Abstract TP117: Outcomes of Elective Carotid Stenting in the Octogenarians

Background: The CREST trial showed that risk of stroke, MI, death, and composite of the any of the 3 adverse events during the periprocedural period of carotid artery stent (CAS) is 4.1%, 1.1%. 0.7%, and 7.2% respectively. We aim to assess trends of periprocedural outcomes after CAS based on different age strata. Methods: A cohort of patients with CAS is identified from the National In patient Sample database using the procedure codes (00.63) for the years 2001 through 2009. We only included elective admissions for CAS. Missing observations on the death status are eliminated. Age was stratified as follows: < 60, 61-70, 71-80, and > 80. Trend analysis for the following periprocedural outcomes: peri-procedure stroke, myocardial infarction ‘MI’, and death; was performed across different age strata. The Cochrane-Armitage test was used for trend analysis. Results: Over 9 years, 10,655 CAS procedures were performed; 1818 (17.1%) were performed in the octogenarians. Race and gender distribution was similar across the age strata; men and Whites were predominant. In addition to age, co-morbid high risk factors were documented in 91% of the octogenarians compared to 83.2% of those < 60. The overall periprocedural outcome of stroke, MI and death across all ages is 2.37%, (stroke 1.6%, MI 0.66% and death 0.37%). Unfavorable periprocedural outcomes in different age strata are as follows: < 60 (1.1%), 61-70 (1.9%), 71-80 (3%), and > 80 (2.75%); trend P value < 0.0001. The risk of stroke is as follows: < 60 (0.72%), 61-70 (1.3%), 71-80 (2.0%), and > 80 (1.9%), P value < 0.0003; and MI < 60 (0.33%), 61-70 (0.52%), 71-80 (0.85%), and > 80 (0.77%), P value < 0.03. Mortality remained between 0.27 and 0.44 in different age strata; P = 0.54. Conclusion: In this study, periprocedural risks of stroke and MI are lower than what was reported in the CREST trial. A slight increase in these risks is noted with age, though appeared to plateau after age of 70 years.

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Risk factors and hospitalization costs of Dementia patients: Examining race and gender variations

Indian Journal of Community Medicine ◽

10.4103/0970-0218.164396 ◽

2015 ◽

Vol 40 (4) ◽

pp. 258 ◽

Cited By ~ 2

Author(s):

Baqar Husaini ◽

AashraiS V Gudlavalleti ◽

Van Cain ◽

Robert Levine ◽

Majaz Moonis

Keyword(s):

Risk Factors ◽

Race And Gender ◽

Dementia Patients ◽

Hospitalization Costs ◽

And Gender ◽

Gender Variations

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The distribution of refraction by age and gender in a non-myopic Chinese children population aged 6–12 years

BMC Ophthalmology ◽

10.1186/s12886-020-01709-1 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Xiyan Zhang ◽

Yonglin Zhou ◽

Jie Yang ◽

Yan Wang ◽

Wenyi Yang ◽

...

Keyword(s):

Risk Factors ◽

Age Groups ◽

Chinese Children ◽

Threshold Values ◽

Work Activities ◽

Outdoor Activities ◽

High Risk Factors ◽

Gender Based ◽

And Gender ◽

Near Work

Abstract Background The Prevalence of myopia is increasing in China. This study aimed to explore the distribution of spherical equivalent (SE) and its association with age, body mass index (BMI), gender in a non-myopic Chinese children population aged 6 to 12 years. Methods A total of 6362 students were recruited for ophthalmological investigation. Demographic and myopia related behavioral information was collected. SE value was measured by the Topcon RM-8900 or KR-800autorefractors. Potential independent risk factors were determined with Odds Ratio (OR) and 95% Confidence Interval (CI) by logistic regression analysis. We further constructed the nomogram model to predict future onset of myopia. Results Among the study population, 3900 (61.3%) were non-myopic. The prevalence of myopia is 38.0% for boys and 39.5% for girls. The average SE values were 0.50 ± 0.70 D for boys and 0.60 ± 0.80 D for girls. The mean SE values decreased with age, and the value of height and BMI took on a stable trend. Threshold values for myopia varied across age groups and gender. Paternal myopia (OR: 1.22, 95%CI: 1.01–1.48), near-work activities on weekends (2.56, 1.17–5.61), and outdoor activities (0.68, 0.54–0.86) were associated with potential myopic in students. Conclusion A series of age-gender based SE threshold values were established to predict myopia in Chinese children aged 6 to 12 years. High risk factors for myopia included paternal myopia, near-work activities on weekends, and outdoor activities. Countermeasures are encouraged to reverse the increasing trend of myopia in children.

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Abstract 1430: Do race and gender independently predict risk factors associated with the Human papillomavirus

10.1158/1538-7445.am2016-1430 ◽

2016 ◽

Author(s):

Rebecca L. Rohde ◽

Nosayaba Osazuwa-Peters ◽

Eric Adjei Boakye ◽

Rajan Ganesh ◽

Ammar Moiyadi ◽

...

Keyword(s):

Risk Factors ◽

Human Papillomavirus ◽

Race And Gender ◽

Factors Associated ◽

And Gender

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Age Distribution, Comorbidities and Risk Factors for Thrombosis in Prader–Willi Syndrome

Genes ◽

10.3390/genes11010067 ◽

2020 ◽

Vol 11 (1) ◽

pp. 67 ◽

Cited By ~ 1

Author(s):

Merlin G. Butler ◽

Aderonke Oyetunji ◽

Ann M. Manzardo

Keyword(s):

Risk Factors ◽

Age Distribution ◽

Health Claims ◽

P Value ◽

Age Difference ◽

Prader Willi Syndrome ◽

Age Cohorts ◽

Risk Of Death ◽

Diagnostic Codes ◽

And Gender

Prader–Willi syndrome (PWS) is an imprinting disorder caused by lack of expression of the paternally inherited 15q11.2–q13 chromosome region. The risk of death from obesity-related complications can worsen with age, but survival trends are improving. Comorbidities and their complications such as thrombosis or blood clots and venous thromboembolism (VTE) are uncommon but reported in PWS. Two phases of analyses were conducted in our study: unadjusted and adjusted frequency with odds ratios and a regression analysis of risk factors. Individuals with PWS or non-PWS controls with exogenous obesity were identified by specific International Classification of Diseases (ICD)-9 diagnostic codes reported on more than one occasion to confirm the diagnosis of PWS or exogenous obesity in available national health claims insurance datasets. The overall average age or average age per age interval (0–17 year, 18–64 year, and 65 year+) and gender distribution in each population were similar in 3136 patients with PWS and 3945 non-PWS controls for comparison purposes, with exogenous obesity identified from two insurance health claims dataset sources (i.e., commercial and Medicare advantage or Medicaid). For example, 65.1% of the 3136 patients with PWS were less than 18 years old (subadults), 33.2% were 18–64 years old (adults), and 1.7% were 65 years or older. After adjusting for comorbidities that were identified with diagnostic codes, we found that commercially insured PWS individuals across all age cohorts were 2.55 times more likely to experience pulmonary embolism (PE) or deep vein thrombosis (DVT) than for obese controls (p-value: 0.013; confidence interval (CI): 1.22–5.32). Medicaid-insured individuals across all age cohorts with PWS were 0.85 times more likely to experience PE or DVT than obese controls (p-value: 0.60; CI: 0.46–1.56), with no indicated age difference. Age and gender were statistically significant predictors of VTEs, and they were independent of insurance coverage. There was an increase in occurrence of thrombotic events across all age cohorts within the PWS patient population when compared with their obese counterparts, regardless of insurance type.

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A phase II study of a temozolomide-based chemoradiotherapy regimen for high-risk low-grade gliomas: Preliminary results of RTOG 0424.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.2008 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. 2008-2008 ◽

Cited By ~ 18

Author(s):

Barbara Jean Fisher ◽

Jeff Lui ◽

David R. Macdonald ◽

Glenn Jay Lesser ◽

Stephen Coons ◽

...

Keyword(s):

Risk Factors ◽

High Risk ◽

Progression Free Survival ◽

P Value ◽

Low Grade ◽

Herpes Encephalitis ◽

Radiation Quality ◽

Significance Level ◽

High Risk Factors

2008 Background: The primary endpoint of RTOG 0424 was to compare the 3-year survival (OS) of a regimen of concurrent and adjuvant temozolomide (TMZ) and radiotherapy (RT) in a high-risk low-grade glioma (LGG) population to the 3 year (yr) OS rate of the high risk EORTC LGG patients (pts) reported by Pignatti et al (J Clin Oncol 2002;20(8):2076-84). Secondary endpoints were: progression-free survival (PFS), toxicity, neurocognitive and quality of life data and molecular analysis. Methods: Pts with LGG's and >=3 high risk factors (age> = 40, astrocytoma dominant histology, tumor crossing midline, tumor > = 6 cm or preoperative neurological function status >1) were eligible and treated with conformal RT (54 Gy/30 fractions) plus concurrent TMZ 75 mg/m2 /day for 6 weeks and post-RT TMZ 150-200 mg/m2/day days 1-5 q28 days for up to 12 cycles. The study was designed to detect a 43% increase in median survival time (MST) from 40.5 to 57.9 months, and a 20% improvement in 3 yr OS rate from 54% to 65%, at a 10% significance level (1 sided) and 96% power. Results: Between January 2005-August 2009 136 pts were accrued, 129 (75 males, 54 females) were evaluable. Median age was 49 years, 91% had a Zubrod score 0-1 and 69%, 25% and 6% of pts had 3,4 and 5 high risk factors respectively. With a median follow-up time of 4.1 yrs, minimum follow-up of 3 yrs, MST has not yet been reached. Three year OS rate was 73.1% (95%CI:65.3-80.8%), significantly improved from historical control with a p-value <0.0001. No difference in OS rates for pts with 3, 4 or 5 high risk factors was seen. 3 year PFS was 59.2% (95% CI:50.7-67.8%). Grade 3 adverse events (AE) occurred in 43% of pts and grade 4 AE in 10%, primarily hematologic, constitutional or gastrointestinal (nausea, anorexia) toxicity. One patient died of herpes encephalitis. Secondary analyses are ongoing. Radiation Quality Assurance was per protocol/ acceptable in 95% and 74% of pts completed chemotherapy per protocol. Conclusions: The 3 year OS rate of 73.1% for these high risk LGG pts is significantly higher than those reported for historical controls (54%, p < 0.0001, one-sided) and the study-hypothesized 65%. Supported by RTOG U10 CA21661 and CCOP U10 CA37422 grants from NCI and Merck Clinical trial information: NCT00114140.

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The distribution of refraction by age and gender in a non-myopic Chinese children population aged 6-12 years

10.21203/rs.2.16778/v4 ◽

2020 ◽

Author(s):

Xiyan Zhang ◽

Yonglin Zhou ◽

Jie Yang ◽

Yan Wang ◽

Wenyi Yang ◽

...

Keyword(s):

Risk Factors ◽

Age Groups ◽

Chinese Children ◽

Threshold Values ◽

Work Activities ◽

Outdoor Activities ◽

High Risk Factors ◽

Gender Based ◽

And Gender ◽

Near Work

Abstract Background: The Prevalence of myopia is increasing in China. This study aimed to explore the distribution of spherical equivalent (SE) and its association with age, body mass index (BMI), gender in a non-myopic Chinese children population aged 6 to 12 years. Methods: A total of 6362 students were recruited for ophthalmological investigation. Demographic and myopia related behavioral information was collected. SE value was measured by the Topcon RM-8900 or KR-800autorefractors. Potential independent risk factors were determined with Odds Ratio (OR) and 95% Confidence Interval (CI) by logistic regression analysis. We further constructed the nomogram model to predict future onset of myopia.Results: Among the study population, 3900 (61.3%) were non-myopic. The prevalence of myopia is 38.0% for boys and 39.5% for girls. The average SE values were 0.50±0.70 D for boys and 0.60±0.80 D for girls. The mean SE values decreased with age, and the value of height and BMI took on a stable trend. Threshold values for myopia varied across age groups and gender. Paternal myopia (OR: 1.22, 95%CI: 1.01-1.48), near-work activities on weekends (2.56, 1.17-5.61), and outdoor activities (0.68, 0.54-0.86) were associated with potential myopic in students. Conclusion: A series of age-gender based SE threshold values were established to predict myopia in Chinese children aged 6 to 12 years. High risk factors for myopia included paternal myopia, near-work activities on weekends, and outdoor activities. Countermeasures are encouraged to reverse the increasing trend of myopia in children.

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The distribution of refraction by age and gender in a non-myopic Chinese children population aged 6-12 years

10.21203/rs.2.16778/v3 ◽

2020 ◽

Author(s):

Xiyan Zhang ◽

Yonglin Zhou ◽

Jie Yang ◽

Yan Wang ◽

Wenyi Yang ◽

...

Keyword(s):

Risk Factors ◽

Age Groups ◽

Chinese Children ◽

Threshold Values ◽

Work Activities ◽

Outdoor Activities ◽

High Risk Factors ◽

Gender Based ◽

And Gender ◽

Near Work

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Risk Stratification in Post-ERCP Pancreatitis: How Do Procedures, Patient Characteristics, and Clinical Indicators Influence Outcomes?

Pathophysiology ◽

10.3390/pathophysiology28010007 ◽

2021 ◽

Vol 28 (1) ◽

pp. 76-85

Author(s):

Kapil Kohli ◽

Hrishikesh Samant ◽

Kashif Khan ◽

Sudha Pandit ◽

Kelli Morgan ◽

...

Keyword(s):

Risk Factors ◽

Alkaline Phosphatase ◽

African American ◽

Prior History ◽

Race And Gender ◽

History Of ◽

Risk Scoring ◽

Gender Based ◽

And Gender ◽

Risk Scoring System

Background. Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) remains common, and severe complications are associated with ERCP. There is no previous study detailing the effect of race and gender in a US-based population on risk of PEP. Methods. Data were collected on 269 “first-performed” consecutive ERCPs followed by division by race (White vs. African-American) and sex (Female vs. Male). A total of 53 probable risk factors were evaluated by uni- and multivariate analysis followed by outcomes expressed as an odds ratio (OR) (with a 95% confidence interval, 95% CI). Finally, a principal component analysis was performed to construct a risk prediction model for PEP, which can be used by clinicians at bedside. Results. After analyzing the risk factors based on race and gender-based groups, Caucasian males with PEP are more likely to have prior history of pancreatitis (p = 0.009), lower hemoglobin (p = 0.02)/blood urea nitrogen (BUN) (p = 0.01)/creatinine before ERCP (p = 0.07) and lower BUN (p = 0.01)/creatinine after ERCP (p = 0.07), while Caucasian females with PEP are more likely to have higher white blood cell (WBC) count before ERCP (p = 0.08) and lower amylase (p = 0.10)/bilirubin (p = 0.09)/ aspartate aminotransferase (AST) after ERCP (p = 0.08). African-American males with PEP are more likely to have lower weight (p = 0.001)/smaller height (p = 0.0005)/lower alkaline phosphatase (p = 0.002)/AST (p = 0.04)/ alanine transaminase (ALT) (p = 0.03) before ERCP and lower alkaline phosphatase (p = 0.002)/AST (p = 0.01)/ALT (p = 0.004) after ERCP, while African-American females with PEP are more likely to have prior history of pancreatitis (p = 0.004)/higher lipase before (p = 0.0001) and after (p = 0.05) ERCP along with increased risk with pancreatic duct cannulation (p = 0.0001) and injection (p = 0.0001)/biliary sphincterotomy (p = 0.0001). Importantly, prior history of ERCP, elevated AST after ERCP, and BUN prior to ERCP were found to be important clinical features predicting post-ERCP pancreatitis. To our knowledge, this is a first known attempt at developing a risk scoring system for PEP in a US population with decision tree learning. Conclusions. It is very evident that both patient and procedure-related risk factors vary by race and gender in the US population, leading to the development of a new risk assessment tool for PEP that can be used in clinical practice. We need to follow up with a larger prospective study to validate this novel race and gender-based risk scoring system for PEP.

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Subarachnoid Hemorrhage is a Preventable Disease with a Heritable Component

Stroke ◽

10.1161/str.32.suppl_1.364-c ◽

2001 ◽

Vol 32 (suppl_1) ◽

pp. 364-364

Author(s):

Brett M Kissela ◽

Laura Sauerbeck ◽

Daniel Woo ◽

Jane C Khoury ◽

Rakesh Shukla ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Subarachnoid Hemorrhage ◽

Family History ◽

Univariate Analysis ◽

Multivariable Analysis ◽

Cost Effective ◽

Population Based ◽

Race And Gender ◽

And Gender

P141 Background: Subarachnoid hemorrhage (SAH) affects ≥ 16,000 Americans annually and ≥ 40% die within the first 30 days. Prevention of SAH is therefore of paramount importance. We present a preliminary analysis of risk factors for SAH from our case-control, population-based study. Methods: Cases were prospectively collected and matched to 2 age-, race-, and gender-matched controls. Risk factor history, family history, neuroimaging data, and genetic samples were obtained. Multivariable analysis was performed using logistic regression. Results: Between 6/97 and 2/00, 107 cases and 197 controls were enrolled in this study. By univariate analysis: hypertension, family history of SAH or intracranial aneurysm (IA), smoking (current or ever), alcohol use, low education level, low body mass index (BMI), and low estrogen state were risk factors for SAH (p < 0.05). Results of the multivariable analysis are presented below. Conclusion: Our data confirms previous reports that SAH is a heritable condition. Further work must be done to identify the genetic basis of SAH, so that families can be screened in an efficient and cost effective way. Risk for SAH may be reduced by treating hypertension, smoking cessation, and reduced alcohol intake. The importance of low BMI as a risk factor has been previously reported but is biologically puzzling and requires further study.

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