Deprivation, weight loss and intake in the rat as a function of age: Evidence for an obligatory growth factor

1977 ◽  
Vol 1 (4) ◽  
pp. 207-212
Author(s):  
Robert C. Bolles ◽  
F. Robert Treichler
Keyword(s):  
Weight Loss ◽  
Growth Factor

Fibroblast growth factor 21 (FGF-21) in obese children: no relationship to growth, IGF-1, and IGFBP-3

2016 ◽  
Vol 30 (2) ◽  
Author(s):  
Thomas Reinehr ◽  
Christian L. Roth ◽  
Joachim Woelfle
Keyword(s):  
Weight Loss ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Critical Role ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Obese Children ◽  
Pubertal Stage ◽  
The Impact ◽  
Igfbp 3

AbstractBackground:Fibroblast growth factor 21 (FGF-21) is a hepatic protein that plays a critical role in liver, adipose tissue, and bone metabolism. Animal models reported an increase of FGF-21 and associated growth disturbances in undernutrition. Therefore, we studied the impact of weight loss in obese children on growth, FGF-21, and insulin-like factor 1 (IGF-1) concentrations.Methods:We analyzed height, serum concentrations of FGF-21, IGF-1, IGFBP-3, leptin, and insulin at baseline and 1 year later in 30 obese children with substantial weight loss (reduction >0.5 BMI-SDS) and in 30 obese children of similar age, gender, and pubertal stage with stable BMI-SDS. All children participated in a 1-year lifestyle intervention. Height and IGF-1 was transformed to standard deviation score (SDS). Multiple linear regression analyses adjusted for age, gender, and pubertal stage were performed.Results:At baseline, height-SDS was significantly related to IGF-1-SDS (β-coefficient 0.68 95% confidence interval (95% CI)±0.49; p=0.008) and leptin (β-coefficient 0.042 95% CI±0.030; p=0.008), but not to FGF-21 or insulin. FGF-21 was not significantly associated with IGF-1 or IGFBP-3. In longitudinal analysis, changes of FGF-21 were not significantly related to changes of height, IGF-1-SDS or IGFBP-3. However, in the subgroup of 30 children with substantial BMI-SDS reduction, FGF-21, leptin, insulin, and HOMA decreased significantly.Conclusion:As there was no significant association between FGF-21 and growth or IGF-1 both in cross-sectional and longitudinal analyses, these findings do not support the hypothesis that FGF-21 is involved in growth of obese children. Further studies are necessary to understand the multiple alterations in the growth hormone (GH) axis in obese children.

Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation

2003 ◽  
Vol 285 (3) ◽  
pp. L602-L610 ◽  
Author(s):  
Imad Y. Haddad ◽  
Carlos Milla ◽  
Shuxia Yang ◽  
Angela Panoskaltsis-Mortari ◽  
Samuel Hawgood ◽  
...  
Keyword(s):  
Weight Loss ◽  
Growth Factor ◽  
Marrow Transplantation ◽  
Keratinocyte Growth Factor ◽  
Allogeneic Bone Marrow Transplantation ◽  
Protein A ◽  
Conditioning Regimen ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Allogeneic Bone

We reported an association between the ability of recombinant human keratinocyte growth factor (rHuKGF) to upregulate the expression of surfactant protein A (SP-A) and to downregulate pulmonary inflammation that occurs after allogeneic bone marrow transplantation (BMT). To establish a causal relationship, rHuKGF (5 mg/kg) was administered subcutaneously for three consecutive days before irradiation to SP-A-sufficient and -deficient [SP-A(+/+) and SP-A(-/-), respectively] mice given inflammation-inducing allogeneic spleen T cells at the time of BMT. In contrast with SP-A(+/+) mice, rHuKGF failed to suppress the high levels of TNF-α, IFN-γ, and nitric oxide contained in bronchoalveolar lavage fluids collected on day 7 after BMT from SP-A(-/-) mice. Early post-BMT weight loss was attenuated by rHuKGF in both SP-A(+/+) and SP-A(-/-) recipients. In the absence of supportive respiratory care, however, SP-A deficiency eventually abolished the ability of rHuKGF to prevent weight loss and to improve survival monitored for 1 mo after allogeneic BMT. In further experiments, the addition of cyclophosphamide (which is known to cause severe injury to the alveolar epithelium in donor T cell-recipient mice) to the conditioning regimen prevented rHuKGF-induced upregulation of SP-A and suppression of lung inflammation in both SP-A(+/+) and SP-A(-/-) mice. We conclude that endogenous baseline SP-A levels and optimal upregulation of SP-A are required for the anti-inflammatory protective effects of KGF after allogeneic transplantation.

scholarly journals Effect of Weight Loss Surgery on Biomarkers of Angiogenesis in Obese Patients

2020 ◽  
Vol 30 (9) ◽  
pp. 3417-3425 ◽  
Author(s):  
Maciej Wiewiora ◽  
Anna Mertas ◽  
Marek Gluck ◽  
Alicja Nowowiejska-Wiewiora ◽  
Zenon Czuba ◽  
...  
Keyword(s):  
Weight Loss ◽  
Growth Factor ◽  
Weight Loss Surgery ◽  
Significant Negative Correlation ◽  
Vascular Endothelial ◽  
Obese Patients ◽  
Platelet Endothelial Cell Adhesion ◽  
Angiopoietin 2 ◽  
Endothelial Growth Factor ◽  
Circulating Levels

Abstract Background The present study aims to clarify the effects of weight loss on biomarkers associated with angiogenesis in patients who underwent laparoscopic sleeve gastrectomy (SG) or adjustable gastric banding (LAGB) in the 12-month follow-up study. Materials and Methods We studied 24 obese patients who underwent laparoscopic weight loss surgery, 13 of whom underwent SG and 11 of whom underwent LAGB. We evaluated the circulating level of angiogenesis biomarkers preoperatively and 12 months after surgery. Results Before surgery, the following angiogenic circulating factors were significantly higher than those of healthy subjects: angiopoietin 2 (ANG-2) (p < .05), granulocyte colony-stimulating factor (G-CSF) (p < .05), hepatocyte growth factor (HGF) (p < .01), platelet endothelial cell adhesion molecule (PECAM-1) (p < .01), and vascular endothelial growth factor (VEGF) (p < .05). The following angiogenesis biomarkers decreased significantly after weight loss compared with their baseline values: ANG-2 (p < .05), follistatin (p < .05), HGF (p < .01), PECAM-1 (p < .01), and VEGF (p < .05). There were no significant differences in the circulating levels of angiogenesis biomarkers between individuals who underwent SG and those who underwent LAGB; however, HGF, PECAM-1, and VEGF tended to be lower after SG. %BMI correlated negatively with HGF, PECAM-1, and VEGF. A similar significant negative correlation was found for %WL and %EWL. WHR correlated with PDGF-B and VEGF. Conclusions We concluded that weight loss surgery induces the changes of circulating levels of angiogenesis biomarkers in obese patients. The changes in angiogenesis status in obese patients who lost weight after bariatric surgery depended on the amount of weight loss.

Low serum insulin-like growth factor-1 level is a predictor of low total weight loss percentage after sleeve gastrectomy

2020 ◽  
Vol 16 (12) ◽  
pp. 1978-1987
Author(s):  
Masahiro Ohira ◽  
Yasuhiro Watanabe ◽  
Takashi Yamaguchi ◽  
Atsuhito Saiki ◽  
Takashi Oshiro ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Growth Factor ◽  
Serum Insulin ◽  
Total Weight ◽  
Total Weight Loss ◽  
Insulin Like Growth Factor ◽  
Weight Loss Percentage ◽  
Low Serum

Baseline Insulin-Like Growth Factor-I Plasma Levels, Systemic Inflammation, Weight Loss and Clinical Outcome in Metastatic Non-Small Cell Lung Cancer Patients

Oncology ◽  
2011 ◽  
Vol 81 (2) ◽  
pp. 113-118 ◽  
Author(s):  
P.J. Vlachostergios ◽  
I. Gioulbasanis ◽  
K. Kamposioras ◽  
P. Georgoulias ◽  
V.E. Baracos ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Weight Loss ◽  
Growth Factor ◽  
Clinical Outcome ◽  
Cancer Patients ◽  
Plasma Levels ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Factor I

scholarly journals Effect of Weight Loss on Free Insulin-Like Growth Factor-I in Obese Women With Hyposomatotropism*

Obesity ◽  
2007 ◽  
Vol 15 (4) ◽  
pp. 879-886 ◽  
Author(s):  
Michael H. Rasmussen ◽  
Anders Juul ◽  
Jannik Hilsted
Keyword(s):  
Weight Loss ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Obese Women ◽  
Factor I ◽  
Free Insulin ◽  
Growth Factor I

scholarly journals Effects of Human Growth Hormone, Insulin-Like Growth Factor I, and Diet and Exercise on Body Composition of Obese Postmenopausal Women1

1998 ◽  
Vol 83 (5) ◽  
pp. 1477-1484 ◽  
Author(s):  
J. L. Thompson ◽  
G. E. Butterfield ◽  
U. K. Gylfadottir ◽  
J. Yesavage ◽  
R. Marcus ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Growth Factor ◽  
Muscle Strength ◽  
Postmenopausal Women ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Diet And Exercise ◽  
Igf I ◽  
Growth Factor I

To determine the effects of GH and insulin-like growth factor I (IGF-I) administration, diet, and exercise on weight loss, body composition, basal metabolic rate (BMR), muscle strength, and psychological status, 33 moderately obese postmenopausal women (67.1 ± 5.2 yr) participated in a 12-week randomized, double blind study. Participants were placed on a diet that provided 500 Cal/day less than that needed for weight maintenance, and they walked 3 days and strength trained 2 days each week. Subjects also self-injected GH (0.025 mg/kg BW·day), IGF-I (0.015 mg/kg BW·day), a combination of these doses of GH and IGF-I, or placebo (P). Twenty-eight women completed the study, as five subjects dropped out due to intolerable side-effects (e.g. edema). Weight loss occurred in all groups, with the largest decrease occurring in the GH plus IGF-I group (5.6 ± 1.4 kg). Fat mass significantly decreased in all groups, with the largest losses observed in GH and GH plus IGF-I groups (6.3 ± 1.8 and 8.4 ± 2.8 kg, respectively). Despite weight loss, BMR was maintained in all groups. Muscle strength increased with training for all groups, and depression and anxiety scores decreased in groups receiving IGF-I. These data show that obese postmenopausal women can lose weight and fat without compromising fat free mass, BMR, or gains in muscle strength, and that GH and IGF-I given together may enhance fat loss over either given alone.

Effects of exercise training with weight loss on skeletal muscle expression of angiogenic factors in overweight and obese older men

2021 ◽  
Author(s):  
William S. Evans ◽  
Jacob B Blumenthal ◽  
James M Heilman ◽  
Alice S. Ryan ◽  
Steven J. Prior
Keyword(s):  
Skeletal Muscle ◽  
Weight Loss ◽  
Growth Factor ◽  
Exercise Training ◽  
Glucose Tolerance ◽  
Tyrosine Kinase Receptor ◽  
Oral Glucose ◽  
Vastus Lateralis Muscle ◽  
Angiogenic Growth Factor ◽  
Angiogenic Growth Factors

Low skeletal muscle capillarization is associated with impaired glucose tolerance (IGT); however, aerobic exercise training with weight loss (AEX+WL) increases skeletal muscle capillarization and improves glucose tolerance in adults with IGT. Given that expression of angiogenic growth factors mediates skeletal muscle capillarization, we sought to determine whether angiogenic growth factor levels are associated with low capillarization in those with IGT vs. normal glucose tolerance (NGT), or to the benefits of AEX+WL in both groups. Sixteen overweight or obese men 50-75 years of age completed 6 months of AEX+WL with oral glucose tolerance tests and vastus lateralis muscle biopsies for measurement of muscle vascular endothelial growth factor (VEGF), placental growth factor (PlGF), soluble fms-like tyrosine kinase receptor-1 (sFlt-1) and basic fibroblast growth factor (bFGF). At baseline, all growth factor levels were numerically lower in IGT compared with NGT, but these did not reach statistical significance (P=0.06-0.33). Following AEX+WL, aerobic capacity (VO2max) increased by 16%, while body weight and 120-minute postprandial glucose levels decreased by 10% and 15%, respectively (P ≤ 0.001 for all). There was a main effect of AEX+WL to increase VEGF (0.095±0.016 vs. 0.114±0.018 ng/µg, P<0.05), PlGF (0.004±0.001 vs. 0.005±0.001 ng/µg, P<0.05), and sFlt-1 (0.216±0.029 vs. 0.264±0.036 ng/µg, P<0.01) with overall increases driven by the IGT group. These results suggest that 6 months of AEX+WL increases skeletal muscle angiogenic growth factor levels in older, obese adults with IGT and NGT, which may contribute to our previous findings that AEX+WL increases capillarization to improve glucose tolerance in those with IGT.

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