Evaluation of antihyperglycaemic and antihyperlipidemic activity of Citrus sinensis peel extract on streptozotocin-induced diabetic rats

Objective: The present study was aimed to evaluate antihyperglycemic and antihyperlipidemic activities of methanolic extract of Aristolochia bracteolata (MEAB) against dexamethasone-induced diabetic rat model.Methods: Methanolic extract was prepared by soxhlet extraction and was evaluated for antihyperglycemic and antihyperlipidemic activity using dexamethasone-induced model. The MEAB was administered orally at a dose of 200 and 400 mg/kg body weight glibenclamide was used as standard drug. On 0th and 11th day, blood was collected by retro-orbit plexus.Results: In this model blood glucose levels were determined on 0th and 11th days and MEAB significantly reduced the blood glucose levels in diabetic rats. The effect of MEAB on serum lipid profile such as total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), very LDL (VLDL), and high-density lipoprotein (HDL) was also measured on the 11th day in the diabetic rats. Significant reduction in TC, TGs, LDL, and VLDL levels and improvement in HDL level were observed in diabetic rats.Conclusion: From the results, it was found that the MEAB possess antihyperglycemic and antihyperlipidemic activities.

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Larvicidal, pupicidal, repellent and adulticidal activity of Citrus sinensis orange peel extract against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae)

Parasitology Research ◽

10.1007/s00436-012-3021-8 ◽

2012 ◽

Vol 111 (4) ◽

pp. 1757-1769 ◽

Cited By ~ 49

Author(s):

Kadarkarai Murugan ◽

Palanisamy Mahesh Kumar ◽

Kalimuthu Kovendan ◽

Duraisamy Amerasan ◽

Jayapal Subrmaniam ◽

...

Keyword(s):

Aedes Aegypti ◽

Culex Quinquefasciatus ◽

Citrus Sinensis ◽

Anopheles Stephensi ◽

Orange Peel ◽

Adulticidal Activity ◽

Orange Peel Extract ◽

Peel Extract

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ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF JATROPHA GOSSYPIFOLIA METHANOLIC EXTRACT IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED DIABETIC RATS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i11.20985 ◽

2017 ◽

Vol 10 (11) ◽

pp. 326 ◽

Cited By ~ 2

Author(s):

Issac Praveen Kumar ◽

Ishan Malhotra ◽

Sujatha Sundaresan ◽

Alwin Dev

Keyword(s):

Liver Function ◽

Glycogen Content ◽

Methanolic Extract ◽

Density Lipoprotein ◽

Experimental Period ◽

Liver Glycogen ◽

Treated Group ◽

Diabetic Rats ◽

Antihyperlipidemic Activity ◽

Jatropha Gossypifolia

Objective: The objective of the present study is to explore the antihyperglycemic and antihyperlipidemic activities of Jatropha gossypifolia methanolic extract (ME) in streptozotocin (STZ)-nicotinamide (NIC) induced diabetic model.Methods: Type II diabetes was induced by a single dose of NIC (110 mg/kg) and STZ (50 mg/kg b.w.) intraperitoneally. The diabetic animals were treated with ME (50 mg/kg and 100 mg/kg b.w.) of J. gossypifolia. At the end of experimental period, the effect of the ME on creatinine level, triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very LDL (VLDL) were analyzed. Liver function parameters such as glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) were analyzed and liver glycogen content was estimated spectrophotometrically. After scarification of animals, the liver was collected and subjected to histopathology analysis. Glycogen content was estimated spectrophotometrically.Results: The ME treated diabetic rats showed a significant increase in HDL level and a decrease in creatinine, TG, TC, and VLDL levels. The treated group showed a significant decrease in liver function parameters such as GOT and GPT levels and significantly increased the liver glycogen content.Conclusion: These findings demonstrate that ME possess antihyperglycemic and antihyperlipidemic activity against STZ - NIC induced diabetic rats.

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Antidiabetic and Antihyperlipidemic Activity of Canthium parviflorum Extracts in Streptozotocin-Induced Diabetic Rats

Rajiv Gandhi University of Health Sciences Journal of Pharmaceutical Sciences ◽

10.5530/rjps.2015.4.8 ◽

2016 ◽

Vol 5 (4) ◽

pp. 181-190

Author(s):

Neelakanth M. Jeedi ◽

B. C. Koti

Keyword(s):

Diabetic Rats ◽

Antihyperlipidemic Activity

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Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats

Process Biochemistry ◽

10.1016/j.procbio.2009.12.004 ◽

2010 ◽

Vol 45 (4) ◽

pp. 581-585 ◽

Cited By ~ 30

Author(s):

Osama Y. Althunibat ◽

Ahmed H. Al-Mustafa ◽

Khaled Tarawneh ◽

Khaled M. Khleifat ◽

B.H. Ridzwan ◽

...

Keyword(s):

Oxidative Damage ◽

Punica Granatum ◽

Protective Role ◽

Diabetic Rats ◽

Punica Granatum L ◽

Peel Extract

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Antidiabetic and antihyperlipidemic activity of ethyl acetate:Isopropanol (1:1) fraction of Vernonia anthelmintica seeds in Streptozotocin induced diabetic rats

Food and Chemical Toxicology ◽

10.1016/j.fct.2009.10.048 ◽

2010 ◽

Vol 48 (2) ◽

pp. 495-501 ◽

Cited By ~ 42

Author(s):

Shaik Sameena Fatima ◽

Maddirala Dilip Rajasekhar ◽

Kondeti Vinay Kumar ◽

Mekala Thur Sampath Kumar ◽

Kasetti Ramesh Babu ◽

...

Keyword(s):

Diabetic Rats ◽

Antihyperlipidemic Activity ◽

Vernonia Anthelmintica

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Biosynthesis of silver nanoparticles using citrus sinensis peel extract and its antibacterial activity

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ◽

10.1016/j.saa.2011.03.040 ◽

2011 ◽

Vol 79 (3) ◽

pp. 594-598 ◽

Cited By ~ 375

Author(s):

S. Kaviya ◽

J. Santhanalakshmi ◽

B. Viswanathan ◽

J. Muthumary ◽

K. Srinivasan

Keyword(s):

Silver Nanoparticles ◽

Antibacterial Activity ◽

Citrus Sinensis ◽

Peel Extract

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Efficacy of jamun Syzygium cumini seed and orange Citrus sinensis peel extracts against microcystin LR induced histological damage in the kidney of rat

Brazilian Journal of Biological Sciences ◽

10.21472/bjbs(2020)071702 ◽

2020 ◽

Vol 7 (17) ◽

pp. 247-259

Author(s):

Babita Deep Srivastava ◽

Manish Srivastava ◽

Makoto Urata ◽

Nobuo Suzuki ◽

Ajai Kumar Srivastav

Keyword(s):

Epithelial Cells ◽

Citrus Sinensis ◽

Orange Peel ◽

Seed Extract ◽

Male Rats ◽

Syzygium Cumini ◽

Group B ◽

Group D ◽

Orange Peel Extract ◽

Peel Extract

In this study we evaluated the protective effects of jamun Syzygium cumini seed and orange Citrus sinensis peel extracts on renotoxicity of microcystin LR in male rats. Groups A-F were given daily treatments for 30 days. Group A (Control): No treatment was given; Group B: microcystin (10 µg/kg body wt); Group C: microcystin (10 µg/kg body wt) and jamun seed extract (200 mg/kg body wt); Group D: microcystin (10 µg/kg body wt) and orange peel extract (200 mg/kg body wt; Group E: orange peel extract (200 mg/kg body wt); Group F: jamun seed extract (200 mg/kg body wt). Kidney were fixed at 15th and 30th day after the treatments. In 15 day MCLR (group B) treated rats shrunken glomeruli, hypertrophy of epithelial cells of tubules. vacuolation of cytoplasm and obliterated tubular lumina were noticed. In MCLR+JSE (group C) and MCLR+OPE (group D) treated rats almost similar changes were noticed as seen in MCLR treated rats. In OPE (group E) and JSE (group F) treated rats no visible morphological alterations were nojticed. Following 30 day MCLR treatment (group B), increased cellularity of glomeruli, no space between the Bowman's capsule and glomerulus, glomerular degeneration, dilated tubules, separation of tubular epithelial cells from underlying basement membrane, tubular vacuolization and degeneration with necrotic nuclei in lumina and deposition of eosin-positive material in the tubules were observed. In MCLR+JSE (group C) and MCLR+OPE (group D) treated rats the glomeruli were swollen showing increased cellularity. No degeneration was noticed in glomeruli. Tubules were dilated, however, at few places few epithelial cells were degenerating. Necrotic nuclei were not seen in tubular lumina. In OPE (group E) and JSE (group F) treated rats the kidney exhibited no histological changes.

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