scholarly journals Inheritance vs. infectivity as a mechanism of malady and death of Frederic Chopin

2021 ◽  
Author(s):  
Michał Witt ◽  
Tadeusz Dobosz
Keyword(s):  
Respiratory Tract ◽  
Cause Of Death ◽  
Physical Condition ◽  
High Probability ◽  
Rare Complication ◽  
Frederic Chopin ◽  
Progressive Deterioration ◽  
Tuberculous Pericarditis ◽  
Short Period ◽  
Macroscopic Analysis

AbstractBased on a macroscopic analysis of the heart of Frederic Chopin performed in 2014, it can be stated with high probability that the composer suffered from a long lasting tuberculosis as a primary disease, which was the cause of progressive deterioration of his physical condition and numerous symptoms mainly from the respiratory tract. Tuberculous pericarditis rapidly progressing within a rather short period of time, a relatively rare complication of diffuse tuberculosis, might have been an immediate cause of death. This would aptly coincide with a startling opinion that in an autopsy picture the composer’s heart had been more affected by the disease than the lungs.

SUDDEN AND UNEXPECTED DEATH IN INFANCY AND CHILDHOOD

PEDIATRICS ◽  
1956 ◽  
Vol 17 (5) ◽  
pp. 663-699 ◽  
Author(s):  
Lester Adelson ◽  
Eleanor Roberts Kinney
Keyword(s):  
Sudden Death ◽  
Respiratory Tract ◽  
Pulmonary Edema ◽  
Cause Of Death ◽  
Respiratory Infections ◽  
Past History ◽  
Prognostic Significance ◽  
Control Group ◽  
Unexpected Death ◽  
History Of

One hundred twenty-six consecutive cases of sudden and unexpected death in children between the ages of 10 days and 2 years were studied. Anatomic and microbiologic studies were carried out and an investigation was made at the home in each case. Both sexes were equally vulnerable. Eighty-five per cent of the children were less than 6 months old. The peak incidence was at 2 months. Ninety-nine children were found dead and 27 were observed to die. The same variety and severity of anatomic lesions were found in both categories. Sixteen children in the same age range who died rapidly following known lethal voilence were studied as a control group. Of the nontraumatic sudden death ("unexplained") series 106 (84 per cent) revealed microscopic inflammatory changes in 1 or more sites of the respiratory tract, and histologic evidence of inflammatory disease in other organs was seen in many cases. Acute hemorrhagic pulmonary edema was a common anatomic finding (82 per cent). It was usually accompanied by visceral and cerebral congestion and hemorrhages. Special investigative procedures including staining of the liver for glycogen, determination of the glucose level of the cerebrospinal fluid and study of the adrenals for sudanophilia and birefringence indicated that these factors are without significance in sudden death in early life. A variety of congenital and acquired abnormalities, the presence of which had been unsuspected, was demonstrated at necropsy. Eleven per cent of the 126 cases showed no anatomic abnormalities other than the circulatory phenomena. No single bacterial organism or group of organisms was isolated with any degree of consistency from any site. All attempts to isolate viruses were negative. Ante-mortem symptomatology, circumstances of death, history of contact with infectious disease, and past history of repeated respiratory infection were without prognostic significance and were not pathognomic as to the cause of death. Eighty children had histories of mild illness for 48 hours or less prior to death. Fifty-three children had received some form of treatment during this interval. Sixty-nine children had histories of contact with infectious diseases. Forty-one children had past histories of repeated respiratory infections. The cases came from every social level. Sixty-five per cent had received good care while 35 per cent had received poor care. Many of the control cases showed inflamatory disease in the respiratory tract similar to that seen in the natural death group as well as anatomic evidence of lethal trauma. The inflammatory lesions are thus not incompatible with life. Several hypotheses are offered in an effort to link microscopic inflammatory respiratory tract changes with hemorrhagic pulmonary edema and sudden death. Anatomic and anamnestic evidence exclude mechanical suffocation by bedding. No statement as to the cause of death of an infant who has died suddenly and unexpectedly should be made without complete gross and microscopic studies and thorough investigation of the scene and circumstances of death.

Using Digital Programs and Technologies to Simulate Business Development

2021 ◽  
pp. 71-87
Author(s):  
Ionica Oncioiu ◽  
Mihaela Mirela Dogaru ◽  
Manoela Popescu
Keyword(s):  
Human Capital ◽  
Decision Maker ◽  
High Probability ◽  
Optimal Solution ◽  
Digital Age ◽  
Business Development ◽  
Organizational Goal ◽  
Business People ◽  
Proper Management ◽  
Short Period

The priorities of business people in the digital age are human capital and innovation. As the changes are fast, in the digital age, the decision maker will not look for the optimal solution, but will stop at the first solution that he considers satisfactory and will put it into practice as soon as possible, given the fact that there is a high probability that the opportunity or the conditions for materializing the decision must change, even before the implementation of the decision. The use of digital programs and technologies to simulate the company's development decisions can circumvent these shortcomings, at least for a short period of time. This chapter shows that, in an increasingly digitized world, there is widespread recognition that a strong organizational goal is essential for any company, as well as an awareness that trust is becoming increasingly difficult to gain. Also, the proper management of the growing expectations of stakeholders contributes to building the confidence needed for an organization to survive and thrive.

Successful treatment of pure red cell aplasia with rituximab in patients with chronic lymphocytic leukemia

Blood ◽  
2002 ◽  
Vol 99 (3) ◽  
pp. 1092-1094 ◽  
Author(s):  
Hassan Ghazal
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
De Novo ◽  
Rare Complication ◽  
Pure Red Cell Aplasia ◽  
High Serum ◽  
Lymphocytic Leukemia ◽  
Red Cell ◽  
Coombs Test ◽  
Red Cell Aplasia ◽  
Short Period

Abstract Pure red cell aplasia (PRCA) is a rare complication in patients with chronic lymphocytic leukemia (CLL). It is characterized by reticulocytopenia and by an absence of red cell precursors in the bone marrow. Unlike autoimmune hemolytic anemia, which is characterized by an increased number of reticulocytes, positive Coombs test findings, and a high serum level of lactate dehydrogenase. Two patients with B-cell CLL are reported to have developed PRCA, one while on chemotherapy with fludarabine and one seeking treatment for de novo PRCA. Both responded dramatically to therapy with monoclonal antibody rituximab (Rituxan) in a short period of time and continued to be transfusion-independent. These are the first 2 reported patients for whom rituximab treatment for PRCA in CLL was successful, and this treatment deserves further investigation.

Hua Kuo-feng and the Arrest of the “Gang of Four”

1978 ◽  
Vol 75 ◽  
pp. 540-565 ◽  
Author(s):  
Andres D. Onate
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cause Of Death ◽  
Physical Condition ◽  
Not Given ◽  
Cerebral Arteriosclerosis ◽  
Advanced Parkinson’S Disease

On 9 September 1976, at 4 p.m., Peking time, Radio Peking announced that Chairman Mao Tse-tung had died that morning at ten minutes past midnight, at the age of 82, because of his steadily worsening physical condition. The actual cause of death, beyond his age, was not given, but it was generally believed that he died of advanced Parkinson's disease or cerebral arteriosclerosis.

scholarly journals The Basics and the Advancements in Diagnosis of Bacterial Lower Respiratory Tract Infections

Diagnostics ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 37 ◽  
Author(s):  
Stephanie Noviello ◽  
David Huang
Keyword(s):  
Respiratory Tract ◽  
Cause Of Death ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Point Of Care ◽  
Patient Treatment ◽  
Resistant Bacteria ◽  
Lower Respiratory Tract Infections ◽  
Reactive Protein ◽  
Tract Infections

Lower respiratory tract infections (LRTIs) are the leading infectious cause of death and the sixth-leading cause of death overall worldwide. Streptococcus pneumoniae, with more than 90 serotypes, remains the most common identified cause of community-acquired acute bacterial pneumonia. Antibiotics treat LRTIs with a bacterial etiology. With the potential for antibiotic-resistant bacteria, defining the etiology of the LRTI is imperative for appropriate patient treatment. C-reactive protein and procalcitonin are point-of-care tests that may differentiate bacterial versus viral etiologies of LRTIs. Major advancements are currently advancing the ability to make rapid diagnoses and identification of the bacterial etiology of LRTIs, which will continue to support antimicrobial stewardship, and is the focus of this review.

scholarly journals Massive transient pulmonary air embolism during permanent cardiac pacemaker implantation

2018 ◽  
Vol 2018 (2) ◽  
Author(s):  
Emre Ozdemir ◽  
Fatma Kayaalti Esin ◽  
Cem Nazli
Keyword(s):  
High Probability ◽  
Rare Complication ◽  
Pacemaker Implantation ◽  
Cardiac Pacemaker ◽  
Air Embolism ◽  
Pulmonary Trunk ◽  
Probability Of Death ◽  
Permanent Cardiac Pacemaker ◽  
Avoidable Complication ◽  
Implantation Procedure

Pulmonary air embolism is a rare complication with a high probability of death. We present an air embolism case during permanent cardiac pacemaker implantation procedure. When the patient worsened hemodynamically, we saw a large air embolism in the main pulmonary trunk. Air embolism can be fatal, it is always iatrogenic, but is an avoidable complication.

scholarly journals Mucins and Asthma: Are We Headed to the Revolutionary Road?

2019 ◽  
Vol 8 (11) ◽  
pp. 1955
Author(s):  
Pierachille Santus ◽  
Dejan Radovanovic ◽  
Davide Alberto Chiumello
Keyword(s):  
Respiratory Tract ◽  
Severe Asthma ◽  
Cause Of Death ◽  
Airway Epithelium ◽  
Mucociliary Clearance ◽  
Tissue Remodeling ◽  
Potential Treatment ◽  
First Line ◽  
Mucus Hypersecretion ◽  
Fatal Asthma

Mucus represents the first line of defense of our respiratory tract and mucociliary clearance is essential for maintaining the homeostasis of airway epithelium. The latter mechanisms are altered in asthma and mucus plugging of proximal and distal airways is the main cause of death in cases of fatal asthma. Starting from the influential review performed by Luke R. Bonser and David J. Erle in 2017, we discuss the latest evidence in terms of mucins regulation and potential treatment of mucus hypersecretion and tissue remodeling in severe asthma.

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