scholarly journals Latency duration beyond viability in women undergoing ultrasound-indicated cerclage

2022 ◽  
Vol 226 (1) ◽  
pp. S550-S551
Author(s):  
Brian E. Brocato ◽  
John Owen ◽  
Jeff M. Szychowski
Keyword(s):  
Latency Duration

scholarly journals Reliability of diaphragmatic motor-evoked potentials induced by transcranial magnetic stimulation

2020 ◽  
Vol 129 (6) ◽  
pp. 1393-1404
Author(s):  
Joseph F. Welch ◽  
Patrick J. Argento ◽  
Gordon S. Mitchell ◽  
Emily J. Fox
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Evoked Potentials ◽  
Magnetic Stimulation ◽  
Motor Evoked Potentials ◽  
Surface Emg ◽  
Noninvasive Technique ◽  
Large Variability ◽  
Adult Men ◽  
Latency Duration ◽  
Excellent Reproducibility

Transcranial magnetic stimulation (TMS) is a noninvasive technique to assess neural impulse conduction along the cortico-diaphragmatic pathway. The reliability of diaphragm motor-evoked potentials (MEP) induced by TMS is unknown. Notwithstanding large variability in MEP amplitude, we found good-to-excellent reproducibility of all MEP characteristics (latency, duration, amplitude, and area) both within- and between-day in healthy adult men and women. Our findings support the use of TMS and surface EMG to assess diaphragm activation in humans.

scholarly journals Neonatal Survivability following Previable PPROM after Hospital Readmission for Intervention

2020 ◽  
Vol 10 (04) ◽  
pp. e395-e402
Author(s):  
Felicia LeMoine ◽  
Robert C. Moore ◽  
Andrew Chapple ◽  
Ferney A. Moore ◽  
Elizabeth Sutton
Keyword(s):  
Gestational Age ◽  
Neonatal Intensive Care ◽  
Intensive Care Unit Discharge ◽  
Expectant Management ◽  
Antibiotic Administration ◽  
Tertiary Referral Center ◽  
Membrane Rupture ◽  
South Central ◽  
Prelabor Rupture Of Membranes ◽  
Latency Duration

Abstract Objective To describe our hospital's experience following expectant management of previable preterm prelabor rupture of membranes (pPPROM). Study Design Retrospective review of neonatal survival and maternal and neonatal outcomes of pPPROM cases between 2012 and 2019 at a tertiary referral center in South Central Louisiana. Regression analyses were performed to identify predictors of neonatal survival. Results Of 81 cases of pPPROM prior to 23 weeks gestational age (WGA), 23 survived to neonatal intensive care unit discharge (28.3%) with gestational age at rupture ranging from 180/7 to 226/7 WGA. Increased latency (adjusted odds ratio [aOR] = 1.30, 95% confidence interval [CI] = 1.11, 1.52) and increased gestational age at rupture (aOR = 1.62, 95% CI = 1.19, 2.21) increased the probability of neonatal survival. Antibiotics prior to delivery were associated with increased latency duration (adjusted hazard ratio = 0.55, 95% CI = 0.42, 0.74). Conclusion Neonatal survival rate following pPPROM was 28.3%. Later gestational age at membrane rupture and increased latency periods are associated with increased neonatal survivability. Antibiotic administration following pPPROM increased latency duration.

scholarly journals The effect of domestication on post-conflict management: wolves reconcile while dogs avoid each other

2018 ◽  
Vol 5 (7) ◽  
pp. 171553 ◽  
Author(s):  
Simona Cafazzo ◽  
Sarah Marshall-Pescini ◽  
Martina Lazzaroni ◽  
Zsófia Virányi ◽  
Friederike Range
Keyword(s):  
Conflict Management ◽  
Environmental Conditions ◽  
Domestic Dogs ◽  
Ecological Conditions ◽  
Functional Relationships ◽  
Social Species ◽  
Post Conflict ◽  
Latency Duration

Highly cooperative social species are expected to engage in frequent reconciliation following conflicts in order to maintain pack cohesiveness and preserve future cooperation. By contrast, in social species with low reliance on cooperation, reconciliation is expected to be less frequent. Here, we investigate the pattern of reconciliation in four captive wolf packs and four captive dog packs. We provide evidence for reconciliation in captive wolves, which are highly dependent on cooperation between pack members, while domestic dogs, which rely on conspecific cooperation less than wolves, avoided interacting with their partners after conflicts. Occurrence, intensity, latency, duration and initiation of wolf reconciliations appeared to vary as a consequence of a compromise between the costs (e.g. risk of further aggression) and the benefits (e.g. restoring relationship with opponents) of such interactions. Our results are in line with previous findings on various wolf packs living under different social and ecological conditions, suggesting that reconciliation is an important strategy for maintaining functional relationships and pack cohesiveness. However, current results on dogs are in contrast to the only other study showing that reconciliation can occur also in this species. Therefore, the occurrence of reconciliation in dogs may be influenced by social and environmental conditions more than in wolves. Which factors promote and modulate reconciliation in dogs needs to be further investigated.

scholarly journals Ameliorative potential of Anacyclus pyrethrum extract in generalized seizures in rat: Possible cholinergic mediated mechanism

2019 ◽  
Vol 14 (4) ◽  
pp. 188-195
Author(s):  
Kenza Bezza ◽  
Zineb El Gabbas ◽  
Jawad Laadraoui ◽  
Mehdi Ait Laaradia ◽  
Sara Oufquir ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Video Clip ◽  
Ethanol Extract ◽  
Control Group ◽  
Anticonvulsant Effect ◽  
Onset Seizure ◽  
Generalized Seizures ◽  
Full Screen ◽  
Time Latency ◽  
Latency Duration

The present study evaluates the anticonvulsant activity of the roots of Anacyclus pyrethrum using pilocarpine-induced experimental model of epilepsy in rat, and to determine its possible anticonvulsant mechanism. Ethanol extract (200 and 400 mg/kg) or alkylamides (25 and 50 mg/kg) was administered orally 45 min before the injection of pilocarpine-induced (400 mg/kg) seizures. The possible anticonvulsant mechanism was investigated by testing the effect of atropine (2 mL/kg) and scopolamine (1 mg/kg). The scoring of seizure severity, seizures time latency, duration of total seizures and percentage of mortality protection were recorded. Ethanol extract and alkylamides prolonged the time of onset seizure and decreased the duration of seizures compared to control group (p<0.001). The seizure protection was 100%. The co-administered of ethanol extract of A. pyrethrum and alkylamides with atropine completely abolished the pilocarpine-induced seizures. Video Clip of Methodology: Anticonvulsant effect: 6 min 7 sec:  Full Screen   Alternate

scholarly journals Evaluation of Disk Halo Size after Implantation of a Collamer Lens with a Central Hole (ICL V4c)

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Xun Chen ◽  
Tian Han ◽  
Feng Zhao ◽  
Huamao Miao ◽  
Xiaoying Wang ◽  
...  
Keyword(s):  
Light Response ◽  
Pupillary Response ◽  
Central Hole ◽  
Implantable Collamer Lens ◽  
Contraction Amplitude ◽  
Pupillary Light ◽  
Significant Difference ◽  
Icl V4c ◽  
Latency Duration ◽  
Average Pupil

Purpose. To investigate disk halo size changes produced by a glare source after surgical insertion of an implantable collamer lens with a central hole (ICL V4c) for myopia correction. Methods. In this prospective study, disk halo size and pupillary light response with a vision monitor were measured preoperatively and at 1 week, 1 month, and 3 months postoperatively. Pupillary light response parameters included contraction amplitude, latency, duration, and velocity; dilation latency, duration, and velocity; and initial, maximum, minimum, and average pupil diameters. Results. Forty-two right eyes of 42 patients were enrolled. Postoperative uncorrected distance visual acuity was better than or equal to 20/20 in all eyes. Compared to preoperative values, disk halo size showed no significant difference at 1 week postoperatively (P>0.05) and then decreased significantly at 1 and 3 months postoperatively (both P<0.001). Contraction amplitude and velocity, as well as dilation velocity, decreased significantly at all postoperative time points (all P<0.001). Disk halo size at 3 months postoperatively was significantly correlated with initial (r = 0.446, P=0.003), maximum (r = 0.483, P=0.001), minimum (r = 0.425, P=0.005), and average pupil diameters (r = 0.474, P=0.002). Conclusions. After ICL V4c implantation, disk halo size was reduced in the short term. Patients with smaller pupil sizes during pupillary response to light experienced smaller halos after ICL V4c implantation.

Co-administration of ondansetron and casopitant mesylate, a novel NK-1 receptor antagonist, results in augmented anti-emetic activity in the ferret

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 18608-18608 ◽  
Author(s):  
R. C. Gagnon ◽  
A. G. King
Keyword(s):  
Receptor Antagonist ◽  
Complete Response ◽  
Clinical Development ◽  
Phase Iii ◽  
Pharmacokinetic Analysis ◽  
Depression And Anxiety ◽  
Complete Protection ◽  
Highly Emetogenic Chemotherapy ◽  
Phase Iii Trials ◽  
Latency Duration

18608 Background: As monotherapies, ondansetron (a 5HT3 receptor antagonist) and casopitant mesylate ( GW679769 ) are effective anti-emetics in models of chemotherapy-induced nausea and vomiting in the ferret. To demonstrate the potential benefit of combination therapy, suboptimal doses of both ondansetron and casopitant mesylate were administered to ferrets receiving cisplatin. Methods: A 4x4 factorial design was utilized to test for therapeutically synergistic anti-emetic activity. Suboptimal doses (administered as monotherapy, which reduced vomiting and retching by >50% compared to control ferrets but did not result in complete protection) of each compound alone and in combination (0.3, 0.1, and 0.03 mg/kg) were administered 25 minutes prior to injection with cisplatin (10 mg/kg, IP). All emetic events/behaviors were recorded digitally via camera and DVR. Normal behaviors (eating, drinking, urination, defecation), emetic events (vomits, retches), and peri-emetic events (excessive mouth licking, burrowing, eye squinting, backward walking, and body scratching) were recorded temporally. All events were analyzed by finding the cumulative sum of events over time. Therapeutic synergy calculations were determined by analysis of variance. Results: Analysis of emetic events demonstrated the combination of ondansetron and casopitant mesylate resulted in significantly fewer events than either agent alone. Similar activity was demonstrated for vomits, retches, event latency, duration of emesis, water intake, food intake, and complete response. Conclusions: Co-administration of ondansetron and casopitant mesylate results in therapeutically synergistic anti-emetic and potential anti-nausea activity in this cisplatin-induced emesis model in ferrets. Pharmacokinetic analysis indicated no alteration of disposition of either agent. Therefore, we believe the synergy observed between ondansetron and casopitant mesylate is the result of their complementary mechanisms of pharmacologic action. Casopitant mesylate is currently in phase III trials for the prevention of PONV and CINV from moderately and highly emetogenic chemotherapy. It is also in clinical development for depression and anxiety. [Table: see text]

Narcissistic People Cannot Be Moved Easily by Visual Stimulation

Perception ◽  
10.1068/p7062 ◽  
2011 ◽  
Vol 40 (11) ◽  
pp. 1390-1392 ◽  
Author(s):  
Takeharu Seno ◽  
Yuki Yamada ◽  
Keiko Ihaya
Keyword(s):  
Motion Perception ◽  
Visual Stimulation ◽  
Psychological Experiment ◽  
Personality Assessments ◽  
Latency Duration ◽  
Self Motion ◽  
The Relationship

We examined the relationship between personality and visually induced self-motion perception (latency, duration, and magnitude). A psychological experiment with radially expanding patterns that induced self-motion perception along the fore and aft axis was conducted, followed by personality assessments. We found that all the measures of self-motion perception we examined correlated negatively with the degree of narcissistic traits.

scholarly journals Latency duration of preterm premature rupture of membranes and neonatal outcome: a retrospective single-center experience

2021 ◽  
Author(s):  
Hanna Müller ◽  
Ann-Christin Stähling ◽  
Nora Bruns ◽  
Christel Weiss ◽  
Maria Ai ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Bronchopulmonary Dysplasia ◽  
Gestational Age ◽  
Distress Syndrome ◽  
Neonatal Outcome ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Latency Duration

AbstractIn preterm premature rupture of membranes (PPROM), a decision between early delivery with prematurity complications and pregnancy prolongation bearing the risk of chorioamnionitis has to be made. To define disadvantages of delayed prolongation, latency duration of PPROM in expectantly managed pregnancies was investigated. We included those PPROMs > 48 h leading to preterm birth prior 37 weeks’ gestation and retrospectively analyzed 84 preterm infants fulfilling these criteria. The association between latency duration/appearance of PPROM and respiratory outcome (primary outcomes) and neurological outcome (secondary outcomes) was investigated. The study showed that latency duration of PPROM is not associated with clinical or histological chorioamnionitis (p = 0.275; p = 0.332). As the numerous clinical parameters show multicollinearity between each other, we performed a multiple regression analysis to consider this fact. Respiratory distress syndrome is significantly associated with gestational age at PPROM (p < 0.001), and surfactant application is significantly associated with PPROM duration (p = 0.014). The other respiratory parameters including steroids and diuretics therapy, bronchopulmonary dysplasia, and the neurological parameters (intraventricular hemorrhage, Bayley II testing at a corrected age of 24 months) were not significantly associated with PPROM duration or gestational age at PPROM diagnosis.Conclusion: Latency duration of PPROM was not associated with adverse neonatal outcome in expectantly and carefully managed pregnancies, but respiratory distress syndrome was pronounced. The observed effect of pronounced respiratory distress syndrome can be treated with surfactant preparations and was not followed by increased rate of bronchopulmonary dysplasia. What is Known:• In case of preterm premature rupture of membranes, a decision between pregnancy prolongation with the risk of chorioamnionitis and early delivery with prematurity complications has to be made.• Chorioamnionitis is a dangerous situation for the pregnant woman and the fetus.• Impaired neurodevelopmental outcome is strongly correlated with pronounced prematurity due to the increased rate of serious complications. What is New:• Respiratory distress syndrome is significantly associated with gestational age at PPROM, and surfactant application is significantly associated with PPROM duration.• Latency duration of PPROM is not associated with adverse respiratory neonatal outcome (therapy with continuous positive airway pressure, therapy with diuretics and/or steroids, bronchopulmonary dysplasia) in expectantly and carefully managed pregnancies.• Intraventricular hemorrhage and Bayley II testing at a corrected age of 24 months are not associated with latency duration of PPROM when pregnancies are carefully observed.

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