Improved clinical outcome and high rate of return to low impact sport and work after double level osteotomy for bifocal varus malalignment

2021 ◽  
Author(s):  
Marco-Christopher Rupp ◽  
Lukas N. Muench ◽  
Yannick J. Ehmann ◽  
Alexander Themessl ◽  
Philipp W. Winkler ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
High Rate ◽  
Rate Of Return ◽  
Varus Malalignment ◽  
Impact Sport

STUDY ON THRIVE SCORE IN THE PROGNOSIS OF ISCHEMIC STROKE

2017 ◽  
pp. 22-24
Author(s):  
Thi Thao Nhi Tran ◽  
Dinh Toan Nguyen
Keyword(s):  
Ischemic Stroke ◽  
Clinical Outcome ◽  
Regression Models ◽  
Cross Sectional Study ◽  
High Rate ◽  
Vascular Events ◽  
Cross Sectional ◽  
Key Words Ischemic Stroke ◽  
Outcome Mortality ◽  
Better Than

Background and Purpose: Stroke is the second cause of mortality and the leading cause of disability. Using the clinical scale to predict the outcome of the patient play an important role in clinical practice. The Totaled Health Risks in Vascular Events (THRIVE) score has shown broad utility, allowing prediction of clinical outcome and death. Methods: A cross-sectional study conducting on 102 patients with acute ischemic stroke using THRIVE score. The outcome of patient was assessed by mRankin in the day of 30 after stroke. Statistic analysis using SPSS 15.0. Results: There was 60.4% patient in the group with THRIVE score 0 – 2 points having a good outcome (mRS 0 - 2), patient group with THRIVE score 6 - 9 having a high rate of bad outcome and mortality. Having a positive correlation between THRIVE score on admission and mRankin score at the day 30 after stroke with r = 0.712. THRIVE score strongly predicts clinical outcome with ROC-AUC was 0.814 (95% CI 0.735 - 0.893, p<0.001), Se 69%, Sp 84% and the cut-off was 2. THRIVE score strongly predicts mortality with ROC-AUC was 0.856 (95% CI 0.756 - 0.956, p<0.01), Se 86%, Sp 77% and the cut-off was 3. Analysis of prognostic factors by multivariate regression models showed that THRIVE score was only independent prognostic factor for the outcome of post stroke patients. Conclusions: The THRIVE score is a simple-to-use tool to predict clinical outcome, mortality in patients with ischemic stroke. Despite its simplicity, the THRIVE score performs better than several other outcome prediction tools. Key words: Ischemic stroke, THRIVE, prognosis, outcome, mortality

scholarly journals Return to Sport After Ankle Syndesmotic Injury: A Systematic Review

2018 ◽  
Vol 11 (2) ◽  
pp. 116-122 ◽  
Author(s):  
Seline Y. Vancolen ◽  
Ibrahim Nadeem ◽  
Nolan S. Horner ◽  
Herman Johal ◽  
Bashar Alolabi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Study Design ◽  
Return To Sport ◽  
Nonoperative Treatment ◽  
High Rate ◽  
Rate Of Return ◽  
Syndesmotic Injury ◽  
Level Of Evidence ◽  
Treatment Groups ◽  
Pertinent Data

Context: Ankle syndesmotic injuries present a significant challenge for athletes due to prolonged disability and recovery periods. The optimal management of these injuries and rates of return to sport in athletes remains unclear. Objective: The purpose of this study was to evaluate return to sport for athletes after ankle syndesmotic injuries. Data Source: The electronic databases MEDLINE, EMBASE, and PubMed were searched for relevant studies from database inception to January 15, 2017, and pertinent data were abstracted. Study Selection: Only studies reporting return-to-sport rates after ankle syndesmotic injuries were included. Study Design: Systematic review. Level of Evidence: Level 4. Data Extraction: Two reviewers extracted data from the included studies, which were stored in a standardized collection form (Microsoft Excel). Recorded data included demographics (eg, author, year of publication, study design), descriptive statistics (eg, patient age, percentage male, number of athletes, sample size), and outcomes (eg, time to return to sport, proportion of those who returned to sport, the self-reported questionnaire the Olerud-Molander Ankle Score). Results: A total of 10 studies and 312 patients with ankle syndesmotic injuries were included in this systematic review. The rate of return to preinjury or any injury level of sport after ankle syndesmotic injuries was 93.8% ± 1.2% and 97.6% ± 1.5%, respectively, for the corresponding 7 and 3 studies that reported this characteristic. The mean time to return to sport was 46.4 days (range, 15.4-70 days), with 55.2 ± 15.8 and 41.7 ± 9.8 days for operative and nonoperative management, respectively. Conclusion: This systematic review found a high rate of return to any as well as preinjury level of sport after ankle syndesmotic injury in both operative and nonoperative treatment groups. However, further high-level studies are required to compare operative and nonoperative treatment groups associated with return to sport after ankle syndesmotic injury.

Clinical outcome and evidence of high rate post-surgical anterior hypopituitarism in a cohort of TSH-secreting adenoma patients: Might somatostatin analogs have a role as first-line therapy?

Pituitary ◽  
2014 ◽  
Vol 18 (5) ◽  
pp. 583-591 ◽  
Author(s):  
Federico Gatto ◽  
Ludovica F. Grasso ◽  
Elena Nazzari ◽  
Thomas Cuny ◽  
Pasquale Anania ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Somatostatin Analogs ◽  
High Rate ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

Clinical outcome of pediatric Hodgkin’s disease in upper Egypt

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 9035-9035 ◽  
Author(s):  
E. N. Ebeid ◽  
M. Zaghloul ◽  
M. Khairy
Keyword(s):  
Bone Marrow ◽  
Clinical Outcome ◽  
Rural Areas ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Supportive Therapy ◽  
High Rate ◽  
Secondary Malignancy ◽  
Involved Field ◽  
Involved Field Radiotherapy

9035 Background: To assess clinical outcome of chemotherapy and involved field radiotherapy in all stages of pediatric Hodgkin’s Disease in rural areas of Egypt treated at Menya oncology centre which is located 300km south the capital. Methods: Between April 2000 and November 2005, 27 previously untreated patients were investigated, treated and analyzed for remission and survival. Results: There were 21 males and 6 girls with a median age of 11 years, 29.6% were less than 10 years, 70.3% had advanced stage disease (IIB-IV), bulky mediastinal mass in 19 cases spleen involvement in 6 cases, bone marrow aspirate was free in all cases, bone marrow biopsy was not done. patients with stage I and IIA received 2 courses of EOPA (etopsid, vincristine, prednisone and doxorubicin), patients with stage IIb and IIIa received 2 courses of EOPA and 2 courses of ECOP (etopsid, cyclophophamide, vincristine and prednisone), while patients with stage IIIb and IV received 2courses of EOPA and 4 courses of ECOP, All patients received involved field radiotherapy according to stage. Complete remission was achieved in 96.2%. Progressive disease in 1 (3.7%) which required change line of therapy. Out of the 27 patients 3 (11.1%) have relapsed (17, 22 and 25 months) post completion of chemotherapy and were treated with another line of chemotherapy. The 2 years DFS was 90.9% with 95% of CI (73%-100%). Treatment was given outpatient, with no supportive therapy or toxic deaths and no secondary malignancy from etopsid Conclusions: This regimen provides high rate of durable remission in rural areas of Egypt with limited resources (drugs availability and supportive measures). No significant financial relationships to disclose.

scholarly journals Clinical Implications of Microsatellite Instability and MLH1 Gene Inactivation in Sporadic Insulinomas

2009 ◽  
Vol 94 (9) ◽  
pp. 3448-3457 ◽  
Author(s):  
Mei Mei ◽  
Dajun Deng ◽  
Tong-Hua Liu ◽  
Xin-Ting Sang ◽  
Xin Lu ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Microsatellite Instability ◽  
Promoter Methylation ◽  
Clinicopathological Characteristics ◽  
High Rate ◽  
Mlh1 Gene ◽  
Multivariate Statistic ◽  
Incurable Disease ◽  
Multivariate Statistic Analysis ◽  
Mlh1 Protein

Context: The molecular pathogenesis of sporadic insulinomas is unknown. There is a lack of biomarker to distinguish benign and malignant form of insulinoma. Objective: Our objective was to confirm the occurrence of microsatellite instability (MSI) in insulinomas, to identify alterations of mismatch repair (MMR) genes in the tumors, and to evaluate the possibility to distinguish benign and malignant insulinoma or to predict the clinical outcome of patients with these alterations. Design and Patients: We detected MSI and inactivation of MLH1 gene in 55 sporadic insulinomas by PCR, immunohistochemical staining, allelic typing, analysis of promoter methylation, and exon mutations. Their correlations with clinicopathological characteristics were analyzed with univariate and multivariate statistic analysis. Results: A high rate of MSI (MSI-H) was found in 33% of sporadic insulinomas. Reduced expression of mutL homolog 1 (MLH1) protein was observed in 36% of insulinomas and correlated with MSI-H (P = 0.008). Promoter methylation and loss of heterozygosity of MLH1 gene was found in 31 and 49% of insulinomas, respectively. Reduced expression of MLH1 and MSI-H were significantly associated with both tumor malignancy (P = 0.033 and P = 4.8 × 10−6, respectively) and incurable disease (P = 0.006 and P = 0.001, respectively). Conclusion: High frequency of MSI occurred in sporadic insulinomas. The silencing of MLH1 gene may partially contribute to the MSI-H in the tumors. Assessing MSI-H and expressions of MLH1 could be used to distinguish benign and malignant insulinomas and to predict the outcome of patients. Detecting of a high rate of microsatellite instability can be used to distinguish malignancy from benign, and predict clinical outcome of the sporadic insulinomas.

scholarly journals Treatment and Outcome of Anterior Inferior Cerebellar Artery (AICA) Aneurysms: Helsinki Series of 15 Consecutive Patients.

2021 ◽  
Author(s):  
Sajjad Muhammad ◽  
Ahmad Hafez ◽  
Hanna Kaukovalta ◽  
Behnam Jahromi ◽  
Riku Kivisaari ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Clinical Outcome ◽  
High Rate ◽  
Anterior Inferior Cerebellar Artery ◽  
Parent Vessel ◽  
Vessel Occlusion ◽  
Cerebellar Artery ◽  
Parent Vessel Occlusion ◽  
Good Grade ◽  
Anterior Petrosectomy

Abstract Background: Anterior inferior cerebellar artery (AICA) aneurysms are rare posterior circulation lesions that are challenging to treat.Objectives: To present the treatment and clinical outcome of AICA aneurysms in an unselected cohort of patients.Methods: A retrospective analysis of patient record files, DSA and CT angiography images of 15 consecutive patients harboring AICA aneurysms treated between 1968 to 2017. Results: Eighty percent of the AICA aneurysm patients were females. Twenty percent presented with intracerebral hemorrhage (ICH) and 40% had intraventricular hemorrhage. Eleven (73%) patients suffered from subarachnoid hemorrhage (SAH); a good-grade SAH (Hunt and Hess grade 1-3) was observed in 82 % SAH patients. Surgery was performed in 73 % patients. Coil embolization was done in 7% patients and 20 % patients were treated conservatively. In 73 % patients retrosigmoid approach was used and in 27 % patients a sub-temporal approach with anterior petrosectomy was applied. A parent vessel occlusion was needed to occlude the aneurysm in 18 % patients.Conclusion: Surgical treatment of AICA aneurysms has a high rate of cranial nerve deficits but most of patients have a good long-term clinical outcome. Surgical treatment may be an option only in selected cases of AICA aneurysms.

scholarly journals Laparoscopic Anterior 180° Partial Fundoplication - Indian Perspective

2021 ◽  
Vol 7 (3) ◽  
pp. 22-29
Author(s):  
Dr. Biswabasu Das ◽  
◽  
Dr. Sandeep Sahu ◽  
Dr. Radhakrishna Y ◽  
Bibhabasu Das ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Clinical Outcome ◽  
Tertiary Care ◽  
Case Series ◽  
Outcome Data ◽  
High Rate ◽  
Partial Fundoplication ◽  
Tertiary Care Centers ◽  
Almost All

Aim: To evaluate Laparoscopic anterior 180° partial fundoplication for its good long-term relief forsymptoms of gastroesophageal reflux disease and association with adverse effects. Methods:Study design: Prospectively evaluated case series. Settings: Tertiary care centers Patients: Theclinical outcomes were determined for all patients who had undergone a laparoscopic anterior partialfundoplication by us between January 1, 2013 to March 31, 2021. Interventions: Clinical outcome,complications, and follow-up after laparoscopic anterior 180° partial fundoplication was obtainedusing a structured questionnaire. Results and Discussion: 228 procedures were performed. Theoutcome at 0 to 8 years (mean, 4 years) follow-up was determined for 195 patients. 1 death waslinked to the laparoscopic procedure and 2 patients died during follow-up due to unrelated causes.For 186 patients (95%) with clinical outcome data at late follow-up, gastroesophageal refluxsymptoms were significantly improved following surgery and were well controlled in 9 patients(4.5%). In a subset of 85 patients with more than 5 years of follow-up, relief of heartburn was foundin 59 patients (69%). Incidence and severity of heartburn were reduced after surgery in 22 patients(26%), decreased dyspepsia in 80 patients (94%). Normal belching was preserved in 84 patients(99%) and almost all patients were able to eat normally. Conclusion: Laparoscopic anterior 180°partial fundoplication is an effective procedure for the surgical treatment of gastroesophageal refluxand is associated with a high rate of patient satisfaction at late follow-up. Compared to Nissen'sfundoplication it is as good as control of recurrent reflux as well as reduced adverse effects. Thepatient goes home in 3-4 days. Hence we recommend it as the procedure of choice for refluxsymptoms.

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