PTPN22 gene functional polymorphism (rs2476601) in older adults with frailty syndrome

ABSTRACT Objectives: To analyze and reflect on the potential applicability of the contribution of the physical resilience conceptual model of Whitson et al. in the care for older adults. Method: The present article of reflection was structured based on the consultation of articles and definition of inherent concepts, with analysis and reason of the potentialities of its application in geriatric nursing care. Results: Physical resilience is influenced by diverse stimuli. The identification of stressors and early intervention enable the delay of the functional capacity decline. In practice, the planning of interventions that depend on the innate capacity of older adults is of utmost importance. Conclusion: The trajectory outlined over a debilitating event is relevant to understand the factors that contribute to the development of frailty or pre-frailty conditions. This knowledge allows nurses to adjust their practice and contribute to the effectiveness of interventions and a better prevention of the frailty syndrome.

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Effect of Physical Therapy on Fall-Risk and Physical Status in Older Adults with Frailty and Metabolic Syndrome

Ukraïnsʹkij žurnal medicini bìologìï ta sportu ◽

10.26693/jmbs05.06.282 ◽

2020 ◽

Vol 5 (6) ◽

pp. 282-291

Author(s):

N. P. Koval ◽

◽

M. G. Aravitska

Keyword(s):

Physical Activity ◽

Older Adults ◽

Metabolic Syndrome ◽

Physical Therapy ◽

Therapeutic Alliance ◽

Fall Risk ◽

Physical Therapist ◽

Main Group ◽

Frailty Syndrome ◽

Physical Status

The constant increase in the proportion of the disabled or partially disabled elderly population and, accordingly, patients of this age contingent, leads to the need for rehabilitation and physical therapy of persons with geriatric syndromes and various comorbid pathologies. The purpose of the study was to determine the effectiveness of a physical therapy program based on the dynamics of indicators of the fall-risk and physical status in older adults with frailty syndrome and metabolic syndrome. Material and methods. 96 older adults were examined. The control group consisted of persons without metabolic syndrome and without frailty syndrome. The main group 1 consisted of persons with metabolic syndrome and frailty syndrome who did not express a desire to cooperate with a physical therapist and / or actively improve their health on their own (low level of therapeutic alliance). They were provided with recommendations on the WHO CINDI program (diet modification, extension of household and training physical activity). Main group 2 included patients who showed consent to take active steps to improve their own health under the supervision of a physical therapist (high level of therapeutic alliance). We developed a physical therapy program for them using kinesitherapy, massage, nutritional correction, education of the patient and his family, elements of cognitive training and occupational therapy for one year. The dynamics of the state was assessed according to the results of the Short Physical Performance Battery, hand dynamometry, Senior Fitness Test, the Berg Balance Scale. Results and discussion. Older adults with metabolic syndrome and frailty syndrome demonstrated a high fall-risk (according to the results of a Short battery of physical activity tests and the Berg scale) and a statistically significant lag in physical status parameters (coordination, balance, strength, flexibility, endurance, agility) according to the parameters of the Senior Fitness Test, hand dynamometry, Short battery of physical activity tests) from their peers. These results increase the risk of adverse health effects, loss of autonomy and death. The use of physical therapy in main group 1 subjects led to a statistically significant (р<0.05) improvement in physical qualities, a decrease in the intensity of frailty signs; leveling the fall-risk in them. The low level of therapeutic alliance of persons in the main group 2 led to unsatisfactory fulfillment or non-fulfillment of the recommendations provided and is associated with a lack of improvement in their physical status and a high fall-risk. Conclusion. It is advisable to include physical therapy means in the rehabilitation programs for elderly patients with comorbid pathology of frailty and metabolic syndrome

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Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors

Antioxidants ◽

10.3390/antiox10121975 ◽

2021 ◽

Vol 10 (12) ◽

pp. 1975

Author(s):

Armanda Teixeira-Gomes ◽

Blanca Laffon ◽

Vanessa Valdiglesias ◽

Johanna M. Gostner ◽

Thomas Felder ◽

...

Keyword(s):

Older Adults ◽

Immune Activation ◽

Future Research ◽

Clinical Parameters ◽

Frailty Syndrome ◽

Immune Markers ◽

Frailty Phenotype ◽

Age Related ◽

Inflammatory Molecules ◽

The Relationship

Ageing is accompanied with a decline in several physiological systems. Frailty is an age-related syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with increase in the risk of disability, comorbidity, hospitalisation, and death in older adults. The aim of this study was to understand the relationship between frailty syndrome, immune activation, and oxidative stress. Serum concentrations of vitamins A and E were also evaluated, as well as inflammatory biomarkers (CRP and IL-6) and oxidative DNA levels. A group of Portuguese older adults (≥65 years old) was engaged in this study and classified according to Fried’s frailty phenotype. Significant increases in the inflammatory mediators (CRP and IL-6), neopterin levels, kynurenine to tryptophan ratio (Kyn/Trp), and phenylalanine to tyrosine ratio (Phe/Tyr), and significant decreases in Trp and Tyr concentrations were observed in the presence of frailty. IL-6, neopterin, and Kyn/Trp showed potential as predictable biomarkers of frailty syndrome. Several clinical parameters such as nutrition, dependency scales, and polypharmacy were related to frailty and, consequently, may influence the associations observed. Results obtained show a progressive immune activation and production of pro-inflammatory molecules in the presence of frailty, agreeing with the inflammageing model. Future research should include different dimensions of frailty, including psychological, social, biological, and environmental factors.

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Prevalence of frailty syndrome and its associated factors among community-dwelling elderly in East Coast of Peninsular Malaysia

SAGE Open Medicine ◽

10.1177/2050312118775581 ◽

2018 ◽

Vol 6 ◽

pp. 205031211877558 ◽

Cited By ~ 10

Author(s):

Fairus Asma Mohd Hamidin ◽

Siti Nur’Asyura Adznam ◽

Zuriati Ibrahim ◽

Yoke Mun Chan ◽

Nur Hafizah Abdul Aziz

Keyword(s):

Older Adults ◽

Binary Logistic Regression ◽

Peninsular Malaysia ◽

Clinical Syndrome ◽

Community Dwelling ◽

Frailty Syndrome ◽

Increased Risk ◽

Health Related ◽

Prevention Programmes ◽

Community Dwelling Older Adults

Objective: Frailty is a clinical syndrome with increased risk of poor health outcomes and particularly prevalent in older adults and community population. The study’s aim was therefore to determine the prevalence of frailty and its association with sociodemographic and socioeconomic characteristics, health-related status, and anthropometric measurements among community-dwelling older adults. Methods: A total of 279 older adults aged 60 years and above were randomly selected. Respondents were classified as non-frail (<2 criteria) or frail (≥3 criteria) based on the ‘phenotype of frailty’. A binary logistic regression was used to determine predictors of frailty. Results: The prevalence of frailty was 18.3%. The frail older adults were positively associated with advanced age, being unmarried, hospitalisation in the previous year, poor self-rated health, and lower body mass index. Discussion: These results give an overview on underlying effects and guiding actions for prevention programmes functioning to reverse and minimise the adverse effects of frailty syndrome.

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Factors associated with frailty in older adults

Revista de Saúde Pública ◽

10.11606/s1518-8787.2018052000497 ◽

2018 ◽

Vol 52 ◽

pp. 74 ◽

Cited By ~ 7

Author(s):

Jack Roberto Silva Fhon ◽

Rosalina Aparecida Partezani Rodrigues ◽

Jair Lício Ferreira Santos ◽

Marina Aleixo Diniz ◽

Emanuella Barros dos Santos ◽

...

Keyword(s):

Older Adults ◽

Data Collection ◽

Functional Capacity ◽

Generalized Estimating Equations ◽

Estimating Equations ◽

Functional Independence ◽

Wilcoxon Test ◽

Frailty Syndrome ◽

Older Individuals ◽

Generalized Estimating

OBJECTIVE: To determine the demographic and health factors related to the frailty syndrome in older adults. METHODS: This is a longitudinal quantitative study carried out with 262 older adults aged 65 years and older, of both sexes, living at home. Data collection was carried out in Period 1 between October 2007 and February 2008, and in Period 2 between July and December 2013. For data collection, we used the sociodemographic profile instrument, the Edmonton Frail Scale, the Mini-Mental State Examination, the number of falls in the last 12 months, the number of self-reported diseases and used drugs, the Functional Independence Measure, and the Lawton and Brody Scale. We used descriptive statistics for data analysis, in the comparison of the means between periods, the nonparametric Wilcoxon test, and the method of Generalized Estimating Equations, which is considered an extension of the Generalized Linear Models with p ≤ 0.05. RESULTS: Of the 515 participants, 262 completed the follow-up, with a predominance of females, older individuals, and those who had no partner; there was an increase in frail older adults. In the Generalized Estimating Equations analysis, frailty score was related to sociodemographic (increase in age, no partner, and low education level) and health variables (more diseases, drugs, falls, and decrease in functional capacity). There was an association between the variables of age (older), marital status (no partner), and loss of functional capacity. CONCLUSIONS: Frailty syndrome was associated with increasing age, having no partner, and decreased functional capacity over time, and investments are required to prevent this syndrome and promote quality in aging.

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Frailty syndrome in older adults

Journal of Medical Society ◽

10.4103/jms.jms_24_17 ◽

2017 ◽

Vol 31 (2) ◽

pp. 71

Author(s):

Taruni Ngangbam

Keyword(s):

Older Adults ◽

Frailty Syndrome

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Prevalence of Poor Self-Rated Health and Associated Risk Factors among Older Adults in Cali, Colombia

Colombia Medica ◽

10.25100/cm.v44i4.1362 ◽

2013 ◽

pp. 224-231 ◽

Cited By ~ 12

Author(s):

Jose Mauricio Ocampo-Chaparro ◽

Helmer de Jesus Zapata-Ossa ◽

Angela M Cubides-Munévar ◽

Carmen Lucia Curcio ◽

Juan de Dios Villegas ◽

...

Keyword(s):

Risk Factors ◽

Older Adults ◽

Fear Of Falling ◽

Population Based ◽

Cross Sectional Study ◽

Cluster Sampling ◽

Frailty Syndrome ◽

Cross Sectional ◽

Self Rated Health ◽

Modifiable Factors

Introduction: Self-rated health (SRH) has beeen considered an important marker of quality of life and an independent predictor of mortality in older adults. Objective: To determine the prevalence of poor SRH and identify risk factors associated with poor SRH among older adults residing in the Commune 18 of the city of Cali, Colombia, in 2009. Methods: A population-based cross-sectional study with a single-stage cluster sampling design. Sample included 314 persons aged 60 and older. The dependent variable, SRH was dichotomized into good (excellent, very good, good) and poor (fair, poor). Independent variables were sociodemographic, biological, mental, functional and geriatric syndromes. Logistic regression was used for multivariate statistical modeling. Results: Overall, 40.1% reported poor SRH (women 42.9%, men 35.0%). Factors independently associated with poor SRH were diabetes mellitus, depression, fear of falling and frailty syndrome (frail and pre-frail vs. non-frail). Widowed men reported poorer health than married men while other marital status (single/separated/divorced) was associated with better self rated health in women. Conclusion: Potential modifiable factors such as depression and frailty syndrome are important determinants for poor SRH in Colombian older adults.

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COVID-19 aus Sicht der Geriatrie

DMW - Deutsche Medizinische Wochenschrift ◽

10.1055/a-1164-4261 ◽

2020 ◽

Vol 145 (15) ◽

pp. 1039-1043

Author(s):

Cornel Sieber

Keyword(s):

Older Adults ◽

Older People ◽

Social Isolation ◽

Load Capacity ◽

Limited Resources ◽

Care Planning ◽

Frailty Syndrome ◽

Virus Infections ◽

Advance Care ◽

The Many

AbstractThe pandemic due to the SARS-CoV-2 virus challenges all of us in the many areas of life. Our health systems are tested for their sustainability and load capacity. SARS-CoV-2 virus-infections will become part of our lives, but they mainly threaten vulnerable and multimorbid older adults. Older people with a frailty-syndrome are challenged not only in physical, but also psychological and social domains. Adapted caring structures are required and the pandemic will introduce important ethical discussions. As examples, distribution of limited resources, requests for more Advance Care Planning as well as balancing between infection protection versus the drawbacks of long-lasting social isolation should be named. This article therefore focuses on ethical questions for older adults in times of the SARS-CoV-2 virus pandemic.

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Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo

Biomarker Insights ◽

10.1177/1177271920903038 ◽

2020 ◽

Vol 15 ◽

pp. 117727192090303

Author(s):

Ghaleb Bin Huraib ◽

Fahad Al Harthi ◽

Misbahul Arfin ◽

Abdulrahman Aljamal ◽

Abdulqader Saeed Alrawi ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Amplification Refractory Mutation System ◽

Functional Polymorphism ◽

Ptpn22 Gene ◽

Protein Tyrosine ◽

Mutation System ◽

Pcr Method ◽

Polymerase Chain ◽

Saudi Arabians

The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with susceptibility to autoimmune diseases. The functional polymorphism in PTPN22 at 1857 is a strong risk factor for vitiligo susceptibility in Europeans; however, controversy exits in other populations. Present study was aimed to determine whether the PTPN22 C1857T polymorphism confers susceptibility to vitiligo in Saudi Arabians. Genomic DNA was extracted and amplified using tetra primer amplification-refractory mutation system polymerase chain reaction (ARMS-PCR) method. The frequencies of allele T and genotype CT of PTPN22 C1858T polymorphism were significantly higher, whereas those of allele C and genotype CC were lower in patients as compared with controls ( P < 0.0001). The genotype TT was absent in both the patients and controls. It is concluded that PTPN22 C1858T polymorphism is strongly associated with vitiligo susceptibility. However, additional studies are warranted using large number of samples from different ethnicities and geographical areas.

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