scholarly journals The impact of probiotics on gut health via alternation of immune status of monogastric animals

2020 ◽  
Author(s):  
Sujuan Ding ◽  
Wenxin Yan ◽  
Yong Ma ◽  
Jun Fang
Keyword(s):  
Immune Status ◽  
Gut Health ◽  
The Impact

The Impact of Chlamydia Pneumoniae Infection on the Immune Status of Children

2018 ◽  
pp. 756-758
Author(s):  
I. Solovyeva ◽  
L. Shalunova ◽  
A. Solovyeva ◽  
K. Zakuraeva ◽  
T. Krivozubova ◽  
...  
Keyword(s):  
Chlamydia Pneumoniae ◽  
Immune Status ◽  
The Impact

scholarly journals Impact of Glucosamine Supplementation on Gut Health

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2180
Author(s):  
Jessica M. Moon ◽  
Peter Finnegan ◽  
Richard A. Stecker ◽  
Hanna Lee ◽  
Kayla M. Ratliff ◽  
...  
Keyword(s):  
Gastrointestinal Symptoms ◽  
Short Chain Fatty Acids ◽  
Fecal Microbiota ◽  
Bowel Habit ◽  
Total Amino Acid ◽  
Crossover Fashion ◽  
Gut Health ◽  
Double Blind ◽  
Branched Chain ◽  
The Impact

Glucosamine (GLU) is a natural compound found in cartilage, and supplementation with glucosamine has been shown to improve joint heath and has been linked to reduced mortality rates. GLU is poorly absorbed and may exhibit functional properties in the gut. The purpose of this study was to examine the impact of glucosamine on gastrointestinal function as well as changes in fecal microbiota and metabolome. Healthy males (n = 6) and females (n = 5) (33.4 ± 7.7 years, 174.1 ± 12.0 cm, 76.5 ± 12.9 kg, 25.2 ± 3.1 kg/m2, n = 11) completed two supplementation protocols that each spanned three weeks separated by a washout period that lasted two weeks. In a randomized, double-blind, placebo-controlled, crossover fashion, participants ingested a daily dose of GLU hydrochloride (3000 mg GlucosaGreen®, TSI Group Ltd., USA) or maltodextrin placebo. Study participants completed bowel habit and gastrointestinal symptoms questionnaires in addition to providing a stool sample that was analyzed for fecal microbiota and metabolome at baseline and after the completion of each supplementation period. GLU significantly reduced stomach bloating and showed a trend towards reducing constipation and hard stools. Phylogenetic diversity (Faith’s PD) and proportions of Pseudomonadaceae, Peptococcaceae, and Bacillaceae were significantly reduced following GLU consumption. GLU supplementation significantly reduced individual, total branched-chain, and total amino acid excretion, with no glucosamine being detected in any of the fecal samples. GLU had no effect on fecal short-chain fatty acids levels. GLU supplementation provided functional gut health benefits and induced fecal microbiota and metabolome changes.

scholarly journals High association of COVID-19 severity with poor gut health score in Lebanese patients

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258913
Author(s):  
Imad Al Kassaa ◽  
Sarah El Omari ◽  
Nada Abbas ◽  
Nicolas Papon ◽  
Djamel Drider ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Models ◽  
Equal Proportion ◽  
Gut Health ◽  
Kendall’S Tau ◽  
High Association ◽  
Kendall's Tau ◽  
Health Score ◽  
Logistic Regression Models ◽  
The Impact

Background Coronavirus disease 2019 (COVID-19) has affected millions of lives globally. However, the disease has presented more extreme challenges for developing countries that are experiencing economic crises. Studies on COVID-19 symptoms and gut health are scarce and have not fully analyzed possible associations between gut health and disease pathophysiology. Therefore, this study aimed to demonstrate a potential association between gut health and COVID-19 severity in the Lebanese community, which has been experiencing a severe economic crisis. Methods This cross-sectional study investigated SARS-CoV-2 PCR-positive Lebanese patients. Participants were interviewed and gut health, COVID-19 symptoms, and different metrics were analyzed using simple and multiple logistic regression models. Results Analysis of the data showed that 25% of participants were asymptomatic, while an equal proportion experienced severe symptoms, including dyspnea (22.7%), oxygen need (7.5%), and hospitalization (3.1%). The mean age of the participants was 38.3 ±0.8 years, and the majority were males (63.9%), married (68.2%), and currently employed (66.7%). A negative correlation was found between gut health score and COVID-19 symptoms (Kendall’s tau-b = -0.153, P = 0.004); indicating that low gut health was associated with more severe COVID-19 cases. Additionally, participants who reported unhealthy food intake were more likely to experience severe symptoms (Kendall’s tau-b = 0.118, P = 0.049). When all items were taken into consideration, multiple ordinal logistic regression models showed a significant association between COVID-19 symptoms and each of the following variables: working status, flu-like illness episodes, and gut health score. COVID-19 severe symptoms were more common among patients having poor gut health scores (OR:1.31, 95%CI:1.07–1.61; P = 0.008), experiencing more than one episode of flu-like illness per year (OR:2.85, 95%CI:1.58–5.15; P = 0.001), and owning a job (OR:2.00, 95%CI:1.1–3.65; P = 0.023). Conclusions To our knowledge, this is the first study that showed the impact of gut health and exposure to respiratory viruses on COVID-19 severity in Lebanon. These findings can facilitate combating the pandemic in Lebanon.

scholarly journals Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status

mBio ◽  
2018 ◽  
Vol 9 (4) ◽  
Author(s):  
Kuppan Gokulan ◽  
Matthew G. Arnold ◽  
Jake Jensen ◽  
Michelle Vanlandingham ◽  
Nathan C. Twaddle ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Immune Status ◽  
Arsenic Exposure ◽  
Intestinal Bacteria ◽  
Repeated Exposure ◽  
Potential Toxicity ◽  
Microbial Composition ◽  
Arsenic Resistance ◽  
Immune System Development ◽  
The Impact

ABSTRACT Intestinal microbiota composition and gut-associated immune response can contribute to the toxicity of arsenic. We investigated the potential toxicity of short-term arsenic exposure on gut microbiome composition, intestinal immune status, microbial arsenic resistance gene, and arsenic metabolic profiles in adult and developmental stages of CD-1 mice. The potential toxicity of arsenite [As(III)] was determined for two life stages: (i) adult animals at 24 or 48 h after single gavage (0.05 mg/kg body weight [b.w.] [low dose], 0.1 mg/kg b.w. [medium dose], and 0.2 mg/kg b.w. [high dose]) and repeated exposure at 1 mg/liter for 8 days and (ii) postnatal day 10 (PND10) and PND21 after single gavage (0.05 mg/kg b.w.). Dose- and time-dependent responses in bacterial recovery/microbial composition were observed in adults after a single gavage. Repeated exposure caused a transient decrease in the recovery of intestinal bacteria, a shift in the bacterial population with abundance of arsenic resistance genes, and evidence for host metabolism of arsenite into less-reactive trivalent methylated species. Arsenic exposure in adult animals induced high levels of CC chemokines and of proinflammatory and anti-inflammatory cytokine secretion in intestine. Arsenic exposure at PND21 resulted in the development of distinct bacterial populations. Results of this study highlight significant changes in the intestinal microbiome and gut-associated immune status during a single or repeated exposure to arsenic in juvenile and adult animals. The data warrant investigation of the long-term effects of oral arsenic exposure on the microbiome and of immune system development and responses. IMPORTANCE Transformation of organic arsenic to toxic inorganic arsenic (iAs) is likely carried out by intestinal bacteria, and iAs may alter the viability of certain microbial populations. This study addressed the impact of arsenic exposure on intestinal microbiota diversity and host gut-associated immune mediators during early development or adulthood using scenarios of acute or repeated doses. During acute arsenic exposure, animals developed defense functions characterized by higher abundances of bacteria that are involved in arsenic resistance or detoxification mechanisms. Arsenite had a negative effect on the abundance of bacterial species that are involved in the conversion of protein to butyrate, which is an alternative energy source in the intestine. The intestinal mucosal immune cytokine profile reflected a mechanism of protection from arsenic toxicity.

The impacts of a fibrolytic enzyme additive on digestibility and performance in the grower period, and supplemental Saccharomyces cerevisiae on performance and rumen health in the finisher period for feedlot steers

2021 ◽  
Author(s):  
Melissa S. Williams ◽  
Ousama AlZahal ◽  
Ira B. Mandell ◽  
Brian McBride ◽  
Katie Wood
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Growth Performance ◽  
Mrna Expression ◽  
Experimental Treatment ◽  
Gut Health ◽  
Feed Conversion ◽  
Ruminal Ph ◽  
Gut Barrier Function ◽  
And Performance ◽  
The Impact

Two experiments were conducted to determine the effects of a fibrolytic enzyme pretreatment on growth performance, apparent total tract digestibility, and ruminal pH throughout the grower and early finisher period (Exp. 1), and to examine the impact of Saccharomyces cerevisiae supplementation on intake, performance, and indicators of gut health in the late finisher period (Exp. 2). Fifty-four steers were randomly assigned to a subgroup determining experimental treatment groups. In Exp. 1, steers were randomized to: control (CON1; no enzyme) or enzyme (ENZ; 0.75 ml kg-1 DM of feed) dietary treatments. Digestibility was improved (P≤0.05) in ENZ steers for DM, CP, NEg, and sugars, but did not affect (P≥0.12) DMI, ADG, or reticulo-ruminal pH. In Exp. 2, the treatments were: control (CON2; no yeast) or yeast (YST; 3.0 g animal-1 daily) supplemented diets. Rumen papillae were collected for mRNA expression of gut barrier function (OCLN, CLDN, ZO1, ZO2) and immune response (TLR2, TLR4, FCAR) genes and histological measurements. YST decreased (P<0.001) DMI by 31%, reduced variation in dry matter intake, and improved feed conversion ratios, but did not impact rumen health mRNA expression or histology measures (P≥0.07). Overall, ENZ improved the digestibility of some nutrients in the grower period, and YST improved feed efficiency, without impacting growth performance or gut health.

scholarly journals In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Gut Microbiota in Normal Weight and Overweight/Obese Subjects

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1560-1560
Author(s):  
Inah Gu ◽  
Wing Shun Lam ◽  
Daya Marasini ◽  
Cindi Brownmiller ◽  
Brett Savary ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Rice Bran ◽  
Block Design ◽  
16S Rrna Gene Sequencing ◽  
Short Chain Fatty Acids ◽  
Normal Weight ◽  
Rrna Gene ◽  
Gut Health ◽  
The Impact

Abstract Objectives Arabinoxylan is a non-starch polysaccharide and rich in wheat, rice and many other cereal grains. Diets high in fiber help promoting gut health in obesity. The objective of this study was to investigate the impact of arabinoxylan from rice bran on the gut microbiota and short chain fatty acids (SCFA) in normal weight (NW) and overweight/obese (OO) subjects through in vitro fecal fermentation. Methods Arabinoxylan was extracted from rice bran fiber. For in vitro fecal fermentation, each fecal sample from NW (n = 6, 3 males and 3 females) and OO (n = 7, 3 males and 4 females) was diluted into anaerobic medium with three treatments: control (no substrates), fructooligosaccharides (FOS, a well-known prebiotic), and arabinoxylan. Samples were incubated at 37˚C and aliquots were taken at 0, 4, 8, 12 and 24 h. SCFA content from samples at all timepoints was analyzed using HPLC. Samples at 0 and 24 h were used for gut microbiota analysis through 16S rRNA gene sequencing. Statistical analyses were performed for the randomized complete block design, where the weight classes are confounded with blocks (subjects). Friedman test was used to determine the difference at 5% level of significance. Results As a result, arabinoxylan treatment significantly increased total SCFA concentration in both NW and OO subjects than control (P &lt; 0.05), comparable to FOS treatment. Between weight classes under arabinoxylan treatment, OO group showed a significantly higher total SCFA content than NW group (P &lt; 0.05). Arabinoxylan changed gut microbial population at the genus level, stimulating Bifidobacterium, Collinsella and Blautia and decreasing Clostridium XIVa and b, Dorea and Oscillibacter (P &lt; 0.05). In addition, different microbiome population was shown in weight classes with three treatments, showing higher Bacteroides in NW and higher Prevotella in OO. Conclusions These results showed that arabinoxylan from rice bran modified gut microbiota in both weight classes, increasing total SCFA content. This study suggests that arabinoxylan from rice bran may have a potential impact on microbial gut health in obesity with prebiotic activities. Funding Sources University of Arkansas.

Gut Health = Mental Health? The Impact of Diet and Dietary Supplements on Mood Disorders

2020 ◽  
Vol 9 (4) ◽  
pp. 361-368
Author(s):  
Michael Mueller ◽  
Ravindra Ganesh ◽  
Sara Bonnes
Keyword(s):  
Mental Health ◽  
Dietary Supplements ◽  
Mood Disorders ◽  
Gut Health ◽  
The Impact

scholarly journals Research progress on gut health of farmers teleost fish: a viewpoint concerning the intestinal mucosal barrier and the impact of its damage

2020 ◽  
Vol 30 (4) ◽  
pp. 569-586
Author(s):  
Hongling Zhang ◽  
Chao Ran ◽  
Tsegay Teame ◽  
Qianwen Ding ◽  
Seyed Hossein Hoseinifar ◽  
...  
Keyword(s):  
Teleost Fish ◽  
Research Progress ◽  
Mucosal Barrier ◽  
Gut Health ◽  
Intestinal Mucosal Barrier ◽  
The Impact

scholarly journals Effects of maternal supplementation with fully oxidised β-carotene on the reproductive performance and immune response of sows, as well as the growth performance of nursing piglets

2020 ◽  
Vol 125 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Jun Chen ◽  
Jiaming Chen ◽  
Yinzhi Zhang ◽  
Yantao Lv ◽  
Hanzhen Qiao ◽  
...  
Keyword(s):  
Immune Status ◽  
Basal Diet ◽  
Perinatal Period ◽  
Litter Weight ◽  
Lactose Concentration ◽  
Biological Similarity ◽  
Maternal Supplementation ◽  
Dietary Treatments ◽  
The Impact ◽  
Β Carotene

AbstractThe present study was conducted to evaluate the impact of dietary fully oxidised β-carotene (OxBC, C40H60O15) supplementation during the perinatal period on immune status and productivity in a sow model. At day 85 of pregnancy, 150 sows were allocated to one of three dietary treatments with fifty sows per treatment. The three experimental diets were supplemented with 0, 4 or 8 mg/kg OxBC in the basal diet. The feeding trial was conducted from gestation day 85 until day 21 of lactation. Dietary OxBC supplementation greatly enhanced colostrum IgM, IgA and IgG levels, and the IgM and IgG content of 14-d milk. Dietary OxBC supplementation decreased the TNF-α and IL-8 levels in colostrum, as well as the TNF-α and IL-18 levels in 14-d milk. There was also a tendency towards an increase in the soluble CD14 level in 14-d milk. Although dietary treatments did not affect average daily feed intake nor backfat thickness loss during lactation, dietary OxBC supplementation tended to enhance litter weight and individual piglet weight at weaning. There was a trend towards increased lactose concentration in 14-d milk with increasing dietary OxBC. It is concluded that dietary supplementation with OxBC during the perinatal period enhances the lactose concentration of sow milk and the immune status of sows, which is reflected by improved cytokine status and immunoglobulin concentrations in colostrum and milk, and thus tending to increase litter weight and individual piglet weight at weaning. The results also provide a scientific nutritional reference for perinatal mothers due to the biological similarity between pigs and humans.

scholarly journals Effects of dietary seaweed extract supplementation in sows and post-weaned pigs on performance, intestinal morphology, intestinal microflora and immune status

2011 ◽  
Vol 106 (5) ◽  
pp. 688-699 ◽  
Author(s):  
S. G. Leonard ◽  
T. Sweeney ◽  
B. Bahar ◽  
B. P. Lynch ◽  
J. V. O'Doherty
Keyword(s):  
Growth Performance ◽  
Intestinal Microflora ◽  
Immune Status ◽  
Average Daily Gain ◽  
Intestinal Morphology ◽  
Seaweed Extract ◽  
Gut Health ◽  
Weaned Pigs ◽  
Treatment Groups ◽  
Daily Gain

The present study investigated the effects of dietary supplementation of a seaweed extract (SWE) to sows and weaned pigs on post-weaning growth performance, intestinal morphology, intestinal microflora, volatile fatty acid concentrations and immune status of pigs at days 11 and 117 post-weaning. Gestating sows (n20) were supplemented with a SWE (0v.10·0 g/d) from day 107 of gestation until weaning (day 26). At weaning, pigs (four pigs per sow) were divided into two groups based on sow diet during lactation and supplemented with a SWE (0v.2·8 g/kg diet), resulting in four treatment groups: (1) BB (basal sows–basal pigs); (2) BS (basal sows–treated pigs); (3) SB (treated sows–basal pigs); (4) SS (treated sows–treated pigs). Pigs weaned from SWE-supplemented sows had a higher average daily gain (ADG) between days 0 and 21 (P < 0·05) post-weaning compared with pigs weaned from non-SWE-supplemented sows. Pigs offered post-weaning diets (PW) containing SWE had decreased colonicEscherichia colipopulations on day 11 (P < 0·01) and decreased colonic Enterobacteriaceae numbers on day 117 (P < 0·05). Pigs offered PW containing SWE had a greater mRNA abundance ofMUC2in the colon at day 11 post-weaning (P < 0·05) compared with pigs offered unsupplemented diets. In conclusion, these results demonstrate that SWE supplementation post-weaning provides a dietary means to improve gut health and to enhance growth performance in starter pigs. Dietary SWE supplementation increased ADG during the grower–finisher (GF) phases. However, there was no growth response to SWE inclusion in GF diets when pigs were weaned from SWE-supplemented sows.

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