Determination of potential drug–drug interactions in prescription orders dispensed in a community pharmacy setting using Micromedex® and Lexicomp®: a retrospective observational study

2021 ◽  
Author(s):  
Afraa Abbas ◽  
Samaher Al-Shaibi ◽  
Sowndramalingam Sankaralingam ◽  
Ahmed Awaisu ◽  
Vyas S. Kattezhathu ◽  
...  
Keyword(s):  
Observational Study ◽  
Drug Interactions ◽  
Community Pharmacy ◽  
Retrospective Observational Study ◽  
Potential Drug ◽  
Pharmacy Setting

scholarly journals Determination of Potential Drug–Drug Interactions Using Various Software Programs in a Community Pharmacy Setting

2019 ◽  
Vol 16 (1) ◽  
pp. 14-19
Author(s):  
Mesut SANCAR ◽  
Aksa KAŞIK ◽  
Betul OKUYAN ◽  
Sevda BATUHAN ◽  
Fikret Vehbi İZZETTİN
Keyword(s):  
Drug Interactions ◽  
Community Pharmacy ◽  
Potential Drug ◽  
Software Programs ◽  
Pharmacy Setting

scholarly journals Prevalence of Potential Drug–Drug Interaction Risk among Chronic Kidney Disease Patients in a Spanish Hospital

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 713
Author(s):  
Gracia Santos-Díaz ◽  
Ana María Pérez-Pico ◽  
Miguel Ángel Suárez-Santisteban ◽  
Vanesa García-Bernalt ◽  
Raquel Mayordomo ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Drug Interactions ◽  
Cross Sectional Study ◽  
Potential Drug ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Major Health ◽  
Spanish Hospital

Chronic kidney disease (CKD) is a major health problem worldwide and, in Spain, it is present in 15.1% of individuals. CKD is frequently associated with some comorbidities and patients need to be prescribed multiple medications. Polypharmacy increases the risk of adverse drug reactions (ADRs). There are no published studies evaluating the prevalence of potential drug–drug interactions (pDDIs) among CKD patients in any European country. This study was aimed to determine the prevalence, pattern, and factors associated with pDDIs among CKD patients using a drug interactions program. An observational cross-sectional study was carried out at Plasencia Hospital, located in Spain. Data were collected among patients with CKD diagnoses and pDDIs were assessed by the Lexicomp® Drug Interactions platform. Data were obtained from 112 CKD patients. A total number of 957 prescribed medications were acknowledged, and 928 pDDIs were identified in 91% of patients. Age and concomitant drugs were significantly associated with the number of pDDIs (p < 0.05). According to the results, the use of programs for the determination of pDDIs (such as Lexicomp®) is recommended in the clinical practice of CKD patients in order to avoid serious adverse effects, as is paying attention to contraindicated drug combinations.

scholarly journals A prospective observational study to evaluate potential drug-drug interactions in patients admitted in intensive care unit, at BRIMS tertiary care hospital in Bidar, India

2018 ◽  
Vol 7 (4) ◽  
pp. 655 ◽  
Author(s):  
Shailander Singh ◽  
Swetha K.
Keyword(s):  
Observational Study ◽  
Drug Interactions ◽  
Prospective Observational Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Potential Drug ◽  
Icu Patients ◽  
Study Population ◽  
Type C

Background: Drug interaction occurs when presence of one drug affects the activity of another when, both are co-administered. 6-30% of adverse events (AEs) with significant hospitalizations or death are by drug-drug interactions(DDI). There is increased possibility to prevent the potential drug-drug interactions (pDDIs), if their prevalence and pattern are determined accurately before their occurrence. Hence this study aimed to evaluate the prevalence of pDDIs in ICU patients at BRIMS tertiary care hospital, Bidar.Methods: This prospective observational study included 30 patients admitted in ICU of BRIMS hospital for >24hrs of either gender, aged >18yrs. The study was conducted for a period of 3 months. Data was collected from the case records of patients on the predesigned proforma. Potential drug-drug interactions were classified based on their severity and the risk of Potential drug-drug interactions was estimated by Lexicomp, inc.version; 3.0.1.drug interact android mobile application.Results: Out of 35 patients admitted in the ICU, 30 cases were included in the study. The mean age of study population was 56.3years. The study population was exposed to a total of 330 medicines during the hospital stay with an average of 11.7 drugs per patient. The prevalence of pDDI was 93.3% (28) with an average of 9.75 pDDI per patient. According to Lexicomp drug interact android mobile application majority (63%) of pDDI were found to be moderate in their severity, 67% belonged to type C risk.Conclusions: The study showed higher prevalence of pDDI among ICU patients due to the complexity of the pharmacotherapies administered.

Potential drug–drug interactions between anti-cancer agents and community pharmacy dispensed drugs

2010 ◽  
Vol 32 (5) ◽  
pp. 575-580 ◽  
Author(s):  
Marsha L. Voll ◽  
Kim D. Yap ◽  
Wim E. Terpstra ◽  
Mirjam Crul
Keyword(s):  
Drug Interactions ◽  
Community Pharmacy ◽  
Potential Drug ◽  
Anti Cancer

scholarly journals Statin drug-drug interactions in a Romanian community pharmacy

2016 ◽  
Vol 89 (2) ◽  
pp. 273-278 ◽  
Author(s):  
Raluca Badiu ◽  
Camelia Bucsa ◽  
Cristina Mogosan ◽  
Dan Dumitrascu
Keyword(s):  
Drug Interaction ◽  
Adverse Effects ◽  
Drug Interactions ◽  
Community Pharmacy ◽  
Safety Profile ◽  
Potential Drug ◽  
Online Program ◽  
High Prevalence ◽  
Statin Drug

Background and aim. Statins are frequently prescribed for patients with dyslipidemia and have a well-established safety profile. However, when associated with interacting dugs, the risk of adverse effects, especially muscular toxicity, is increased.The objective of this study was to identify, characterize and quantify the prevalence of the potential drug-drug interactions (pDDIs) of statins in reimbursed prescriptions from a community pharmacy in Bucharest.Methods. We analyzed the reimbursed prescriptions including statins collected during one month in a community pharmacy. The online program Medscape Drug Interaction Checker was used for checking the drug interactions and their classification based on severity: Serious – Use alternative, Significant – Monitor closely and Minor.Results. 132 prescriptions pertaining to 125 patients were included in the analysis. Our study showed that 25% of the patients who were prescribed statins were exposed to pDDIs: 37 Serious and Significant interactions in 31 of the statins prescriptions. The statins involved were atorvastatin, simvastatin and rosuvastatin.Conclusions. Statin pDDIs have a high prevalence and patients should be monitored closely in order to prevent the development of adverse effects that result from statin interactions.

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