Highly porous Ti as a bone substitute: triboelectrochemical characterization of highly porous Ti against Ti alloy under fretting-corrosion conditions

Abstract Background We developed a porous Ti alloy/PEEK composite interbody cage by utilizing the advantages of polyetheretherketone (PEEK) and titanium alloy (Ti alloy) in combination with additive manufacturing technology. Methods Porous Ti alloy/PEEK composite cages were manufactured using various controlled porosities. Anterior intervertebral lumbar fusion and posterior augmentation were performed at three vertebral levels on 20 female pigs. Each level was randomly implanted with one of the five cages that were tested: a commercialized pure PEEK cage, a Ti alloy/PEEK composite cage with nonporous Ti alloy endplates, and three composite cages with porosities of 40, 60, and 80%, respectively. Micro-computed tomography (CT), backscattered-electron SEM (BSE-SEM), and histological analyses were performed. Results Micro-CT and histological analyses revealed improved bone growth in high-porosity groups. Micro-CT and BSE-SEM demonstrated that structures with high porosities, especially 60 and 80%, facilitated more bone formation inside the implant but not outside the implant. Histological analysis also showed that bone formation was higher in Ti alloy groups than in the PEEK group. Conclusion The composite cage presents the biological advantages of Ti alloy porous endplates and the mechanical and radiographic advantages of the PEEK central core, which makes it suitable for use as a single implant for intervertebral fusion.

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Preparation and Characterization of Chitosan-Casein Phosphopeptides Biocomposite Coatings on the Medical Titanium Alloy

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.480-481.1065 ◽

2011 ◽

Vol 480-481 ◽

pp. 1065-1069

Author(s):

Bin Liu ◽

Lin Wang ◽

Yin Zhong Bu ◽

Sheng Rong Yang ◽

Jin Qing Wang

Keyword(s):

Photoelectron Spectroscopy ◽

Attenuated Total Reflectance ◽

Ti Alloy ◽

Force Microscopy ◽

Implant Materials ◽

Atomic Force ◽

Casein Phosphopeptides ◽

Potential Applications ◽

First Time

Titanium (Ti) and its alloys have been applied in orthopedics as one of the most popular biomedical metallic implant materials. In this work, to enhance the bioactivity, the surface of Ti alloy pre-modified by silane coupling agent and glutaraldehyde was covalently grafted with chitosan (CS) via biochemical multistep self-assembled method. Then, for the first time, the achieved surface was further immobilized with casein phosphopeptides (CPP), which are one group of bioactive peptides released from caseins in the digestive tract and can facilitate the calcium adsorption and usage, to form CS-CPP biocomposite coatings. The structure and composition of the fabricated coatings were characterized by X-ray photoelectron spectroscopy (XPS), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and atomic force microscopy (AFM). As the experimental results indicated, multi-step assembly was successfully performed, and the CS and CPP were assembled onto the Ti alloy surface orderly. It is anticipated that the Ti alloys modified by CS-CPP biocomposite coatings will find potential applications as implant materials in biomedical fields.

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Development and Characterization of Biomedical Porous Ti–20Nb–5Ag Alloy: Microstructure, Mechanical Properties, Surface Bioactivity and Cell Viability Studies

Metals and Materials International ◽

10.1007/s12540-020-00915-2 ◽

2021 ◽

Author(s):

M. J. Shivaram ◽

Shashi Bhushan Arya ◽

Jagannath Nayak ◽

Bharat B. Panigrahi

Keyword(s):

Mechanical Properties ◽

Cell Viability ◽

Porous Ti ◽

Alloy Microstructure

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Characterization of highly porous nanoparticle deposits by permeance measurements

Powder Technology ◽

10.1016/j.powtec.2010.11.009 ◽

2011 ◽

Vol 207 (1-3) ◽

pp. 279-289 ◽

Cited By ~ 13

Author(s):

Tobias D. Elmøe ◽

Antonio Tricoli ◽

Jan-Dierk Grunwaldt

Keyword(s):

Highly Porous

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Thermal and morphological characterization of highly porous nanocomposites for possible application in potassium controlled release

Journal of Thermal Analysis and Calorimetry ◽

10.1007/s10973-017-6755-9 ◽

2017 ◽

Vol 131 (3) ◽

pp. 2205-2212 ◽

Cited By ~ 5

Author(s):

Carlos Roberto Ferreira Junior ◽

Fabrício Nunes Tanaka ◽

Adriel Bortolin ◽

Márcia Regina de Moura ◽

Fauze Ahmad Aouada

Keyword(s):

Controlled Release ◽

Morphological Characterization ◽

Porous Nanocomposites ◽

Highly Porous

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Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/borax /CaCO3 and Demineralized Bone Matrix

10.20944/preprints202106.0545.v1 ◽

2021 ◽

Author(s):

Daniela Medrano-David ◽

Aura Maria Lopera ◽

Martha Elena Londoño ◽

Pedronel Araque-Marín

Keyword(s):

Bone Substitute ◽

Demineralized Bone Matrix ◽

Bone Matrix ◽

Particulate Material ◽

Bone Tissue Regeneration ◽

Bone Implant ◽

Injectable Scaffold ◽

The World ◽

Demineralized Bone

The occurrence of bone-related disorders and diseases has increased dramatically in recent years around the world. Demineralized bone matrix (DBM) has been widely used as a bone implant due to its osteoinduction and bioactivity. However, the use of DBM is limited because it is a particulate material, which makes it difficult to manipulate and implant with precision, in addition, these particles are susceptible to migrate to other sites. To address this situation, DBM is commonly incorporated into a variety of carriers. An injectable scaffold has advantages over bone grafts or preformed scaffolds, such as the ability to flow and fill the bone defect. The aim of this research is to develop a DBM carrier with such viscoelastic properties to obtain an injectable bone substitute (IBS). The DBM carrier developed consisted of a PVA/glycerol network cross-linked with borax and reinforced with CaCO3 as a pH neutralizer, porosity generator, and source of Ca. The physicochemical properties were determined by the injectability test, FTIR, SEM, and TGA. Porosity, degradation, bioactivity, possible cytotoxic effect, and proliferation in osteoblasts were also determined. The results show that the developed material has great potential to be used in bone tissue regeneration

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Additive-Manufactured Ti-6Al-4V/Polyetheretherketone Composite Porous Cage for Interbody Fusion: Bone Growth and Biocompatibility Evaluation in a Porcine Model

10.21203/rs.3.rs-57333/v1 ◽

2020 ◽

Author(s):

Pei-I Tsai ◽

Meng-Huang Wu ◽

Yen-Yao Li ◽

Tzu-Hung Lin ◽

Jane SC Tsai ◽

...

Keyword(s):

Bone Formation ◽

Bone Growth ◽

Lumbar Fusion ◽

High Porosity ◽

Ti Alloy ◽

Micro Ct ◽

Micro Computed Tomography ◽

Intervertebral Fusion ◽

Porous Ti ◽

Peek Composite

Abstract Background: We developed a porous Ti alloy/PEEK composite interbody cage by utilizing the advantages of polyetheretherketone (PEEK) and titanium alloy (Ti alloy) in combination with additive manufacturing technology. Methods: Porous Ti alloy/PEEK composite cages were manufactured using various controlled porosities. Anterior intervertebral lumbar fusion and posterior augmentation were performed at three vertebral levels on 20 female pigs. Each level was randomly implanted with one of the five cages that were tested: a commercialized pure PEEK cage, a Ti alloy/PEEK composite cage with nonporous Ti alloy endplates, and three composite cages with porosities of 40%, 60%, and 80%, respectively. Micro-computed tomography (CT), backscattered-electron SEM (BSE-SEM), and histological analyses were performed.Results: Micro-CT and histological analyses revealed improved bone growth in high-porosity groups. Micro-CT and BSE-SEM demonstrated that structures with high porosities, especially 60% and 80%, facilitated more bone formation inside the implant but not outside the implant. Histological analysis also showed that bone formation was higher in Ti alloy groups than in the PEEK group. Conclusion: The composite cage presents the biological advantages of Ti alloy porous endplates and the mechanical and radiographic advantages of the PEEK central core, which makes it suitable for use as a single implant for intervertebral fusion.

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Preparation and Characterization of Ni/ZrCoCe Stack Getter Films

Materials Science Forum ◽

10.4028/www.scientific.net/msf.944.619 ◽

2019 ◽

Vol 944 ◽

pp. 619-624

Author(s):

Peng Yuan ◽

Yao Zong Sui ◽

Xiao Zhang ◽

Hao Liu ◽

Feng Wei ◽

...

Keyword(s):

Electron Microscope ◽

Scanning Electron Microscope ◽

Magnetron Sputtering ◽

Film Surface ◽

Protective Layer ◽

Sem Analysis ◽

And Diffusion ◽

Highly Porous ◽

Scanning Electron

In order to improve the oxidation resistance of the ZrCoCe getter, highly porous Ni/ZrCoCe stack getter films were grown by the magnetron sputtering method. Scanning electron microscope (SEM) analysis indicate that the Ni/ZrCoCe stack film is composed of isolated columns. The film surface with cauliflower-like topography is formed among finely packed nanocrystals. Gas sorption investigation shows that the Ni/ZrCoCe stack film can be activated at 300 °C for 30 min and exhibits more favorable sorption capability than ZrCoCe bi-layered film. XPS results show that the Ni protective layer can play an important role in protecting the ZrCoCe film against oxidation. It can also improve the surface dissociation and diffusion of H2.

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From Bio-waste to Bone Substitute

Chemical and Biochemical Engineering Quarterly ◽

10.15255/cabeq.2020.1783 ◽

2020 ◽

Vol 34 (2) ◽

pp. 59-71

Author(s):

Antonia Ressler ◽

Karla Zadro ◽

Hrvoje Ivanković ◽

Marica Ivanković ◽

Matija Cvetnić ◽

...

Keyword(s):

Calcium Phosphate ◽

Bone Substitute ◽

Bone Growth ◽

Composite Scaffold ◽

Composite Scaffolds ◽

Nanocomposite Structure ◽

Na Ions ◽

Biomimetic Hydroxyapatite ◽

Highly Porous ◽

Interconnected Pores

Nanocomposite structure of the bone can be mimicked by chitosan/hydroxyapatite (CS/HAp) composite scaffold. Biological hydroxyapatite (HAp) contains various ions, which have a crucial role in bone growth. The aim of the present work was to synthesize biomimetic hydroxyapatite and prepare composite scaffolds based on chitosan, where HAp was synthesised from hen eggshells, seashells and cuttlefish bone. The powders were composed of nano-structured calcium deficient HAp and amorphous calcium phosphate (ACP). In the as-prepared powders, Sr2+, Mg2+ and Na+ ions were detected as a result of using biogenic precursor of Ca2+ ions. Highly porous CS/HAp structures have been prepared by freeze-gelation technique. The CS/HAp scaffolds have shown highly porous structure with very well interconnected pores and homogeneously dispersed HAp particles. The MTT assay of CS/HAp scaffolds has shown no toxicity, and the live/dead assay has confirmed good viability and proliferation of seeded cells.

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