Long-term hormonal contraceptive use is associated with a reversible suppression of antral follicle count and a break from hormonal contraception may improve oocyte yield

Abstract Background: Prevalence of obesity in adult females in Indonesia is 32,9% in 2013. Hormonal contraceptives (pills, injections and implants) are widely used by reproductive-age women in Indonesia, and the prevalence is 45%. Objective: The aim of this study is to identify whether reproductive-age women who use hormonal contraceptives are at risk of developing obesity compared to WUS who do not use hormonal contraceptives. Method: The design of this study is a cross sectional study using secondary data (5th Indonesia Family Life Survey, and the sample is reproductive-age women (15-49 years old) consisting of 6045 respondents. The variables of this study are obesity, hormonal contraceptive use, age, education, occupation, and duration of contraceptive use. Data were analysed by using Cox Regression. Result: The results of bivariate analysis showed that hormonal contaceptive use, age, education, occupation, and duration of contraceptive use were associated with obesity among reproductive-age womenand statistically significant (P-Value <0,05). Multivariate analysis showed that hormonal contraceptive use did not increase the risk of obesity among reproductive-age women in Indonesia (PR 0.939; CI 95% 0.869 - 1.013). Conclusion: The use of hormonal contraception did not increase the risk of obesity among reproductive-age women. Key words: Hormonal Contraception; Obesity; Reproductive Age-Women Abstrak Latar belakang : Prevalensi obesitas pada perempuan dewasa di Indonesia sebesar 32,9 persen pada tahun 2013. Kontrasepsi hormonal (pil, suntikan dan implan) merupakan jenis kontrasepsi yang paling banyak digunakan oleh wanita usia subur (WUS) di Indonesia, dengan prevalensi sebesar 45%. Tujuan : untuk mengetahui apakah wanita usia subur (WUS) yang menggunakan kontrasepsi hormonal berisiko mengalami obesitas dibandingkan WUS yang tidak menggunakan kontrasepsi hormonal. Metode : Desain penelitian ini adalah studi cross- sectional dengan menggunakan data sekunder IFLS 5 tahun 2014. Sampel adalah WUS (15-49 tahun) sebanyak 6.045 responden. Variabel dalam penilitian ini adalah obesitas pada WUS, penggunaan kontrasepsi hormonal, umur, pendidikan, pekerjaan, serta lama penggunaan kontrasepsi. Analisis data yang digunakan adalah Cox Regression. Hasil : Hasil analisis bivariat menunjukkan bahwa variabel penggunaan kontrasepsi hormonal, umur, pendidikan dan status pekerjaan, serta lama penggunaan kontrasepsi berhubungan dengan obesitas pada WUS (p-value <0,05). Analisis multivariat menunjukkan bahwa penggunaan kontrasepsi hormonal tidak meningkatkan risiko obesitas secara bermakna pada WUS di Indonesia (PR 0,939; CI 95% 0,869 – 1,013). Kesimpulan: Penggunaan kontrasepsi hormonal tidak meningkatkan risiko WUS untuk mengalami obesitas. Kata kunci: Kontrasepsi Hormonal; Obesitas; Wanita Usia Subur

Download Full-text

The Lived Experience of Discontinuing Hormonal Contraception Among Women in Rural Uganda

International Journal for Human Caring ◽

10.20467/1091-5710.15.1.56 ◽

2011 ◽

Vol 15 (1) ◽

pp. 56-64

Author(s):

Joseph Mwizerwa, ◽

Rozzano C. Locsin,

Keyword(s):

Content Analysis ◽

Lived Experience ◽

Nursing Practice ◽

Contraceptive Use ◽

Hormonal Contraception ◽

Hormonal Contraceptive ◽

Unprotected Sex ◽

Practice Research ◽

Research And Education

The purpose of the study was to describe the experience of discontinuing hormonal contraceptive use among women in rural Uganda. Asignificant number of women in Uganda discontinue hormonal contraception even though such method has been effective. Consequently, these women have unprotected sex, although not wanting to conceive. Narrative descriptions of the experiences by eight women were analyzed using content analysis. The findings describe the experience as Frustration and Helplessness, Living in Fear of Uncertainty, Ingenuity of using other methods of contraception, thus fostering the Accomplishments of being a wife, mother, and woman. Implications for nursing practice, research, and education are described.

Download Full-text

Hormonal contraceptive use, bone density and biochemical markers of bone metabolism in British Army recruits

BMJ Military Health ◽

10.1136/bmjmilitary-2020-001745 ◽

2021 ◽

pp. bmjmilitary-2020-001745

Author(s):

Charlotte V Coombs ◽

T J O'Leary ◽

J C Y Tang ◽

W D Fraser ◽

J P Greeves

Keyword(s):

Bone Density ◽

Bone Metabolism ◽

Cortical Bone ◽

Biochemical Markers ◽

Contraceptive Use ◽

Military Training ◽

Hormonal Contraception ◽

Hormonal Contraceptive ◽

British Army ◽

Army Recruits

IntroductionHormonal contraceptive use might impair bone health and increase the risk of stress fracture by decreasing endogenous oestrogen production, a central regulator of bone metabolism. This cross-sectional study investigated bone density and biochemical markers of bone metabolism in women taking hormonal contraceptives on entry to basic military training.MethodsForty-five female British Army recruits had biochemical markers of bone metabolism, areal bone mineral density (aBMD) and tibial speed of sound (tSOS) measured at the start of basic military training. Participants were compared by their method of hormonal contraception: no hormonal contraception (NONE), combined contraceptive pill (CP) or depot-medroxyprogesterone acetate (DMPA) (20±2.8 years, 1.64±0.63 m, 61.7±6.2 kg).ResultsaBMD was not different between groups (p≥0.204), but tSOS was higher in NONE (3%, p=0.014) when compared with DMPA users. Beta C-terminal telopeptide was higher in NONE (45%, p=0.037) and DMPA users (90%, p=0.003) compared with CP users. Procollagen type 1 N-terminal propeptide was higher in DMPA users compared with NONE (43%, p=0.045) and CP users (127%, p=0.001), and higher in NONE compared with CP users (59%, p=0.014). Bone alkaline phosphatase was higher in DMPA users compared with CP users (56%, p=0.044).ConclusionsDMPA use was associated with increased bone turnover and decreased cortical bone integrity of the tibia. Lower cortical bone integrity in DMPA users was possibly mediated by increased intracortical remodelling, but trabecular bone was not affected by contraceptive use.

Download Full-text

Oocyte donor anti-mullerian hormone (AMH) and antral follicle count (AFC) predict donor oocyte yield and recipient implantation

Fertility and Sterility ◽

10.1016/j.fertnstert.2013.07.1574 ◽

2013 ◽

Vol 100 (3) ◽

pp. S140

Author(s):

K.N. Fru ◽

M.J. Hill ◽

E.R. Bertone-Johnson ◽

A.H. DeCherney ◽

E.D. Levens ◽

...

Keyword(s):

Antral Follicle ◽

Antral Follicle Count ◽

Oocyte Donor ◽

Donor Oocyte ◽

Oocyte Yield

Download Full-text

Studi Lama dan Jenis Kontrasepsi Hormonal yang Digunakan dengan Gangguan Menstruasi Akseptor KB Aktif di Wilayah Kerja Puskesmas Jati Raya Kota Kendari

bionature ◽

10.35580/bionature.v20i2.11282 ◽

2019 ◽

Vol 20 (2) ◽

pp. 123

Author(s):

Amiruddin Amiruddin ◽

Agriansyah A Agriansyah A ◽

Risna Risna

Keyword(s):

Family Planning ◽

Health Center ◽

Contraceptive Use ◽

Hormonal Contraception ◽

Hormonal Contraceptive ◽

Cross Sectional Study ◽

Hormonal Contraceptives ◽

Menstrual Disorders ◽

Chi Square ◽

Cross Sectional

Abstract. Based on initial observations on hormonal contraceptive KB acceptors in the working area of the Jati Raya Health Center in Kendari City, many acceptors experience menstrual disorders. This study aims to determine the relationship between duration of use and the type of hormonal contraception used with menstrual disorders inactive family planning acceptors in the working area of Jati Raya Health Center, Kendari City. This type of research is an association with the Cross-Sectional Study design. The population in this study was 153 acceptors. The sample was determined by purposive sampling of 138 respondents using a questionnaire. The results showed respondents with a duration of use <6 months (45.7%), 6 months - 1 year (31.2%), and> 1 year (23.2%), the type of hormonal contraception used is; injections (80.4%), pills (13.8%) and implants (5.8%), menstrual disorders before using hormonal contraceptives namely; normal (39.1%) and mild disorders (60.9%) and after using hormonal contraception, mild disorders (15.9%), moderate (39.1%) and severe (44.9%). The results of data analysis with the chi-square test concluded that the length of hormonal contraceptive use was significantly related to menstrual disorders in active KB acceptors in the working area of the Jati Raya Health Center in Kendari City and the type of hormonal contraception used was significantly related to menstrual disorders in active KB acceptors in the Puskesmas work area. Jati Raya Kendari City (p <0.05). Keywords: old, hormonal contraception, menstrual disorders, family planning acceptors.

Download Full-text

Risk of meningioma associated with exposure of hormonal contraception. A case control study

Majalah Obstetri & Ginekologi ◽

10.20473/mog.v26i12018.36-41 ◽

2018 ◽

Vol 26 (1) ◽

pp. 36

Author(s):

Joni Wahyuhadi ◽

Dini Heryani ◽

Hari Basuki

Keyword(s):

Contraceptive Use ◽

Case Control Study ◽

Hormonal Contraception ◽

Hormonal Contraceptive ◽

Case Control ◽

Control Group ◽

Contraceptive Pills ◽

Increased Risk ◽

History Of ◽

Control Study

Objective: To identify the effect of hormonal contraceptive exposure to the occurrence of meningioma.Materials and Methods: This study, conducted in 2016, was a case-control study by collecting a group of cases comprising all patients diagnosed histopathologically with meningioma in 2012-2013 and treated in dr. Soetomo Hospital, Surabaya, Indonesia. Medical record data were analyzed and compared to control group of patients diagnosed with non-meningioma who underwent contrast head ct scan and direct interviews. We obtained 101 cases and 101 controls. Data were analyzed using univariate logistic regression test.Results: Based on the history of hormonal contraceptive use, patients who had history of hormonal contraceptive use had 12.31 times higher risk (p=0.000). In this study, those who had contraceptive injections for one month and used contraceptive pills had a meningioma risk lower than those who used injectables 3 months. Patients who used hormonal contraception more than 10 years had an increased risk for meningioma as much as 18.216 times (p=0.000). Histopathologically, we found a non-significant association between history of hormonal contraceptive use and the distribution of histopathology, but based on descriptive data showed it was found that the most histopatological meningioma was of the transitional type in cases group.Conclusion: There is a significant association between hormonal contraceptive use, the type of injectable hormonal contraception for 3 months, the duration of hormonal contraceptive use >10 years, and no significant association between meningioma grade and the history of hormonal contraception exposure.

Download Full-text

Hormonal Contraceptive Use Related to Menopausal Age

Archives of The Medicine and Case Reports ◽

10.37275/amcr.v2i4.155 ◽

2021 ◽

Vol 2 (4) ◽

pp. 214-218

Author(s):

Destri Safhira Siahaan ◽

Adek Amansyah ◽

Irza Haicha Pratama

Keyword(s):

Contraceptive Use ◽

Hormonal Contraception ◽

Hormonal Contraceptive ◽

Primary Data ◽

Hormonal Contraceptives ◽

Research Subjects ◽

Cross Sectional ◽

Number Of Children ◽

Menopausal Women ◽

Cross Sectional Design

The change in the pattern and timing of menopause is an exciting and exploratory phenomenon that requires more detailed research to be carried out using hormonal contraception. This study was aimed to explore the relationship between hormonal contraceptive use and menopausal age. This study used a cross-sectional design. The study was conducted at Royal Prima General Hospital Medan from May to August 2021. A total of 68 research subjects participated in this study with the following inclusion criteria: menopausal women, aged 50-60 years, using hormonal contraceptives (pills, injections, implants), able to remember history previous contraceptive use. This study uses primary data obtained directly from guided interviews with respondents. Participants were dominated by ≥ 55 years old women with 57 people (83.81%), 62 Muslims (91.2%), menarche age >13 years as many as 28 people (41.2%). The number of children 2-4 were 32 people (47.1%) with an average menopause age of 51.93 and the smallest for 1 was 8 people (11.8%) with an average menopause age of 50.37. There were 49 users of hormonal contraception (72.1%) and 48 people (70.6%). In conclusion, we found that the use of hormonal contraceptives is significantly related to menopausal age.

Download Full-text

Antimüllerian hormone and antral follicle count are lower in female cancer survivors and healthy women taking hormonal contraception

Fertility and Sterility ◽

10.1016/j.fertnstert.2014.05.026 ◽

2014 ◽

Vol 102 (3) ◽

pp. 774-781.e3 ◽

Cited By ~ 19

Author(s):

Lauren N.C. Johnson ◽

Mary D. Sammel ◽

Katherine E. Dillon ◽

Lara Lechtenberg ◽

Allison Schanne ◽

...

Keyword(s):

Cancer Survivors ◽

Hormonal Contraception ◽

Antral Follicle ◽

Antral Follicle Count ◽

Healthy Women ◽

Antimullerian Hormone ◽

Antimüllerian Hormone ◽

Female Cancer Survivors

Download Full-text

Profil Kejadian Kanker Serviks Di Rumkital Dr Ramelan Periode Januari – Desember 2018

Hang Tuah Medical journal ◽

10.30649/htmj.v19i1.63 ◽

2021 ◽

Vol 19 (1) ◽

pp. 25-40

Author(s):

SASTRA JENDRA HAYUNINGTYAS

Keyword(s):

Cervical Cancer ◽

Sexual Intercourse ◽

Contraceptive Use ◽

Hormonal Contraception ◽

Hormonal Contraceptive ◽

Sexual Partners ◽

Multiple Sexual Partners ◽

First Sexual Intercourse ◽

Central Java ◽

History Of

Background: cervical cancer as the highest case in Indonesia in 2013, especially in the regions of East Java and Central Java. For the main cause itself is a persistent infection of the Human Papilloma Virus (HPV). However, there are also many factors that can be a risk such as age, parity, hormonal contraceptive use, and sexual activity. Because of the high incidence of cervical cancer in East Java, the purpose of this study was to determine the profile of cervical cancer events in Rumkital DR Ramelan Surabaya during the period January - December 2018. Method : descriptive study with a qualitative approach carried out at the Rumkital Oncology Clinic DR Ramelan surabaya during May - August 2019. The results showed that the majority of cervical cancer cases occur in women > 51 years old. Women with a history of parity ≥ 3 children have the highest percentage of 60%. The age group for first sexual intercourse has the same incidence both at age ≤ 20 years and > 20 years which is 50%. As many as 60% of women have a history of hormonal contraceptive use longer than 4 years. And the highest history of changing sexual partners occurred in those with only one sexual partner, which was 93.3%. Conclusions women aged > 51 years, have a history of parity ≥ 3 children, have sex at an early age ≤ 20 years, and use hormonal contraception ≥ 4 years, have a high risk of being cervical cancer. Keywords: cervical cancer, age, parity, age at first sexual intercourse, duration of use of hormonal contraception, multiple sexual partners.

Download Full-text