The impact of race and ethnicity on thyroid nodules, malignancy risk, and surgical management commentary on “comparing the rate and extent of malignancy in surgically excised thyroid nodules across race and ethnicity”

2021 ◽  
Author(s):  
Kimberly M. Ramonell ◽  
Linwah Yip
Keyword(s):  
Surgical Management ◽  
Race And Ethnicity ◽  
Thyroid Nodules ◽  
Malignancy Risk ◽  
Management Commentary ◽  
The Impact

The Impact of Molecular Testing on the Surgical Management of Patients with Thyroid Nodules

2014 ◽  
Vol 21 (6) ◽  
pp. 1862-1869 ◽  
Author(s):  
Patricia Aragon Han ◽  
Matthew T. Olson ◽  
Roghayeh Fazeli ◽  
Jason D. Prescott ◽  
Sara I. Pai ◽  
...  
Keyword(s):  
Surgical Management ◽  
Thyroid Nodules ◽  
Molecular Testing ◽  
The Impact

Impact of the ultrasonography assessment method on the malignancy risk and diagnostic performance of five risk stratification systems in thyroid nodules

2021 ◽  
Author(s):  
Go Eun Yang ◽  
Dong Gyu Na
Keyword(s):  
High Risk ◽  
Risk Stratification ◽  
Diagnostic Performance ◽  
Thyroid Nodules ◽  
Assessment Method ◽  
Malignant Tumours ◽  
Malignancy Risk ◽  
Significant Difference ◽  
Estimated Risk ◽  
The Impact

Abstract Purpose Ultrasonographic (US) assessment methods may affect the estimated malignancy risk of thyroid nodules. This study aimed to investigate the impact of retrospective and prospective US assessments on the estimated malignancy risk of US features, classified categories, and diagnostic performance of five risk stratification systems (RSSs) in thyroid nodules. Methods A total of 3685 consecutive thyroid nodules (≥ 1 cm) with final diagnoses (retrospective dataset, n = 2180; prospective dataset, n = 1505) were included in this study. We compared the estimated malignancy risk of US features, classified categories, and diagnostic performances of the five common RSSs between retrospective (static US images without cine clips) and prospective datasets of real-time US assessment. Results There was no significant difference in the prevalence and histological type of malignant tumours between the two datasets (p ≥ 0.216). The malignancy risk of solid composition and nonparallel orientation was higher and that of microcalcification was lower in the prospective dataset than in the retrospective dataset (p < 0.001, p = 0.018, p = 0.007, respectively). The retrospective US assessment overestimated the malignancy risk of intermediate-or high-risk nodules according to the RSSs. Prospective US assessment showed lower specificities and higher unnecessary biopsy rates by all RSSs compared to the retrospective US assessment (p ≤ 0.006, p ≤ 0.045, respectively). Conclusions The overestimated malignancy risk of microcalcification by retrospective US assessment mainly affected the estimated risk of classified categories by RSSs. The retrospective US assessment overestimated the specificities and underestimated the unnecessary biopsy rates by all RSSs.

Molecular genetic markers for thyroid FNAB

2015 ◽  
Vol 54 (03) ◽  
pp. 94-100 ◽  
Author(s):  
P. B. Musholt ◽  
T. J. Musholt
Keyword(s):  
Genetic Markers ◽  
Thyroid Nodules ◽  
Molecular Genetic ◽  
Genetic Alterations ◽  
Diagnostic Tools ◽  
Ultrasound Screening ◽  
Thyroid Malignancy ◽  
Thyroid Carcinomas ◽  
Molecular Genetic Markers ◽  
The Impact

SummaryAim: Thyroid nodules > 1 cm are observed in about 12% of unselected adult employees aged 18–65 years screened by ultrasound scan (40). While intensive ultrasound screening leads to early detection of thyroid diseases, the determination of benign or malignant behaviour remains uncertain and may trigger anxieties in many patients and their physicians. A considerable number of thyroid resections are consecutively performed due to suspicion of malignancy in the detected nodes. Fine needle aspiration biopsy (FNAB) has been recommended for the assessment of thyroid nodules to facilitate detection of thyroid carcinomas but also to rule out malignancy and thereby avoid unnecessary thyroid resections. However, cytology results are dependent on experience of the respective cytologist and unfortunately inconclusive in many cases. Methods: Molecular genetic markers are already used nowadays to enhance sensitivity and specificity of FNAB cytology in some centers in Germany. The most clinically relevant molecular genetic markers as pre-operative diagnostic tools and the clinical implications for the intraoperative and postoperative management were reviewed. Results: Molecular genetic markers predominantly focus on the preoperative detection of thyroid malignancies rather than the exclusion of thyroid carcinomas. While some centers routinely assess FNABs, other centers concentrate on FNABs with cytology results of follicular neoplasia or suspicion of thyroid carcinoma. Predominantly mutations of BRAF, RET/PTC, RAS, and PAX8/PPARγ or expression of miRNAs are analyzed. However, only the detection of BRAF mutations predicts the presence of (papillary) thyroid malignancy with almost 98% probability, indicating necessity of oncologic thyroid resections irrespective of the cytology result. Other genetic alterations are associated with thyroid malignancy with varying frequency and achieve less impact on the clinical management. Conclusion: Molecular genetic analysis of FNABs is increasingly performed in Germany. Standardization, quality controls, and validation of various methods need to be implemented in the near future to be able to compare the results. With increasing knowledge about the impact of genetic alterations on the prognosis of thyroid carcinomas, recommendations have to be defined that may lead to individually optimized treatment strategies.

Contemporary Surgical Management of Juvenile Nasopharyngeal Angiofibroma

2021 ◽  
Author(s):  
Salomon Cohen-Cohen ◽  
Kristen M. Scheitler ◽  
Garret Choby ◽  
Jeffrey Janus ◽  
Eric J. Moore ◽  
...  
Keyword(s):  
Surgical Management ◽  
Intracranial Extension ◽  
Preoperative Embolization ◽  
Tumor Diameter ◽  
Historical Cohort ◽  
Nasopharyngeal Angiofibroma ◽  
Estimated Blood Loss ◽  
The Impact ◽  
Previous Series

Abstract Objectives Juvenile nasopharyngeal angiofibromas (JNAs) are uncommon tumors with an evolving treatment paradigm. The objective of this study was to compare our prior experience reported in 2005 with our most contemporary series to compare practice improvements and the impact of expanded endonasal procedures. Design Retrospective review comparing a contemporary 22 patients with JNA who underwent surgical management between 2005 and 2019, compared with a historical cohort of 65 patients from the same center. Results The most common presenting symptom was epistaxis (68%). The median maximum tumor diameter was 4.4 cm. All patients underwent preoperative embolization. An endoscopic endonasal approach (EEA) was used in 18 patients (82%), compared with 9% in the series prior to 2005. Gross total resection was achieved in all patients. The median estimated blood loss was 175 and 350 mL for EEA and open (transfacial) cases, respectively. Only two patients (9%) required a blood transfusion compared with 52% on the previous series. The median follow-up was 19 months. The overall recurrence rate was 9% in this series and 24% in the previous series. No patient required radiation therapy in follow-up compared with 3% in our historical cohort. Conclusion There have been significant changes regarding the management of patients with JNA compared with the previous Mayo Clinic experience. The EEA has become the preferred route over the transfacial approaches to treat JNA in selected patients who do not have intracranial extension. Preoperative embolization has aided in reducing the postoperative transfusion rates.

scholarly journals Recognizing Human Races through Machine Learning—A Multi-Network, Multi-Features Study

Mathematics ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 195
Author(s):  
Adrian Sergiu Darabant ◽  
Diana Borza ◽  
Radu Danescu
Keyword(s):  
Race And Ethnicity ◽  
Large Scale ◽  
Recognition Rate ◽  
Social Signals ◽  
Image Characteristics ◽  
Race Effect ◽  
Race Ethnicity ◽  
The Impact ◽  
Facial Images ◽  
Ethnicity Classification

The human face holds a privileged position in multi-disciplinary research as it conveys much information—demographical attributes (age, race, gender, ethnicity), social signals, emotion expression, and so forth. Studies have shown that due to the distribution of ethnicity/race in training datasets, biometric algorithms suffer from “cross race effect”—their performance is better on subjects closer to the “country of origin” of the algorithm. The contributions of this paper are two-fold: (a) first, we gathered, annotated and made public a large-scale database of (over 175,000) facial images by automatically crawling the Internet for celebrities’ images belonging to various ethnicity/races, and (b) we trained and compared four state of the art convolutional neural networks on the problem of race and ethnicity classification. To the best of our knowledge, this is the largest, data-balanced, publicly-available face database annotated with race and ethnicity information. We also studied the impact of various face traits and image characteristics on the race/ethnicity deep learning classification methods and compared the obtained results with the ones extracted from psychological studies and anthropomorphic studies. Extensive tests were performed in order to determine the facial features to which the networks are sensitive to. These tests and a recognition rate of 96.64% on the problem of human race classification demonstrate the effectiveness of the proposed solution.

Colonial Ideologies, Narratives, and Popular Perceptions of Ethno-racial Otherness in the Dynamics of Urban Exclusion: Debates and Evidence from Mexico, Colombia, Chile, and Argentina

2021 ◽  
Vol 48 (6) ◽  
pp. 48-66
Author(s):  
Javier Ruiz-Tagle ◽  
Carolina Aguilera
Keyword(s):  
Social Sciences ◽  
Latin American ◽  
Residential Segregation ◽  
Urban Studies ◽  
Race And Ethnicity ◽  
Research Agenda ◽  
Critical Perspective ◽  
Indigenous Social Movements ◽  
New Research ◽  
The Impact

Although ethnic differentiations began with colonialism, racism was not widely addressed in Latin American social sciences until recently, since class perspectives were predominant. Within this, studies on residential segregation and urban exclusion have ignored race and ethnicity, with the exceptions of Brazil and Colombia. However, these issues have recently become crucial because of the adoption of multiculturalism, the impact of postcolonialism and postmodernism, the emergence of black and indigenous social movements, changes in state policy, and new trends in migration. A review of debates and evidence from Mexico, Colombia, Chile, and Argentina shows that persistent colonial ideologies, narratives, and popular perceptions of ethno-racial denial sustain various kinds of urban exclusion in the region. The evidence calls for a new research agenda to decolonize urban studies that adopts a critical perspective on the coloniality of power. Aunque las diferenciaciones étnicas comenzaron con el colonialismo, el racismo no se abordó ampliamente en las ciencias sociales latinoamericanas hasta hace poco, ya que predominaban las perspectivas de clase. Los estudios sobre la segregación residencial y la exclusión urbana han ignorado la raza y el origen étnico, con excepción de Brasil y Colombia. Sin embargo, estas cuestiones se han vuelto cruciales recientemente debido a la adopción del multiculturalismo, el impacto del poscolonialismo y el posmodernismo, la aparición de movimientos sociales negros e indígenas, los cambios en la política estatal y nuevas tendencias en la migración. Una revisión de los debates y evidencia en México, Colombia, Chile y Argentina muestra que las ideologías coloniales persistentes, las narrativas y las percepciones populares de la negación etnoracial sostienen varios tipos de exclusión urbana en la región. La evidencia exige una nueva agenda de investigación para descolonizar los estudios urbanos y adoptar una perspectiva crítica sobre la colonialidad del poder.

scholarly journals European Thyroid Association Guidelines for Ultrasound Malignancy Risk Stratification of Thyroid Nodules in Adults: The EU-TIRADS

2017 ◽  
Vol 6 (5) ◽  
pp. 225-237 ◽  
Author(s):  
Gilles Russ ◽  
Steen J. Bonnema ◽  
Murat Faik Erdogan ◽  
Cosimo Durante ◽  
Rose Ngu ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Thyroid Nodules ◽  
Malignancy Risk ◽  
The Eu
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