Evaluation of the role of ischemia modified albumin as a new biochemical marker for differentiation between ischemic and hemorrhagic stroke

Background: Stroke is the second single most common cause of death in the world causing approximately 6.7 million deaths each year. It has a greater disability impact on an individual than any other chronic disease. The aim of the study is to review the value of CTA in detection and evaluation of non-traumatic cervicocerebral vascular disease (stroke). Subjects & Methods: A prospective observational study conducted in the Department of Radiodiagnosis, Kamineni Hospitals, L.B. Nagar, Hyderabad over 60 patients during April 2016 to May 2017. Results: Out of 60 patients, 35(58.3%) patients had ischemic stroke, 25(41.6%) had hemorrhagic stroke. Overall stroke was seen mostly in the age group of 61-70 (28.3%) years, with a Male to female ratio of 3:2. Conclusion: Hypertension was the most common risk factor associated with this disease, followed by diabetes. CTA helps in accurate diagnosis, risk stratification and planning management protocols.

Download Full-text

Supper Timing and Cardiovascular Mortality: The Japan Collaborative Cohort Study

Nutrients ◽

10.3390/nu13103389 ◽

2021 ◽

Vol 13 (10) ◽

pp. 3389

Author(s):

Jingyun Tang ◽

Jia-Yi Dong ◽

Ehab S. Eshak ◽

Renzhe Cui ◽

Kokoro Shirai ◽

...

Keyword(s):

Hemorrhagic Stroke ◽

Proportional Hazards ◽

Cox Proportional Hazards ◽

Stroke Mortality ◽

Hazard Ratios ◽

Risk Of Mortality ◽

Increased Risk ◽

Study Participants

Evidence on the role of supper timing in the development of cardiovascular disease (CVD) is limited. In this study, we examined the associations between supper timing and risks of mortality from stroke, coronary heart disease (CHD), and total CVD. A total of 28,625 males and 43,213 females, aged 40 to 79 years, free from CVD and cancers at baseline were involved in this study. Participants were divided into three groups: the early supper group (before 8:00 p.m.), the irregular supper group (time irregular), and the late supper group (after 8:00 p.m.). Cox proportional hazards regression models were used to calculate hazard ratios (HRs) for stroke, CHD, and total CVD according to the supper time groups. During the 19-year follow-up, we identified 4706 deaths from total CVD. Compared with the early supper group, the multivariable HR of hemorrhagic stroke mortality for the irregular supper group was 1.44 (95% confidence interval [CI]: 1.05–1.97). There was no significant association between supper timing and the risk of mortality from other types of stroke, CHD, and CVD. We found that adopting an irregular supper timing compared with having dinner before 8:00 p.m. was associated with an increased risk of hemorrhagic stroke mortality.

Download Full-text

The Role of Blood Pressure and Aldosterone in the Production of Hemorrhagic Stroke in Captopril-Treated Hypertensive Rats

Stroke ◽

10.1161/01.str.28.9.1821 ◽

1997 ◽

Vol 28 (9) ◽

pp. 1821-1829 ◽

Cited By ~ 40

Author(s):

Andrew B. MacLeod ◽

Sudesh Vasdev ◽

John S. Smeda

Keyword(s):

Blood Pressure ◽

Hemorrhagic Stroke ◽

Hypertensive Rats

Download Full-text

The role of ischemia-modified albumin levels in the diagnosis of acute appendicitis

Translational Surgery ◽

10.4103/ts.ts_13_17 ◽

2017 ◽

Vol 2 (3) ◽

pp. 62 ◽

Cited By ~ 1

Author(s):

Baris Sevinç ◽

Ersin Turan ◽

Hüseyin Kurku ◽

Gürcan Simsek ◽

Recep Demirgül ◽

...

Keyword(s):

Acute Appendicitis ◽

Ischemia Modified Albumin

Download Full-text

The Role of Mast Cells in Stroke

Cells ◽

10.3390/cells8050437 ◽

2019 ◽

Vol 8 (5) ◽

pp. 437 ◽

Cited By ~ 8

Author(s):

Edoardo Parrella ◽

Vanessa Porrini ◽

Marina Benarese ◽

Marina Pizzi

Keyword(s):

Central Nervous System ◽

Immune Response ◽

Nervous System ◽

Mast Cells ◽

Brain Edema ◽

Hemorrhagic Stroke ◽

Inflammatory Responses ◽

Adult Brain ◽

The Central Nervous System

Mast cells (MCs) are densely granulated perivascular resident cells of hematopoietic origin. Through the release of preformed mediators stored in their granules and newly synthesized molecules, they are able to initiate, modulate, and prolong the immune response upon activation. Their presence in the central nervous system (CNS) has been documented for more than a century. Over the years, MCs have been associated with various neuroinflammatory conditions of CNS, including stroke. They can exacerbate CNS damage in models of ischemic and hemorrhagic stroke by amplifying the inflammatory responses and promoting brain–blood barrier disruption, brain edema, extravasation, and hemorrhage. Here, we review the role of these peculiar cells in the pathophysiology of stroke, in both immature and adult brain. Further, we discuss the role of MCs as potential targets for the treatment of stroke and the compounds potentially active as MCs modulators.

Download Full-text

Current role of ischemia-modified albumin in routine clinical practice

Biomarkers ◽

10.3109/1354750x.2010.513449 ◽

2010 ◽

Vol 15 (8) ◽

pp. 655-662 ◽

Cited By ~ 27

Author(s):

Alberto Dominguez-Rodriguez ◽

Pedro Abreu-Gonzalez

Keyword(s):

Clinical Practice ◽

Routine Clinical Practice ◽

Current Role ◽

Ischemia Modified Albumin

Download Full-text

Ischemia-modified albumin as a biochemical marker in children with neuroblastoma and soft tissue sarcomas

Journal of Clinical Laboratory Analysis ◽

10.1002/jcla.20469 ◽

2011 ◽

Vol 25 (4) ◽

pp. 255-258 ◽

Cited By ~ 4

Author(s):

Teresa Stachowicz-Stencel ◽

Anna Synakiewicz ◽

Anna Owczarzak ◽

Aleksandra Sliwińska ◽

Ewa Aleksandrowicz-Wrona ◽

...

Keyword(s):

Soft Tissue ◽

Biochemical Marker ◽

Soft Tissue Sarcomas ◽

Ischemia Modified Albumin

Download Full-text

Uric Acid Level is Positively Associated With NT-proBNP Concentration in Slovak Heart Failure Patients

Physiological Research ◽

10.33549/physiolres.934186 ◽

2019 ◽

pp. 767-774

Author(s):

P. SABAKA ◽

A. DUKAT ◽

J. GAJDOSIK ◽

M. CAPRNDA ◽

M. BENDZALA ◽

...

Keyword(s):

Heart Failure ◽

Multivariate Analysis ◽

Uric Acid ◽

Biochemical Marker ◽

Nyha Class ◽

Function Class ◽

Clinical Severity ◽

Slovak Population ◽

Primary Care Patients

Increased concentration of uric acid (UA) is positively associated with the clinical severity but negatively associated with the prognosis of heart failure (HF). However, data related to the association between UA concentration and N-terminal pro brain natriuretic peptide (NT-proBNP) are still lacking. The aim of the study was to analyze the relationships between UA, NT-proBNP, clearance of creatinine and NYHA function class and echocardiographic variables in the Slovak population of primary care patients diagnosed with HF. The association between UA and NT-proBNP was assessed by multivariate analysis. 848 patients (402 men, 446 women) with HF were included in the study. NT-proBNP correlated with UA in both men and women after adjustment based on age, BMI and glomerular filtration rate (r=0.263, p<0.0001; r=0.293, p<0.0001). UA concentration rose with the severity of the NYHA class and was significantly higher in patients with moderate and severe systolic dysfunctions as well as with diastolic dysfunction in the multivariate analysis. In conclusion, our study in Slovak population with HF has revealed a positive correlation between the concentration of UA and NT-proBNP, and the independency of this association on confounding factors. The results support the role of UA as a biochemical marker of HF severity and prognosis.

Download Full-text