where a lethal contagion is ubiquitous across the globe, vaccination is of supreme significance. Vaccines provide immunity to individuals, rendering them less susceptible to SARS-CoV-2 infection or their symptoms less severe should they ultimately become infected. Vaccinating an adequate proportion of the population can majorly contribute to the achievement of herd immunity, consequently depressing the spread of the Coronavirus and ushering humanity towards eventual subjugation of the ongoing pandemic. Unfortunately, there are obstacles preventing such a roseate prospect from realization, one of which is vaccine hesitancy. Interestingly, past research in various regions around the world has associated this factor, partially, with the public’s knowledge and attitude concerning COVID-19, which could be measured by the Knowledge, Attitude and Practice (KAP) towards COVID-19 scale. Such an association plausibly intimates that a public campaign shedding light on accurate information about the contagion might be of help in augmenting people’s willingness to receive vaccination against the SARS-CoV-2 virus. Because circumstances inevitably varied from place to place, population to population, this study was undertaken to explore whether any similar association existed in Bangkok, Thailand, where the pandemic has been growing progressively worse, with the initial hypothesis that it did. However, results revealed that while there was indeed a statistically significant correlation between Bangkokians’ willingness to receive COVID-19 vaccines and their KAP towards the contagion, the correlation was weak (r = 0.30). This evinces the need for a more thorough and farther-reaching study and, until such a study has been meaningfully concluded, the appropriacy of apposite agencies concentrating elsewhere in their efforts to vanquish vaccine hesitancy and accomplish herd immunity against COVID-19.

scholarly journals COVID-19 Vaccine Acceptability and Hesitancy in Africa: Implications for Addressing Vaccine Hesitancy

2021 ◽  
Vol 2 (10) ◽  
pp. 999-1004
Author(s):  
Steward Mudenda
Keyword(s):  
Healthcare Workers ◽  
Herd Immunity ◽  
Swine Flu ◽  
Vaccine Hesitancy ◽  
African Countries ◽  
Vaccine Acceptability ◽  
H1n1 Vaccine ◽  
Flu Vaccine ◽  
Pandemic Vaccine ◽  
To Receive

Background: Increased acceptance and uptake of Coronavirus Disease 2019 (COVID-19) vaccines is very essential in containing the ongoing COVID-19 pandemic. Vaccine hesitancy is a threat to public health containment of infectious diseases. Aim: The main aim of this study was to review published articles regarding COVID-19 vaccine acceptability and hesitancy across all populations in Africa. Materials and methods: This was a narrative review. A comprehensive literature search was done using PubMed, Google Scholar, Scopus, and EMBASE using the keywords vaccine acceptability, vaccine hesitancy, COVID-19 vaccine, COVID-19 pandemic, H1N1 vaccine, swine flu, swine flu vaccine, Africa, and the Boolean word AND. The cited literature was published between March 2001 and June 2021. Results: The few studies were done in Africa so far are among healthcare workers and medical students. Acceptance of vaccination against COVID-19 in Africa ranged from 15.4% to 55.9%. This shows increased hesitancy to receive the COVID-19 vaccines in African countries. Many people were concerned about the potential adverse effects and ineffectiveness of COVID-19 vaccines. Misinformation about the COVID-19 vaccines has contributed to the hesitancy reported from different studies. Moreover, sociodemographic characteristics were also predictors of the acceptability of COVID-19 vaccines. Conclusion: Low acceptability rates reported in Africa indicates increased hesitancy to vaccination against COVID-19. The low acceptance of vaccines in Africa can hinder the required 60-70% vaccinations to achieve herd immunity. Therefore, there is a need to develop strategies that will address hesitancy against the COVID-19 vaccines across countries and populations in Africa and the entire globe.

scholarly journals Psychological predictors of vaccination intentions among U.S. undergraduates and online panel workers during the 2020 COVID-19 pandemic

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260380
Author(s):  
Suryaa Gupta ◽  
Shoko Watanabe ◽  
Sean M. Laurent
Keyword(s):  
Undergraduate Students ◽  
Herd Immunity ◽  
Past Research ◽  
Collective Responsibility ◽  
Vaccine Uptake ◽  
Vaccine Hesitancy ◽  
Online Panel ◽  
Conspiracy Beliefs ◽  
Flu Vaccine ◽  
To Receive

Objective Availability of safe and effective vaccines against COVID-19 is critical for controlling the pandemic, but herd immunity can only be achieved with high vaccination coverage. The present research examined psychological factors associated with intentions to receive COVID-19 vaccination and whether reluctance towards novel pandemic vaccines are similar to vaccine hesitancy captured by a hypothetical measure used in previous research. Method Study 1 was administered to undergraduate students when COVID-19 was spreading exponentially (February-April 2020). Study 2 was conducted with online panel workers toward the end of the first U.S. wave (July 2020) as a pre-registered replication and extension of Study 1. In both studies, participants (total N = 1,022) rated their willingness to receive the COVID-19 vaccination and to vaccinate a hypothetical child for a fictitious disease, and then responded to various psychological measures. Results In both studies, vaccination intentions were positively associated with past flu vaccine uptake, self-reported vaccine knowledge, vaccine confidence, and sense of collective responsibility. Complacency (not perceiving disease as high-risk), anti-vaccine conspiracy beliefs, perceived vaccine danger, and mistrust in science/scientists were negative correlates of vaccination intentions. Constraints (psychological barriers), calculation (extensive information-searching), analytical thinking, perceived disease vulnerability, self-other overlap, and conservatism were weakly associated with vaccination intentions but not consistently across both studies or vaccine types. Additionally, similar factors were associated with both real and hypothetical vaccination intentions, suggesting that conclusions from pre-COVID vaccine hesitancy research mostly generalize to the current pandemic situation. Conclusion Encouraging flu vaccine uptake, enhancing confidence in a novel vaccine, and fostering a sense of collective responsibility are particularly important as they uniquely predict COVID-19 vaccination intentions. By including both actual pandemic-related hesitancy measures and hypothetical hesitancy measures from past research in the same study, this work provides key context for the generalizability of earlier non-pandemic research.

scholarly journals Intention to Receive COVID-19 Vaccine by U.S. Health Sciences University Employees

2021 ◽  
Vol 12 ◽  
pp. 215013272110366
Author(s):  
Travis S. Dowdle ◽  
Jeff Dennis ◽  
Kenneth M. Nugent ◽  
Theresa Byrd
Keyword(s):  
United States ◽  
Health Professionals ◽  
Herd Immunity ◽  
Total Sample ◽  
The United States ◽  
Cross Sectional Study ◽  
Health Sciences ◽  
Vaccine Hesitancy ◽  
Cross Sectional ◽  
To Receive

Objectives: Understanding vaccine intentions and attitudes of health professionals is critical as the Pfizer-BioNTech and the Moderna COVID19 vaccines are being administered throughout the United States. This study estimates the level of vaccine hesitancy at a health sciences center in West Texas prior to the distribution of the vaccines. Methods: An analytical cross-sectional study was performed via anonymous Qualtrics survey administered to approximately 4500 faculty, staff, postdoctoral research associates/medical residents, and employees at a multi-campus health sciences university in the United States. Respondents were asked demographic questions and intention to receive the vaccine. Factors associated with the intention to receive a vaccine were determined using logistic regression analysis. Results: A total sample of 2258 subjects were evaluated (50.0% response rate). Among all respondents, 64.6% reported that they would probably or definitely receive the COVID-19 vaccine. Men had higher levels of intention to receive the vaccine (OR = 2.11, 95% CI 1.64-2.71); respondents who indicated yearly influenza vaccines are necessary were also more likely to receive the vaccine (OR = 6.04, 95% CI 4.70-7.75). Eighty-three percent of faculty and 56% of the staff reported intention to receive the vaccine. Respondents who had previously tested positive for COVID-19 reported more interest in receiving the vaccine (58.5% yes vs 41.5% no). Conclusion: In this study, the intention to receive the COVID-19 vaccination at a United States health sciences center falls below the necessary herd immunity estimates. Public health initiatives must be developed to decrease vaccine hesitancy, especially among health professionals.

scholarly journals Early evidence of COVID-19 vaccine effectiveness within the general population of California

2021 ◽  
Author(s):  
Kristin Andrejko ◽  
Jake M Pry ◽  
Jennifer F Myers ◽  
Nicholas P Jewell ◽  
John Openshaw ◽  
...  
Keyword(s):  
General Population ◽  
Diagnostic Testing ◽  
Herd Immunity ◽  
Geographic Region ◽  
Vaccine Effectiveness ◽  
Vaccine Uptake ◽  
Vaccine Hesitancy ◽  
Molecular Diagnostic ◽  
California Department ◽  
To Receive

Importance: Evidence is needed to determine COVID-19 vaccine effectiveness under real world conditions of use. Objective: To determine the effectiveness of authorized vaccines against COVID-19 in the context of substantial circulation of SARS-CoV-2 variants of concern, and identify vaccine uptake barriers. Design: We recruited cases (testing positive) and controls (testing negative) based on SARS-CoV-2 molecular diagnostic test results from 24 February-7 April 2021. Controls were individually matched to cases by age, sex, and geographic region. We identified cases and controls via random sampling within predetermined demographic strata. We conducted enrollment and administered study questionnaires via telephone-based facilitated interviews. Setting: Population-based surveillance of all SARS-CoV-2 molecular diagnostic testing reported to the California Department of Public Health. During the study period, 69% of sequenced SARS-CoV-2 isolates in California belonged to variants of concern B.1.1.7, B.1.427, or B.1.429. Participants: We enrolled 645 adults aged ≥18y, including 325 cases and 320 controls Exposures: We assessed participants' self-reported history of COVID-19 vaccine receipt (BNT162b2 and mRNA-1273). Individuals were considered fully vaccinated two weeks after second dose receipt. Main Outcomes and Measures: The primary endpoint was a positive SARS-CoV-2 molecular test result. For unvaccinated participants, we assessed willingness to receive vaccination, when eligible. We measured vaccine effectiveness via the matched odds ratio of prior vaccination, comparing cases with controls. Results: Among 325 cases, 23 (7%) and 13 (4%) received BNT162b2 and mRNA-1273, respectively; 8 (2%) were fully vaccinated with either product. Among 260 controls, 49 (19%) and 49 (19%) received BNT162b2 and mRNA-1273, respectively; 42 (16%) were fully vaccinated with either product. Among fully vaccinated individuals, vaccine effectiveness was 86% (95% confidence interval: 67-94%). Vaccine effectiveness was 66% (-69% to 93%) and 78% (23% to 94%) one week following a first and second dose, respectively. Among unvaccinated participants, 39% of those residing in rural regions and 23% of those residing in urban regions reported hesitancy to receive COVID-19 vaccines, when eligible. In contrast, vaccine hesitancy did not significantly differ by age, sex, household income, or race/ethnicity. Conclusions and Relevance: Ongoing vaccination efforts are preventing SARS-CoV-2 infection in the general population in California. Vaccine hesitancy presents a barrier to reaching coverage levels needed for herd immunity.

scholarly journals COVID-19 vaccination intention and vaccine characteristics influencing vaccination acceptance: a global survey of 17 countries

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Li Ping Wong ◽  
Haridah Alias ◽  
Mahmoud Danaee ◽  
Jamil Ahmed ◽  
Abhishek Lachyan ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Local Population ◽  
Herd Immunity ◽  
Vaccine Hesitancy ◽  
Multivariable Logistic Regression Analysis ◽  
Individual Country ◽  
Vaccine Acceptance ◽  
Vaccination Acceptance ◽  
Mrna Technology ◽  
To Receive

Abstract Background The availability of various types of COVID-19 vaccines and diverse characteristics of the vaccines present a dilemma in vaccination choices, which may result in individuals refusing a particular COVID-19 vaccine offered, hence presenting a threat to immunisation coverage and reaching herd immunity. The study aimed to assess global COVID-19 vaccination intention, vaccine characteristics influencing vaccination acceptance and desirable vaccine characteristics influencing the choice of vaccines. Methods An anonymous cross-sectional survey was conducted between 4 January and 5 March 2021 in 17 countries worldwide. Proportions and the corresponding 95% confidence intervals (CI) of COVID-19 vaccine acceptance and vaccine characteristics influencing vaccination acceptance were generated and compared across countries and regions. Multivariable logistic regression analysis was used to determine the factors associated with COVID-19 vaccine hesitancy. Results Of the 19,714 responses received, 90.4% (95% CI 81.8–95.3) reported likely or extremely likely to receive COVID-19 vaccine. A high proportion of likely or extremely likely to receive the COVID-19 vaccine was reported in Australia (96.4%), China (95.3%) and Norway (95.3%), while a high proportion reported being unlikely or extremely unlikely to receive the vaccine in Japan (34.6%), the U.S. (29.4%) and Iran (27.9%). Males, those with a lower educational level and those of older age expressed a higher level of COVID-19 vaccine hesitancy. Less than two-thirds (59.7%; 95% CI 58.4–61.0) reported only being willing to accept a vaccine with an effectiveness of more than 90%, and 74.5% (95% CI 73.4–75.5) said they would accept a COVID-19 vaccine with minor adverse reactions. A total of 21.0% (95% CI 20.0–22.0) reported not accepting an mRNA vaccine and 51.8% (95% CI 50.3–53.1) reported that they would only accept a COVID-19 vaccine from a specific country‐of‐origin. Countries from the Southeast Asia region reported the highest proportion of not accepting mRNA technology. The highest proportion from Europe and the Americas would only accept a vaccine produced by certain countries. The foremost important vaccine characteristic influencing vaccine choice is adverse reactions (40.6%; 95% CI 39.3–41.9) of a vaccine and effectiveness threshold (35.1%; 95% CI 33.9–36.4). Conclusions The inter-regional and individual country disparities in COVID-19 vaccine hesitancy highlight the importance of designing an efficient plan for the delivery of interventions dynamically tailored to the local population. Graphic Abstract

scholarly journals COVID-19 Vaccine Hesitancy and Attitude toward Booster Doses among US Healthcare Workers

Vaccines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1358
Author(s):  
Suman Pal ◽  
Rahul Shekhar ◽  
Saket Kottewar ◽  
Shubhra Upadhyay ◽  
Mriganka Singh ◽  
...  
Keyword(s):  
Racial Identity ◽  
Healthcare Workers ◽  
Booster Dose ◽  
Vaccine Hesitancy ◽  
Pharmaceutical Companies ◽  
Education Attainment ◽  
Level Of Education ◽  
Younger Age ◽  
Modeling Behavior ◽  
To Receive

Vaccine reluctance among healthcare workers (HCW) can have widespread negative ramifications, including modeling behavior for the general population and challenges with maintaining a healthy workforce so we can respond to a resurgence of the pandemic. We previously reported that only one-third of HCW were willing to take the vaccine as soon as it became available prior to its Emergency Use Authorization (EUA). Here, we re-examine the attitude toward COVID-19 vaccines among HCW several months after the vaccines have been made widely available. In this study, only 7.9% (n = 107) of respondents were hesitant to take the first or second dose of the vaccine. Younger age (18–40 years) and lower level of education attainment (GED or less) were associated with higher vaccine hesitancy, whereas self-identified Asian racial identity was associated with greater acceptance of COVID-19 vaccination. Among the vaccine-hesitant group, more respondents noted mistrust of regulatory authorities (45.3%), government (48.6%), and pharmaceutical companies (50%) than mistrust of doctors (25.4%). Nearly two-thirds of respondents were concerned that vaccination may be ineffective against new strains and booster doses may be required; however, vaccine-hesitant respondents’ acceptance of a hypothetical booster dose was only 14.3%. Overall, vaccine hesitancy was observed to have demographic predictors similar to those previously reported; the hesitancy of some US HCW to receive booster doses may reflect a general hesitancy to receive other forms of vaccination.

scholarly journals Willingness to Vaccinate against Coronavirus Disease 2019 and Related Predictors among Non-Healthcare Personnel in Indonesia

2021 ◽  
Vol 9 (E) ◽  
pp. 1097-1103
Author(s):  
Faridah Baroroh ◽  
Ferawati Suzalin ◽  
Indriani Indriani ◽  
Siti Sangadah ◽  
Istiningrum Istiningrum ◽  
...  
Keyword(s):  
Herd Immunity ◽  
Demographic Characteristics ◽  
Vaccine Hesitancy ◽  
Healthcare Personnel ◽  
Research Subjects ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Relationship Analysis ◽  
To Receive ◽  
Difference Test

BACKGROUND: Herd immunity against COVID-19 can be realized when a minimum of 62% of the vulnerable population has been vaccinated. However, achieving uptake of recommended vaccination in the targeted population ultimately lies with the community's willingness. Vaccine skepticism varies across demographic characteristics and stems from the perceived threats of being infected with COVID-19 while receiving the vaccine. AIM: This research was intended to determine the willingness to vaccinate against COVID-19 and its associated factors. METHODS: It employed a cross-sectional, then the collected data were analyzed using descriptive analytics: difference test and relationship analysis. Study with two online surveys on Google Forms and non-healthcare personnel as the research subjects. Screening with inclusion and exclusion criteria yielded 862 respondents spread over 32 provinces in Indonesia Results: showed no difference in COVID-19 knowledge scores in surveys 1 and 2 (76.0‒77.2; p=0.08). Age and education level are significantly related to COVID-19 knowledge scores (p<0.05). About 42.4% of respondents in survey 1 and 55.6% in survey 2 were willing to receive the vaccine, with 36.8‒45.3% feeling hesitant. The main reason for vaccine hesitancy (42.2%) and unwillingness (43.2%) was mistrust in the effects or benefits of the vaccine. Although demographic characteristics are not related to the willingness (p>0.05), the opposite is true for the COVID-19 knowledge level [OR:1.66; 95% CI:1.26–2.18]. Conclusion about half of the non-healthcare personnel (42.4‒55.6%) are willing to receive the vaccine, with knowledge of the disease being a predictor (p=0.00).

scholarly journals Increasing but inadequate intention to receive Covid-19 vaccination over the first 50 days of impact of the more infectious variant and roll-out of vaccination in UK: indicators for public health messaging

2021 ◽  
Author(s):  
Patrik Bachtiger ◽  
Alexander Adamson ◽  
William A Maclean ◽  
Jennifer K Quint ◽  
Nicholas S Peters
Keyword(s):  
Public Health ◽  
Language Processing ◽  
Herd Immunity ◽  
Vaccine Hesitancy ◽  
Free Text ◽  
New Variant ◽  
The Impact ◽  
To Receive ◽  
Roll Out ◽  
Health Messaging

ABSTRACTObjectivesTo inform critical public health messaging by determining how changes in Covid-19 vaccine hesitancy, attitudes to the priorities for administration, the emergence of new variants and availability of vaccines may affect the trajectory and achievement of herd immunity.Methods>9,000 respondents in an ongoing cross-sectional participatory longitudinal epidemiology study (LoC-19, n=18,581) completed a questionnaire within their personal electronic health record in the week reporting first effective Covid-19 vaccines, and then again after widespread publicity of the increased transmissibility of a new variant (November 13th and December 31st 2020 respectively). Questions covered willingness to receive Covid-19 vaccination and attitudes to prioritisation. Descriptive statistics, unadjusted and adjusted odds ratios (ORs) and natural language processing of free-text responses are reported, and how changes over the first 50 days of both vaccination roll-out and new-variant impact modelling of anticipated transmission rates and the likelihood and time to herd immunity.FindingsCompared with the week reporting the first efficacious vaccine there was a 15% increase in acceptance of Covid-19 vaccination, attributable in one third to the impact of the new variant, with 75% of respondents “shielding” – staying at home and not leaving unless essential – regardless of health status or tier rules. 12.5% of respondents plan to change their behaviour two weeks after completing vaccination compared with 45% intending to do so only when cases have reduced to a low level. Despite the increase from 71% to 86% over this critical 50-day period, modelling of planned uptake of vaccination remains below that required for rapid effective herd immunity – now estimated to be 90 percent in the presence of a new variant escalating R0 to levels requiring further lockdowns. To inform the public messaging essential therefore to improve uptake, age and female gender were, respectively, strongly positively and negatively associated with wanting a vaccine. 22.7% disagreed with the prioritisation list, though 70.3% were against being able to expedite vaccination through payment. Teachers (988, 12.6%) and Black, Asian and Minority Ethnic (BAME) (837, 10.7%) groups were most cited by respondents for prioritisation.InterpretationIn this sample, the growing impact of personal choice among the increasingly informed public highlights a decrease in Covid-19 vaccine hesitancy over time, with news of a new variant motivating increased willingness for vaccination but at levels below what may be required for effective herd immunity. We identify public preferences for next-in-line priorities, headed by teachers and BAME groups, consideration of which will help build trust and community engagement critical for maximising compliance with not only the vaccination programme but also all other public health measures.

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