Race and gender are not independent risk factors of allograft loss after kidney transplantation

Background: The CREST trial showed that risk of stroke, MI, death, and composite of the any of the 3 adverse events during the periprocedural period of carotid artery stent (CAS) is 4.1%, 1.1%. 0.7%, and 7.2% respectively. We aim to assess trends of periprocedural outcomes after CAS based on different age strata. Methods: A cohort of patients with CAS is identified from the National In patient Sample database using the procedure codes (00.63) for the years 2001 through 2009. We only included elective admissions for CAS. Missing observations on the death status are eliminated. Age was stratified as follows: < 60, 61-70, 71-80, and > 80. Trend analysis for the following periprocedural outcomes: peri-procedure stroke, myocardial infarction ‘MI’, and death; was performed across different age strata. The Cochrane-Armitage test was used for trend analysis. Results: Over 9 years, 10,655 CAS procedures were performed; 1818 (17.1%) were performed in the octogenarians. Race and gender distribution was similar across the age strata; men and Whites were predominant. In addition to age, co-morbid high risk factors were documented in 91% of the octogenarians compared to 83.2% of those < 60. The overall periprocedural outcome of stroke, MI and death across all ages is 2.37%, (stroke 1.6%, MI 0.66% and death 0.37%). Unfavorable periprocedural outcomes in different age strata are as follows: < 60 (1.1%), 61-70 (1.9%), 71-80 (3%), and > 80 (2.75%); trend P value < 0.0001. The risk of stroke is as follows: < 60 (0.72%), 61-70 (1.3%), 71-80 (2.0%), and > 80 (1.9%), P value < 0.0003; and MI < 60 (0.33%), 61-70 (0.52%), 71-80 (0.85%), and > 80 (0.77%), P value < 0.03. Mortality remained between 0.27 and 0.44 in different age strata; P = 0.54. Conclusion: In this study, periprocedural risks of stroke and MI are lower than what was reported in the CREST trial. A slight increase in these risks is noted with age, though appeared to plateau after age of 70 years.

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Abstract 1430: Do race and gender independently predict risk factors associated with the Human papillomavirus

10.1158/1538-7445.am2016-1430 ◽

2016 ◽

Author(s):

Rebecca L. Rohde ◽

Nosayaba Osazuwa-Peters ◽

Eric Adjei Boakye ◽

Rajan Ganesh ◽

Ammar Moiyadi ◽

...

Keyword(s):

Risk Factors ◽

Human Papillomavirus ◽

Race And Gender ◽

Factors Associated ◽

And Gender

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Impact of specialized electrophysiological care on outcome of catheter ablation for supraventricular tachycardias in adults with congenital heart disease: Independent risk factors and gender aspects

Heart Rhythm ◽

10.1016/j.hrthm.2021.07.009 ◽

2021 ◽

Author(s):

Alicia Jeanette Fischer ◽

Dominic Enders ◽

Kristina Wasmer ◽

Ursula Marschall ◽

Helmut Baumgartner ◽

...

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Heart Disease ◽

Catheter Ablation ◽

Congenital Heart ◽

Independent Risk Factors ◽

Gender Aspects ◽

And Gender ◽

Supraventricular Tachycardias

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Features for deep vein thrombosis in the uninjured limbs of lower extremity fractures: a retrospective study 1454 patients

10.21203/rs.3.rs-23768/v1 ◽

2020 ◽

Author(s):

Shuang-Wei Qu ◽

Yu-Xuan Cong ◽

Peng-Fei Wang ◽

Chen Fei ◽

Zhi Li ◽

...

Keyword(s):

Risk Factors ◽

Lower Extremity ◽

Doppler Ultrasonography ◽

Vein Thrombosis ◽

Before And After ◽

Independent Risk Factors ◽

And Gender ◽

Deep Vein ◽

Actual Incidence ◽

D Dimer

Abstract Objective: The purpose of this study was to investigate the incidence of and independent risk factors for deep venous thrombosis (DVT) in the uninjured limb, before and after operation, in patients with lower extremity fractures.Methods: We collected the clinical data of patients with lower extremities fractures who presented at Xi’an Honghui Hospital between 1 July, 2015 and 31 October, 2017. Doppler ultrasonography was used to diagnose the DVT. Patients were examined pre- and postoperatively. The patients were then divided into a thrombosis group and a no thrombosis group according to the preoperative and postoperative ultrasonography results. The thrombosis group was defined as patients admitted to our hospital with DVT in the uninjured limb and the no thrombosis group was defined as patients without DVT in the uninjured limb.Results: This study enrolled 1454 patients who met the inclusion criteria. The incidence of preoperative DVT in the uninjured limb was 9.63% whereas the postoperative incidence was 20.29%. Age (OR=0.965, 95 CI%: 0.954 - 0.977; P=0.000) and gender (OR=0.667, 95% CI: 0.451-0.986, P=0.042) were independent risk factors for preoperative DVT in the uninjured limb. Blood loss (OR=0.997, 95 CI%: 0.995-1.000; P=0.020), D-dimer levels at admission (OR=0.941, 95 CI%: 0.887-0.999; P=0.045), and postoperative day 5 D-dimer levels (OR=0.889, 95 CI%: 0.819-0.965; P=0.005), were independent risk factors for postoperative DVT in the uninjured limb.Conclusion: In conclusion, the actual incidence of DVT in the uninjured lower extremity after fracture may currently be underestimated and should be pay more attention.

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Deep Vein Thrombosis in the Uninjured Limbs of Lower Extremity Fractures: A Retrospective Study of 1454 Patients

10.21203/rs.3.rs-88284/v1 ◽

2020 ◽

Author(s):

Shuang-Wei Qu ◽

Yu-Xuan Cong ◽

Peng-Fei Wang ◽

Chen Fei ◽

Zhi Li ◽

...

Keyword(s):

Risk Factors ◽

Lower Extremity ◽

Doppler Ultrasonography ◽

Vein Thrombosis ◽

Before And After ◽

Independent Risk Factors ◽

And Gender ◽

Deep Vein ◽

Actual Incidence ◽

D Dimer

Abstract Objective: The purpose of this study was to investigate the incidence of deep venous thrombosis (DVT) in the uninjured limb, before and after operation, in patients with lower extremity fractures.Methods: We collected the clinical data of patients with lower extremities fractures who presented at Xi’an Honghui Hospital between 1 July, 2015 and 31 October, 2017. Doppler ultrasonography was used to diagnose the DVT. Patients were examined pre- and postoperatively. The patients were then divided into a thrombosis group and a no thrombosis group according to the preoperative and postoperative ultrasonography results. The thrombosis group was defined as patients admitted to our hospital with DVT in the uninjured limb and the no thrombosis group was defined as patients without DVT in the uninjured limb. Results: This study enrolled 1454 patients who met the inclusion criteria. The incidence of preoperative DVT in the uninjured limb was 9.63% whereas the postoperative incidence was 20.29%. Age (OR=0.965, 95 CI%: 0.954 - 0.977; P≤0.001) and gender (OR=0.667, 95% CI: 0.451-0.986, P=0.042) were independent risk factors for preoperative DVT in the uninjured limb. Blood loss (OR=0.997, 95 CI%: 0.995-1.000; P=0.020), D-dimer levels at admission (OR=0.941, 95 CI%: 0.887-0.999; P=0.045), and postoperative day 5 D-dimer levels (OR=0.889, 95 CI%: 0.819-0.965; P=0.005), were independent risk factors for postoperative DVT in the uninjured limb.Conclusion: In conclusion, the actual incidence of DVT in the uninjured lower extremity after fracture may currently be underestimated and should be pay more attention.

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Characteristics of Clostridioides difficile infection in inflammatory bowel disease

10.21203/rs.3.rs-38076/v1 ◽

2020 ◽

Author(s):

Chenjie Tang ◽

Chengcheng Liu ◽

Yaping Han ◽

Xiaohui Zhang ◽

Wenying Xia ◽

...

Keyword(s):

Risk Factors ◽

Inflammatory Bowel Disease ◽

Molecular Epidemiology ◽

Bowel Disease ◽

Treatment Plan ◽

Clostridioides Difficile ◽

Quinolone Antibiotics ◽

Inflammatory Bowel ◽

Independent Risk Factors ◽

And Gender

Abstract Background: The epidemiology of Clostridioides difficile infection(CDI) in China is different from western countries and the characteristics of CDI among inflammatory bowel disease (IBD) in China may be unique. The aim of this study was to investigate the molecular epidemiology and to find out the risk factors of CDI among IBD inpatients in Jiangsu Province, China. Methods: Patients with IBD admitted to the First Affiliated Hospital with Nanjing Medical University from August 2013 to December 2018 were enrolled. IBD patients were matched with non IBD patients according to age and gender. Diarrhea samples were sent for CDI diagnosis and the molecular epidemiology investigation was performed. Finally, patients’ information was collected and logistic regression analysis was performed to analyze the independent risk factors of CDI in IBD patients. Results: In this study, the incidence of CDI in IBD patients was much higher than that in non IBD patients (24.6% vs. 9.0%) and community acquired infection was the main kind. The predominant type of epidemic strain of C. difficile in this study was ST54. The shorter history of IBD and recent use of quinolone antibiotics were independent risk factors for CDI among diarrhea patients with IBD. Conclusion: If the duration of IBD is within one year or quinolone antibiotics have been used recently, clinicians should consider the possibility of IBD patients complicated with CDI and adjust the treatment plan.

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Characteristics and Prognostic Factors of Patients with Chondrosarcoma Older Than 60 Years ： An Analysis of 610 Cases from the SEER Database

10.21203/rs.3.rs-689163/v2 ◽

2021 ◽

Author(s):

Tailong Chen ◽

Nan Zhou ◽

Zhongxin Tang ◽

Xing Guo ◽

Wengang Wang

Keyword(s):

Prognostic Factors ◽

Distant Metastasis ◽

Seer Database ◽

Dedifferentiated Chondrosarcoma ◽

Rare Type ◽

Histologic Subtype ◽

Race And Gender ◽

Kaplan Meier ◽

Independent Risk Factors ◽

And Gender

Abstract Background: Chondrosarcoma is a rare type of bone tumor which more commonly found in adults range from 40 to 60 years old. Few studies has described the characteristic and prognostic factors of patients older than 60 years. This study aimed to study this feature and identify the prognostic factors based on SEER database.Methods: Thus, we collected clinicopathological data of chondrosarcoma patients in the Surveillance, Epidemiology, and End Results registry database from 1975 to 2018, and then use the Kaplan-Meier to analyze the patients’ survival. We also utilize Cox proportional hazard model to explore the prognostic factors and relevant characteristic including patients’ baseline demographics (age, race, and gender), tumor characteristics (tumor extension, histologic subtype, therapy, primary site, stage and grade.Results: After the implementation of exclusion criteria, there were 610 patients with chondrosarcoma older than 60 years. Our data showed that the incidence of chondrosarcoma is slightly higher in men than in women (52.3% vs 47.7%). In general, 90.8% of tumor had metastasized to distant sites. Meanwhile, 41.8% of tumors occurred in axial location (pelvis, spine, and ribs), 50.8% of tumors occurred in extremity (long or short bones of the upper or lower extremity), and 7.4% in other location (mandible, skull, and other atypical locations). Dedifferentiated chondrosarcoma (hazard ratio [HR] =2.553; 95% confidence interval [CI]= 1.754-3.716), grade (g2:HR:=1.299; 95% CI:=0.888-1.900, g3:HR=1.839;95% CI= 1.174-2.881, g4:HR=3.284,95%CI=2.053-5.253), distant metastasis (HR=3.264; 95% CI= (2.288-4.058), non-surgery perform (HR = 2.854; 95% CI= 2.022-4.028) were independent risk factors for 5-year overall survival.Conclusion: In conclusion, higher grade, non-surgery perform, dedifferentiated chondrosarcoma and distant metastasis indicated worse prognosis survival. Surgery can significantly improve the survival time of patients.

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The Impact of Graft Nephrectomy on Subsequent Transplants: Multivariate Analysis of Risk Factors for Second Graft Loss and for Multiple Transplantations–A Single-Center Retrospective Study

ISRN Transplantation ◽

10.5402/2013/362571 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Emmanouil Giorgakis ◽

Asim Syed ◽

Hector Gonzalez

Keyword(s):

Risk Factors ◽

Multivariate Analysis ◽

Risk Factor ◽

Retrospective Study ◽

Independent Risk Factor ◽

Graft Loss ◽

Kaplan Meier ◽

Independent Risk Factors ◽

Allograft Loss ◽

The Impact

Introduction. The management of a failed primary allograft remains unclear and the evidence of the effect of transplantectomy to future transplants conflicting. Aim of this study is to review the impact of failed primary graft nephrectomy on future transplants. Materials/Methods. Retrospective study of 101 patients retransplanted in a single institution. Median follow-up was 68 months. Patients were divided into two groups; G1 (n=49) was the nephrectomy group; G2 (n=52) was the graft in situ group. The patients’ and second graft survival were analysed with the Kaplan-Meier method. The patients’ and transplant characteristics were analyzed with student’s t-test. The retransplant risk factors and the risk factors for multiple transplants were obtained via a logistic regression model. Results. The odds of second graft loss post-transplantectomy were high (OR = 5.24). Demographics, HLA mismatch and first graft rejection rates were similar among the two groups and did not affect the outcome. Transplantectomy accelerated the loss of a future failing graft. Multivariate analysis showed transplantectomy as independent risk factor for second allograft loss. Transplantectomy and younger age are significant independent risk factors for future multiple transplants. Conclusion. Transplantectomy of the failed primary graft is an independent risk factor for retransplant loss and for multiple renal transplants.

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