Hematological reference values of healthy adult Sangsari sheep (Iranian fat-tailed sheep) estimated by Reference Value Advisor

The reference values of laboratory tests are affected by factors such as instruments and methods of tests, which are always beingdeveloped. For these reasons, each laboratory is recommended to determine their own reference values. To determine the reference valuesof complete blood count in healthy adult people, and compare them to the reference values which is taken from the references. A crosssectional study was conducted on 200 healthy adult people, aged 18-60 years, selected during blood donation. The eight haematologicalparameters were estimated using Sysmex Xt-1800i at Dr.Wahidin Sudirohusodo Hospital. The data were analyzed statistically by SPSS11.5 programs. The reference values of leukocyte, erythrocyte, haemoglobin, hematocrit, MCV, MCH, MCHC and platelet were: 4400 to10000 /µL; %:4.2–6.2 × 106/µL; &:3.8–5.5 × 106/µL; %:12.5–17.3 g/dL; &:11.8–15.4 g/dL; %:38.1–50.4 %; &:31.1–49.7 %; 80,1to 94,3 fL, 25,9–31,9 pg, 31,4–35,2 g/dL, and %:171.2–405.1 × 103/µL; &:191.8–441.5 × 103/µL, respectively. Significant differenceswere observed in the MCH and platelet values (p< 0,005). The values found in this study were similar to the reference value commonlyused in our laboratory, except for the MCH value which was lower and the platelet value which was higher..

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From evidence to practice: development of web-based Dutch lipid reference values

Netherlands Heart Journal ◽

10.1007/s12471-021-01562-x ◽

2021 ◽

Author(s):

N. S. Nurmohamed ◽

D. Collard ◽

J. W. Balder ◽

J. A. Kuivenhoven ◽

E. S. G. Stroes ◽

...

Keyword(s):

The Netherlands ◽

Reference Values ◽

Plasma Lipids ◽

Digital Health ◽

Reference Value ◽

Lipid Lowering ◽

Lipid Lowering Therapy ◽

Lowering Therapy ◽

Cascading Style Sheets ◽

Age And Sex

Abstract Introduction In the Netherlands, the total number of yearly measured lipid profiles exceeds 500,000. While lipid values are strongly affected by age and sex, until recently, no up-to-date age- and sex-specific lipid reference values were available. We describe the translation of big-cohort lipid data into accessible reference values, which can be easily incorporated in daily clinical practice. Methods Lipid values (total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides) from all healthy adults and children in the LifeLines cohort were used to generate age- and sex-specific percentiles. A combination of RStudio, Cascading Style Sheets and HyperText Markup Language was used to interactively display the percentiles in a responsive web layout. Results After exclusion of subjects reporting cardiovascular disease or lipid-lowering therapy at baseline, 141,611 subjects were included. On the website, input fields were created for age, sex and all main plasma lipids. Upon input of these values, corresponding percentiles are calculated, and output is displayed in a table and an interactive graph for each lipid. The website has been made available in both Dutch and English and can be accessed at www.lipidtools.com. Conclusion We constructed the first searchable, national lipid reference value tool with graphical display in the Netherlands to use in screening for dyslipidaemias and to reduce the underuse of lipid-lowering therapy in Dutch primary prevention. This study illustrates that data collected in big-cohort studies can be made easily accessible with modern digital techniques and preludes the digital health revolution yet to come.

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SAT0464 Bone Mineral Density Reference Value by Densitometry (DXA) and Prevalence of Osteoporosis in A Healthy Adult Population from Bogota, Colombia

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.6025 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 761.3-762

Author(s):

E. Jáuregui ◽

M. Galvis ◽

V. Moncaleano ◽

C. Aldana ◽

Y. Muñoz

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Healthy Adult ◽

Adult Population ◽

Reference Value ◽

Mineral Density ◽

Prevalence Of Osteoporosis

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Assessment of oxygen-uptake efficiency slope in healthy children and children with heart disease: Generation of appropriate reference values for the OUES variable

European Journal of Preventive Cardiology ◽

10.1177/2047487318807977 ◽

2018 ◽

Vol 26 (2) ◽

pp. 177-184 ◽

Cited By ~ 6

Author(s):

Carlos AC Hossri ◽

Isabela PM Alves de Souza ◽

Joana ST de Oliveira ◽

Luiz E Mastrocola

Keyword(s):

Heart Disease ◽

Oxygen Uptake ◽

Children And Adolescents ◽

Surface Area ◽

Reference Values ◽

Functional Capacity ◽

Body Surface ◽

Congenital Heart ◽

Reference Value ◽

Oxygen Uptake Efficiency Slope

Background Oxygen-uptake efficiency slope (OUES) is an objective measure of functional capacity that does not require a maximal effort but is considerably dependent on anthropometric variables and requires the generation of an appropriate reference value in children. This study aimed to establish normal reference values for OUES/kg in children with and without congenital heart diseases. Besides that, reference values are presented secondarily for OUES per body surface area (OUES/BSA). Design Cross-sectional. Methods Six hundred and seventy-six children and adolescents performed a maximal cardiopulmonary exercise test (305 healthy controls and 371 individuals with congenital heart defect), between four and 21 years old (481 males and 195 females, with a mean age of 12 years). Results The OUES reference value for the classification of children and adolescents with normal functional capacity (>80% of predicted maximum oxygen uptake) was 34.63 (sensitivity 77% and specificity 83%, p < 0.05). Regarding the body surface area, considering healthy patients and those with heart disease, the cutoff value of the OUES/BSA was 1151 with sensitivity of 79% and specificity of 79%. Conclusions OUES/kg may be an important marker tool in the differentiation between preserved or abnormal functional capacity in children and adolescents with and without congenital heart disease, even at the submaximal level of exercise.

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A model for the effect of bias for cholesterol on the population at risk.

Clinical Chemistry ◽

10.1093/clinchem/34.11.2256 ◽

1988 ◽

Vol 34 (11) ◽

pp. 2256-2259 ◽

Cited By ~ 5

Author(s):

M H Kroll ◽

M Ruddel ◽

R J Elin

Keyword(s):

At Risk ◽

Standard Deviation ◽

Reference Values ◽

Gaussian Distribution ◽

Population Distribution ◽

Reference Value ◽

Mean Value ◽

The Body ◽

Methodological Bias ◽

The Mean

Abstract The location of the Reference Value for an analyte within the population distribution affects the magnitude of error due to methodological bias. Using the gaussian distribution, we evaluated the effects of systematic and proportional biases of the method (positive and negative), mean value, and standard deviation on the magnitude of error. We chose four Reference Values for cholesterol as a model. For a population with a mean of 2.0 and SD of 0.36 g of cholesterol per liter, a 3% positive proportional bias causes sixfold more error at the 50th percentile than at the 97.5th. In general, the error for a given bias (proportional or systematic) is greater for a Reference Value within the body than at the tails of the distribution. Further, the magnitude of the error varies as a function of the mean and standard deviation of the population.

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Evaluation of sediment contamination by trace elements and the zooplankton community analysis in area affected by gold exploration in Southeast (SE) of the Iron Quadrangle, Alto Rio Doce, (MG) Brazil

Acta Limnologica Brasiliensia ◽

10.1590/s2179-975x2013000200006 ◽

2013 ◽

Vol 25 (2) ◽

pp. 150-157

Author(s):

Cláudia de Lima e Silva ◽

Adivane Terezinha da Costa ◽

Giovanni Guimarães Landa ◽

Herton Fabrício Camargos Fonseca ◽

Aléssio Silveira

Keyword(s):

Trace Elements ◽

Reference Values ◽

Zooplankton Community ◽

Reference Value ◽

Community Analysis ◽

Major And Trace Elements ◽

Geochemical Composition ◽

Gold Exploration ◽

Local Reference ◽

High Concentrations

AIM: The aim was to verify the geochemical composition of sediments samples (riverbed and bank) and the relationship of the following elements: Al, As, Cd. Cr, Cu, Fe, Mn, Ni and Zn with the zooplankton community. METHODS: Bank and riverbed sediments were collected in four sampling points along the studied area, in June/2010 (dry season) and March/2011 (rainy season). Three types of analysis were performed: granulometric, mineralogical (by X-Ray diffractometer) and geochemical (by ICPOES), where for the last two types, only a fraction of silt/clay (<0.062 mm) was used, and the results were compared with the following reference values: Local Reference Value (Costa et al., 2010), Quality Reference Values (São Paulo, 2005), PEC and TEC values (MacDonald et al., 2000). For identification of the zooplankton community, riverbed and bank samples were collected in polyethylene bottles, suspended with deionized water (bank sample only), stained with Rose Bengal and preserved in formalin at 4%. RESULTS: As concentrations at Col sampled point were 18 times greater than the Local Reference Value (3.84 mg.kg-1). Cd concentrations were greater than the values established by the QRV (<0.5 mg.kg-1) and PEC (4.98 mg.kg-1) in almost all the sampled points, regarding seasonality. The following zooplanktonic species were identified: Arcella costata (Ehrenberg, 1847), Arcella discoides (Ehrenberg, 1843), Arcella vulgaris (Ehrenberg, 1830), Centropyxis aculeata (Ehrenberg, 1838), Centropyxis ecornis (Ehrenberg, 1841), Difflugia sp., Difflugia acuminata (Ehrenberg, 1838), Euglypha laevis (Perty, 1849), Trynema enchelys (Ehrenberg, 1938), Asplanchna priodonta (Gosse, 1850), and Bedelloida, with, approximately 81% belonging to the Protozoa group. CONCLUSIONS: The studied area, with the exception of the Tripuí point, was found to be impacted by historical gold exploration in the region, as well as by the growing urbanization. Within the elements considered to be the most toxic to the biota, As and Cd violated all their reference values. In spite of high concentrations of major and trace elements encountered at downstream points, testacea species were identified, suggesting that this group has the capacity to adapt to adverse situations.

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Revised Reference Values for Potassium Intake

Annals of Nutrition and Metabolism ◽

10.1159/000479705 ◽

2017 ◽

Vol 71 (1-2) ◽

pp. 118-124 ◽

Cited By ~ 4

Author(s):

Daniela Strohm ◽

Sabine Ellinger ◽

Eva Leschik-Bonnet ◽

Friederike Maretzke ◽

Helmut Heseker ◽

...

Keyword(s):

Breast Milk ◽

Children And Adolescents ◽

Reference Values ◽

Health Benefit ◽

Reference Value ◽

Potassium Excretion ◽

Lactating Women ◽

Potassium Intake ◽

Breastfed Infants ◽

Urinary Potassium

Background: The nutrition societies of Germany, Austria and Switzerland have revised the reference values for potassium intake in January 2017. Methods: For adults, the estimated value was based on the 24-h urinary potassium excretion and on preventive considerations regarding hypertension and stroke. The estimated values for children and adolescents were extrapolated from the adult estimated value considering differences in body mass. For infants aged 0 to under 4 months, the estimated value was set based on the potassium intake via breast milk. From this reference value, the estimated value for infants aged 4 to under 12 months was also derived by extrapolation. The estimated value for lactating women takes into account the potassium loss via breast milk. Results: The estimated values for potassium intake are set at 400 mg/day for breastfed infants aged 0 to under 4 months, 600 mg/day for infants aged 4 to under 12 months, 1,100-4,000 mg/day for children and adolescents, 4,000 mg/day for adults and pregnant women and 4,400 mg/day for lactating women. Conclusions: The consumption of potassium-rich foods should be generally increased. Supplemental intake beyond the estimated values has no health benefit and is therefore not recommended.

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Revised D-A-CH Reference Values for the Intake of Vitamin B6

Annals of Nutrition and Metabolism ◽

10.1159/000508618 ◽

2020 ◽

Vol 76 (4) ◽

pp. 213-222

Author(s):

Alexandra Jungert ◽

Jakob Linseisen ◽

Karl-Heinz Wagner ◽

Margrit Richter ◽

Keyword(s):

Children And Adolescents ◽

Reference Values ◽

Coefficient Of Variation ◽

Reference Value ◽

First Trimester ◽

Vitamin B ◽

Adult Males ◽

Allometric Exponent ◽

Lactating Women ◽

Adult Females

Background: The Nutrition Societies of Germany, Austria, and Switzerland as the joint editors of the “D-A-CH reference values for nutrient intake” have revised the reference values for vitamin B6 in summer 2019. Summary: For women, the average requirement (AR) for vitamin B6 intake was derived on the basis of balance studies using a pyridoxal-5′-phosphate (PLP) plasma concentration of ≥30 nmol/L as a biomarker of an adequate vitamin B6 status. The recommended intake (RI) was derived considering a coefficient of variation of 10%. The RIs of vitamin B6 for men, children, and adolescents were extrapolated from the vitamin B6 requirement for women considering differences in body weight, an allometric exponent, growth factors as appropriate, and a coefficient of variation. For infants aged 0 to under 4 months, an estimated value was set based on the vitamin B6 intake via breast feeding. The reference value for infants aged 4 to under 12 months was extrapolated from the estimated value for infants under 4 months of age and the average vitamin B6 requirement for adults. The reference values for pregnant and lactating women consider the requirements for the foetus and the loss via breast milk. Key Messages: According to the combined analysis of 5 balance studies, the AR for vitamin B6 to ensure a plasma PLP concentration of ≥30 nmol/L is 1.2 mg/day for adult females and the extrapolated AR for adult males is 1.3 mg/day. The corresponding RIs of vitamin B6 are 1.4 mg/day for adult females and 1.6 mg/day for adult males, independent of age. For infants, the estimated value is 0.1 mg/day and 0.3 mg/day, depending on age. The AR of vitamin B6 for children and adolescents ranges between 0.5 and 1.5 mg/day, and the RI is between 0.6 mg/day and 1.6 mg/day. During pregnancy, the AR is 1.3 mg/day in the first trimester and 1.5 mg/day in the second and third trimesters; the RI is 1.5 mg/day in the first trimester and 1.8 mg/day in the second and third trimesters. For lactating women, the AR is 1.3 mg/day and the RI is 1.6 mg/day.

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P1562 Normal reference values of three-dimensional speckle-tracking echocardiography-derived right atrial volumes and volume-based functional properties in healthy adult subjects

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez319.983 ◽

2020 ◽

Vol 21 (Supplement_1) ◽

Author(s):

A Nemes ◽

A Kormanyos ◽

P Domsik ◽

A Kalapos ◽

N Ambrus ◽

...

Keyword(s):

Functional Properties ◽

Reference Values ◽

Speckle Tracking ◽

Healthy Adult ◽

Speckle Tracking Echocardiography ◽

Three Dimensional ◽

Right Atrial ◽

Normal Reference ◽

Significant Difference ◽

Significant Impairment

Abstract Introduction The right atrium (RA) has several roles including a systolic reservoir, early diastolic conduit and late-diastolic booster pump functions. The present study aimed to assess normal reference values of three-dimensional speckle-tracking echocardiography (3DSTE)-derived RA volumetric data and volume-based functional properties (stroke volumes, SVs and emptying fractions, EFs) in healthy adult subjects. Methods 260 healthy adult subjects in sinus rhythm with complete clinical and demographic dataset have been included in the present study. However, due to inferior image quality 110 subjects have been excluded. The remaining population comprised 150 cases (31.0 ± 11.6 years, 79 males). Complete two-dimensional Doppler echocardiography and 3DSTE have been performed in all subjects. Results While systolic maximum RA volume did not change over age decades, early and late-diastolic RA pre-atrial contraction volume and minimum RA volume increased over time. Significantly larger values could be detected in more than 50 year-old healthy subjects as compared to younger subjects. Total atrial SV remained almost unchanged over age decades with a significant reduction in subjects aged >50 years. Passive atrial SV showed a continuous reduction over age decades and significant difference could be demonstrated between subjects aged 18-29 years and >50 years. Active atrial SV increased over age decades with a significant reduction in subjects aged >50 years. Total atrial EF did not show any changes over age decades, but a significant reduction could be demonstrated in cases aged >50 years. Passive atrial EF showed significant continuous reduction over age decades. Active atrial EF did not change in younger ages, it was the highest at ages 40-49 years with a significant impairment after 50 years. Females proved to have tendentiously higher RA volumes respecting the cardiac cycle regardless of age. No significant differences could be demonstrated between RA stroke volumes between genders except between 40-49 years when females had tendentiously higher values. RA emptying fractions were non-significantly, but tendentiously higher in females as compared to that of males regardless of age. Conclusions Normal reference values of 3DSTE-derived RA volumes and volume-based functional properties and their age- and gender dependency were defined in healthy adult subjects.

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