Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels

2010 ◽  
Vol 43 (9) ◽  
pp. 754-758 ◽  
Author(s):  
Hirschfeldova Katerina ◽  
Sedova Michaela ◽  
Vrablik Michal ◽  
Svobodova Helena ◽  
Zvarova Jana ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hdl Cholesterol ◽  
Sequence Variants ◽  
Cholesterol Levels ◽  
Common Sequence

scholarly journals PENGARUH SINBIOTIK KEFIR PISANG BATU TERHADAP KADAR KOLESTEROL-LDL DAN KOLESTEROL-HDL TIKUS MODEL SINDROM METABOLIK

2020 ◽  
Vol 7 (2) ◽  
pp. 280-288
Author(s):  
Dina Khoiriyah ◽  
Taufik Maryusman ◽  
Santi Herlina
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Positive Control ◽  
Negative Control ◽  
Sprague Dawley ◽  
Musa Balbisiana ◽  
Cholesterol Levels ◽  
Sprague Dawley Rats

Effect of Banana Kefir Synbiotic on LDL-Cholesterol and HDL-Cholesterol of Metabolic Syndrome Rats Metabolic syndrome (SM) is characterized by several risk factors including dyslipidemia. This study aims to analyze the effect of kefir synbiotic produced from banana stone flour (Musa balbisiana) on LDL-cholesterol and HDL-cholesterol of metabolic syndrome rat model. The 24 Sprague Dawley rats were divided into four groups, namely negative control (healthy rats fed standard feed), positive control (metabolic syndrome rats fed standard feed), treatment I and treatment II (metabolic syndrome rats each given synbiotic kefir banana stone flour 1.8 mL/200 g mouse BW/day and 3.6 mL/200 g mouse BW/day, respectively). The intervention was carried out for three weeks. After the intervention, the levels of LDL-cholesterol in treatment I and II experienced a decrease of 44.66% and 56.94%, respectively, while the-HDL-cholesterol levels in treatment I and II experienced an increase of 104.5% and 172.71%, respectively. The biggest change occurred in treatment II. Synbiotic kefir banana stone flour improved lipid profile in metabolic syndrome rats. Sindrom metabolik (SM) ditandai dengan beberapa faktor risiko termasuk dislipidemia. Penelitian ini bertujuan untuk menganalisis pengaruh sinbiotik kefir tepung pisang batu (Musa balbisiana) terhadap kadar kolesterol-LDL dan kolesterol-HDL tikus model SM. Subjek menggunakan 24 ekor tikus Sprague Dawley yang dibagi menjadi empat kelompok, yaitu kontrol negatif (tikus sehat yang diberi pakan standar), kontrol positif (tikus model SM yang diberi pakan standar), perlakuan I dan perlakuan II (tikus model SM yang masing-masing diberi sinbiotik kefir tepung pisang batu 1,8 mL/200 g BB tikus/hari dan 3,6 mL/200 g BB tikus/hari). Proses intervensi dilakukan selama tiga minggu. Setelah intervensi, kadar kolesterol-LDL perlakuan I dan II mengalami penurunan sebesar 44,66% dan 56,94%, sedangkan kadar kolesterol-HDL perlakuan I dan II mengalami peningkatan sebesar 104,5% dan 172,71%. Perubahan terbesar terjadi pada perlakuan II. Sinbiotik kefir tepung pisang batu memperbaiki profil lipid tikus sindrom metabolik.

Correlation between sarcopenia and atherosclerosis/cardiovascular risk factors in the elderly

2020 ◽  
Vol 30 (Supplement_2) ◽  
Author(s):  
A Sousa-Coelho ◽  
M Botelho ◽  
C Guerreiro ◽  
S Pais
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Muscle Strength ◽  
Total Cholesterol ◽  
Muscle Function ◽  
Hdl Cholesterol ◽  
The Elderly ◽  
Cholesterol Ratio ◽  
Cholesterol Levels ◽  
Risk Of Falls

Abstract Introduction Sarcopenia is the age-related loss of skeletal muscle mass, strength and function. Uncontrolled diabetes, obesity, chronic inflammation and lipid abnormalities, cause decreases in muscle strength, which contributes to disease-related morbidity. Objectives The main goal of this study was to correlate the prevalence of sarcopenia with atherosclerosis and cardiovascular risk factors, mainly estimated by cholesterol, triglycerides, C-reactive protein (CRP) and HbA1c levels, in the elderly. Methodology A quantitative observational cross-sectional study was performed in a convenience sample of individuals aged over 60 years old recruited non-randomly. Main study variables were body composition (seca® mBCA515), muscle strength (peak torque, Humac NORM isokinetic dynamometer), risk of falls (TUG test), muscle function (LEFS) and lipids, inflammation and glycaemic profile (cobas b101-Roche®). Results Total cholesterol levels fully correlated with LDL and non-HDL cholesterol, and partially with triglycerides, but not with HDL-cholesterol levels, HbA1c, or BMI. LDL-cholesterol levels did not correlate with muscle mass (free-fat mass (%)), strength, function, or risk of falls. Similarly, HDL-cholesterol levels did not correlate with muscle function or falls risk. Cholesterol ratio, obtained by dividing total cholesterol by HDL-cholesterol levels, was significantly higher in individuals with CRP levels above 3 mg/L. Interestingly, when compared to normal values, individuals with triglycerides above 150 mg/dL showed a statistically significant decrease in muscle strength. Conclusion From the biochemical measured parameters, our data showed that only high triglycerides levels positively correlated with sarcopenia risk, demonstrated by reduced muscle strength. While cholesterol ratio positively correlated with increased inflammation, blood cholesterol levels seem to be independent factors regarding sarcopenia prevalence.

Dietary sodium:potassium ratio and CVD risk factors among Japanese adults: a retrospective cross-sectional study of pooled data from the National Health and Nutrition Survey, 2003–2017

2020 ◽  
Vol 125 (1) ◽  
pp. 79-91
Author(s):  
Emiko Okada ◽  
Chika Okada ◽  
Mai Matsumoto ◽  
Aya Fujiwara ◽  
Hidemi Takimoto
Keyword(s):  
Risk Factors ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Cvd Risk Factors ◽  
Nutrition Survey ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
Cholesterol Levels ◽  
Japanese Adults

AbstractFew studies have reported associations between the Na:K ratio and risk factors related to CVD among the general population in Asian countries. This study aimed to investigate the dietary Na:K ratio association with CVD risk factors among Japanese adults. This retrospective cross-sectional study included 48 800 Japanese participants (19 386 men and 29 414 women) aged ≥20 years, registered in the 2003–2017 National Health and Nutrition Survey. Multivariate OR and 95 % CI for risk of hypertension, high glycated HbA1c levels, hypercholesterolaemia, low serum levels of HDL-cholesterol and high non-HDL-cholesterol levels according to the Na:K ratio were estimated using logistic regression models. Dietary Na:K ratio decreased for both men and women from 2003 to 2017. Higher Na:K ratio and higher hypertension prevalence were observed (multivariate OR (fifth v. first quintiles) 1·27, 95 % CI 1·15, 1·40; Pfor trend < 0·001 for men and 1·12, 95 % CI 1·01, 1·23; Pfor trend = 0·007 for women). Higher Na:K ratio was associated with higher prevalence of high HbA1c levels in men (multivariate OR 1·56, 95 % CI 1·24, 1·96). Prevalence of low HDL-cholesterol levels was increased with higher Na:K ratio (Pfor trend =0·002 for men and <0·001 for women). No significant associations were found between Na:K ratio and hypercholesterolaemia in men or high non-HDL-cholesterol levels in both men and women. Our findings suggest that dietary Na:K ratio is associated with several CVD risk factors among Japanese adults.

Intravascular Ultrasound in the Determination of the Mechanical Properties of Diabetic Arteries

2000 ◽  
Vol 6 (S2) ◽  
pp. 546-547
Author(s):  
D. Geoffrey Vince ◽  
Azita Tajaddini ◽  
Alex I. Veress
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Protein Complexes ◽  
Elevated Serum ◽  
Fold Increase ◽  
Amino Groups ◽  
Cholesterol Levels ◽  
Vascular Elasticity ◽  
Elevated Serum Cholesterol

Cardiovascular disease is the leading cause of morbidity and mortality in diabetic individuals. Diabetes mellitus is associated with a two- to four-fold increase in risk of coronary heart disease. This risk is independent of other classical risk factors including age, smoking, elevated serum cholesterol levels, and hypertension, and the overall risk of cardiovascular disease increases proportionally with the number of risk factors. Many groups are currently investigating the aetiology of diabetic vascular disease, with particular interesting being paid to the processes involved in the formation of highly cross-linked carbohydrate-protein complexes known as melanoids. These complexes appear to be formed by glycation arising from reactions between glucose and the amino groups on proteins, and their formation within the vessel wall resqlts in a decrease in vascular elasticity. This decrease in elasticity has been implicated in the increased incidence of atherosclerosis in diabetic individuals. Previous testing modalities could not test in the radial direction and required assumptions based on incompressibility in order to determine the radial behavior of the artery.

scholarly journals Diagnostic Accuracy of IGA Anti-Tissue Transglutaminase Antibody Testing in Celiac Disease

2012 ◽  
Vol 31 (2) ◽  
pp. 100-106
Author(s):  
Nevena Eremić ◽  
Mirjana Đerić ◽  
Ljiljana Hadnađev
Keyword(s):  
Celiac Disease ◽  
Diagnostic Accuracy ◽  
Tissue Transglutaminase ◽  
Hdl Cholesterol ◽  
Total Serum ◽  
Antibody Testing ◽  
Cholesterol Levels ◽  
Serum Iga ◽  
Tissue Transglutaminase Antibodies

Diagnostic Accuracy of IGA Anti-Tissue Transglutaminase Antibody Testing in Celiac DiseaseContemporary guidelines for the first-line diagnosis of celiac disease recommend determination of IgA anti-tissue transglutaminase antibodies or IgA antiendomysial antibodies, as well as total serum IgA antibodies. The aim of our study was to assess the validity and clinical significance of serological testing for IgA anti-tissue transglutaminase antibodies in the diagnosis of celiac disease, and to investigate the presence of malabsorption symptoms in celiac patients. IgA anti-tissue transglutaminase antibody testing was performed in 50 subjects with clinically suspected celiac disease (21 men and 29 women). All subjects underwent endoscopy with small intestine biopsy. Celiac disease was confirmed by histopathological findings in four subjects, whereas the IgA anti-tissue transglutaminase test was positive in three subjects. The IgA anti-tissue transglutaminase test showed sensitivity of 75% and specificity of 100%. There were significant differences between men with biopsy-confirmed and excluded celiac disease in the erythrocyte parameters MCV (96.5±7.7 vs. 78.6 ±11.3; p<0.05), MCH (36.9±4.6 vs. 25.9±4.9; p<0.01), and MCHC (382.5±16.3 vs. 326.9±19.1; p<0.005), as well as in the levels of total protein (47.5 ±16.3 vs. 68.3 ± 7.6; p<0.01) and albumins (24.6±9.5 vs. 42.1 ± 6.9; p<0.01). In addition, HDL-cholesterol levels were significantly lower in men with biopsy-confirmed celiac disease (0.42.±0.12 vs. 0.90±0.30; p<0.05). Our results show a high correlation between IgA anti-tissue transglutaminase testing and endoscopy with biopsy as the gold diagnostic standard.

scholarly journals High Density Lipoprotein (HDL) Cholesterol levels in young pregnant Women

2017 ◽  
Vol 1 (2) ◽  
Author(s):  
Shishir Kumar Suman
Keyword(s):  
Risk Factors ◽  
High Density Lipoprotein ◽  
Coronary Disease ◽  
Disease Risk ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Long Term Effects ◽  
Cholesterol Levels ◽  
Increased Risk

A woman's reproductive history may affect her risk for coronary heart disease. Parity has been associated with increased coronary disease risk in some studies, while other studies have shown that nulliparous women are at increased risk (1-3). Pregnancy fre­quency (including frequency of spontaneous abortion (4, 5)) and age at first pregnancy (6) have also been associated with increased coronary disease risk. Although reports of associations of coronary disease risk with parity, age at menarche, or incidence of miscar­riage are not all consistent (7, 8), the majority of cohort studies have shown an increased risk of coro­nary disease among women with high gravidity or parity (9). Long-term effects of pregnancy on coronary disease risk factors, such as lipoproteins (10, 11), are potential mechanisms for an association between par­ity and coronary artery disease risk. Marked increases in lipoprotein concentrations oc­cur during pregnancy (12) and have been correlated with pregnancy-related increases in insulin, 17-beta estradiol, progesterone, and human placental lactogen (13). Total and low density lipoprotein (LDL) choles­terol and triglyceride levels progressively increase during gestation (10, 14). Although triglycerides have been reported to decrease rapidly during the postpar­tum period, total and LDL cholesterol levels may require several months to return to baseline (10, 14). High density lipoprotein (HDL) cholesterol, which has been shown to be inversely associated with coronary disease risk among women (15, 16), peaks at mid- gestation and then falls to levels approximately 15 percent above baseline at term (12). Few data are available on the long-term effects of pregnancy on lipoproteins; however, there are reports of inverse associations between parity and postpartum HDL cho­lesterol levels (17-20). In order to examine further relations of parity with lipid risk factors, we assessed plasma lipids at baseline and at the year 1 and year 2 follow-up examinations among young adult women in an ongoing epidemiologic study.

P6234The relationship of alcohol consumption with risk factors of coronary heart disease and the intake of macro- and micro-nutrients in Japanese: the INTERLIPID study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
H Yamauchi ◽  
K Kondo ◽  
S Tanaka ◽  
N Okuda ◽  
H Nakagawa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alcohol Consumption ◽  
Lower Risk ◽  
Nutrient Intake ◽  
Hdl Cholesterol ◽  
Men And Women ◽  
Cholesterol Levels ◽  
Chd Risk ◽  
Drinking Status ◽  
Chd Risk Factors

Abstract Background Many studies have reported the J-shaped relationship between alcohol consumption and coronary heart disease (CHD) risk; therefore, light-drinkers is generally recognized to be associated with the lower risk of CHD. However, the mechanisms of lower risk for CHD in light-drinkers are still unclear. Alcohol drinking status is likely to be associated with not only CHD risk factors but also dietary intake. Nevertheless, few studies report these relationships in detail. Purpose The purpose of this study is to evaluate the relationships of alcohol drinking status with CHD classical risk factors and the intake of macro- and micro- nutrients in Japanese. Methods Study participants were 1,090 Japanese men and women aged 40–59 years from The INTERLIPID study excepted for 55 individuals who had missing data (n=26) and were past-drinkers (n=29). Alcohol consumption was assessed with two 7-day alcohol records, and average ethanol intake (per week) was calculated. Participants were classified into following 4 groups: non-drinkers (0g/week), light-drinkers (<100 g/week), moderate-drinkers (100–299 g/week), and heavy-drinkers (≥300 g/week). Serum LDL and HDL cholesterol, blood pressure (BP), the prevalence of hypertension and dyslipidemia, and smoking status were assessed as CHD risk factors. The intake of energy and macro- and micro-nutrients were evaluated from the four-timed in-depth 24-hr dietary recalls. Nutrient intake densities were calculated per total energy intake without alcohol. The analysis of variance and chi-squared test were used to evaluate the relations of alcohol status with CHD risk factors and nutrient intake. Results Serum HDL cholesterol levels increased and LDL cholesterol levels decreased with increasing alcohol consumption. Systolic and diastolic BP increased with increasing alcohol consumption. J-shaped relationships with alcohol consumption were observed for the proportion of current smoker, number of cigarettes, and the prevalence of hypertension; that is, light-drinkers was lowest among all groups. The prevalence of dyslipidemia was the highest in non-drinkers, and decreased with increasing alcohol consumption. In heavy-drinkers, total energy (kcal/day) was the highest, but energy intake without alcohol (kcal/day) was the lowest. For macronutrients, the intake of carbohydrate (%kcal) decreased, and the intakes of total and animal protein (%kcal) increased with increasing alcohol consumption. The intakes of total cholesterol (mg/1000kcal) and sodium (mg/1000kcal) increased, and total fiber (g/1000kcal) decreased with increasing alcohol consumption. These associations were similar in men and women. Conclusions Alcohol consumption was related with not only CHD classical risk factors but also the intake of macro- and micro-nutrients. Non-drinkers had a higher proportion of some CHD risk factors than light-drinkers. These results might influence on J-shaped relationship between alcohol consumption and CHD risk. Acknowledgement/Funding 1: Ministry of Education, Science, Sports, and Culture of Japan, 2: National Institutes of Health, Bethesda, MD, USA

Risk prediction of incident coronary heart disease in the Netherlands: re-estimation and improvement of the SCORE risk function

2011 ◽  
Vol 19 (4) ◽  
pp. 840-848 ◽  
Author(s):  
Audrey HH Merry ◽  
Jolanda MA Boer ◽  
Leo J Schouten ◽  
Ton Ambergen ◽  
Ewout W Steyerberg ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Risk Prediction ◽  
Risk Function ◽  
Hdl Cholesterol ◽  
Risk Category ◽  
Cholesterol Ratio ◽  
Cholesterol Levels ◽  
C Statistic ◽  
Score Risk

Aims: To re-estimate the SCORE risk function using individual data on risk factors and coronary heart disease (CHD) incidence from the Dutch Cardiovascular Registry Maastricht (CAREMA) population-based cohort study; to evaluate changes that may improve risk prediction after re-estimation; and to compare the performance of the resulting CAREMA risk function with that of existing risk scores. Methods and results: The cohort consisted of 21,148 participants, born in 1927–1977 and randomly sampled from the Maastricht region in 1987–1997. After follow-up (median 10.9 years), 783 incident CHD cases occurred. Model performance was assessed by discrimination and calibration. The additional value of including other risk factors or current risk factors in a different manner was evaluated using the net reclassification index (NRI). The c statistic of the re-estimated SCORE model was 0.799 (95% CI 0.782–0.816). Separating the total/high-density lipoprotein (HDL) cholesterol ratio into total and HDL cholesterol levels did not improve the c statistic ( p = 0.22), but reclassified 6.0% of the participants into a more appropriate risk category ( p < 0.001) compared with the re-estimated model. The resulting CAREMA function reclassified 28% of the participants into a more appropriate risk category than the Framingham score. Compared with the SCORE functions for high- and low-risk regions, the NRIs were 28% and 35%, respectively, which can largely be explained by the difference in outcome definition (CHD incidence vs. CHD mortality). Conclusion: In this Dutch population, a re-estimated SCORE function with total and HDL cholesterol levels instead of the cholesterol ratio can be used for the risk prediction of CHD incidence.

Sign in / Sign up

Export Citation Format

Share Document