The effects of A. senticosus supplementation on serum lipid profiles, biomarkers of oxidative stress, and lymphocyte DNA damage in postmenopausal women

The aim of this study was to investigate the effects of taurine (TA) on serum lipid profiles following chronic coadministration of chlorpyrifos (CP) and lead acetate (Pb) in male Wistar rats. Fifty rats randomly distributed into five groups served as subjects. Distilled water (DW) was given to DW group, while soya oil (SO; 1 mL kg−1) was given to SO group. The TA group was treated with TA (50 mg kg−1). The CP + Pb group was administered sequentially with CP (4.25 mg kg−1; 1/20th median lethal dose (LD50)) and Pb at 233.25 mg kg−1 (1/20th LD50), while the TA + CP + Pb group received TA (50 mg kg−1), CP (4.25 mg kg−1), and Pb (233.25 mg kg−1) sequentially. The treatments were administered once daily by oral gavage for 16 weeks. The rats were euthanised, and the blood samples were collected at the termination of the study. Sera obtained from the blood samples were analyzed for total cholesterol, high-density lipoprotein cholesterol, triglycerides, and malondialdehyde, and also the activities of serum antioxidant enzymes including superoxide dismutase, catalase and glutathione peroxidase were analyzed. The low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and atherogenic index were calculated. The results showed that CP and Pb induced alterations in the serum lipid profiles and evoked oxidative stress. TA alleviated the disruptions in the serum lipid profiles of the rats partially by mitigating oxidative stress. It was concluded that TA may be used for prophylaxis against serum lipid disorders in animals that were constantly co-exposed to CP and Pb in the environment.

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Association of P2X7R gene with serum lipid profiles in Chinese postmenopausal women with osteoporosis

Climacteric ◽

10.1080/13697137.2019.1604654 ◽

2019 ◽

Vol 22 (5) ◽

pp. 498-506 ◽

Cited By ~ 2

Author(s):

W. Xiao ◽

C. Gong ◽

X. Liu ◽

Y. Liu ◽

S. Peng ◽

...

Keyword(s):

Postmenopausal Women ◽

Serum Lipid ◽

Lipid Profiles ◽

Chinese Postmenopausal Women

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Physical Exercise and Redox Balance in Type 2 Diabetics: Effects of Moderate Training on Biomarkers of Oxidative Stress and DNA Damage Evaluated through Comet Assay

Oxidative Medicine and Cellular Longevity ◽

10.1155/2015/981242 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 24

Author(s):

Monica Pittaluga ◽

Antonio Sgadari ◽

Ivan Dimauro ◽

Barbara Tavazzi ◽

Paolo Parisi ◽

...

Keyword(s):

Oxidative Stress ◽

Type 2 Diabetes ◽

Dna Damage ◽

Ascorbic Acid ◽

Exercise Training ◽

Comet Assay ◽

Redox Homeostasis ◽

Diabetic Patients ◽

Biomarkers Of Oxidative Stress

Objective.Hyperglycemia leads to increased production of reactive oxygen species (ROS) in type 2 diabetes, which reduces cellular antioxidant defenses and induces DNA lesions. The aim of this study was to investigate the effects on redox homeostasis and DNA oxidative damage of exercise training in patients with type 2 diabetes compared with nondiabetic individuals.Methods and Results.12 sedentary type 2 diabetic males (62.1 ± 4.3 yrs) and 12 sedentary healthy males (61.7 ± 3.9 yrs) were exposed to 4-month moderate training, 3 times per week, to evaluate the effect on plasma biomarkers of oxidative stress malondialdehyde and antioxidant status (GSSG, GSH/GSSG, and ascorbic acid) as well as basal and H2O2-induced DNA damage trough alkaline comet assay in peripheral blood lymphocytes. After training, glutathione and ascorbic acid levels increased in both groups, but only in diabetics the malondialdehyde as well as the DNA damage decreased.Conclusion.Our study demonstrates for the first time that moderate exercise training is not only effective in improving the redox homeostasis, through an increase of the endogenous antioxidant defences in healthy as well as in diabetic patients, but also, specifically in diabetic patients, effective in lowering the susceptibility to oxidative DNA damage and the lipid peroxidation levels.

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Association Between Global Biomarkers of Oxidative Stress and Hip Fracture in Postmenopausal Women: A Prospective Study

Journal of Bone and Mineral Research ◽

10.1002/jbmr.2302 ◽

2014 ◽

Vol 29 (12) ◽

pp. 2577-2583 ◽

Cited By ~ 18

Author(s):

Shuman Yang ◽

Diane Feskanich ◽

Walter C Willett ◽

A Heather Eliassen ◽

Tianying Wu

Keyword(s):

Oxidative Stress ◽

Hip Fracture ◽

Prospective Study ◽

Postmenopausal Women ◽

A Prospective Study ◽

Biomarkers Of Oxidative Stress

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Biomarkers of oxidative stress and DNA damage in agricultural workers: A pilot study

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2007.10.027 ◽

2008 ◽

Vol 227 (1) ◽

pp. 97-107 ◽

Cited By ~ 128

Author(s):

Juan F. Muniz ◽

Linda McCauley ◽

J. Scherer ◽

M. Lasarev ◽

M. Koshy ◽

...

Keyword(s):

Oxidative Stress ◽

Dna Damage ◽

Pilot Study ◽

Agricultural Workers ◽

Biomarkers Of Oxidative Stress

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Pharmacological Effects of Methotrexate and Infliximab in a Rats Model of Diet-Induced Dyslipidemia and Beta-3 Overexpression on Endothelial Cells

Journal of Clinical Medicine ◽

10.3390/jcm10143143 ◽

2021 ◽

Vol 10 (14) ◽

pp. 3143

Author(s):

Denisa-Mădălina Zălar ◽

Cristina Pop ◽

Elena Buzdugan ◽

Bela Kiss ◽

Maria-Georgia Ştefan ◽

...

Keyword(s):

Oxidative Stress ◽

Endothelial Cells ◽

Drug Treatment ◽

Serum Lipid ◽

Vascular Complications ◽

Lipid Profiles ◽

Histopathological Analysis ◽

Standard Diet ◽

Sprague Dawley ◽

And Oxidative Stress

Background: Hyperlipidemia and inflammation are critical components in the pathophysiology of endothelial disorder, which can lead to vascular complications. Our study aimed to evaluate the effects of immunomodulatory therapy (methotrexate and infliximab) in a diet-induced hyperlipidemia rat model. Methods: Sprague-Dawley (wild type (WT), male, n = 32) rats were divided into four groups: one group fed with standard diet (SD), one group fed with high lipid diet (HLD), and two groups that received HLD and drug treatment (methotrexate (Mtx) or infliximab (Ifx)). In order to evaluate if modifications to the endothelial cells may influence the risk of vascular complications following hyperlipidemia or treatment reactivity, each group was doubled by a rats group that overexpressed beta-3 receptors on the endothelial cells (transgenic (TG-beta 3), male, n = 32). Serum lipid profile, liver enzymes, oxidative stress, and inflammation markers were determined. Histopathologic analysis of the liver and aorta was performed. Results: After 9 weeks of HLD, rats exhibited significant pathologic serum lipid profiles, elevated oxidative stress, and pro-inflammatory markers. Additionally, the aortic histopathological analysis revealed aorta media-intima thickening (p < 0.05) in the transgenic group. Methotrexate and infliximab significantly decreased inflammation and oxidative stress parameters, but presented opposing effects on lipid profiles (methotrexate decreased, whereas infliximab increased the atherosclerosis index). Drug treatment decreased the aorta media-intima thickness (p < 0.05) only in transgenic rats. Conclusions: HLD was associated with hyperlipidemia, inflammation and oxidative stress. The overexpression of beta-3 receptors on endothelial cells increased aortic thickening in response to the HLD. Methotrexate and infliximab reduced oxidative stress and inflammation in all groups, but led to favorable histopathologic vascular results only in the transgenic groups.

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