Effect of particle size of calcium phosphate based bioceramic drug delivery carrier on the release kinetics of ciprofloxacin hydrochloride: an in vitro study

Objective: Site-specific drug delivery into the colonic region is extremely fascinating for local treatment of various colonic diseases like ulcerative colitis, colon cancer but it should be capable of saving the drug from hydrolysis and degradation. The present study reports the application of jackfruit seed starch and its thiol derivative as a drug delivery carrier for the colon. Methods: The starch was extracted from the jackfruit seeds by water extraction method and modified by the esterification reaction with thioglycolic acid. The thiolated starch was characterized for morphology, functional and flow properties. The safety profile of the thiolated starch was confirmed by acute toxicity study in a mice model as per OECD guidelines 423. The microspheres based on thiolated starch were prepared by ionic gelation method incorporating Ibuprofen as a model drug. The prepared microspheres were characterized for particle size, drug entrapment efficiency, drug loading, compatibility study, surface morphology, in vitro drug release and release kinetics. Results: The result attributed that starch was successfully modified by the thiolation with a degree of substitution of 3.30. The size of prepared microspheres ranges from 825.5±4.58 to 857±6.24 µm, the entrapment efficiencies ranges from 69.23±1.19 to 76.15±0.83 % and the drug loading capacity ranges from 17.75±0.30 to 46.05±0.49 %. The FT-IR, DSC and XRD studies confirmed that there is no interaction within drug and excipients. The thiolated starch microspheres show the maximum release of drug at pH 7.4 in the presence of rat caecal content as compared to pH 1.2 and pH 6.8 for up to 24 h and are following first order release kinetics. Conclusion: These results suggest the application of thiolated jackfruit seed starch could be promising as a long-term drug delivery carrier for the colon.

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Kinetics of drug release from a biodegradable local drug delivery system and its effect on Porphyromonas gingivalis isolates: An in vitro study

Journal of Indian Society of Periodontology ◽

10.4103/0972-124x.118311 ◽

2013 ◽

Vol 17 (4) ◽

pp. 429 ◽

Cited By ~ 1

Author(s):

Ranganathan Vijayalashmi ◽

SabithaManhalore Ravindranath ◽

NadathurDoraiswamy Jayakumar ◽

Padmalatha ◽

SheejaH Vargheese ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Porphyromonas Gingivalis ◽

Delivery System ◽

In Vitro Study ◽

Local Drug Delivery ◽

Local Drug Delivery System ◽

Kinetics Of

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Nanotechnology in oncology: Characterization and in vitro release kinetics of cisplatin-loaded albumin nanoparticles: Implications in anticancer drug delivery

Indian Journal of Pharmacology ◽

10.4103/0253-7613.83111 ◽

2011 ◽

Vol 43 (4) ◽

pp. 409 ◽

Cited By ~ 15

Author(s):

Saikat Das ◽

Rajesh Isiah ◽

Selvamani Backianathan ◽

Lavanya Jagan ◽

B Rajesh ◽

...

Keyword(s):

Drug Delivery ◽

Anticancer Drug ◽

Release Kinetics ◽

In Vitro Release ◽

Anticancer Drug Delivery ◽

Albumin Nanoparticles ◽

Kinetics Of ◽

Vitro Release

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Degradation behavior of theophylline/chitosan/?-cyclodextrin microspheres for pulmonary drug delivery

Bangladesh Journal of Pharmacology ◽

10.3329/bjp.v11is1.25634 ◽

2016 ◽

Vol 11 ◽

pp. S116-S122 ◽

Cited By ~ 3

Author(s):

Li Wang ◽

Tingting Yang ◽

Weiping Ju ◽

Ming Ren ◽

Zhanqin Feng ◽

...

Keyword(s):

Drug Delivery ◽

Phosphate Buffer ◽

In Vitro Study ◽

Pulmonary Drug Delivery ◽

Degradation Behavior ◽

Sprague Dawley ◽

Phosphate Buffer Saline ◽

Drug Delivery Carrier

To evaluate the degradation behavior of theophylline/chitosan/?-cyclo-dextrin microspheres, we performed both in vitro study by putting the microspheres in phosphate buffered saline or in phosphate buffer saline with enzyme and in vivo study by implanting the microspheres into the back of male Sprague-Dawley rats. The results showed that microspheres were degraded in enzymatic hydrolysis and phosphate buffer saline, which were degraded faster in 0.2 mg/mL lysozyme than in phosphate buffer saline. The morphology of microspheres in phosphate buffer saline and enzyme solution developed rough surfaces, and showed irregular shape and pores after 8 weeks. The microspheres were degraded in vivo within 8 weeks with irregular, sheet, porous morphology, and the diameters were smaller than 5 ?m. These results indicated that the theophylline/chitosan/?-cyclodextrin microspheres had a good degradation both in vitro and in vivo which can be used as a pulmonary drug delivery carrier.

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Hydrogen Peroxide Release Kinetics of Four Tooth Whitening Products—In Vitro Study

Materials ◽

10.3390/ma14247597 ◽

2021 ◽

Vol 14 (24) ◽

pp. 7597

Author(s):

Susana Dias ◽

António Mata ◽

João Silveira ◽

Ruben Pereira ◽

Angelo Putignano ◽

...

Keyword(s):

Hydrogen Peroxide ◽

Release Kinetics ◽

Pearson Correlation ◽

In Vitro Release ◽

In Vitro Study ◽

Vitro Study ◽

Tooth Whitening ◽

Mean Values ◽

Kinetics Of

Tooth whitening efficacy can be influenced by several factors, of which concentration and application time are two of the most important. This in vitro study aimed to evaluate the initial content and release kinetics of the hydrogen peroxide (HP) content, or the carbamide peroxide (CP) content as converted to its HP equivalent, of four tooth whitening products with different concentrations (6% HP, 16% CP, 10% CP, and 5% CP). Titrations with Cerium Sulphate IV were performed to determine HP concentration. HP release kinetics were evaluated by a spectrophotometric technique. The results were expressed as the mean values and 95% confidence interval of the percentage of hydrogen peroxide content during release kinetics. One sample t-test, one-way ANOVA, Tukey post hoc testing, and Pearson correlation testing were used, as appropriate, with a significance level of α = 0.05. The concentration of titrated HP was higher than that indicated by the manufacturers in all tested products (p < 0.01). At the minimum application times indicated by the manufacturers, all products released at least 85% of HP content; the gel containing 10% CP registered the lowest release at 85.49 (81.52–89.46). There was a significant HP release in all products during the application times indicated by the manufacturers. Further studies are needed to assess in vitro release kinetics.

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Pectin-Based Nanomaterials: Synthesis, Toxicity and Applications

Asian Journal of Chemistry ◽

10.14233/ajchem.2021.23382 ◽

2021 ◽

Vol 33 (11) ◽

pp. 2579-2588

Author(s):

Mandeep Kaur ◽

Aditya Wadhwa ◽

Vineet Kumar

Keyword(s):

Drug Delivery ◽

Human Body ◽

Release Kinetics ◽

Drug Carrier ◽

Biological Origin ◽

Nanomaterials Synthesis ◽

The Stability ◽

Kinetics Of

Nanomaterials of biological origin are very useful for drug delivery applications. The stability, biodegradability and biocompatibility of pectin nanomaterials in the human body make them an effective drug carrier. This review focus on different aspect of synthesis, drug encapsulation, drug release and safety of pectin-based nanomaterials. The nanomaterials can be used for the delivery of different hydrophilic and hydrophobic drugs to various organs. The release kinetics of drug loaded pectin-based nanoparticles can be studied in vitro as well as in vivo. The pectin-based nanomaterials have good pharmaco-kinetics and can ensure controlled drug delivery. However, the toxicity of pectin-based nanomaterials to human body needs to be evaluated carefully before industrial scale application.

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Chitosan-Based Coacervate Polymers for Propolis Encapsulation: Release and Cytotoxicity Studies

International Journal of Molecular Sciences ◽

10.3390/ijms21124561 ◽

2020 ◽

Vol 21 (12) ◽

pp. 4561 ◽

Cited By ~ 5

Author(s):

Tabata Sato ◽

Daphne Mello ◽

Luana Vasconcellos ◽

Artur Valente ◽

Alexandre Borges

Keyword(s):

Drug Delivery ◽

High Performance ◽

Release Kinetics ◽

Mg63 Cell ◽

Strong Band ◽

Drug Delivery Carrier ◽

Sustained Drug Delivery ◽

Cytotoxicity Studies ◽

Freeze Dried

Chitosan-DNA (CS-DNA) and Chitosan-Pectin (CS-P) hydrogels were formulated as a sustained drug delivery carrier for drug delivery. For this, hydrogels were prepared by emulsion technique: mixing aqueous phase of the CS and DNA or P solution with benzyl alcohol using a high-performance dispersing instrument. Green Propolis (GP) was incorporated by imbibition: hydrogels were placed in GP aqueous solution (70 µg/mL) for 2 h. The specimens were freeze-dried and then characterized using different techniques. In vitro cell viability and morphology were also performed using the MG63 cell line. The presence of P was evidenced by the occurrence of a strong band at 1745 cm−1, also occurring in the blend. DNA and CS-DNA showed a strong band at 1650 cm−1, slightly shifted from the chitosan band. The sorption of GP induced a significant modification of the gel surface morphology and some phase separation occurs between chitosan and DNA. Drug release kinetics in water and in saliva follow a two-step mechanism. Significant biocompatibility revealed that these hydrogels were non-toxic and provided acceptable support for cell survival. Thus, the hydrogel complexation of chitosan with DNA and with Pectin provides favorable micro-environment for cell growth and is a viable alternative drug delivery system for Green Propolis.

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