The impacts of an eight-week moderate aerobic exercise training on some gene expression involved in cholesterol metabolism in ovariectomized rats

2021 ◽  
Author(s):  
Maryam Emamian Rostami ◽  
Rozita Fathi ◽  
Khadijeh Nasiri
Keyword(s):  
Gene Expression ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Cholesterol Metabolism ◽  
Aerobic Exercise Training ◽  
Ovariectomized Rats

The roles of aerobic exercise training and suppression IL-6 gene expression by RNA interference in the development of insulin resistance

Cytokine ◽  
2013 ◽  
Vol 61 (2) ◽  
pp. 394-405 ◽  
Author(s):  
Hui Tang ◽  
Min-hao Xie ◽  
Yu Lei ◽  
Liang Zhou ◽  
Yu-ping Xu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Rna Interference ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training

Acute high-intensity aerobic exercise increases gene expression of calcium-related proteins and activates endoplasmic reticulum stress responses in diabetic hearts

2020 ◽  
pp. 1-14
Author(s):  
H.O. Ness ◽  
K. Ljones ◽  
M. Pinho ◽  
M.A. Høydal
Keyword(s):  
Gene Expression ◽  
Exercise Training ◽  
Er Stress ◽  
Aerobic Exercise ◽  
Stress Responses ◽  
Mitochondrial Respiration ◽  
High Intensity ◽  
Acute Exercise ◽  
Contractile Function ◽  
Aerobic Exercise Training

Regular aerobic exercise training has a wide range of beneficial cardiac effects, but recent data also show that acute very strenuous aerobic exercise may impose a transient cardiac exhaustion. The aim of this study was to assess the response to acute high-intensity aerobic exercise on properties of mitochondrial respiration, cardiomyocyte contractile function, Ca2+ handling and transcriptional changes for key proteins facilitating Ca2+ handling and endoplasmic reticulum (ER) stress responses in type 2 diabetic mice. Diabetic mice were assigned to either sedentary control or an acute bout of exercise, consisting of a 10×4 minutes high-intensity interval treadmill run. Mitochondrial respiration, contractile and Ca2+ handling properties of cardiomyocytes were analysed 1 hour after completion of exercise. Gene expression levels of key Ca2+ handling and ER stress response proteins were measured in cardiac tissue samples harvested 1 hour and 24 hours after exercise. We found no significant changes in mitochondrial respiration, cardiomyocyte contractile function or Ca2+ handling 1 hour after the acute exercise. However, gene expression of Atp2a2, Slc8a1 and Ryr2, encoding proteins involved in cardiomyocyte Ca2+ handling, were all significantly upregulated 24 hours after the acute exercise bout. Acute exercise also altered gene expression of several key proteins in ER stress response and unfolded protein response, including Grp94, total Xbp1, Gadd34, and Atf6. The present results show that despite no significant alterations in functional properties of cardiomyocyte function, Ca2+ handling or mitochondrial respiration following one bout of high intensity aerobic exercise training, the expression of genes involved in Ca2+ handling and key components in ER stress and the unfolded protein response were changed. These transcriptional changes may constitute important steps in initiating adaptive remodelling to exercise training in type 2 diabetes.

scholarly journals Epicardial fat gene expression after aerobic exercise training in pigs with coronary atherosclerosis: relationship to visceral and subcutaneous fat

2010 ◽  
Vol 109 (6) ◽  
pp. 1904-1912 ◽  
Author(s):  
Joseph M. Company ◽  
Frank W. Booth ◽  
M. Harold Laughlin ◽  
Arturo A. Arce-Esquivel ◽  
Harold S. Sacks ◽  
...  
Keyword(s):  
Gene Expression ◽  
Exercise Training ◽  
Inflammatory Response ◽  
Aerobic Exercise ◽  
Coronary Atherosclerosis ◽  
Expression Profiles ◽  
Subcutaneous Fat ◽  
Aerobic Exercise Training ◽  
Adipose Tissues ◽  
Castrate Male

Epicardial adipose tissue (EAT) is contiguous with coronary arteries and myocardium and potentially may play a role in coronary atherosclerosis (CAD). Exercise is known to improve cardiovascular disease risk factors. The purpose of this study was to investigate the effect of aerobic exercise training on the expression of 18 genes, measured by RT-PCR and selected for their role in chronic inflammation, oxidative stress, and adipocyte metabolism, in peri-coronary epicardial (cEAT), peri-myocardial epicardial (mEAT), visceral abdominal (VAT), and subcutaneous (SAT) adipose tissues from a castrate male pig model of familial hypercholesterolemia with CAD. We tested the hypothesis that aerobic exercise training for 16 wk would reduce the inflammatory profile of mRNAs in both components of EAT and VAT but would have little effect on SAT. Exercise increased mEAT and total heart weights. EAT and heart weights were directly correlated. Compared with sedentary pigs matched for body weight to exercised animals, aerobic exercise training reduced the inflammatory response in mEAT but not cEAT, had no effect on inflammatory genes but preferentially decreased expression of adiponectin and other adipocyte-specific genes in VAT, and had no effect in SAT except that IL-6 mRNA went down and VEGFa mRNA went up. We conclude that 1) EAT is not homogeneous in its inflammatory response to aerobic exercise training, 2) cEAT around CAD remains proinflammatory after chronic exercise, 3) cEAT and VAT share similar inflammatory expression profiles but different metabolic mRNA responses to exercise, and 4) gene expression in SAT cannot be extrapolated to VAT and heart adipose tissues in exercise intervention studies.

Effects of Aerobic Exercise Training on Whole Body Insulin Sensitivity and PBMC Gene Expression of Adiponectin Receptors in Healthy Adults

2013 ◽  
Vol 24 (3) ◽  
pp. 445-453
Author(s):  
shinho Lee ◽  
조진경 ◽  
Hyun-Sik Kang ◽  
박승우 ◽  
하창덕
Keyword(s):  
Gene Expression ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Healthy Adults ◽  
Aerobic Exercise Training ◽  
Whole Body ◽  
Adiponectin Receptors

scholarly journals Aerobic Exercise Training Prevents Insulin Resistance and Hepatic Lipid Accumulation in LDL Receptor Knockout Mice Chronically Fed a Low-Sodium Diet

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2174
Author(s):  
Guilherme da Silva Ferreira ◽  
Ana Paula Garcia Bochi ◽  
Paula Ramos Pinto ◽  
Vanessa Del Bianco ◽  
Letícia Gomes Rodrigues ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Body Mass ◽  
Ldl Receptor ◽  
Oxidative Capacity ◽  
Aerobic Exercise Training ◽  
Low Sodium

Background: A low-sodium (LS) diet reduces blood pressure, contributing to the prevention of cardiovascular diseases. However, intense dietary sodium restriction impairs insulin sensitivity and worsens lipid profile. Considering the benefits of aerobic exercise training (AET), the effect of LS diet and AET in hepatic lipid content and gene expression was investigated in LDL receptor knockout (LDLr-KO) mice. Methods: Twelve-week-old male LDLr-KO mice fed a normal sodium (NS) or LS diet were kept sedentary (S) or trained (T) for 90 days. Body mass, plasma lipids, insulin tolerance testing, hepatic triglyceride (TG) content, gene expression, and citrate synthase (CS) activity were determined. Results were compared by 2-way ANOVA and Tukey’s post-test. Results: Compared to NS, LS increased body mass and plasma TG, and impaired insulin sensitivity, which was prevented by AET. The LS-S group, but not the LS-T group, presented greater hepatic TG than the NS-S group. The LS diet increased the expression of genes related to insulin resistance (ApocIII, G6pc, Pck1) and reduced those involved in oxidative capacity (Prkaa1, Prkaa2, Ppara, Lipe) and lipoprotein assembly (Mttp). Conclusion: AET prevented the LS-diet-induced TG accumulation in the liver by improving insulin sensitivity and the expression of insulin-regulated genes and oxidative capacity.

scholarly journals microRNA‐206 modulates important regulators of gene expression in response to aerobic exercise training in human skeletal muscle (706.3)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Cleber Alves ◽  
José Junior ◽  
Tiago Fernandes ◽  
Guilherme Alves ◽  
Carlos Negrão ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Human Skeletal Muscle ◽  
Aerobic Exercise Training
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