Erratum to: Photocurable O-carboxymethyl chitosan derivatives for biomedical applications: Synthesis, in vitro biocompatibility, and their wound healing effects

The effects of anodized titanium (Ti) with a potential hydrogen fluoride (HF) acid pretreatment through cathodization on the formation of nano-porous Ti dioxide (TiO2) layer were characterized using field-emission scanning electron microscopy, grazing incidence X-ray diffractometer, and contact angle goniometer. The biocompatibility was determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) test. Analytical results found that a well-aligned nano-porous structure was formed on the anodized Ti surface with HF pretreatment concentration above 0.5%. Microstructure of the nano-porous Ti dioxide surface generated by anodization with HF pretreatment was composed of anatase and rutile phases, while the anodized Ti sample with HF pretreatment concentration of 0.5% presented excellent hydrophilicity surface. An in-vitro biocompatibility also indicated that osteoblast cells grown on the surface of the anodized Ti sample with HF pretreatment increased with the increase of culture time. The filopodia of osteoblast cells not only adhered flat, but also tightly grabbed the nano-porous structure for promoting cell adhesion and proliferation. Therefore, the anodized Ti with HF pretreatment can form a functionalized surface with great biocompatibility for biomedical applications, particularly for dental implants.

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Wound Healing Activity of Nanoclay/Spring Water Hydrogels

Pharmaceutics ◽

10.3390/pharmaceutics12050467 ◽

2020 ◽

Vol 12 (5) ◽

pp. 467 ◽

Cited By ~ 4

Author(s):

Fátima García-Villén ◽

Angela Faccendini ◽

Dalila Miele ◽

Marco Ruggeri ◽

Rita Sánchez-Espejo ◽

...

Keyword(s):

Wound Healing ◽

Laser Scanning ◽

Healing Process ◽

Spring Water ◽

Laser Scanning Microscopy ◽

Confocal Laser ◽

Wound Healing Process ◽

Accelerate Wound Healing ◽

In Vitro Biocompatibility

Background: hydrogels prepared with natural inorganic excipients and spring waters are commonly used in medical hydrology. Design of these clay-based formulations continues to be a field scarcely addressed. Safety and wound healing properties of different fibrous nanoclay/spring water hydrogels were addressed. Methods: in vitro biocompatibility, by means of MTT assay, and wound healing properties were studied. Confocal Laser Scanning Microscopy was used to study the morphology of fibroblasts during the wound healing process. Results: all the ingredients demonstrated to be biocompatible towards fibroblasts. Particularly, the formulation of nanoclays as hydrogels improved biocompatibility with respect to powder samples at the same concentration. Spring waters and hydrogels were even able to promote in vitro fibroblasts motility and, therefore, accelerate wound healing with respect to the control. Conclusion: fibrous nanoclay/spring water hydrogels proved to be skin-biocompatible and to possess a high potential as wound healing formulations. Moreover, these results open new prospects for these ingredients to be used in new therapeutic or cosmetic formulations.

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Preparation and In Vitro Biological Evaluation of Lawsone Loaded O‐Carboxymethyl Chitosan/Zinc Oxide Nanocomposite for Wound‐Healing Application

ChemistrySelect ◽

10.1002/slct.201904159 ◽

2020 ◽

Vol 5 (9) ◽

pp. 2710-2718

Author(s):

Nagarajan Sakthiguru ◽

Mohamed Aboobucker Sithique

Keyword(s):

Wound Healing ◽

Zinc Oxide ◽

Biological Evaluation ◽

Carboxymethyl Chitosan

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3D Printed PLA/PCL/TiO2 Composite for Bone Replacement and Grafting

MRS Advances ◽

10.1557/adv.2018.375 ◽

2018 ◽

Vol 3 (40) ◽

pp. 2373-2378 ◽

Cited By ~ 9

Author(s):

Sandra E. Nájera ◽

Monica Michel ◽

Nam-Soo Kim

Keyword(s):

Biomedical Applications ◽

Fused Deposition Modeling ◽

Fracture Strain ◽

Fused Deposition ◽

In Vitro Biocompatibility ◽

Bone Replacement ◽

Deposition Modeling ◽

3D Printed ◽

The Stability

ABSTRACTPolymer composites of Polylactic acid (PLA) and poly-ε-caprolactone (PCL), containing small amounts of titanium oxide (TiO2) were developed for biomedical applications. These composite materials were prepared, and then printed using Fused Deposition Modeling (FDM). 3D printed structures were characterized to determine their mechanical properties and biocompatibility. DSC analysis yielded useful information regarding the immiscibility of the different polymers, and it was observed that the particles of TiO2 improved the stability of the polymers. The ultimate tensile strength and the fracture strain increased by adding TiO2 as a filler, resulting in values of approximately 45 MPa and 5.5 % elongation. The printed composites show excellent in vitro biocompatibility including cell proliferation and adhesion, and are therefore promising candidates to be used in the biomedical field for bone replacement procedures, due to their properties similar to those of cancellous bone.

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Enhanced Biocompatibility of GPC by Ion Implantation and Deposition

MRS Proceedings ◽

10.1557/proc-0908-oo16-04 ◽

2005 ◽

Vol 908 ◽

Author(s):

Robert Lee Zimmerman ◽

Ismet Gürhan ◽

Claudiu I. Muntele ◽

Daryush Ila ◽

Feyzan Özdal-Kurt ◽

...

Keyword(s):

Ion Implantation ◽

Biomedical Applications ◽

Heart Valves ◽

Cell Attachment ◽

Blood Stream ◽

Silver Deposition ◽

In Vitro Biocompatibility ◽

Artificial Heart Valves ◽

Model Cell

AbstractBiocompatible Glassy Polymeric Carbon (GPC) is used for artificial heart valves and in other biomedical applications. Although it is ideally suited for implants in the blood stream, tissue that normally forms around the moving parts of a GPC heart valve sometimes loses adhesion and creates embolisms downstream. Here we compare silver ion implantation and silver deposition, each of which strongly inhibits cell attachment on GPC. Inhibition of cell adhesion is a desirable improvement to current GPC cardiac implants. In vitro biocompatibility tests have been carried out with model cell lines to demonstrate that traces of silver can favorably influence the surface of GPC for biomedical applications.

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Preparation of bio - adhesive hydrogel based on chitosan for wound sealant

Science and Technology Development Journal ◽

10.32508/stdj.v18i2.1136 ◽

2015 ◽

Vol 18 (2) ◽

pp. 88-95

Author(s):

Diem Thi My Pham ◽

Hoa Thi Hoang ◽

Vu Dinh Dang ◽

Quyen Ngoc Tran

Keyword(s):

Hydrogen Peroxide ◽

Wound Healing ◽

Horseradish Peroxidase ◽

Biomedical Applications ◽

Fibroblast Cell ◽

Tissue Adhesive ◽

Chitosan Hydrogel ◽

Tissue Adhesion ◽

Adhesive Forces

In this study, we introduce a new kind of hydrogel based on oxidized chitosan for tissue adhesion. The hydrogel formed rapidly in a few seconds in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The in vitro cytocompatible experiment with fibroblast cell using kit live/dead assay showed that the hydrogel was highly biocompatible. Evaluation of tissue adhesion performed on pork skin the maximum tissue adhesive forces are 88 kPa for chitosan hydrogel and 105 kPa for oxidized chitosan hydrogel.. These results suggest that chitosan hydrogel possessed the wound healing ability and promises a tissue adhesive devices for biomedical applications.

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A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds

Molecules ◽

10.3390/molecules25133050 ◽

2020 ◽

Vol 25 (13) ◽

pp. 3050

Author(s):

Yujie Chen ◽

Runjing Zhang ◽

Baiqin Zheng ◽

Chao Cai ◽

Zhen Chen ◽

...

Keyword(s):

Biomedical Applications ◽

Clinical Applications ◽

Carboxymethyl Chitosan ◽

Self Healing ◽

Stimuli Responsive ◽

Covalent Bonds ◽

Injectable Hydrogels ◽

Handling Performance ◽

Natural Polysaccharide

Injectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels with desirable nontoxicity are suffering from limited functions, failing to fulfill the requirements of clinical biomaterials. The development of novel injectable biomaterials with a combination of biocompatibility and adequate functional properties is a growing urgency toward biomedical applications. In this contribution, we report a simple and effective approach to fabricate multi-functional CMC-OSA-DTP hydrogels. Two kinds of natural polysaccharide derived polymers, carboxymethyl chitosan (CMC) and oxidized alginate (OSA) along with 3,3′-dithiopropionic acid dihydrazide (DTP) were utilized to introduce three dynamic covalent bonds. Owing to the existence of triple dynamic bonds, this unique CMC-OSA-DTP hydrogel possessed smart redox and pH stimuli-responsive property, injectability as well as self-healing ability. In addition, the CCK-8 and live/dead assays demonstrated satisfying cytocompatibility of the CMC-OSA-DTP hydrogel in vitro. Based on its attractive properties, this easy-fabricated and multi-functional hydrogel demonstrated the great potential as an injectable biomaterial in a variety of biomedical applications.

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Oxytetracycline versus Doxycycline Collagen Sponges Designed as Potential Carrier Supports in Biomedical Applications

Pharmaceutics ◽

10.3390/pharmaceutics11080363 ◽

2019 ◽

Vol 11 (8) ◽

pp. 363 ◽

Cited By ~ 2

Author(s):

Tihan ◽

Rău ◽

Zgârian ◽

Ungureanu ◽

Barbaresso ◽

...

Keyword(s):

Biomedical Applications ◽

Structural Integrity ◽

Release Kinetics ◽

Collagen Sponge ◽

Application Site ◽

Cross Linking ◽

Drug Kinetic ◽

In Vitro Biocompatibility ◽

Kinetic Release

Many research studies are directed toward developing safe and efficient collagen-based biomaterials as carriers for drug delivery systems. This article presents a comparative study of the properties of new collagen sponges prepared and characterized by different methods intended for biomedical applications. The structural integrity is one of the main properties for a biomaterial in order for it to be easily removed from the treated area. Thus, the effect of combining a natural polymer such as collagen with an antimicrobial drug such as oxytetracycline or doxycycline and glutaraldehyde as the chemical cross-linking agent influences the cross-linking degree of the material, which is in direct relation to its resistance to collagenase digestion, the drug kinetic release profile, and in vitro biocompatibility. The enzymatic degradation results identified oxytetracycline as the best inhibitor of collagenase when the collagen sponge was cross-linked with 0.5% glutaraldehyde. The drug release kinetics revealed an extended release of the antibiotic for oxytetracycline-loaded collagen sponges compared with doxycycline-loaded collagen sponges. Considering the behavior of differently prepared sponges, the collagen sponge with oxytetracycline and 0.5% glutaraldehyde could represent a viable polymeric support for the prevention/treatment of infections at the application site, favoring tissue regeneration.

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