Rosmarinic acid in Perilla frutescens and perilla herb analyzed by HPLC

2019 ◽  
Vol 74 (2) ◽  
pp. 341-352 ◽  
Author(s):  
Yuya Deguchi ◽  
Michiho Ito
Keyword(s):  
Rosmarinic Acid ◽  
Perilla Frutescens

Protective effect of a rosmarinic acid-rich extract from cold-pressed Perilla frutescens seed flour on oxidative hepatotoxicity in vitro and in vivo

2018 ◽  
Vol 42 (2) ◽  
pp. e12492 ◽  
Author(s):  
Yajie Zhang ◽  
Xigang Mei ◽  
Qi Zhang ◽  
Manna Li ◽  
Xingwang Wu ◽  
...  
Keyword(s):  
Protective Effect ◽  
Rosmarinic Acid ◽  
Perilla Frutescens ◽  
Seed Flour ◽  
Cold Pressed

The hepatoprotection of caffeic acid and rosmarinic acid, major compounds of Perilla frutescens, against t-BHP-induced oxidative liver damage

2013 ◽  
Vol 55 ◽  
pp. 92-99 ◽  
Author(s):  
Sung-Yong Yang ◽  
Chung-Oui Hong ◽  
Gung Pyo Lee ◽  
Cheong-Tae Kim ◽  
Kwang-Won Lee
Keyword(s):  
Caffeic Acid ◽  
Liver Damage ◽  
Rosmarinic Acid ◽  
Perilla Frutescens

Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans

2004 ◽  
Vol 44 (1) ◽  
pp. 1-9 ◽  
Author(s):  
S. Baba ◽  
N. Osakabe ◽  
M. Natsume ◽  
A. Yasuda ◽  
Y. Muto ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Rosmarinic Acid ◽  
Perilla Frutescens

Analytical Validation of Rosmarinic Acid in Water Extract of Perilla frutescens Britton var. acuta Kudo as Functional Health Ingredient

2015 ◽  
Vol 44 (1) ◽  
pp. 85-88 ◽  
Author(s):  
Sung-Yong Park ◽  
Jung-Eun Kim ◽  
Chul-Yung Choi ◽  
Dong-Wook Lee ◽  
Ki-Man Kim ◽  
...  
Keyword(s):  
Rosmarinic Acid ◽  
Water Extract ◽  
Perilla Frutescens ◽  
Functional Health ◽  
Analytical Validation

Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in d -galactosamine ( d -GalN)-sensitized mice

2002 ◽  
Vol 33 (6) ◽  
pp. 798-806 ◽  
Author(s):  
Naomi Osakabe ◽  
Akiko Yasuda ◽  
Midori Natsume ◽  
Chiaki Sanbongi ◽  
Yoji Kato ◽  
...  
Keyword(s):  
Liver Injury ◽  
Rosmarinic Acid ◽  
Perilla Frutescens

Perilla frutescens extract ameliorates DSS-induced colitis by suppressing proinflammatory cytokines and inducing anti-inflammatory cytokines

2015 ◽  
Vol 308 (1) ◽  
pp. G32-G41 ◽  
Author(s):  
Hayato Urushima ◽  
Junichi Nishimura ◽  
Tsunekazu Mizushima ◽  
Noriyuki Hayashi ◽  
Kazuhisa Maeda ◽  
...  
Keyword(s):  
Body Weight ◽  
Proinflammatory Cytokines ◽  
Rosmarinic Acid ◽  
Perilla Frutescens ◽  
Control Group ◽  
Distilled Water ◽  
Serum Cytokine ◽  
Therapeutic Protocol ◽  
Tnf Α ◽  
Anti Inflammatory

Anti-inflammatory effects have been reported in Perilla frutescens leaf extract (PE), which is a plant of the genus belonging to the Lamiaceae family. We examined the effect of PE on dextran sulfate sodium (DSS)-induced colitis. Preliminarily, PE was safely administered for 7 wk without any adverse effects. In the preventive protocol, mice were fed 1.5% DSS solution dissolved in distilled water (control group) or 0.54% PE solution (PE group) ad libitum for 7 days. In the therapeutic protocol, distilled water or 0.54% PE solution was given for 10 days just after administration of 1.5% DSS for 5 days. PE intake significantly improved body weight loss. The serum cytokine profile demonstrated that TNF-α, IL-17A, and IL-10 were significantly lower in the PE group than in the control group. In the therapeutic protocol, mice in the PE group showed significantly higher body weight and lower histological colitis scores compared with mice in the control group on day 15. The serum cytokine profile demonstrated that TGF-β was significantly higher in the PE group than in the control group. In distal colon mRNA expression, TNF-α, and IL-17A were significantly downregulated. In vitro analyses of biologically active ingredients, such as luteolin, apigenin, and rosmarinic acid, in PE were performed. Luteolin suppressed production of proinflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-17A. Apigenin also suppressed secretion of IL-17A and increased the anti-inflammatory cytokine IL-10. Rosmarinic acid increased the regulatory T cell population. We conclude that PE might be useful in treatment and prevention of DSS-induced colitis.

Antitumor-Promoting Effect of Ethanolic Extract from Leaves of Perilla frutescens var. crispa (Benth.) In Mouse Skin

MedPharmRes ◽  
2018 ◽  
Vol 2 (3) ◽  
pp. 33-40
Author(s):  
Quyen Vuu ◽  
Thuy Huynh ◽  
Hien Ha ◽  
Trinh Huynh
Keyword(s):  
Thin Layer ◽  
Rosmarinic Acid ◽  
Mouse Skin ◽  
Latency Period ◽  
Ethanolic Extract ◽  
Total Content ◽  
Treated Group ◽  
Reversed Phase ◽  
Perilla Frutescens ◽  
Promoting Effect

This study aimed to investigate the antitumor-promoting effects of total ethanolic extract from Perilla leaf (PLE) in a two-stage chemical carcinogenesis protocol in mice. Quantitative analysis active compounds in PLE were performed by thin layer chromatography with normal phase of silica gel F254 and HPLC-PDA with reversed phase of C18 column at UV 300 nm. The cutaneous tumors were initiated by a single application by 7,12-dimethylbenz[a]anthracene (DMBA) on the dorsal shaved skin, then promoted by repeated applications of croton oil during 20 weeks. PLE was topically applied daily until the end of the experiment. The results observed from thin layer chromatogram highlighted the presence of rosmarinic acid and luteolin in PLE. By means of HPLC-PDA analysis, the total content of rosmarinic acid and luteolin were found in amounts of 1.178 ± 0.011 % (w/w) and 0.105 ± 0.001 % (w/w), respectively. The PLE-treated group prolonged the latency period of tumor appearance up to 2 weeks and also significantly reduced tumor volume in dorsal skin of mice as compared to untreated group. In conclusion, the total ethanolic extract from leaves of Perilla frutescens demonstrated promising antitumor-promotion activity in mouse skin.

Sign in / Sign up

Export Citation Format

Share Document