Across-Polarity Quantification Method for Broad Metabolome Coverage Based on Consecutive Nanoconfined Liquid Phase Nanoextraction Technology: Application in Discovering the Plasma Potential Biomarkers of Different Types of Cancer

2021 ◽  
pp. 338577
Author(s):  
Chunyu Yu ◽  
Qian Zhang ◽  
Yilin Zou ◽  
Ran Liu ◽  
Jinhua Zhao ◽  
...  
2021 ◽  
Vol 7 (3) ◽  
pp. 38
Author(s):  
Alexandra Korotaeva ◽  
Danzan Mansorunov ◽  
Natalya Apanovich ◽  
Anna Kuzevanova ◽  
Alexander Karpukhin

Neuroendocrine neoplasms (NEN) are infrequent malignant tumors of a neuroendocrine nature that arise in various organs. They occur most frequently in the lungs, intestines, stomach and pancreas. Molecular diagnostics and prognosis of NEN development are highly relevant. The role of clinical biomarkers can be played by microRNAs (miRNAs). This work is devoted to the analysis of data on miRNA expression in NENs. For the first time, a search for specificity or a community of their functional characteristics in different types of NEN was carried out. Their properties as biomarkers were also analyzed. To date, more than 100 miRNAs have been characterized as differentially expressed and significant for the development of NEN tumors. Only about 10% of the studied miRNAs are expressed in several types of NEN; differential expression of the remaining 90% was found only in tumors of specific localizations. A significant number of miRNAs have been identified as potential biomarkers. However, only a few miRNAs have values that characterized their quality as markers. The analysis demonstrates the predominant specific expression of miRNA in each studied type of NEN. This indicates that miRNA’s functional features are predominantly influenced by the tissue in which they are formed.


2011 ◽  
Vol 391-392 ◽  
pp. 60-64
Author(s):  
Fang Yi Long ◽  
Sheng Li Wu ◽  
Juan Zhu ◽  
Yuan Du ◽  
Guo Liang Zhang

The bonding intensity of four kinds of ores from Brazil, Australia and South Africa is researched in this study, and the influence factors are analyzed. The results show that, the ores of different types have apparently differences in bonding intensity, ores from Brazil and South Africa have high bonding intensity, while ores from Australia have low bonding intensity; The foundation of generation of effective liquid is adequate liquid phase fluidity and the lower porosity of core ore; The ratio of porosity of core ore and the index of liquid phase fluidity has negative correlation with the bonding intensity.


2014 ◽  
Vol 10 ◽  
pp. 2729-2737 ◽  
Author(s):  
Gerald Jarre ◽  
Steffen Heyer ◽  
Elisabeth Memmel ◽  
Thomas Meinhardt ◽  
Anke Krueger

Nanodiamonds functionalized with different organic moieties carrying terminal amino groups have been synthesized. These include conjugates generated by Diels–Alder reactions of ortho-quinodimethanes formed in situ from pyrazine and 5,6-dihydrocyclobuta[d]pyrimidine derivatives. For the quantification of primary amino groups a modified photometric assay based on the Kaiser test has been developed and validated for different types of aminated nanodiamond. The results correspond well to values obtained by thermogravimetry. The method represents an alternative wet-chemical quantification method in cases where other techniques like elemental analysis fail due to unfavourable combustion behaviour of the analyte or other impediments.


2017 ◽  
Vol 19 (22) ◽  
pp. 5269-5302 ◽  
Author(s):  
Willinton Y. Hernández ◽  
Jeroen Lauwaert ◽  
Pascal Van Der Voort ◽  
An Verberckmoes

Layered double hydroxides (LDHs) and derived materials have been widely used as heterogeneous catalysts for different types of reactions either in gas or in liquid phase.


2013 ◽  
Vol 200 ◽  
pp. 256-260 ◽  
Author(s):  
I.I. Syvorotka ◽  
Igor M. Syvorotka ◽  
S.B. Ubizskii

The series of (LuBi)3Fe5O12 film were grown on (111) oriented GGG substrate with diameters 1, 2 and 3 inch by liquid phase epitaxy using Bi2O3-base flux. Different types of surface morphology on the grown films were observed. The films’ surface was smooth and mirror while the film thickness was less than 13 μm and becomes rough for thickness above this value. The grown films were characterized by measuring magnetization loops and magneto-optic Faraday rotation under magnetization reversal as well as ferromagnetic resonance (FMR). All films with mirror surface demonstrate the in-plane magnetization, high Faraday rotation and FMR linewidth about 0.8 Oe at 9.1 GHz and room temperature.


2019 ◽  
Vol 23 (4) ◽  
pp. 41-45
Author(s):  
V.A. Zhigulsky ◽  
D.V. Zhigulskaya ◽  
V.F. Shuisky ◽  
E.Yu. Maximova

The technology of a pre-project comparative assessment of alternative options for locating production facilities, developed by the St. Petersburg ecological project company Eco-Express-Service, is presented. Comparison of options is carried out on the basis of a multi-criteria score-rating assessment in two stages: first, the determination and comparison of values of the environmental safety criteria, then a generalized summary assessment across the totality of the criteria. To bring the obtained results into a general comparative scoring, four competitive methods are used, differing in the degree of detail of the accounting for the indicator significance of the criteria and the ratio of different types of object sites. The stages of technology application are illustrated with concrete examples. The main positive effects and advantages of its use are due to the increased environmental safety of construction and significant (by an order of magnitude) savings of the federal, regional and local budgets and investors owing eliminating unfavorable placement options for the object at the early stages of development.


Author(s):  
Kathy T. Do ◽  
Mitchell J. Prinstein ◽  
Eva H. Telzer

Peers have a profound impact on shaping adolescents’ attitudes and norms about the consequences of engaging in health risk behaviors. However, not all adolescents are equally susceptible to peer influence. Thus, a question that remains unanswered is whether there are potential biomarkers that index an individual’s level of susceptibility to peer environments. The present review considers emerging evidence on the construct of peer influence susceptibility and proposes neurobiological biomarkers that might render some adolescents more susceptible to peer influence than others. Using a differential susceptibility framework, this chapter discusses how individual variation in peer influence susceptibility interacts with different types of peer environments (e.g., risk-promoting versus risk-averse) to predict shifts in adolescent behavior. This perspective suggests that a heightened susceptibility to peer influence may not only increase maladaptive, antisocial behavior in negative peer environments, but may also promote adaptive, prosocial behavior in positive peer environments.


2012 ◽  
Vol 624 ◽  
pp. 186-189
Author(s):  
Zhong Zhou Yi ◽  
Hong Yan Sun ◽  
Yi Ming Liu ◽  
Feng Rui Zhai

YSZ/NiO composite powders were successfully synthesized by chemical liquid phase co-precipitation process. YSZ/NiO composite ceramic bodies were prepared by gel casting. Three different types and amounts of pore-formers were added into the YSZ/NiO suspension. The results show that the YSZ/NiO composite with the best properties and optimal porosity of 42.18% was obtained when the 7wt.% corn meal was used as pore-former.


T-Comm ◽  
2021 ◽  
Vol 15 (7) ◽  
pp. 50-54
Author(s):  
Nikita S. Kalmykov ◽  
◽  
Vladimir A. Dokuchaev ◽  

In this article the structure, main components and functioning of Segment Routing (SR) are analyzed. Segment routing is a WAN traffic routing technique existing on MPLS and only-BGP networks. Segment routing is also considered as a way of improving the infrastructure performance and efficiency. The main advantages of SR are achieved through the implementation of the SDN concept approach, without changing the standard data transferring plane for each of the technologies, above which SR can be applied. The article also covers the main areas of SR technology application, interaction in a centralized and decentralized network. The article provides the examples of controllers for SDN implementation using SR. The presence of a controller in the network permits the realization of bandwidth on demand, traffic prioritize, selection of the most suitable route in the network for different types of traffic easier and more often without any protocols or devices. Another important advantage of controller’s implementation on networks using SR can be a reduction of the services recovery time after a failure, because the route will be rebuilt faster (compared to MPLS). SR can be considered as an opportunity to refuse from such protocols as LDP or RSVP for situation when used on a network in tandem with a controller. IPv6 networks, using SR, are able to acquire additional capabilities in programmability and flexibility.


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