scholarly journals Eidetic Variation: a Self-Correcting and Integrative Account

Axiomathes ◽  
2021 ◽  
Author(s):  
Jaakko Belt
Keyword(s):  
Conscious Experience ◽  
A Priori ◽  
Critical Role ◽  
Real Life ◽  
The Self ◽  
Epistemic Status ◽  
Empirical Knowledge ◽  
Eidetic Variation ◽  
Epistemic Function ◽  
Historical Reflection

AbstractEdmund Husserl’s eidetic phenomenology seeks a priori knowledge of essences and eidetic laws pertaining to conscious experience and its objects. Husserl believes that such eidetic knowledge has a higher epistemic status than the inherently fallible empirical knowledge, but a closer reading of his work shows that even eidetic claims are subject to error and open to modification. In this article, I develop a self-correcting account of Husserl’s method of eidetic variation, arguing that eidetic variation plays a critical role in both challenging and improving upon the eidetic results in phenomenology. More specifically, I argue that the self-correcting account of eidetic variation 1) is consistent with Husserl’s own formulations of his eidetic methodology and epistemic principles; 2) captures the dual epistemic function of eidetic variation as means for both testing and intuitively validating eidetic claims; and 3) offers methodological support for contemporary attempts to integrate eidetic variation with non-eidetic methods and resources. To substantiate these claims, I first contrast the self-correcting account with the falsificationist interpretations of eidetic variation. Then, I turn to three applications of eidetic variation in order to examine how eidetic phenomenology could draw from real-life deviations, artificial variations, and critical–historical reflection. The goal is to lay the methodological groundwork for a self-correcting and integrative account of eidetic variation and illustrate its usefulness in research practice.

Phenomenology of Interior Life and the Trinity

2020 ◽  
Vol 25 (1) ◽  
pp. 71-88
Author(s):  
Robert Farrugia
Keyword(s):  
Conscious Experience ◽  
A Priori ◽  
The Self ◽  
Christian Theology ◽  
Inner Life ◽  
The World ◽  
Doctrine Of The Trinity ◽  
Michel Henry ◽  
The Trinity ◽  
Static Nature

Michel Henry radicalises phenomenology by putting forward the idea of a double manifestation: the “Truth of Life” and “truth of the world.” For Henry, the world turns out to be empty of Life. To find its essence, the self must dive completely inward, away from the exterior movements of intentionality. Hence, Life, or God, for Henry, lies in non‑intentional, immanent self-experience, which is felt and yet remains invisible, in an absolutist sense, as an a priori condition of all conscious experience. In Christian theology, the doctrine of the Trinity illuminates the distinction between the immanent Trinity (God’s self‑relation) and the economic workings of the Trinity (God‑world relation). However, the mystery of God’s inmost being and the economy of salvation are here understood as inseparable. In light of this, the paper aims to: 1) elucidate the significance of Henry’s engagement with the phenomenological tradition and his proposal of a phenomenology of Life which advocates an immanent auto‑affection, radically separate from the ek‑static nature of intentionality, and 2) confront the division between Life and world in Henry’s Christian phenomenology and its discordancy with the doctrine of the Trinity, as the latter attests to the harmonious unity that subsists between inner life and the world.

scholarly journals Apriority and Essential Truth

Metaphysica ◽  
2020 ◽  
Vol 21 (1) ◽  
pp. 1-8
Author(s):  
Tristan Grøtvedt Haze
Keyword(s):  
A Priori ◽  
Epistemic Status ◽  
Empirical Knowledge ◽  
Recent Philosophy ◽  
Tight Connection ◽  
And Mathematics ◽  
In Virtue Of

AbstractThere is a line of thought, neglected in recent philosophy, according to which a priori knowable truths such as those of logic and mathematics have their special epistemic status in virtue of a certain tight connection between their meaning and their truth. Historical associations notwithstanding, this view does not mandate any kind of problematic deflationism about meaning, modality or essence. On the contrary, we should be upfront about it being a highly debatable metaphysical idea, while nonetheless insisting that it be given due consideration. From this standpoint, I suggest that the Finean distinction between essence and modality allows us to refine the view. While liberal about meaning, modality and essence, the view is not without bite: it is reasonable to suppose that it is able to ward off philosophical confusions stemming from the undue assimilation of a priori to empirical knowledge.

Metabolic Regulation and Related Molecular Mechanisms in Various Stem Cell Functions

2020 ◽  
Vol 15 (6) ◽  
pp. 531-546 ◽  
Author(s):  
Hwa-Yong Lee ◽  
In-Sun Hong
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Oxidative Phosphorylation ◽  
Metabolic Pathways ◽  
Critical Role ◽  
The Self ◽  
Specific Cell ◽  
Differentiation Potential ◽  
Self Renewal ◽  
Cell Functions

Recent studies on the mechanisms that link metabolic changes with stem cell fate have deepened our understanding of how specific metabolic pathways can regulate various stem cell functions during the development of an organism. Although it was originally thought to be merely a consequence of the specific cell state, metabolism is currently known to play a critical role in regulating the self-renewal capacity, differentiation potential, and quiescence of stem cells. Many studies in recent years have revealed that metabolic pathways regulate various stem cell behaviors (e.g., selfrenewal, migration, and differentiation) by modulating energy production through glycolysis or oxidative phosphorylation and by regulating the generation of metabolites, which can modulate multiple signaling pathways. Therefore, a more comprehensive understanding of stem cell metabolism could allow us to establish optimal culture conditions and differentiation methods that would increase stem cell expansion and function for cell-based therapies. However, little is known about how metabolic pathways regulate various stem cell functions. In this context, we review the current advances in metabolic research that have revealed functional roles for mitochondrial oxidative phosphorylation, anaerobic glycolysis, and oxidative stress during the self-renewal, differentiation and aging of various adult stem cell types. These approaches could provide novel strategies for the development of metabolic or pharmacological therapies to promote the regenerative potential of stem cells and subsequently promote their therapeutic utility.

Expressing the Self

2018 ◽  
Keyword(s):  
Philosophy Of Mind ◽  
The Self ◽  
Epistemic Status ◽  
First Person ◽  
Semantic Categories ◽  
Wide Range ◽  
Person Reference ◽  
De Se ◽  
Novel Method ◽  
Cultural Pragmatics

This book addresses different linguistic and philosophical aspects of referring to the self in a wide range of languages from different language families, including Amharic, English, French, Japanese, Korean, Mandarin, Newari (Sino-Tibetan), Polish, Tariana (Arawak), and Thai. In the domain of speaking about oneself, languages use a myriad of expressions that cut across grammatical and semantic categories, as well as a wide variety of constructions. Languages of Southeast and East Asia famously employ a great number of terms for first-person reference to signal honorification. The number and mixed properties of these terms make them debatable candidates for pronounhood, with many grammar-driven classifications opting to classify them with nouns. Some languages make use of egophors or logophors, and many exhibit an interaction between expressing the self and expressing evidentiality qua the epistemic status of information held from the ego perspective. The volume’s focus on expressing the self, however, is not directly motivated by an interest in the grammar or lexicon, but instead stems from philosophical discussions of the special status of thoughts about oneself, known as de se thoughts. It is this interdisciplinary understanding of expressing the self that underlies this volume, comprising philosophy of mind at one end of the spectrum and cross-cultural pragmatics of self-expression at the other. This unprecedented juxtaposition results in a novel method of approaching de se and de se expressions, in which research methods from linguistics and philosophy inform each other. The importance of this interdisciplinary perspective on expressing the self cannot be overemphasized. Crucially, the volume also demonstrates that linguistic research on first-person reference makes a valuable contribution to research on the self tout court, by exploring the ways in which the self is expressed, and thereby adding to the insights gained through philosophy, psychology, and cognitive science.

scholarly journals Agency and the Successive Structure of Time-Consciousness

Erkenntnis ◽  
2021 ◽  
Author(s):  
Camden Alexander McKenna
Keyword(s):  
Temporal Structure ◽  
Basic Structure ◽  
The Self ◽  
Necessary Condition ◽  
Epistemic Status ◽  
Mental Attitude ◽  
Time Consciousness ◽  
Possibility Space ◽  
The Right ◽  
Wrong Sort

AbstractI argue for constraining the nomological possibility space of temporal experiences and endorsing the Succession Requirement for agents. The Succession Requirement holds that the basic structure of temporal experience must be successive for agentive subjects, at least in worlds that are law-like in the same way as ours. I aim to establish the Succession Requirement by showing non-successively experiencing agents are not possible for three main reasons, namely that they (1) fail to stand in the right sort of causal relationship to the outcomes of their actions, (2) exhibit the wrong sort of epistemic status for agency, and (3) lack the requisite agentive mental attitude of intentionality. I conclude that agency is incompatible with non-successive experience and therefore we should view the successive temporal structure of experience as a necessary condition for agency. I also suggest that the Succession Requirement may actually extend beyond my main focus on agency, offering preliminary considerations in favor of seeing successive experience as a precondition for selfhood as well. The consequences of the Succession Requirement are wide-ranging, and I discuss various implications for our understanding of agency, the self, time consciousness, and theology, among other things.

scholarly journals A Systematic Review and Qualitative Synthesis Resulting in a Typology of Elementary Classroom Movement Integration Interventions

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Spyridoula Vazou ◽  
Collin A. Webster ◽  
Gregory Stewart ◽  
Priscila Candal ◽  
Cate A. Egan ◽  
...  
Keyword(s):  
Physical Activity ◽  
Teacher Collaboration ◽  
A Priori ◽  
Real Life ◽  
Dose Intensity ◽  
Routine Practice ◽  
Qualitative Synthesis ◽  
Wide Range ◽  
Meta Analyses ◽  
Movement Integration

Abstract Background/Objective Movement integration (MI) involves infusing physical activity into normal classroom time. A wide range of MI interventions have succeeded in increasing children’s participation in physical activity. However, no previous research has attempted to unpack the various MI intervention approaches. Therefore, this study aimed to systematically review, qualitatively analyze, and develop a typology of MI interventions conducted in primary/elementary school settings. Subjects/Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed to identify published MI interventions. Irrelevant records were removed first by title, then by abstract, and finally by full texts of articles, resulting in 72 studies being retained for qualitative analysis. A deductive approach, using previous MI research as an a priori analytic framework, alongside inductive techniques were used to analyze the data. Results Four types of MI interventions were identified and labeled based on their design: student-driven, teacher-driven, researcher-teacher collaboration, and researcher-driven. Each type was further refined based on the MI strategies (movement breaks, active lessons, other: opening activity, transitions, reward, awareness), the level of intrapersonal and institutional support (training, resources), and the delivery (dose, intensity, type, fidelity). Nearly half of the interventions were researcher-driven, which may undermine the sustainability of MI as a routine practice by teachers in schools. An imbalance is evident on the MI strategies, with transitions, opening and awareness activities, and rewards being limitedly studied. Delivery should be further examined with a strong focus on reporting fidelity. Conclusions There are distinct approaches that are most often employed to promote the use of MI and these approaches may often lack a minimum standard for reporting MI intervention details. This typology may be useful to effectively translate the evidence into practice in real-life settings to better understand and study MI interventions.

scholarly journals Communities and the individual: Beyond the liberal–communitarian divide

2021 ◽  
Vol 47 (4) ◽  
pp. 392-401
Author(s):  
Volker Kaul
Keyword(s):  
Personal Autonomy ◽  
A Priori ◽  
Significant Others ◽  
The Self ◽  
Global Perspective ◽  
Self And Identity ◽  
Default Position ◽  
The Individual

Liberalism believes that individuals are endowed a priori with reason or at least agency and it is up to that reason and agency to make choices, commitments and so on. Communitarianism criticizes liberalism’s explicit and deliberate neglect of the self and insists that we attain a self and identity only through the effective recognition of significant others. However, personal autonomy does not seem to be a default position, neither reason nor community is going to provide it inevitably. Therefore, it is so important to go beyond the liberal–communitarian divide. This article is analysing various proposals in this direction, asks about the place of communities and the individual in times of populism and the pandemic and provides a global perspective on the liberal–communitarian debate.

Personal Information as Symmetry Breaker in Disagreements

Philosophy ◽  
2021 ◽  
pp. 1-20
Author(s):  
Diego E. Machuca
Keyword(s):  
Personal Information ◽  
Conscious Experience ◽  
Real Life ◽  
Cognitive Capacities ◽  
First Order ◽  
Natural Reaction ◽  
Epistemic Standing

Abstract When involved in a disagreement, a common reaction is to tell oneself that, given that the information about one's own epistemic standing is clearly superior in both amount and quality to the information about one's opponent's epistemic standing, one is justified in one's confidence that one's view is correct. In line with this natural reaction to disagreement, some contributors to the debate on its epistemic significance have claimed that one can stick to one's guns by relying in part on information about one's first-order evidence and the functioning of one's cognitive capacities. In this article, I argue that such a manoeuvre to settle controversies encounters the problem that both disputants can make use of it, the problem that one may be wrong about one's current conscious experience, and the problem that it is a live possibility that many of one's beliefs are the product of epistemically distorting factors. I also argue that, even if we grant that personal information is reliable, when it comes to real-life rather than idealized disagreements, the extent of the unpossessed information about one's opponent's epistemic standing provides a reason for doubting that personal information can function as a symmetry breaker.

scholarly journals A biomimetic platelet based on assembling peptides initiates artificial coagulation

2020 ◽  
Vol 6 (22) ◽  
pp. eaaz4107
Author(s):  
Pei-Pei Yang ◽  
Kuo Zhang ◽  
Ping-Ping He ◽  
Yu Fan ◽  
Xuejiao J. Gao ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Binding Sites ◽  
Therapeutic Strategy ◽  
Critical Role ◽  
The Self ◽  
Membrane Glycoprotein ◽  
Tumor Site ◽  
Self Assembling ◽  
Receptor Interactions

Platelets play a critical role in the regulation of coagulation, one of the essential processes in life, attracting great attention. However, mimicking platelets for in vivo artificial coagulation is still a great challenge due to the complexity of the process. Here, we design platelet-like nanoparticles (pNPs) based on self-assembled peptides that initiate coagulation and form clots in blood vessels. The pNPs first bind specifically to a membrane glycoprotein (i.e., CD105) overexpressed on angiogenetic endothelial cells in the tumor site and simultaneously transform into activated platelet-like nanofibers (apNFs) through ligand-receptor interactions. Next, the apNFs expose more binding sites and recruit and activate additional pNPs, forming artificial clots in both phantom and animal models. The pNPs are proven to be safe in mice without systemic coagulation. The self-assembling peptides mimic platelets and achieve artificial coagulation in vivo, thus providing a promising therapeutic strategy for tumors.

Langdell Laughs

1999 ◽  
Vol 17 (1) ◽  
pp. 141-144
Author(s):  
William P. LaPiana
Keyword(s):  
Twentieth Century ◽  
Critical Role ◽  
Teaching Profession ◽  
The Self ◽  
Primary Sources ◽  
Christopher Columbus ◽  
Self Image ◽  
American Law

The amount of ink spilled in consideration of the life, thought, accomplishments, and legacy of Christopher Columbus Langdell is eloquent testimony to the critical role he plays in the self-image of the American law teaching profession. It is both wonderful and astounding, therefore, to find that critical primary sources remained unread and unused at the very end of the twentieth century. Now that Bruce Kimball has brought them to light, we have a more complete view of the man and his thought, one that, not surprisingly, reveals to us someone quite different from the cruelly and crudely caricatured inventor of those twin devices for stifling young minds, the case and Socratic methods.

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