It is expected that in 2050, there will be more than 20% of senior citizens aged over 60 years
worldwide. Such alarming statistics require immediate attention to improve the health of the aging
population. Since aging is closely related to the loss of antioxidant defense mechanisms, this situation
eventually leads to numerous health problems, including fertility reduction. Furthermore, plant extracts
have been used in traditional medicine as potent antioxidant sources. Although many experiments had
reported the impact of various bioactive compounds on aging or fertility, there is a lack of review papers
that combine both subjects. In this review, we have collected and discussed various bioactive
compounds from 26 different plant species known to affect both longevity and fertility. These compounds,
including phenolics and terpenes, are mostly involved in the antioxidant defense mechanisms
of diverse organisms such as rats, mites, fruit flies, roundworms, and even roosters. A human clinical
trial should be considered in the future to measure the effects of these bioactive compounds on human
health and longevity. Ultimately, these plant-derived compounds could be developed into health supplements
or potential medical drugs to ensure a healthy aging population.