Role of cell differentiation in high tolerance by prokaryotes of long-term preservation in permafrost

1996 ◽  
Vol 18 (12) ◽  
pp. 97-101 ◽  
Author(s):  
V.S Soina ◽  
E.A Vorobyova
Author(s):  
Derek E. G. Briggs

The nature of organic material and the environment in which it is deposited exert a major influence on the extent to which biomacromolecules are preserved in the fossil record. The role of these factors is explored with a particular focus on the cuticle of arthropods and leaves. Preservation of the original chemistry of arthropod cuticles is favoured by their thickness and degree of sclerotization, and the presence of biominerals. Decay and burial in terrestrial as opposed to marine, and anoxic rather than oxygenated conditions, likewise appear to enhance preservation. The most important factor in the long–term preservation of the chemistry of both animal and plant cuticles, however, is diagenetic alteration to an aliphatic composition. This occurs even in amber, which encapsulates the fossil, eliminating almost all external factors. Some plants contain an original decay–resistant macromolecular aliphatic component but this is not the case in arthropods. It appears that the aliphatic components of many plant as well as animal fossils may be the result of diagenetic polymerization. Selective preservation as a result of decay resistance may explain the initial survival of organic materials in sediments, but in many cases longer–term preservation relies on chemical changes. Selective preservation is only a partial explanation for the origin of kerogen.


2021 ◽  
Author(s):  
Martina Trognitz

In Austria, archaeological research and excavation practice is shaped by a legislative framework and institutional actors. Besides the institutions, the role of private archaeological contractors has grown in the last decade and recently non-commercial associations have been founded. According to the Austrian Monument Protection Act, the Federal Monuments Authority issues permits for any archaeological excavation or survey activity. Documentation and preservation of physical material are regulated by the Monument Protection Act as well as by dedicated guidelines published by the Federal Monuments Authority. With the recent increased use of digital methods, the importance of preserving and disseminating digital data has risen. Although the Austrian government pursues a digitisation agenda including the promotion of Open Science, the availability of repositories suitable for long-term preservation of digital data does not meet the requirements arising from the ever-increasing amount of data.


2017 ◽  
Vol 38 (9) ◽  
pp. 1449-1460 ◽  
Author(s):  
David S Liebeskind

Precision cerebrovascular health or individualized long-term preservation of the brain and associated blood vessels, is predicated on understanding, diagnosing, and tailoring therapies for people at risk of ischemic injury associated with stroke and vascular dementia. The associated imaging patterns are sculpted by the protective effect of the collaterome, the innate compensatory ability of the brain and vasculature to offset hypoperfusion when antegrade or normal arterial inflow pathways are compromised. Theranostics or rational and synchronous use of diagnostic studies in tandem with specific therapies to optimally guide patient outcomes in ischemic brain disorders may capitalize on the pivotal role of the collaterome. Understanding the functional impact of the collaterome across populations of individuals would advance translational science on the brain, while questions with immediate clinical implications may be prioritized. Big data and systematic analyses are necessary to develop normative standards, multimodal imaging atlases, and delineation of specific patterns to guide clinical management. Large-scale, systematic imaging analyses of the collaterome provide a platform for translational work on cerebral collateral circulation and hemodynamics and a theranostic framework with direct clinical implications. This article frames incipient research objectives to guide precision stroke medicine in coming years, building upon the collaterome concept in brain health.


Atlanti ◽  
2015 ◽  
Vol 25 (1) ◽  
pp. 217-224
Author(s):  
Aida Škoro Babić

In the process of creating records the role of IT professionals in present time increased, especially if we compare the role of IT professionals in record management and preservation of not born digital records. The author will try to define the role of archivists in the process of creating, managing, appraising and preserving e-records, as well as the role of IT professionals in the same process. Definition of both will be specified through analysing the processes in life of e-records and what professional and scientific approaches are necessary for long-term preservation of e-records. Through this analyse the author will try to specify what knowledge of both professions are actually necessary in the specific period in life of e-record and to emphasize the need of educating IT professionals in the field of basics of archival science to reach the goal of e-archives according to archival standards and principles.


Author(s):  
Federica Bressan

Sound recordings have proven to be irreplaceable primary sources for disciplines like linguistics, musicology, ethnomusicology and sociology. Their fragile physical nature has activated a number of counter-actions aimed at prolonging the life expectancy of their content. Methodological issues have been raised in the past three decades, considering the relationship between the physical object and its (digitized) intangible content, which is not only complex but develops over time. This article re ects on the role of the emerging discipline known as ‘digital philology’ in the long- term preservation of audio documents, pointing out how some concepts (such as authenticity, reliability and accuracy) may require a ‘customized’ (as opposed to a ‘ready-made’) approach in the preservation work ow – mainly depending on the type of the archive: unique copies, eld recordings, electronic music, oral history, to name some representative cases. The set-up of the laboratory for sound preservation at the Centro di Sonologia Computazionale (CSC) of the University of Padova, Italy, represents one customized approach in which conscious methodological decisions support philologically informed digitization e orts. The methods affect the results, and ultimately the consequences are not merely technological but cultural.


2020 ◽  
Author(s):  
Heike Chauvistré ◽  
Sheena M. Daignault ◽  
Batool Shannan ◽  
Robert J. Ju ◽  
Daniel Picard ◽  
...  

AbstractPhenotypic intratumoral heterogeneity and temporal transitions between cell differentiation states represent major drivers of tumor fitness in melanoma. Expression of the histone H3K4 demethylase KDM5B/JARID1B follows a highly dynamic equilibrium across melanoma cells. When challenged for example with targeted or cytotoxic drugs, the intrinsically slow-cycling KDM5Bhigh cell state becomes initially enriched, whereas under persistent drug-exposure melanomas decrease KDM5B expression again to re-enter cell proliferation for long-term tumor repopulation. However, the exact role of KDM5B for tumor cell differentiation and fate remained elusive so far. Here, we show that melanoma fitness can be overcome by molecular enforcement of high KDM5B expression levels. KDM5B-up-scaled melanoma cells are transcriptionally reprogramed towards a differentiated melanocytic profile including a slow-cycling state. This effect can be phenocopied by a newly identified chemical compound also leading to decelerated tumor growth. Mechanistically, KDM5B represents a checkpoint for coordinating the differentiation phenotype of melanoma cells via transcriptional reprograming, cell cycle delay, and attenuation of cytokinetic abscission. These findings indicate that tumor plasticity per se, i.e. the necessity of cancer cells to dynamically switch between different cell cycling and differentiation states, represents an important oncologic process that can be chemically overcome.


2021 ◽  
Vol 16 (2) ◽  
pp. 176-181
Author(s):  
Ryoga Ishihara ◽  
Isao Hayashi ◽  
◽  

Preserving disaster remains does not always mean inheriting memories of disasters. Without long-term preservation and sustainable utilization of disaster remains, we cannot hand down the stories of disasters to the future generations. Keeping this in mind, a breakout session “Disaster Remains and Passing-on of Memories” was held in the “2020 International Forum on Telling Live Lessons from Disasters,” to grasp the trends of disaster remains inside and outside Japan. The discussions in the breakout session have put a spotlight on the important role of the “mediator” in sustainable utilization of disaster remains. With reference to the reports presented by the speakers at the breakout session, the objective of this study is to discuss the role of the “mediator” in sustainable utilization of disaster remains. The role of the “mediator” has been found to include a role of encouraging the preservation of disaster remains and a role of digging up buried memories.


2001 ◽  
Vol 120 (5) ◽  
pp. A517-A517
Author(s):  
A MIZOGUCHI ◽  
E MIZOGUCHI ◽  
Y DEJONG ◽  
H TAKEDATSU ◽  
F PREFFER ◽  
...  

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