Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia

Cognitive dysfunction, including memory and concentration difficulty, is an emerging treatment target in bipolar disorder. However, a key challenge in the management of these cognitive deficits is the lack of treatments with robust effects on cognition. Further, it is unclear how cognitive dysfunction should be assessed and addressed in the clinical treatment of the disorder. This talk will review the evidence for cognitive impairment in bipolar disorder, including its severity, persistence and impact on patients’ functional recovery. It will then discuss when and how to assess cognition and present some new feasible screening tools for cognitive dysfunction. Finally, it will highlight some novel candidate cognition treatments.Disclosure of interestI have acted as a consultant and received honoraria from Lundbeck and Allergan.

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MiR-520a-3p Inhibited Macrophage Polarization and Promoted the Development of Atherosclerosis via Targeting UVRAG in Apolipoprotein E Knockout Mice

Frontiers in Molecular Biosciences ◽

10.3389/fmolb.2020.621324 ◽

2021 ◽

Vol 7 ◽

Author(s):

Jing Rui Qi ◽

Dian Ru Zhao ◽

Li Zhao ◽

Fan Luo ◽

Mei Yang

Keyword(s):

Macrophage Polarization ◽

M2 Macrophage ◽

Treatment Target ◽

Vessel Disease ◽

Novel Treatment ◽

M1 Macrophage ◽

Apolipoprotein E Knockout Mice ◽

The World ◽

M2 Macrophage Polarization

Atherosclerosis (AS), a kind of chronic inflammatory blood vessel disease, is a main cause of cardiovascular disease, which is a leading cause of mortality around the world. Accumulation of macrophages induced by inflammation contributes to AS development. It has been indicated that microRNAs (miRNAs) are involved in the process of AS. However, the pathway and gene miRNAs targeting are poorly understood. Here we reported that miR-520a-3p was increased in mice with AS and silencing of miR-520a-3p attenuated AS process. Furthermore, inhibition of miR-520a-3p increased the expression of α-SMA and collagen. In addition, miR-520a-3p silencing inhibited the expression of M1 macrophage polarization markers and pro-inflammatory genes and promoted the M2 macrophage polarization. What’s more, forced expression of miR-520a-3p diminished IL4/IL13 induced macrophage autophagy via targeting UVRAG. Collectively, our study reveals the role of miR-520a-3p in macrophage polarization and suggests the potential of miRNA as a novel treatment target of AS.

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Oxytocin’s dynamic role across the lifespan

10.31234/osf.io/gpe7f ◽

2021 ◽

Author(s):

Kristin Audunsdottir ◽

Daniel S Quintana

Keyword(s):

Older Adults ◽

Young Adults ◽

Signaling System ◽

Treatment Target ◽

Novel Treatment ◽

Youth And Young Adults ◽

And Behavior ◽

Age Range ◽

Signaling Activity

Older adults have been neglected in biobehavioral oxytocin research. Emerging research indicates that oxytocin signaling activity fluctuates over the lifespan, which suggests that results from studies investigating youth and young adults cannot be easily generalized to older adults. The recruitment of a wider age range of research participants using a variety of research tools is required to uncover the role of the oxytocin signaling system over the lifespan and may reveal novel treatment target candidates in older adults, beyond social cognition and behavior.

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