What Is the Status of Regenerative Therapy in Heart Failure?

After myocardial infarction, remodeling of the left ventricle involves a wound-healing orchestra involving a variety of cell types. In order for wound healing to be optimal, appropriate communication must occur; these cells all need to come in at the right time, be activated at the right time in the right amount, and know when to exit at the right time. When this occurs, a new homeostasis is obtained within the infarct, such that infarct scar size and quality are sufficient to maintain left ventricular size and shape. The ideal scenario does not always occur in reality. Often, miscommunication can occur between infarct and remote spaces, across the temporal wound-healing spectrum, and across organs. When miscommunication occurs, adverse remodeling can progress to heart failure. This review discusses current knowledge gaps and recent development of the roles of inflammation and the extracellular matrix in myocardial infarction remodeling. In particular, the macrophage is one cell type that provides direct and indirect regulation of both the inflammatory and scar-forming responses. We summarize current research efforts focused on identifying biomarker indicators that reflect the status of each component of the wound-healing process to better predict outcomes.

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EVALUATION OF MEDICATION COMPLIANCE IN PATIENTS WITH CONGESTIVE HEART FAILURE IN YEMEN

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2019v11i4.29988 ◽

2019 ◽

pp. 93-97

Author(s):

AL-ZAAZAAI ET AL ALI AHMED MOHAMMED AL-Z ◽

MANSOUR A. AL-AMRANI ◽

KHALID ALAKHALI ◽

NOURADDEN ALJABER

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Medication Compliance ◽

Smoking Status ◽

Cardiac Care ◽

Tree Leaves ◽

The Status ◽

Friendship Hospital ◽

Care Costs ◽

Cardiac Care Unit

Objective: Non-compliance with heart failure medication is related to the highest mortality, morbidity, and health-care costs. The objective of this study was to evaluate medication compliance with patients with congestive heart failure. Methods:Inpatients of the cardiac care unit and medical ward of Republican Hospital, German Hospital, Revolutionary Hospital, and Chinese–Yemeni Friendship Hospital were recruited for this study. The study was conducted on patients that were diagnosed as having congestive heart failure and were receiving treatment. Questionnaires were distributed and personal interviews to evaluate the patients’ compliance was conducted to determine the reasons for their non-compliance in taking drugs. Results: Of 86 patients, 44% (n = 38) reported compliance and 56% (n = 48) reported non-compliance. The distribution of the patients in terms of sex was as follows: among men, 41% (n = 24) were compliant and 59% (n = 35) were non-compliant; among women, 52% (n = 14) were compliant and 48% (n = 13) were non-compliant. In addition, smoking status was too significantly linked with non-compliance (P = 0.001). Furthermore, the status of chewing of khat tree leaves was also significantly associated with non-compliance (P = 0.007). Conclusion: This study indicates that the reasons for non-compliance with medications among patients can be attributed to lack of education, chewing of khat tree leaves, lack of health insurance, and cigarette smoking. Therefore, healthcare professionals should create strategies to address these reasons in order to increase medication compliance with patients in heart failure.

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Correction to: New treatment strategy for severe heart failure: combination of ventricular assist device and regenerative therapy

Journal of Artificial Organs ◽

10.1007/s10047-020-01201-z ◽

2020 ◽

Author(s):

Keitaro Domae ◽

Shigeru Miyagawa ◽

Koichi Toda ◽

Yoshiki Sawa

Keyword(s):

Heart Failure ◽

Ventricular Assist Device ◽

Treatment Strategy ◽

Severe Heart Failure ◽

Regenerative Therapy ◽

Assist Device ◽

Ventricular Assist ◽

New Treatment

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Regenerative Therapy Prevents Heart Failure Progression in Dyssynchronous Nonischemic Narrow QRS Cardiomyopathy

Journal of the American Heart Association ◽

10.1161/jaha.114.001614 ◽

2015 ◽

Vol 4 (5) ◽

Cited By ~ 12

Author(s):

Satsuki Yamada ◽

D. Kent Arrell ◽

Almudena Martinez‐Fernandez ◽

Atta Behfar ◽

Garvan C. Kane ◽

...

Keyword(s):

Heart Failure ◽

Regenerative Therapy ◽

Narrow Qrs ◽

Heart Failure Progression

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Transcriptomic profiling of peripheral blood nucleated cells in dogs with and without clinical signs of chronic mitral valve disease

Bulletin of the Veterinary Institute in Pulawy ◽

10.2478/bvip-2014-0021 ◽

2014 ◽

Vol 58 (1) ◽

pp. 135-140

Author(s):

Magdalena Garncarz ◽

Magdalena Hulanicka ◽

Marta Parzeniecka-Jaworska ◽

Jacek Garncarz ◽

Michał Jank

Keyword(s):

Gene Expression ◽

Heart Failure ◽

Mitral Valve ◽

Peripheral Blood ◽

Mitral Valve Disease ◽

Clinical Signs ◽

Valve Disease ◽

Non Invasive ◽

The Status ◽

Healthy Dogs

Abstract The aim of the study was to demonstrate differences in the gene expression of signalling pathways between healthy dogs and dogs with chronic mitral valve disease in different heart failure groups. Blood samples were collected from 49 dogs of various breeds between 1.4 and 15.2 years of age. Isolated RNA samples were analysed for quality and integrity and the gene expression profile was determined. The study demonstrated that nucleated cells from peripheral blood can be used to assess the status of heart failure in dogs. Furthermore, significant differences in the expression of the genes were noticed between healthy dogs and dogs with clinical signs of chronic mitral valve disease. This is a preliminary non-invasive study showing the feasibility of genetic testing from peripheral blood nucleated cells, which at the same time has made it possible to set the future directions of genetic studies in clinical cases of canine chronic mitral valve disease.

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The regenerative therapy of heart failure with adult stem cells and cell transplantation

Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics ◽

10.3143/geriatrics.41.166 ◽

2004 ◽

Vol 41 (2) ◽

pp. 166-167

Author(s):

Jun Fujita

Keyword(s):

Heart Failure ◽

Stem Cells ◽

Cell Transplantation ◽

Adult Stem Cells ◽

Regenerative Therapy

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Chronic heart failure in patients with type 2 diabetes mellitus: prevalence, prognosis

Cardiosomatics ◽

10.26442/cs45116 ◽

2015 ◽

Vol 6 (1) ◽

pp. 16-23

Author(s):

S. V Kakorin ◽

I. A Averkova ◽

A. M Mkrtumyan

Keyword(s):

Diabetes Mellitus ◽

Heart Failure ◽

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Type 2 Diabetes Mellitus ◽

Chronic Heart Failure ◽

Carbohydrate Metabolism ◽

The Status ◽

Treatment Prognosis

The article presents a literature review of prevalence, prognosis and treatment of overt tactics of chronic heart failure (CHF) in patients with type 2 diabetes mellitus (T2DM). Diabetes and heart failure acquire the status of the epidemic of the XXI century and require health care costs for prevention and treatment of these diseases. Application of modern pharmacological preparations and instrumental treatment of cardiovascular disease (CVD) increases life expectancy and improves the quality of life of patients with CHF as with normal carbohydrate metabolism (UO), and with type 2 diabetes. However, the risk of cardiovascular mortality (CAS) in patients with type 2 diabetes, compared to having a normal carbohydrate metabolism remains unchanged. The rapidly growing population of patients with type 2 diabetes will soon change this in recent years to improve representation treatment prognosis of cardiovascular disease. Violation of myocardial remodeling in type 2 diabetes is caused by a combination of factors associated with diabetic cardiomyopathy. Reduction of the metabolic activity of cardiomyocytes insufficient glucose transport into cells, endothelial dysfunction, diabetic macro and microangiopathy myocardial fibrosis leading to disruption of filling the left ventricle (LV) and the development of chronic heart failure.Insulin resistance (IR) and compensatory hyperinsulinemia (GI) play a key role in the pathogenesis of type 2 diabetes. With effective treatment of chronic heart failure by cardiologists in patients with type 2 diabetes, affecting therapy with insulin resistance should be mandatory.

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Status of Prostacycline-Thromboxane System and Platelet Functional Activities in Patients with Acute Myocardial Infarction Depending on Stages of Heart Failure

Medicine Today ◽

10.3329/medtoday.v26i2.24227 ◽

2015 ◽

Vol 26 (2) ◽

pp. 83-87

Author(s):

AFM Sakhawat Hossain ◽

Brindaban Biswas ◽

Md Alfazzaman ◽

Mohammad Mohsin ◽

Md Mujibur Rahman

Keyword(s):

Myocardial Infarction ◽

Heart Failure ◽

Acute Myocardial Infarction ◽

Platelet Aggregation ◽

New England ◽

Medical Institute ◽

Functional Activities ◽

The Status ◽

Platelet Functions

Among possible pathogenic and adaptive mechanism of acute myocardial infarction and development of its complications, the system of prostanoids, particularly prostacycline-thromboxane system is of prime importance. But many questions relating the role of prostacycline-thromboxane system in pathogenesis of myocardial infarction associated with heart failure have studied insufficiently. The objective of this work is to study the ststus of prostacycline-thromboxane system in patients of acute myocardial infarction associated with heart failure and its correlation with the platelet functions depending on stages of heart failure. This study was performed in the department of Internal Medicine in Kharkov State Medical Institute, Ukraine in 1985-89. 120 patients with acute myocardial infarction leading to heart failure were studied. The status of prostacycline-thromboxane was considered by the level of stable metabolites of prostacycline and thromboxane - A2 as 6-keto-PGF and TXB2 respectively in venous plasma. 6-Keto-PGF-1a and TXB2 levels were determined by Radio-immunological method with the help of kits manufactured by the English Firm "New England Nuclear". To determine the platelet aggregation properties, the instrument "Bian-120" transmitter was used. It was established clinically that prostacycline- thromboxane activation depends on clinical features of myocardial infarction, i.e. its localization, depth, extension or affected size of MI, first attack or re-infarction. Maximum changes of prostacycline thromboxane system took place in extensive myocardial infarction which was expressed in increased level of TXB2 and significant change of prostanoid imbalance ratio. Parameters of platelet aggregation function and prostacycline thromboxane system were interrelated during heart failure, which were expressed by their changes in aggregation diagram.Medicine Today 2014 Vol.26(2): 83-87

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Follistatin-like 1 in Cardiovascular Disease and Inflammation

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557519666190312161551 ◽

2019 ◽

Vol 19 (16) ◽

pp. 1379-1389 ◽

Cited By ~ 3

Author(s):

Marijn M.C. Peters ◽

Timion A. Meijs ◽

Wouter Gathier ◽

Pieter A.M. Doevendans ◽

Joost P.G. Sluijter ◽

...

Keyword(s):

Heart Failure ◽

Cardiovascular Disease ◽

Posttranslational Modifications ◽

Cardiac Regeneration ◽

Regenerative Therapy ◽

Coronary Syndrome ◽

Disease Mechanisms ◽

Spatiotemporal Regulation ◽

Shed Light

: Follistatin-like 1 (FSTL1), a secreted glycoprotein, has been shown to participate in regulating developmental processes and to be involved in states of disease and injury. Spatiotemporal regulation and posttranslational modifications contribute to its specific functions and make it an intriguing candidate to study disease mechanisms and potentially develop new therapies. With cardiovascular diseases as the primary cause of death worldwide, clarification of mechanisms underlying cardiac regeneration and revascularization remains essential. Recent findings on FSTL1 in both acute coronary syndrome and heart failure emphasize its potential as a target for cardiac regenerative therapy. With this review, we aim to shed light on the role of FSTL1 specifically in cardiovascular disease and inflammation.

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