An overview of the report of the national commission on sleep disorders research

1995 ◽  
Vol 10 (S3) ◽  
pp. 109s-113s ◽  
Author(s):  
T Roth

SummaryThe National Comission on Sleep Disorder Research evaluated the status of insomnia and other sleep disorders in the US. The Commission found that insomnia is prevalent affecting 20–30 million Americans, has significant morbidity especially related to attention and memory processes and cost the US an estimated $ 15 billion a year. It also estimated that all of these figures should rise significantly by the year 2000. Other sleep disorders (eg, narcolepsy and sleep apnea) although less prevalent have significant costs to patients and society associated with them. The Commission recommended that the US develop a research and education program to develop new insights into the basic mechanisms of sleep disorder. The education program needs to be directed to the general public; medical practitioners, as well as patients.

2021 ◽  
Author(s):  
Rebecca Robbins ◽  
Matthew D Weaver ◽  
Stuart Quan ◽  
Jason P Sullivan ◽  
Mairav C Zion ◽  
...  

Sleep deficiency is a hidden cost of our 24-7 society, with 70% of adults in the US admitting that they routinely obtain insufficient sleep. Further, it is estimated that 50-70 million adults in the US have a sleep disorder. Undiagnosed and untreated sleep disorders are associated with diminished health for the individual and increased costs for the employer. Research has shown that adverse impacts on employees and employers can be mitigated through sleep health education and sleep disorder screening and treatment programs. Smartphone applications (app) are increasingly commonplace and represent promising, scalable modalities for such programs. The dayzz app is a personalized sleep training program that incorporates assessment of sleep disorders and offers a personalized comprehensive sleep improvement solution. Using a sample of day workers affiliated with a large institution of higher education, we will conduct a single-site, parallel-group, randomized, waitlist control trial. Participants will be randomly assigned to either use the dayzz app throughout the study or receive the dayzz app at the end of the study. We will collect data on feasibility and acceptability of the dayzz app; employee sleep, including sleep behavioral changes, sleep duration, regularity, and quality; employee presenteeism, absenteeism, and performance; employee mood; adverse and safety outcomes; and healthcare utilization on a monthly basis throughout the study, as well as collect more granular daily data from the employee during pre-specified intervals. Our results will illuminate whether a personalized smartphone app is a viable approach for improving employee sleep, health, and productivity.


PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0260828
Author(s):  
Rebecca Robbins ◽  
Matthew D. Weaver ◽  
Stuart F. Quan ◽  
Jason P. Sullivan ◽  
Mairav Cohen-Zion ◽  
...  

Sleep deficiency is a hidden cost of our 24–7 society, with 70% of adults in the US admitting that they routinely obtain insufficient sleep. Further, it is estimated that 50–70 million adults in the US have a sleep disorder. Undiagnosed and untreated sleep disorders are associated with diminished health for the individual and increased costs for the employer. Research has shown that adverse impacts on employees and employers can be mitigated through sleep health education and sleep disorder screening and treatment programs. Smartphone applications (app) are increasingly commonplace and represent promising, scalable modalities for such programs. The dayzz app is a personalized sleep training program that incorporates assessment of sleep disorders and offers a personalized comprehensive sleep improvement solution. Using a sample of day workers affiliated with a large institution of higher education, we will conduct a single-site, parallel-group, randomized, waitlist control trial. Participants will be randomly assigned to either use the dayzz app throughout the study or receive the dayzz app at the end of the study. We will collect data on feasibility and acceptability of the dayzz app; employee sleep, including sleep behavioral changes, sleep duration, regularity, and quality; employee presenteeism, absenteeism, and performance; employee mood; adverse and safety outcomes; and healthcare utilization on a monthly basis throughout the study, as well as collect more granular daily data from the employee during pre-specified intervals. Our results will illuminate whether a personalized smartphone app is a viable approach for improving employee sleep, health, and productivity. Trial registration: ClinicalTrials.gov Identifier: NCT04224285.


Author(s):  
Peter R. Breggin

BACKGROUND: The vaccine/autism controversy has caused vast scientific and public confusion, and it has set back research and education into genuine vaccine-induced neurological disorders. The great strawman of autism has been so emphasized by the vaccine industry that it, and it alone, often appears in authoritative discussions of adverse effects of the MMR and other vaccines. By dismissing the chimerical vaccine/autism controversy, vaccine defenders often dismiss all genuinely neurological aftereffects of the MMR (measles, mumps, and rubella) and other vaccines, including well-documented events, such as relatively rare cases of encephalopathy and encephalitis. OBJECTIVE: This report explains that autism is not a physical or neurological disorder. It is not caused by injury or disease of the brain. It is a developmental disorder that has no physical origins and no physical symptoms. It is extremely unlikely that vaccines are causing autism; but it is extremely likely that they are causing more neurological damage than currently appreciated, some of it resulting in psychosocial disabilities that can be confused with autism and other psychosocial disorders. This confusion between a developmental, psychosocial disorder and a physical neurological disease has played into the hands of interest groups who want to deny that vaccines have any neurological and associated neuropsychiatric effects. METHODS: A review of the scientific literature, textbooks, and related media commentary is integrated with basic clinical knowledge. RESULTS: This report shows how scientific sources have used the vaccine/autism controversy to avoid dealing with genuine neurological risks associated with vaccines and summarizes evidence that vaccines, including the MMR, can cause serious neurological disorders. Manufacturers have been allowed by the US Food and Drug Administration (FDA) to gain vaccine approval without placebo-controlled clinical trials. CONCLUSIONS: The misleading vaccine autism controversy must be set aside in favor of examining actual neurological harms associated with vaccines, including building on existing research that has been ignored. Manufacturers of vaccines must be required to conduct placebo-controlled clinical studies for existing vaccines and for government approval of new vaccines. Many probable or confirmed neurological adverse events occur within a few days or weeks after immunization and could be detected if the trials were sufficiently large. Contrary to current opinion, large, long-term placebo-controlled trials of existing and new vaccines would be relatively easy and safe to conduct.


2018 ◽  
Vol 26 (2) ◽  
pp. 205-226
Author(s):  
Bonolo Ramadi Dinokopila ◽  
Rhoda Igweta Murangiri

This article examines the transformation of the Kenya National Commission on Human Rights (KNCHR) and discusses the implications of such transformation on the promotion and protection of human rights in Kenya. The article is an exposition of the powers of the Commission and their importance to the realisation of the Bill of Rights under the 2010 Kenyan Constitution. This is done from a normative and institutional perspective with particular emphasis on the extent to which the UN Principles Relating to the Status of National Institutions for the promotion and protection of human rights (the Paris Principles, 1993) have been complied with. The article highlights the role of national human rights commissions in transformative and/or transitional justice in post-conflict Kenya. It also explores the possible complementary relationship(s) between the KNCHR and other Article 59 Commissions for the better enforcement of the bill of rights.


1984 ◽  
Vol 1 (1) ◽  
pp. 27-52
Author(s):  
Mahmud A. Faksh

I.Since the end of World War 11, approximately eighty new states havebeen established. Only two, Pakistan and Cyprus, have undergone theagony of dismemberment when Bangladesh broke off in 1973 and theTurkish Republic of Northern Cyprus was declared in 1983. The worldmay now be witnessing the possible breakup of yet a third state:Lebanon, whose disintegration has been accelerated since the June 1982Israeli invasion.Shortly after the invasion began, Henry Kissinger assessed itsconsequence for Lebanon’s future, concluding, “It is neither desirablenor possible to return to the status quo ante in Lebanon.” One possibleoutcome was that some Syrian and Israeli forces would remain in thenorthern and southern ends, respectively, and the central government’sauthority would ostensibly cover the rest of the country. Implicit in theKissinger diagnosis is the possibility of eventual partition.Though the gloomy assessment by the “wizard” of US. foreign policyshould by no means be construed as a portent of an official shift awayfrom the publicly stated US. support of “Lebanon’s sovereignty andterritorial integrity,” a shadow was cast on the country’s prospects.Subsequent developments have seemed to indicate that Lebanon’sdemise looms larger than at any time since the beginning of the civil warin 1975-76.For over a year and a half national fragmentation has proceededinexorably. What many people once could imagine only with difficulty,they now acknowledge: in reality, Lebanon is facing possible death. TheSouth (35 percent of the land area) is occupied by Israel; the North andthe Biqa’ (45 percent) are controlled by Syria; Kasrawan (15 percent) iscontrolled by the Christian Maronite forces (the Lebanese Front forces),which are not subject to the government’s authority. The rest of thecountry-beleaguered Beirut and environs-was until the February1984 breakdown under the government’s shaky control supported bysymbolic US., French, Italian, and British units. The Multi-NationalForce (MNF) was subject to increasing attacks by Muslim leftist factions,as witnessed in the October 23 bombing of the quarters of U.S.Marines and French troops. Thus, instead of keeping peace, the MNFbecame ,a partisan force trying to protect itself. The US. and Frenchforces in particular seemed to have outlived their usefulness as“peacekeepers.” Recurrent fighting in southern Beirut and in theadjacent Chouf mountains, that pitted Christian Maronites and armyunits against Shi‘ite and Druse Muslims constantly threatened theexistence of President Amin Gemayel’s government and consequently arenewal of the civil war. This situation culminated in February 1984 inthe resignation of the Shafiq al-Wazzan’s cabinet, the loss ofgovernment’s control of West Beirut to Muslim-leftist militias, and theimminent collapse of Amin Gemayel’s presidency ...


Author(s):  
Rosamond C. Rodman

Expanding beyond the text of the Bible, this chapter explores instead a piece of political scripture, namely the Second Amendment of the US Constitution. Over the last half-decade, the Second Amendment has come to enjoy the status of a kind of scripture-within-scripture. Vaulted to a much more prominent status than it had held in the first 150 years or so of its existence, and having undergone a remarkable shift in what most Americans think it means, the Second Amendment provides an opportunity to examine the linguistic, racial, and gendered modes by which these changes were effected, paying particular attention to the ways in which white children and white women were conscripted into the role of the masculine, frontier-defending US citizen.


Author(s):  
Patrick Sze-lok Leung ◽  
Anthony Carty

Okinawa is now considered as Japanese territory, without challenge from most world powers. However, this is debatable from a historical viewpoint. The Ryukyu Kingdom which dominated the islands was integrated into Japan in 1879. The transformation is seen by Wang Hui as a process of modernization. This chapter argues the issue from an international law perspective. It shows that Ryukyu was an independent State as demonstrated by the 1854 Ryukyu–US Treaty, although it sent regular tributes to China. The Japanese integration by coercion is not justifiable. The people of Ryukyu were willing to continue being a tributary State rather than part of Japan. Britain, as the greatest colonial power, did not object. China and the US attempted to intervene in this affair, but no treaty has so far been concluded. Therefore, the status of Ryukyu/Okinawa remains unresolved and may need to be revisited, while putting the history context into consideration.


Pathogens ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1073
Author(s):  
Juan-Carlos Saiz

West Nile virus (WNV) is a widely distributed enveloped flavivirus transmitted by mosquitoes, which main hosts are birds. The virus sporadically infects equids and humans with serious economic and health consequences, as infected individuals can develop a severe neuroinvasive disease that can even lead to death. Nowadays, no WNV-specific therapy is available and vaccines are only licensed for use in horses but not for humans. While several methodologies for WNV vaccine development have been successfully applied and have contributed to significantly reducing its incidence in horses in the US, none have progressed to phase III clinical trials in humans. This review addresses the status of WNV vaccines for horses, birds, and humans, summarizing and discussing the challenges they face for their clinical advance and their introduction to the market.


Pathogens ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 53
Author(s):  
Vivek Khanal ◽  
Harrington Wells ◽  
Akhtar Ali

Field information about viruses infecting crops is fundamental for understanding the severity of the effects they cause in plants. To determine the status of cucurbit viruses, surveys were conducted for three consecutive years (2016–2018) in different agricultural districts of Oklahoma. A total of 1331 leaf samples from >90 fields were randomly collected from both symptomatic and asymptomatic cucurbit plants across 11 counties. All samples were tested with the dot-immunobinding assay (DIBA) against the antisera of 10 known viruses. Samples infected with papaya ringspot virus (PRSV-W), watermelon mosaic virus (WMV), zucchini yellow mosaic virus (ZYMV), and cucurbit aphid-borne-yellows virus (CABYV) were also tested by RT-PCR. Of the 10 viruses, PRSV-W was the most widespread, with an overall prevalence of 59.1%, present in all 11 counties, followed by ZYMV (27.6%), in 10 counties, and WMV (20.7%), in seven counties, while the remaining viruses were present sporadically with low incidence. Approximately 42% of the infected samples were positive, with more than one virus indicating a high proportion of mixed infections. CABYV was detected for the first time in Oklahoma, and the phylogenetic analysis of the first complete genome sequence of a CABYV isolate (BL-4) from the US showed a close relationship with Asian isolates.


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