Autocrine growth factor production and requirements by CD8+ T cells in the generation of tumor-specific CTL in vitro

Cytokine ◽  
1989 ◽  
Vol 1 (1) ◽  
pp. 105
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Cd8 T Cells ◽  
Autocrine Growth ◽  
Autocrine Growth Factor ◽  
Factor Production ◽  
Growth Factor Production

Autocrine Growth Factor Production by Fetal, Keloid, and Normal Dermal Fibroblasts

2003 ◽  
Vol 5 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Matthew M. Hanasono ◽  
Magdalena Kita ◽  
Anthony A. Mikulec ◽  
Devon Lonergan ◽  
R. James Koch
Keyword(s):  
Growth Factor ◽  
Dermal Fibroblasts ◽  
Autocrine Growth ◽  
Autocrine Growth Factor ◽  
Factor Production ◽  
Growth Factor Production

scholarly journals Vascular endothelial growth factor production by human luteinized granulosa cells in vitro

1997 ◽  
Vol 12 (12) ◽  
pp. 2756-2761 ◽  
Author(s):  
A. Lee ◽  
L. K. Christenson ◽  
P. E. Patton ◽  
K. A. Burry ◽  
R. L. Stouffer
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Granulosa Cells ◽  
Vascular Endothelial ◽  
Factor Production ◽  
Growth Factor Production ◽  
Endothelial Growth Factor

scholarly journals Interleukin-11 acts as an autocrine growth factor for human megakaryoblastic cell lines

Blood ◽  
1993 ◽  
Vol 81 (4) ◽  
pp. 889-893 ◽  
Author(s):  
S Kobayashi ◽  
M Teramura ◽  
I Sugawara ◽  
K Oshimi ◽  
H Mizoguchi
Keyword(s):  
Growth Factor ◽  
Cell Lines ◽  
Antisense Oligonucleotides ◽  
Leukemia Cell ◽  
Dependent Manner ◽  
Autocrine Growth ◽  
Autocrine Loop ◽  
Autocrine Growth Factor ◽  
Interleukin 11

Abstract The cytokine interleukin-11 (IL-11) promotes normal human megakaryocytopoiesis in vitro. However, its role in abnormal megakaryocytopoiesis is not well known. Accordingly, we studied its effects on human megakaryoblastic cell lines CMK and Meg-J. IL-11 stimulated the proliferation of CMK and Meg-J in a dose-dependent manner with maximal growth being achieved at the concentration of 50 and 500 ng/mL, respectively. The growth of the cells was inhibited by anti-IL-11 antibody and IL-11 antisense oligonucleotides. IL-11 transcripts were detected in these two cell lines using a reverse transcriptase-polymerase chain reaction assay. These findings indicate that IL-11 might be an autocrine growth factor for megakaryoblastic cells. IL-11 transcripts also existed in other leukemia cell lines: HL- 60, U937, and K562. However, the growth of these cells was not stimulated by IL-11, and was not inhibited by IL-11 antisense oligonucleotides. These results suggested that IL-11 might regulate malignant cells of the megakaryocytic lineage, in part by an autocrine loop.

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