Dysplasia in Random Biopsies from Barrett’s Surveillance Is an Important Marker for More Severe Pathology

Study Design: Violence against women is a challenge in public health. It involves women of all ages, socioeconomic statuses, cultures, and religions. Objective: The objective of this study was to perform an epidemiological survey of facial trauma among women who experienced physical aggression by an intimate partner. Methods: Electronic medical records from a public tertiary referral hospital for trauma in the Brazilian state of Espírito Santo were analyzed between 2013 and 2018. Results: Patients were most commonly between 20 and 29 years of age (33.9%), and 50% of the patients were of mixed race. When separated by days of the week, facial trauma was most commonly inflicted on Sundays (24.2%) and on Saturdays (22.6%). Of the 62 women included in the study, 47 had facial fractures, and 7 had more than 1 concomitant fracture. Forty of the total fractures (72.7%) were on the middle and upper thirds of the face, while 15 fractures (27.3%) were on the lower third of the face. The most commonly observed signs and symptoms of these injuries were edema (56.5%), periorbital ecchymosis (35.5%), deviated nasal dorsum (22.6%), and hematoma (16.1%). Conclusions: Facial trauma may be considered an important marker of attempted femicide. Health care professionals must be aware of and attentive to this correlation, since many cases of attempted femicide go unnoticed or are attributed to another etiology.

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Holocene Key-Marker Tephra Layers in Kamchatka, Russia

Quaternary Research ◽

10.1006/qres.1996.1876 ◽

1997 ◽

Vol 47 (2) ◽

pp. 125-139 ◽

Cited By ~ 109

Author(s):

Olga A. Braitseva ◽

Vera V. Ponomareva ◽

Leopold D. Sulerzhitsky ◽

Ivan V. Melekestsev ◽

John Bailey

Keyword(s):

Grain Size ◽

Size Distribution ◽

Mineral Composition ◽

Kamchatka Peninsula ◽

Explosive Eruptions ◽

Shiveluch Volcano ◽

Stratigraphic Position ◽

Tephra Layers ◽

Characteristic Features ◽

Important Marker

Detailed tephrochronological studies in Kamchatka Peninsula, Russia, permitted documentation of 24 Holocene key-marker tephra layers related to the largest explosive eruptions from 11 volcanic centers. Each layer was traced for tens to hundreds of kilometers away from the source volcano; its stratigraphic position, area of dispersal, age, characteristic features of grain-size distribution, and chemical and mineral composition confirmed its identification. The most important marker tephra horizons covering a large part of the peninsula are (from north to south; ages given in14C yr B.P.) SH2(≈1000 yr B.P.) and SH3(≈1400 yr B.P.) from Shiveluch volcano; KZ (≈7500 yr B.P.) from Kizimen volcano; KRM (≈7900 yr B.P.) from Karymsky caldera; KHG (≈7000 yr B.P.) from Khangar volcano; AV1(≈3500 yr B.P.), AV2(≈4000 yr B.P.), AV4(≈5500 yr B.P.), and AV5(≈5600 yr B.P.) from Avachinsky volcano; OP (≈1500 yr B.P.) from the Baraniy Amfiteatr crater at Opala volcano; KHD (≈2800 yr B.P.) from the “maar” at Khodutka volcano; KS1(≈1800 yr B.P.) and KS2(≈6000 yr B.P.) from the Ksudach calderas; KSht3(A.D. 1907) from Shtyubel cone in Ksudach volcanic massif; and KO (≈7700 yr B.P.) from the Kuril Lake-Iliinsky caldera. Tephra layers SH5(≈2600 yr B.P.) from Shiveluch volcano, AV3(≈4500 yr B.P.) from Avachinsky volcano, OPtr(≈4600 yr B.P.) from Opala volcano, KS3(≈6100 yr B.P.) and KS4(≈8800 yr B.P.) from Ksudach calderas, KSht1(≈1100 yr B.P.) from Shtyubel cone, and ZLT (≈4600 yr B.P.) from Iliinsky volcano cover smaller areas and have local stratigraphic value, as do the ash layers from the historically recorded eruptions of Shiveluch (SH1964) and Bezymianny (B1956) volcanoes. The dated tephra layers provide a record of the most voluminous explosive events in Kamchatka during the Holocene and form a tephrochronological timescale for dating and correlating various deposits.

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Neuronutraceuticals Modulate Lipopolysaccharide- or Amyloid-β 1-42 Peptide-Induced Transglutaminase 2 Overexpression as a Marker of Neuroinflammation in Mouse Microglial Cells

Applied Sciences ◽

10.3390/app11125718 ◽

2021 ◽

Vol 11 (12) ◽

pp. 5718

Author(s):

Nicola Gaetano Gatta ◽

Andrea Parente ◽

Francesca Guida ◽

Sabatino Maione ◽

Vittorio Gentile

Keyword(s):

Microglial Cell ◽

Amyloid Β ◽

Transglutaminase 2 ◽

Microglial Cells ◽

Tissue Type ◽

Microglial Cell Line ◽

Bv2 Cells ◽

Important Marker

Background: Tissue type 2 transglutaminase (TG2, E.C. 2.3.2,13) is reported to be involved in the phagocytosis of apoptotic cells in mouse microglial BV2 cells and peripheral macrophages. In this study, by using lipopolysaccharide (LPS)- or amyloid-β 1-42 (Aβ 1-42) peptide-stimulated microglial cell line BV2 and mouse primary microglial cells, we examined the effects of different neuronutraceutical compounds, such as curcumin (Cu) and N-Palmitoylethanolamine (PEA), known for their anti-inflammatory activity, on TG2 and several inflammatory or neuroprotective biomarker expressions. Methods: Mouse BV2 cells were treated with LPS or Aβ1-42 in the presence of curcumin or PEA, in order to evaluate the expression of TG2 and other inflammatory or neuroprotective markers using Real Time-PCR and Western blot analyses. Results: Curcumin and PEA were capable of reducing TG2 expression in mouse microglial cells during co-treatment with LPS or Aβ 1-42. Conclusions: The results show the role of TG2 as an important marker of neuroinflammation and suggest a possible use of curcumin and PEA in order to reduce LPS- or Aβ1-42-induced TG2 overexpression in mouse microglial cells.

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Arginase Activity in Eisenia andrei Coelomocytes: Function in the Earthworm Innate Response

International Journal of Molecular Sciences ◽

10.3390/ijms22073687 ◽

2021 ◽

Vol 22 (7) ◽

pp. 3687

Author(s):

Joanna Homa ◽

Alina Klosowska ◽

Magdalena Chadzinska

Keyword(s):

Immune Response ◽

Wound Healing ◽

Arginase Activity ◽

Eisenia Andrei ◽

Heavy Metals Ions ◽

First Time ◽

Important Marker

Arginase is the manganese metalloenzyme catalyzing the conversion of l-arginine to l-ornithine and urea. In vertebrates, arginase is involved in the immune response, tissue regeneration, and wound healing and is an important marker of alternative anti-inflammatory polarization of macrophages. In invertebrates, data concerning the role of arginase in these processes are very limited. Therefore, in the present study, we focused on the changes in arginase activity in the coelomocytes of Eisenia andrei. We studied the effects of lipopolysaccharide (LPS), hydrogen peroxide (H2O2), heavy metals ions (e.g., Mn2+), parasite infection, wound healing, and short-term fasting (5 days) on arginase activity. For the first time in earthworms, we described arginase activity in the coelomocytes and found that it can be up-regulated upon in vitro stimulation with LPS and H2O2 and in the presence of Mn2+ ions. Moreover, arginase activity was also up-regulated in animals in vivo infected with nematodes or experiencing segment amputation, but not in fasting earthworms. Furthermore, we confirmed that the activity of coelomocyte arginase can be suppressed by l-norvaline. Our studies strongly suggest that similarly to the vertebrates, also in the earthworms, coelomocyte arginase is an important element of the immune response and wound healing processes.

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CHRONIC ANTIBODY MEDIATED REJECTION: Clq FIXATION BY DSA CORRELATES WITH C4d DEPOSITION IN THE GRAFT AND MORE SEVERE PATHOLOGY

American Journal of Kidney Diseases ◽

10.1053/j.ajkd.2014.01.215 ◽

2014 ◽

Vol 63 (5) ◽

pp. B68

Keyword(s):

Antibody Mediated Rejection ◽

Severe Pathology

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Effectiveness of Treatment for Dissociative Identity Disorder

Psychological Reports ◽

10.2466/pr0.1998.83.2.483 ◽

1998 ◽

Vol 83 (2) ◽

pp. 483-490 ◽

Cited By ~ 4

Author(s):

Russell A. Powell ◽

Andrew J. Howell

Keyword(s):

Dissociative Identity Disorder ◽

Initial Assessment ◽

Systematic Research ◽

Millon Clinical Multiaxial Inventory ◽

Effect Of Treatment ◽

Severe Pathology ◽

Differential Responsiveness ◽

Rule Out ◽

Statistical Criteria

In a recent study by Ellason and Ross, patients with Dissociative Identity Disorder reported a decrease in symptoms on the Millon Clinical Multiaxial Inventory–II over a 2-yr. follow-up period. Patients judged to have achieved integration of their personalities rated themselves as more substantially improved on the Millon–II than did patients judged not to have achieved integration. Ellason and Ross suggested that this improvement reflected the influence of treatment; however, for several reasons, their findings are open to alternative interpretations. First, in the absence of proper control conditions, one cannot rule out the contribution of other factors to the over-all improvement of patients such as regression of symptoms toward the mean following the initial assessment. Second, patients' self-reported improvement was less substantial when data were reanalyzed using more appropriate statistical criteria. Third, the greater improvement observed among integrated patients relative to nonintegrated patients may reflect influences other than differential responsiveness to treatment, such as less severe pathology prior to treatment. More systematic research is needed to clarify the effect of treatment on Dissociative Identity Disorder.

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The Importance of Haemogram Parameters in the Diagnosis and Prognosis of Septic Patients

The Journal of Critical Care Medicine ◽

10.1515/jccm-2017-0019 ◽

2017 ◽

Vol 3 (3) ◽

pp. 105-110 ◽

Cited By ~ 8

Author(s):

Alina Elena Orfanu ◽

Cristina Popescu ◽

Anca Leuștean ◽

Anca Ruxandra Negru ◽

Cătălin Tilişcan ◽

...

Keyword(s):

Immune Status ◽

Complete Blood Count ◽

Therapy Monitoring ◽

Distribution Width ◽

Predictive Values ◽

Prolonged Hospitalisation ◽

Diagnosis And Prognosis ◽

Infectious Focus ◽

Severe Pathology ◽

Sensitivity Specificity

AbstractSepsis represents a severe pathology that requires both rapid and precise positive and differential diagnosis to identify patients who need immediate antimicrobial therapy. Monitoring septic patients′ outcome leads to prolonged hospitalisation and antibacterial therapy, often accompanied by substantial side effects, complications and a high mortality risk. Septic patients present with complex pathophysiological and immunological disorders and with a predominance of pro-inflammatory or anti-inflammatory mediators which are heterogeneous with respect to the infectious focus, the aetiology of sepsis or patients′ immune status or comorbidities. Previous studies performed have analysed inflammatory biomarkers, but a test or combinations of tests that can quickly and precisely establish a diagnosis or prognosis of septic patients has yet to be discovered. Recent research has focused on re-analysing older accessible parameters found in the complete blood count to determine the sensitivity, specificity, positive and negative predictive values for the diagnosis and prognosis of sepsis. The neutrophil/lymphocyte count ratio (NLCR), mean platelet volume (MPV) and red blood cells distribution width (RDW) are haemogram indicators which have been evaluated and which are of proven use in septic patients′ management.

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Vos and tú in the linguistic landscape

Spanish in Context ◽

10.1075/sic.18022.wey ◽

2021 ◽

Author(s):

Joseph R. Weyers

Keyword(s):

Linguistic Landscape ◽

Local Identity ◽

Upward Shift ◽

Positive Attitudes ◽

Verb Forms ◽

Important Marker ◽

Linguistic Attitudes

Abstract Although vos is common in speech in Medellín, it is considered non-prestigious for writing (Agudelo Montoya et al. 2016). Nonetheless, vos is an important marker of local identity (Jang 2013) that increasingly appears in writing (Weyers 2016a). Its presence suggests a potential upward shift in its prestige. For that to happen, favorable attitudes toward its use in writing are called for. Here we examine the linguistic attitudes of 222 medellinenses toward vos, tú, and their corresponding verb forms in advertising. We find that (1) all speakers prefer vos; (2) they favor the pronoun vos over its corresponding verb forms; (3) younger speakers prefer vos over their older counterparts; and (4) men prefer voseo verb forms while women prefer tuteo forms. Given the overall positive attitudes toward vos, it is possible that its prestige will increase.

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