Glycemic control and the risk of microvascular complications in people with diabetes mellitus

2015 ◽  
Vol 53 (1) ◽  
pp. 129-130 ◽  
Author(s):  
Ilker Tasci ◽  
Bilgin Bahadir Basgoz ◽  
Kenan Saglam
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Microvascular Complications

scholarly journals Diabetes Complications and their Relation to Glycemic Control among Patients Attending Diabetic Clinic at King Khalid National Guard Hospital in Jeddah, Saudi Arabia

2011 ◽  
Vol 1 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Abdullah M. Krawagh ◽  
Abdullah M. Alzahrani ◽  
Tariq A. Naser
Keyword(s):  
Diabetes Mellitus ◽  
Saudi Arabia ◽  
Heart Disease ◽  
Glycemic Control ◽  
Ischemic Heart Disease ◽  
National Guard ◽  
Microvascular Complications ◽  
Ischemic Heart ◽  
Diabetic Clinic

This study addresses the prevalence of ischemic heart disease, hypertension and long-term complications of diabetes mellitus among patients attending the diabetic clinic and their relation to glycemic control. Methods: A study was conducted on a cross-section on all consecutive patients attending the diabetic clinic at King Khalid National Guard Hospital in Jeddah, Saudi Arabia, from January 2007 to January 2008. The degree of glycemic control was gauged using blood level of glycosylated hemoglobin (HbA1C) and classified into good (less 7%), fair (7.1-8%), poor (8.1-9%) and very poor (greater than 9%). All patients were screened for hypertension, ischemic heart disease and microvascular complications. Results: Two hundred and ten patients were recruited in the study. Glycemic control was good in 17 (8.1%), fair in 49 (23.2%), poor in 56 (26.6%) and very poor in 88 (41.9%). There was high prevalence of retinopathy (76; 36%), microalbuminuria (80; 37.9%), neuropathy (108; 51.2%) and ischemic heart disease (51; 24.2%), especially among patients with poor and very poor control. Although the presence of hypertension, frank nephropathy and peripheral vascular disease was also disturbingly high among diabetic patients, their frequency was the same among good, fair, poor and very poor glycemic control groups. Conclusion: The prevalence of long-term complications of diabetes mellitus was alarmingly high among Saudi nationals. Microvascular complications and ischemic heart disease were also noticed to be more common in diabetics with poor and very poor glycemic control. This emphasizes the need of national awareness program about the gravity of the problem.

scholarly journals The SGLT-2 Inhibitors in Personalized Therapy of Diabetes Mellitus Patients

2021 ◽  
Vol 11 (12) ◽  
pp. 1249
Author(s):  
Mariana Cornelia Tilinca ◽  
Robert Aurelian Tiuca ◽  
Ioan Tilea ◽  
Andreea Varga
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Microvascular Complications ◽  
Blood Pressure Reduction ◽  
Public Health Problem ◽  
Diabetic Patients ◽  
Major Public Health Problem ◽  
Patient Centered ◽  
Oral Antihyperglycemic Agents ◽  
Modern Drug

Diabetes mellitus (DM) represents a major public health problem, with yearly increasing prevalence. DM is considered a progressive vascular disease that develops macro and microvascular complications, with a great impact on the quality of life of diabetic patients. Over time, DM has become one of the most studied diseases; indeed, finding new pharmacological ways to control it is the main purpose of the research involved in this issue. Sodium–glucose cotransporter 2 inhibitors (SGLT-2i) are a modern drug class of glucose-lowering agents, whose use in DM patients has increased in the past few years. Besides the positive outcomes regarding glycemic control and cardiovascular protection in DM patients, SGLT-2i have also been associated with metabolic benefits, blood pressure reduction, and improved kidney function. The recent perception and understanding of SGLT-2i pathophysiological pathways place this class of drugs towards a particularized patient-centered approach, moving away from the well-known glycemic control strategy. SGLT-2i have been shown not only to reduce death from cardiovascular causes, but also to reduce the risk of stroke and heart failure hospitalization. This article aims to review and highlight the existing literature on the effects of SGLT-2i, emphasizing their role as oral antihyperglycemic agents in type 2 DM, with important cardiovascular and metabolic benefits.

scholarly journals ABNORMALITY OF LIPID METABOLISM IN PATIENTS WITH DIABETES MELLITUS TYPE 1 AND POOR GLYCEMIC CONTROL WITH AND WITHOUT DIABETIC MICROANGIOPATHIES

2016 ◽  
Vol 1 (6) ◽  
pp. 113-117
Author(s):  
Хамнуева ◽  
Larisa Khamnueva ◽  
Съемщиков ◽  
Vladimir Syomshchikov ◽  
Чугунова ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Glycemic Control ◽  
Disease Risk ◽  
Microvascular Complications ◽  
Cardiovascular Disease Risk ◽  
Poor Glycemic Control ◽  
High Density Lipoproteins ◽  
Very Low Density Lipoproteins

Hyperglycemia and dyslipidemia are common metabolic abnormalities in adults with type 1 diabetes mellitus (T1DM) and both increase cardiovascular disease risk. Normalization of lipid metabolism is a mandatory element in preven-tion of diabetic micro- and macroangiopathies in patients with T1DM and it is directly related to improvement of health outcome. We aimed to investigate serum lipid profiles in patients with T1DM and poor glycemic control. Among observed patients with T1DM, 76% were classified as having dyslipidemia, dyslipidemia rate was higher in patients with diabetic microangiopathies. Patients with T1DM and microvascular complications, arterial hypertension (AH) and the level of glycated hemoglobin (HbA1c) >8% had significantly higher levels of total cholesterol (TC), very low density lipoproteins (VLDL), triglycerides (TG) and non-high density lipoproteins (non-HDL). Therefore, management of patients with T1DM at the outpatient stage requires a strict control of lipid metabolism.

The Association of Pulmonary Functions with Glycemic Control and Microvascular Complications in Patients with Type II Diabetes Mellitus

2015 ◽  
Vol 16 (2) ◽  
pp. 48-52
Author(s):  
Gülay Ulusal Okyay ◽  
Ezgi Coskun Yenigün ◽  
Ahmet Hondur ◽  
Yildiz Coruh ◽  
Cagla Pinar Tastan Uzunmehmetoglu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Type Ii Diabetes ◽  
Microvascular Complications ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Pulmonary Functions

scholarly journals Diabetic Myonecrosis: Uncommon Complications in Common Diseases

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Sisira Sran ◽  
Manpreet Sran ◽  
Nicole Ferguson ◽  
Prachi Anand
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Antiphospholipid Syndrome ◽  
Ischemia Reperfusion ◽  
Microvascular Complications ◽  
Poor Glycemic Control ◽  
Thigh Pain ◽  
Muscle Infarction ◽  
Common Diseases

We report a case of sudden thigh pain from spontaneous quadriceps necrosis, also known as diabetic myonecrosis, in a 28-year-old patient with poorly controlled diabetes mellitus. Diabetic muscle infarction is a rare end-organ complication seen in patients with poor glycemic control and advanced chronic microvascular complications. Proposed mechanisms involve atherosclerotic microvascular occlusion, ischemia-reperfusion related injury, vasculitis with microthrombi formation, and an acquired antiphospholipid syndrome. Diabetic myonecrosis most commonly presents as sudden thigh pain with swelling and should be considered in any patient who has poorly controlled diabetes mellitus.

scholarly journals Fibrinogen and Factor VII Levels Improve With Glycemic Control in Patients With Type 1 Diabetes Mellitus Who Have Microvascular Complications

2001 ◽  
Vol 161 (1) ◽  
pp. 98 ◽  
Author(s):  
John A. D'Elia ◽  
Larry A. Weinrauch ◽  
Ray E. Gleason ◽  
Izabela Lipinska ◽  
Joanne Keough ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Factor Vii
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