Metachronous breast cancer in a male with previous history of liposarcoma: A case report from Syria

Popliteal artery thrombosis may present as a complication of an osteochondroma located in the vicinity of the knee joint. This is a case report of a 26-year-old man with symptoms of the right lower extremity ischaemia without a previous history of vascular disease or trauma. Plain radiography, magnetic resonance angiography and Doppler ultrasonography documented the presence of an osteochondrous structure of the proximal tibial metaphysis, which displaced and compressed the popliteal artery, causing its occlusion due to intraluminal thrombosis..The patient was operated and histopathological examination confirmed the diagnosis of osteochondroma.

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Bilateral Florid Papillomatosis of the Nipple: An Unusual Indicator for Metachronous Breast Cancer Development—A Case Report

Case Reports in Oncological Medicine ◽

10.1155/2014/432609 ◽

2014 ◽

Vol 2014 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Walid Sasi ◽

Dibyesh Banerjee ◽

Kefah Mokbel ◽

Anup K. Sharma

Keyword(s):

Breast Cancer ◽

Case Report ◽

Literature Review ◽

Papillary Carcinoma ◽

Rare Case ◽

Benign Disease ◽

Cancer Development ◽

Breast Cancer Development ◽

Histopathological Features ◽

Metachronous Breast Cancer

Adenoma or florid papillomatosis of the nipple (FPN) is a rare benign disease which has histopathological features similar to those of a mammary papillary carcinoma. Here, we report a rare case of bilateral florid papillomatosis of the nipple and breast cancer, with a literature review.

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A patient with a history of breast cancer and multiple bone lesions: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-017-1296-1 ◽

2017 ◽

Vol 11 (1) ◽

Cited By ~ 3

Author(s):

Marie-Angela Schnyder ◽

Paul Stolzmann ◽

Gerhard Frank Huber ◽

Christoph Schmid

Keyword(s):

Breast Cancer ◽

Case Report ◽

Bone Lesions ◽

History Of

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Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report

Frontiers in Immunology ◽

10.3389/fimmu.2020.603428 ◽

2020 ◽

Vol 11 ◽

Author(s):

Sabina Cenciarelli ◽

Valeria Calbi ◽

Federica Barzaghi ◽

Maria Ester Bernardo ◽

Chiara Oltolini ◽

...

Keyword(s):

Gene Therapy ◽

Case Report ◽

Immune Reconstitution ◽

Autoinflammatory Disease ◽

Clinical Phenotype ◽

High Titer ◽

Previous History ◽

Wiskott Aldrich Syndrome ◽

Neutralizing Capacity ◽

History Of

In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.

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Excision of metastatic breast cancer from sternum and reconstruction in two patients with solitary metastatic spread

Journal of Surgical Case Reports ◽

10.1093/jscr/rjaa272 ◽

2020 ◽

Vol 2020 (8) ◽

Author(s):

Saifullah Mohamed ◽

Khurum Mazhar ◽

Ahmed Osman ◽

Akshay Patel ◽

Lakshmi Srinivasan ◽

...

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Previous History ◽

Metastatic Breast ◽

Extent Of Resection ◽

Left Breast ◽

Term Survival ◽

Metastatic Breast Carcinoma ◽

History Of ◽

Treated Breast

Abstract Metastatic breast carcinoma is a relatively common clinical entity. However, the prognosis of oligometastatic and polygometastatic disease differs considerably pertaining to five-year survival. Metastatic breast carcinoma to the sternum has been described as early as 1988. We describe two cases in our institution who presented with solitary sternal metastases with a previous history of treated breast cancer. In both cases, there had been a history of previous left breast cancer treated aggressively with surgical resection and adjuvant oncological therapy and maintenance hormonal therapy. Partial sternectomy or total sternectomy for solitary metastatic sternal deposits is well established with relatively low morbidity and mortality and improvement in quality of life and possible improvement in long-term survival. Furthermore, reconstructive options are inherently dependent on extent of resection performed. These techniques can incorporate the use of sternal plates in order to approximate defects and reinforce the sternum in the setting of partial sternectomy.

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Diagnosis of Metastatic Breast Cancer—A Case Report Using Molecular Cancer Classification

Oncology & Hematology Review (US) ◽

10.17925/ohr.2011.07.2.116 ◽

2011 ◽

Vol 07 (02) ◽

pp. 116

Author(s):

Yogesh Gandhi ◽

Sunil Gandhi ◽

◽

Keyword(s):

Breast Cancer ◽

Case Report ◽

Effective Treatment ◽

Cancer Diagnosis ◽

Treatment Options ◽

Metastatic Breast ◽

Complete Response ◽

Molecular Profiling ◽

History Of

An accurate cancer diagnosis is critical as it can direct the use of site-directed, and potentially more effective, treatment options for specific types of cancer. A differential or uncertain diagnosis could prevent cancer patients from receiving optimal treatment, thus affecting their overall prognosis. Advances in molecular technology have led to the development of molecular cancer classifiers that can direct or confirm the diagnosis of metastatic cancers which would otherwise be considered uncertain or unknown. This case report describes the role of molecular diagnostics in the evaluation of a patient with a large pancreatic mass and a history of breast cancer. Results from a 92-gene molecular profiling assay (CancerTYPE ID®) predicted that this new mass was breast cancer. This diagnosis allowed for effective treatment and complete response in this patient.

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Case control study of hormone replacement therapy (HRT) and breast cancer in Japanese women

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.10012 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 10012-10012

Author(s):

M. Takeuchi ◽

T. Saeki ◽

M. Sano ◽

H. Sonoo ◽

H. Honjo ◽

...

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Menopausal Status ◽

Previous History ◽

Case Control ◽

Japanese Women ◽

Sensitivity Analyses ◽

Control Group ◽

History Of ◽

Control Study

10012 Background: Some prospective studies in US and UK (represented by Women’s Health Initiative and Million Women Study) show that HRT use may increase the risk of breast cancer. However, it is unclear whether or not this perspective is applicable to Japanese women, due to several factors such as the difference in incidence of breast cancer, difference in HRT prevalence, which are to be concerned in this study. To investigate the relationship between HRT use and breast cancer, a case-control study was conducted in Japan. Methods: We sent self-administered questionnaire to 4,500 cases who have a previous history of confirmed histological breast cancer and 4,500 controls who were selected according to the inclusion criteria. All the subjects were between age 45 and 69 at the time of enrollment. Among these subjects, 3,434 in case group and 2,427 in control group sent back their questionnaire (total 5,861). The datacenter was run in Kitasato Univ. and the statistical analysis was performed using SAS (version 9.1). Control was selected by considering the screening record for GI disease and respiratory disorders, with no previous history of breast cancer, gynecological and hormonal disease at the time of screening. We asked about past history of exposure to the factors supposed to be breast cancer-causing; previous or current use of HRT, age at diagnosis, academic background, BMI, lifestyle habits, age of menarche, birth history, history of breast feeding, family history, use of contraceptive agents and menopausal status. Results: As the main analysis result, 164 (5.0%) out of 3,316 cases and 253 (7.4%) out of 2355 controls had used HRT (Odds ratio 0.432 [95% CI 0.352–0.530]. Conclusions: The result of this study shows that HRT users were less likely to develop breast cancer than never users. However, in this study, there was a difference in the observation period for the past use of HRT between cases and controls. Considering the transition of HRT prevalence in Japan, there may be a possibility that this difference can be a cause of a serious bias for the main analysis result. Further sensitivity analyses are needed to evaluate the robustness of the findings and this point is under consideration. No significant financial relationships to disclose.

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Pleomorphic lobular carcinoma in situ: A distinct entity of controversial significance.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.27_suppl.177 ◽

2012 ◽

Vol 30 (27_suppl) ◽

pp. 177-177

Author(s):

Marina De Brot ◽

Shirin Muhsen ◽

Victor P. Andrade ◽

Starr Koslow Mautner ◽

Melissa Murray ◽

...

Keyword(s):

Breast Cancer ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Lobular Carcinoma ◽

Previous History ◽

Prior History ◽

Lobular Carcinoma In Situ ◽

Pleomorphic Lobular Carcinoma ◽

History Of

177 Background: Pleomorphic lobular carcinoma in situ (PLCIS) is an increasingly diagnosed variant of lobular carcinoma in situ. Histologically, it resembles ductal carcinoma in situ (DCIS), leading to controversy over proper management. Yet, the natural history of PLCIS is unknown. Here we describe our experience with PLCIS. Methods: Review of pathology reports (1995–2012) identified 233 cases of LCIS variants. Patients with synchronous ipsilateral DCIS or invasive cancer (IC) were excluded leaving 25 cases for review. Consensus review by 3 pathologists further excluded 7; leaving 18 cases, 12 of which were classified as PLCIS and 6 as LCIS with pleomorphic features (LCIS-PF). (Table) PLCIS was defined by cellular dyshesion, nuclear pleomorphism with a 2-3 fold size variation, conspicuous nucleoli, mitoses and abundant cytoplasm; lesions not meeting all parameters were classified as LCIS-PF. Loss of e-cadherin was confirmed; clinical data were obtained from medical records. Results: Mean patient age at diagnosis of PLCIS/LCIS-PF was 57 yrs (42-67 yrs). All cases presented with imaging abnormalities. A previous history of breast cancer was present in 7/18 (39%) pts (3/7, ipsilateral; 4/7, contralateral). Following PLCIS/LCIS-PF diagnosis, 6/18 (33%) pts underwent mastectomy and 12/18 had excision alone, with (n=3) or without chemoprevention (n=9). Margin status was negative in 4/12 pts; close in 3/12 pts and positive in 5/12 pts undergoing excision. At a median follow-up of 27 mos (2-148 mos), 2/12 pts treated with excision developed ipsilateral breast cancer (1 DCIS; 1 IC). Both had close margins at initial excision; median time to cancer, 54 mos. Conclusions: Pure PLCIS is an uncommon lesion. Synchronous malignancy or prior history of breast cancer are often present in patients with PLCIS, contributing to the difficulty in determining the actual risk conferred by this lesion and appropriate management. Efforts to systematically characterize LCIS variants and prospective documentation of outcomes are needed to clarify the significance of these lesions. [Table: see text]

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Adolescent Catatonia Successfully Treated with Lorazepam and Aripiprazole

Case Reports in Psychiatry ◽

10.1155/2014/309517 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Aaron J. Roberto ◽

Subhash Pinnaka ◽

Abhishek Mohan ◽

Hiejin Yoon ◽

Kyle A. B. Lapidus

Keyword(s):

Case Report ◽

Children And Adolescents ◽

Emotional Distress ◽

Successful Treatment ◽

Previous History ◽

Treatment Modalities ◽

Psychotic Symptoms ◽

First Episode ◽

Significant Impairment ◽

History Of

Catatonia is especially concerning in children and adolescents. It leads to significant impairment, including emotional distress, difficulty communicating, and other debilitating symptoms. In this case report, we discuss a patient with no previous history of neuroleptic medication or psychotic symptoms, presenting with first-episode catatonia in the presence of disorganized, psychotic thoughts. We then review the catatonia syndrome, citing examples in the literature supporting its underdiagnosis in children and adolescents, and discuss successful treatment modalities. It is important to diagnose and treat catatonia as efficiently as possible, to limit functional and emotional distress to the patient.

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